ZNF785

Summary

ZNF785 (zinc finger protein 785, HGNC:26496) is a protein-coding gene on chromosome 16p11.2, encoding Zinc finger protein 785 (A8K8V0). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 146540 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_152458

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26496
Approved symbol	ZNF785
Name	zinc finger protein 785
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ32130
Ensembl gene	ENSG00000197162
Ensembl biotype	protein_coding
Entrez	146540

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 nonsense_mediated_decay

ENST00000395216, ENST00000470110, ENST00000562128, ENST00000567773, ENST00000891565, ENST00000891566, ENST00000912832, ENST00000912833, ENST00000912834, ENST00000971000

RefSeq mRNA: 1 — MANE Select: NM_152458 NM_152458

CCDS: CCDS10685

Canonical transcript exons

ENST00000395216 — 3 exons

Exon	Start	End
ENSE00001520941	30580656	30583443
ENSE00001925588	30585407	30585697
ENSE00003482977	30585122	30585250

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 93.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0964 / max 53.8371, expressed in 1422 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157072	2.4311	1057
157071	1.6652	893

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	93.10	gold quality
oviduct epithelium	UBERON:0004804	88.15	gold quality
kidney epithelium	UBERON:0004819	85.03	gold quality
ganglionic eminence	UBERON:0004023	84.52	gold quality
cortical plate	UBERON:0005343	83.53	gold quality
apex of heart	UBERON:0002098	82.98	gold quality
cerebellar vermis	UBERON:0004720	82.80	gold quality
cerebellar hemisphere	UBERON:0002245	82.74	gold quality
cerebellar cortex	UBERON:0002129	82.71	gold quality
cerebellum	UBERON:0002037	82.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.32	gold quality
pylorus	UBERON:0001166	82.09	gold quality
thymus	UBERON:0002370	81.64	gold quality
cardia of stomach	UBERON:0001162	81.57	gold quality
sural nerve	UBERON:0015488	81.49	gold quality
vena cava	UBERON:0004087	80.98	silver quality
stromal cell of endometrium	CL:0002255	80.93	gold quality
subthalamic nucleus	UBERON:0001906	80.93	gold quality
ventral tegmental area	UBERON:0002691	80.90	gold quality
ventricular zone	UBERON:0003053	80.54	gold quality
dorsal plus ventral thalamus	UBERON:0001897	80.12	gold quality
fallopian tube	UBERON:0003889	80.05	gold quality
left ventricle myocardium	UBERON:0006566	80.04	gold quality
right ovary	UBERON:0002118	80.03	gold quality
cardiac muscle of right atrium	UBERON:0003379	79.94	gold quality
renal medulla	UBERON:0000362	79.89	gold quality
inferior vagus X ganglion	UBERON:0005363	79.69	gold quality
body of uterus	UBERON:0009853	79.64	gold quality
body of tongue	UBERON:0011876	79.64	silver quality
endocervix	UBERON:0000458	79.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

60 targeting ZNF785, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-2681-5P	99.75	67.64	1655
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-372-5P	99.41	69.11	2299
HSA-MIR-508-5P	99.41	64.25	1248
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362

Cross-species orthologs

15 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf646	ENSDARG00000061424
danio_rerio	si:dkey-89b17.4	ENSDARG00000075545
danio_rerio	zgc:66472	ENSDARG00000075916
danio_rerio	si:ch211-148l7.4	ENSDARG00000094469
danio_rerio	znf576.1	ENSDARG00000097819
drosophila_melanogaster	az2	FBGN0025185
drosophila_melanogaster	CG2129	FBGN0030008
drosophila_melanogaster	CG1602	FBGN0033186
drosophila_melanogaster	CG18011	FBGN0033491
drosophila_melanogaster	CG12942	FBGN0033569
drosophila_melanogaster	indra	FBGN0035213
drosophila_melanogaster	CG30020	FBGN0050020
drosophila_melanogaster	mld	FBGN0263490
caenorhabditis_elegans	ztf-15	WBGENE00011066
caenorhabditis_elegans		WBGENE00015649

Paralogs (36): ZNF302 (ENSG00000089335), ZNF184 (ENSG00000096654), CTCF (ENSG00000102974), ZNF574 (ENSG00000105732), ZBTB24 (ENSG00000112365), ZNF142 (ENSG00000115568), CTCFL (ENSG00000124092), ZNF473 (ENSG00000142528), ZNF827 (ENSG00000151612), ZNF689 (ENSG00000156853), ZNF208 (ENSG00000160321), ZNF91 (ENSG00000167232), ZNF526 (ENSG00000167625), ZNF764 (ENSG00000169951), ZNF747 (ENSG00000169955), ZNF282 (ENSG00000170265), ZNF160 (ENSG00000170949), ZNF497 (ENSG00000174586), ZBTB34 (ENSG00000177125), ZNF771 (ENSG00000179965), ZNF48 (ENSG00000180035), ZNF594 (ENSG00000180626), ZBTB37 (ENSG00000185278), ZFP92 (ENSG00000189420), ZNF107 (ENSG00000196247), ZNF729 (ENSG00000196350), ZNF569 (ENSG00000196437), ZNF420 (ENSG00000197050), ZNF665 (ENSG00000197497), ZNF181 (ENSG00000197841), ZNF347 (ENSG00000197937), ZNF84 (ENSG00000198040), ZBTB48 (ENSG00000204859), ZNF845 (ENSG00000213799), ZNF99 (ENSG00000213973), ZNF688 (ENSG00000229809)

Protein

Protein identifiers

Zinc finger protein 785 — A8K8V0 (reviewed: A8K8V0)

All UniProt accessions (3): A8K8V0, H3BR67, I3L119

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
A8K8V0-1	1	yes
A8K8V0-2	2

RefSeq proteins (1): NP_689671* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050589	Ikaros_C2H2-ZF	Family

Pfam: PF00096, PF01352

UniProt features (15 total): zinc finger region 7, region of interest 2, sequence variant 2, chain 1, domain 1, compositionally biased region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8K8V0-F1	63.77	0.10

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 52 (showing top): chr16p11, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, HATADA_METHYLATED_IN_LUNG_CANCER_UP, MARTENS_TRETINOIN_RESPONSE_DN, ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES, BARX1_TARGET_GENES, CREB3L4_TARGET_GENES, DIDO1_TARGET_GENES, E2F2_TARGET_GENES, E2F5_TARGET_GENES, HSD17B8_TARGET_GENES, KAT5_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

482 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF785	KIAA1958	Q8N8K9	425
ZNF785	CCDC74B	Q96LY2	400
ZNF785	CCDC169	A6NNP5	379
ZNF785	CCDC190	Q86UF4	370
ZNF785	CCDC125	Q86Z20	357
ZNF785	RNPEPL1	Q9HAU8	348
ZNF785	CENATAC	Q86UT8	348
ZNF785	GTF3C6	Q969F1	348
ZNF785	ZBTB8A	Q96BR9	348
ZNF785	CCDC171	Q6TFL3	318
ZNF785	MOSPD3	O75425	311
ZNF785	THAP7	Q9BT49	306
ZNF785	AVL9	Q8NBF6	301
ZNF785	ZSWIM4	Q9H7M6	299
ZNF785	SLC25A45	Q8N413	297

IntAct

78 interactions, top by confidence:

A	B	Type	Score
ZNF785	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	ZNF785	psi-mi:“MI:0915”(physical association)	0.670
ZNF785	PNMA2	psi-mi:“MI:0915”(physical association)	0.670
ZNF785	EHMT2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-5	ZNF785	psi-mi:“MI:0915”(physical association)	0.560
HOOK1	ZNF785	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	MID2	psi-mi:“MI:0915”(physical association)	0.560
ZNF785		psi-mi:“MI:0915”(physical association)	0.560
ZNF785	KRTAP10-5	psi-mi:“MI:0915”(physical association)	0.560
	ZNF785	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
CABP2	ZNF785	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	TRIP6	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	MDFI	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	STX2	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (152): ZNF785 (Two-hybrid), ZNF785 (Two-hybrid), ZNF785 (Two-hybrid), ZNF785 (Two-hybrid), KRTAP10-1 (Two-hybrid), KRTAP10-5 (Two-hybrid), BEND3 (Affinity Capture-MS), DOCK6 (Affinity Capture-MS), TRIO (Affinity Capture-MS), SMARCAD1 (Affinity Capture-MS), LZTS2 (Affinity Capture-MS), MTCL1 (Affinity Capture-MS), KIF7 (Affinity Capture-MS), PDZRN3 (Affinity Capture-MS), PPP2R3A (Affinity Capture-MS)

ESM2 similar proteins: A2CE44, A6NFI3, A6NM28, A8K8V0, O15370, O70218, O95201, P0CJ78, P10075, P10754, P28698, P70338, Q04890, Q07120, Q14V87, Q19A40, Q569E7, Q58DK7, Q5DWN0, Q5FWU5, Q5RJR4, Q5T619, Q5TEC3, Q6DD87, Q6IQX8, Q6PD29, Q6PGE4, Q6ZMY9, Q7Z7K2, Q80VM4, Q8BIF9, Q8JZL0, Q8N8E2, Q8NAF0, Q8NCA9, Q8TD94, Q8WUU4, Q96C55, Q96H86, Q96MX3

Diamond homologs: A1L1L7, A3KN32, A3KN36, A6NFI3, A6NM28, A6NN14, A6QLU5, A7MBI1, A8K8V0, A8MTY0, A8MWA4, B4DU55, C9JBD0, G3X9G7, O60765, O75290, O94892, O95780, P0C7X2, P10072, P15622, P16373, P16374, P17023, P17032, P17097, P17098, P21506, P52742, P59923, Q06730, Q08DG8, Q16587, Q29RZ4, Q2TL60, Q3V080, Q49AA0, Q4R6C2, Q4V8A8, Q5FWF6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

512 predictions. Top by Δscore:

Variant	Effect	Δscore
16:30583444:C:CC	acceptor_gain	1.0000
16:30585107:AT:A	donor_gain	1.0000
16:30585127:T:TA	donor_gain	1.0000
16:30583440:GATC:G	acceptor_gain	0.9900
16:30583441:ATC:A	acceptor_gain	0.9900
16:30583442:TC:T	acceptor_gain	0.9900
16:30583443:CC:C	acceptor_gain	0.9900
16:30583443:CCTGA:C	acceptor_loss	0.9900
16:30583444:CTGA:C	acceptor_loss	0.9900
16:30583445:T:C	acceptor_loss	0.9900
16:30583450:C:CT	acceptor_gain	0.9900
16:30585108:T:C	donor_gain	0.9900
16:30585363:C:A	donor_gain	0.9900
16:30585401:CCTCA:C	donor_loss	0.9900
16:30585402:CTCA:C	donor_loss	0.9900
16:30585403:TCA:T	donor_loss	0.9900
16:30585404:CACCC:C	donor_loss	0.9900
16:30585405:A:T	donor_loss	0.9900
16:30585405:AC:A	donor_gain	0.9900
16:30585406:CC:C	donor_gain	0.9900
16:30585445:T:TA	donor_gain	0.9900
16:30585446:C:A	donor_gain	0.9900
16:30583439:GGATC:G	acceptor_gain	0.9800
16:30583451:A:T	acceptor_gain	0.9800
16:30585107:ATC:A	donor_gain	0.9800
16:30585117:AGTAC:A	donor_loss	0.9800
16:30585118:GTAC:G	donor_loss	0.9800
16:30585119:TACC:T	donor_loss	0.9800
16:30585120:ACCT:A	donor_loss	0.9800
16:30585121:C:A	donor_loss	0.9800

AlphaMissense

2650 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:30582731:G:C	F349L	0.999
16:30582731:G:T	F349L	0.999
16:30582733:A:G	F349L	0.999
16:30582815:G:C	F321L	0.999
16:30582815:G:T	F321L	0.999
16:30582817:A:G	F321L	0.999
16:30582899:G:C	F293L	0.999
16:30582899:G:T	F293L	0.999
16:30582901:A:G	F293L	0.999
16:30582983:G:C	F265L	0.999
16:30582983:G:T	F265L	0.999
16:30582985:A:G	F265L	0.999
16:30582732:A:G	F349S	0.998
16:30583067:G:C	F237L	0.998
16:30583067:G:T	F237L	0.998
16:30583069:A:G	F237L	0.998
16:30583151:G:C	F209L	0.998
16:30583151:G:T	F209L	0.998
16:30583153:A:G	F209L	0.998
16:30582790:G:T	H330N	0.997
16:30582816:A:G	F321S	0.997
16:30582867:C:G	R304P	0.997
16:30582874:G:C	H302D	0.997
16:30582874:G:T	H302N	0.997
16:30582958:G:C	H274D	0.997
16:30582958:G:T	H274N	0.997
16:30583068:A:G	F237S	0.997
16:30582788:G:C	H330Q	0.996
16:30582788:G:T	H330Q	0.996
16:30582790:G:C	H330D	0.996

dbSNP variants (sampled 300 via entrez): RS1000474494 (16:30586463 C>T), RS1000775156 (16:30587520 C>T), RS1000780617 (16:30581816 G>A), RS1000922024 (16:30581079 G>A,C), RS1001081696 (16:30587327 C>A,G,T), RS1001234391 (16:30583181 G>A,C), RS1001752651 (16:30587661 A>C,G,T), RS1002639502 (16:30581750 C>A), RS1002953057 (16:30583854 A>C), RS1003079353 (16:30584279 A>G), RS1003724405 (16:30578026 T>C), RS1004152121 (16:30577872 G>A), RS1004245617 (16:30578151 C>T), RS1004494641 (16:30585573 G>A,C,T), RS1005074176 (16:30583709 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004606_92	Eosinophil count	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004842	eosinophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, decreases expression, affects expression	9
Panobinostat	affects cotreatment, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
TAK-243	increases sumoylation	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Coumestrol	decreases expression	1
Diazinon	increases methylation	1
Doxorubicin	increases expression	1
Phthalic Acids	decreases methylation	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Cadmium Chloride	decreases expression	1
Lactic Acid	increases expression	1
Particulate Matter	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW85	HEK293 eGFP-ZNF785	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.