ZNF786

Summary

ZNF786 (zinc finger protein 786, HGNC:21806) is a protein-coding gene on chromosome 7q36.1, encoding Zinc finger protein 786 (Q8N393). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus.

Source: NCBI Gene 136051 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 160 total
• MANE Select transcript: NM_152411

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21806
Approved symbol	ZNF786
Name	zinc finger protein 786
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp762I137
Ensembl gene	ENSG00000197362
Ensembl biotype	protein_coding
Entrez	136051

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000316286, ENST00000491431, ENST00000959840

RefSeq mRNA: 1 — MANE Select: NM_152411 NM_152411

CCDS: CCDS47738

Canonical transcript exons

ENST00000491431 — 4 exons

Exon	Start	End
ENSE00001809588	149090623	149090718
ENSE00001953122	149069641	149072473
ENSE00003577528	149074386	149074538
ENSE00003633022	149080591	149080717

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 82.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.7431 / max 22.5706, expressed in 1264 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86727	2.7431	1264

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper arm skin	UBERON:0004263	82.36	gold quality
tendon of biceps brachii	UBERON:0008188	78.12	gold quality
cortical plate	UBERON:0005343	77.06	gold quality
nipple	UBERON:0002030	76.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.99	gold quality
medial globus pallidus	UBERON:0002477	75.91	gold quality
thymus	UBERON:0002370	75.82	gold quality
granulocyte	CL:0000094	75.29	gold quality
ventricular zone	UBERON:0003053	75.26	gold quality
ganglionic eminence	UBERON:0004023	75.11	gold quality
globus pallidus	UBERON:0001875	74.51	gold quality
prefrontal cortex	UBERON:0000451	74.47	gold quality
cerebellar vermis	UBERON:0004720	73.69	gold quality
mammalian vulva	UBERON:0000997	73.53	gold quality
penis	UBERON:0000989	73.16	gold quality
stromal cell of endometrium	CL:0002255	73.07	gold quality
lower esophagus mucosa	UBERON:0035834	72.41	gold quality
cerebellum	UBERON:0002037	71.84	gold quality
lymph node	UBERON:0000029	71.83	gold quality
frontal cortex	UBERON:0001870	71.82	gold quality
cerebellar cortex	UBERON:0002129	71.48	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.47	gold quality
cerebellar hemisphere	UBERON:0002245	71.40	gold quality
upper leg skin	UBERON:0004262	71.38	gold quality
neocortex	UBERON:0001950	71.33	gold quality
pancreatic ductal cell	CL:0002079	71.27	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.24	gold quality
mucosa of sigmoid colon	UBERON:0004993	71.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.15	gold quality
skin of leg	UBERON:0001511	71.06	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6058	no	19.59
E-ANND-3	no	2.76

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

28 targeting ZNF786, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-4705	99.10	69.10	1091
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-1178-3P	98.57	67.09	890
HSA-MIR-876-5P	97.99	68.49	1345
HSA-MIR-6791-3P	97.45	64.31	1123
HSA-MIR-6829-3P	97.45	64.31	1137
HSA-MIR-3167	96.81	67.09	1236
HSA-MIR-6839-5P	96.74	68.29	1088
HSA-MIR-4794	96.47	65.53	1063
HSA-MIR-203A-5P	96.33	65.03	714
HSA-MIR-1282	91.07	71.26	99
HSA-MIR-3150A-5P	90.54	58.82	91
HSA-MIR-3150B-5P	90.54	58.82	91

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	prdm2a	ENSDARG00000090721
mus_musculus	Zfp786	ENSMUSG00000051499
rattus_norvegicus	Zfp786	ENSRNOG00000006925
drosophila_melanogaster	CG12769	FBGN0033252
caenorhabditis_elegans		WBGENE00001223
caenorhabditis_elegans		WBGENE00017406
caenorhabditis_elegans		WBGENE00019960

Paralogs (7): ZNF423 (ENSG00000102935), ZNF211 (ENSG00000121417), ZNF462 (ENSG00000148143), ZBTB39 (ENSG00000166860), ZNF597 (ENSG00000167981), ZNF445 (ENSG00000185219), ZNF521 (ENSG00000198795)

Protein

Protein identifiers

Zinc finger protein 786 — Q8N393 (reviewed: Q8N393)

All UniProt accessions (2): H7BXP3, Q8N393

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N393-1	1	yes
Q8N393-2	2

RefSeq proteins (1): NP_689624* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050636	C2H2-ZF_domain-containing	Family

Pfam: PF00096, PF01352

UniProt features (23 total): zinc finger region 16, region of interest 2, sequence conflict 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N393-F1	63.70	0.01

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 56 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, BARX1_TARGET_GENES, CBX7_TARGET_GENES, CHAF1B_TARGET_GENES, DLX6_TARGET_GENES, FOXG1_TARGET_GENES, HMG20B_TARGET_GENES, ID1_TARGET_GENES, ID2_TARGET_GENES, NAB2_TARGET_GENES, RBM34_TARGET_GENES, RFX7_TARGET_GENES, SKIL_TARGET_GENES, ZFHX3_TARGET_GENES, ZNF146_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (4): DNA binding (GO:0003677), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF786	C7orf33	Q8WU49	506
ZNF786	DRC11L	A6NCM1	479
ZNF786	A0A087WTJ2	A0A087WTJ2	447
ZNF786	ZBED10P	Q96FA7	434
ZNF786	THTPA	Q9BU02	423
ZNF786	LRRC61	Q9BV99	416
ZNF786	WDR86	Q86TI4	403
ZNF786	CSRNP2	Q9H175	370
ZNF786	METTL22	Q9BUU2	356
ZNF786	C9JR48	C9JR48	353
ZNF786	CRYGN	Q8WXF5	323
ZNF786	TMUB1	Q9BVT8	311
ZNF786	LRP12	Q9Y561	310
ZNF786	GIMAP2	Q9UG22	306
ZNF786	COQ10B	Q9H8M1	305
ZNF786	EIF2B3	Q9NR50	305

IntAct

39 interactions, top by confidence:

A	B	Type	Score
CYSRT1	ZNF786	psi-mi:“MI:0915”(physical association)	0.600
ZNF786	CYSRT1	psi-mi:“MI:0915”(physical association)	0.600
ZNF786		psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLC	ZNF786	psi-mi:“MI:0915”(physical association)	0.560
ZNF786	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-1	ZNF786	psi-mi:“MI:0915”(physical association)	0.560
ZNF786	MDFI	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	ZNF786	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF786	psi-mi:“MI:0915”(physical association)	0.560
CCNDBP1	ZNF786	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-3	ZNF786	psi-mi:“MI:0915”(physical association)	0.560
ZNF786	NKTR	psi-mi:“MI:0914”(association)	0.530
AP2B1	ZNF786	psi-mi:“MI:0407”(direct interaction)	0.440
ZNF786	HYOU1	psi-mi:“MI:0915”(physical association)	0.400
ZNF786	SLC4A1AP	psi-mi:“MI:0915”(physical association)	0.400
KRTAP10-3	ZNF786	psi-mi:“MI:0915”(physical association)	0.370
ZNF786	NEMF	psi-mi:“MI:0914”(association)	0.350
ZNF786	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000
ZNF786	NOTCH2NLC	psi-mi:“MI:0915”(physical association)	0.000
ZNF786	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.000
ZNF786	KRTAP1-1	psi-mi:“MI:0915”(physical association)	0.000
ZNF786	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.000
ZNF786	MDFI	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (27): KRTAP10-3 (Two-hybrid), NKTR (Affinity Capture-MS), TOPORS (Affinity Capture-MS), GPALPP1 (Affinity Capture-MS), PCDHA13 (Affinity Capture-MS), NEMF (Affinity Capture-MS), ZNF786 (Affinity Capture-RNA), KRTAP10-3 (Two-hybrid), ZNF786 (Two-hybrid), ZNF786 (Two-hybrid), ZNF786 (Two-hybrid), ZNF786 (Two-hybrid), ZNF786 (Two-hybrid), KRTAP2-3 (Two-hybrid), KRTAP2-4 (Two-hybrid)

ESM2 similar proteins: A3KN32, A6NM28, A8K8V0, E9PYI1, O75467, O95201, P10072, P10075, P10078, P10754, P28698, P30373, P52736, Q0VCC5, Q14929, Q16587, Q17QR7, Q29RZ4, Q3KNW1, Q3TDE8, Q3US17, Q58DK7, Q5RJR4, Q5T619, Q5TEC3, Q5U4E2, Q62396, Q68H95, Q6AW86, Q6PGE4, Q6ZMY9, Q7Z398, Q7Z7K2, Q8BI73, Q8BIF9, Q8BIQ3, Q8BKK5, Q8JZL0, Q8N393, Q8R0T2

Diamond homologs: A2A761, A6NFI3, A6NK75, A6NM28, A6NP11, A6QPT6, A8MQ14, A8MTY0, A8MUV8, B4DU55, B4DX44, B4DXR9, O60290, O75373, O75437, O95780, P0DPD5, P17014, P17032, P35789, P51523, P52736, P52738, Q02525, Q03923, Q03936, Q05481, Q06730, Q06732, Q14587, Q14593, Q14929, Q15928, Q16587, Q2KI58, Q3B7M4, Q3SXZ3, Q3U133, Q49AA0, Q4R6C2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 15 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	6	33.4×	3e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

160 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	138
Likely benign	14
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

566 predictions. Top by Δscore:

Variant	Effect	Δscore
7:149074450:T:TA	donor_gain	1.0000
7:149090620:TA:T	donor_loss	1.0000
7:149090621:A:AC	donor_gain	1.0000
7:149090621:A:T	donor_loss	1.0000
7:149090621:AC:A	donor_gain	1.0000
7:149090622:C:CC	donor_gain	1.0000
7:149090622:CC:C	donor_gain	1.0000
7:149074384:AC:A	donor_gain	0.9900
7:149074385:CC:C	donor_gain	0.9900
7:149074539:C:CC	acceptor_gain	0.9900
7:149080718:C:CC	acceptor_gain	0.9900
7:149080724:T:TC	acceptor_gain	0.9900
7:149088675:A:C	donor_gain	0.9900
7:149074377:AATAC:A	donor_loss	0.9800
7:149074378:ATACT:A	donor_loss	0.9800
7:149074379:TACT:T	donor_loss	0.9800
7:149074380:AC:A	donor_loss	0.9800
7:149074381:CT:C	donor_loss	0.9800
7:149074382:TCAC:T	donor_loss	0.9800
7:149074383:CAC:C	donor_loss	0.9800
7:149074384:A:AA	donor_loss	0.9800
7:149074384:ACC:A	donor_gain	0.9800
7:149074385:C:A	donor_loss	0.9800
7:149074385:CCC:C	donor_gain	0.9800
7:149074535:TCAT:T	acceptor_gain	0.9800
7:149074536:CAT:C	acceptor_gain	0.9800
7:149074536:CATC:C	acceptor_gain	0.9800
7:149074538:TC:T	acceptor_loss	0.9800
7:149074539:C:T	acceptor_loss	0.9800
7:149074540:T:C	acceptor_loss	0.9800

AlphaMissense

5217 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:149070717:G:C	F685L	0.999
7:149070717:G:T	F685L	0.999
7:149070719:A:G	F685L	0.999
7:149070549:G:C	F741L	0.998
7:149070549:G:T	F741L	0.998
7:149070551:A:G	F741L	0.998
7:149070633:G:C	F713L	0.997
7:149070633:G:T	F713L	0.997
7:149070635:A:G	F713L	0.997
7:149070690:A:C	H694Q	0.997
7:149070690:A:T	H694Q	0.997
7:149070692:G:C	H694D	0.997
7:149070700:A:G	L691P	0.997
7:149070718:A:G	F685S	0.997
7:149070744:A:C	F676L	0.997
7:149070744:A:T	F676L	0.997
7:149070746:A:G	F676L	0.997
7:149070966:G:C	F602L	0.997
7:149070966:G:T	F602L	0.997
7:149070968:A:G	F602L	0.997
7:149071050:G:C	F574L	0.997
7:149071050:G:T	F574L	0.997
7:149071052:A:G	F574L	0.997
7:149071218:G:C	F518L	0.997
7:149071218:G:T	F518L	0.997
7:149071220:A:G	F518L	0.997
7:149070550:A:G	F741S	0.996
7:149070608:G:C	H722D	0.996
7:149070692:G:T	H694N	0.996
7:149070740:A:G	C678R	0.996

dbSNP variants (sampled 300 via entrez): RS1000047007 (7:149077785 G>A), RS1000100585 (7:149080432 A>G), RS1000101943 (7:149082379 T>C), RS1000151714 (7:149071725 C>A,T), RS1000331858 (7:149076666 C>T), RS1000656281 (7:149087459 G>A), RS1000755482 (7:149070464 G>A), RS1001007104 (7:149087139 A>C,G), RS1001616291 (7:149083815 C>T), RS1001719537 (7:149090820 G>A,T), RS1001772037 (7:149090606 C>A,T), RS1001972780 (7:149074191 A>C,G), RS1002053215 (7:149092102 C>A), RS1002094843 (7:149079208 A>G), RS1002145950 (7:149079371 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004620_70	Sum basophil neutrophil counts	4.000000e-10
GCST004629_120	Neutrophil count	1.000000e-10
GCST008163_128	Height	8.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004833	neutrophil count
EFO:0005090	basophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation, increases methylation	4
triphenyl phosphate	affects expression	1
titanium dioxide	increases methylation	1
2-butenal	decreases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	decreases expression	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	affects expression	1
Lead	increases expression	1
Smoke	decreases expression	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	increases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.