ZNF791

Summary

ZNF791 (zinc finger protein 791, HGNC:26895) is a protein-coding gene on chromosome 19p13.13, encoding Zinc finger protein 791 (Q3KP31). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 163049 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 58 total
• MANE Select transcript: NM_153358

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26895
Approved symbol	ZNF791
Name	zinc finger protein 791
Location	19p13.13
Locus type	gene with protein product
Status	Approved
Aliases	FLJ90396
Ensembl gene	ENSG00000173875
Ensembl biotype	protein_coding
Entrez	163049

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000343325, ENST00000446165, ENST00000498389, ENST00000597691, ENST00000598225, ENST00000600752

RefSeq mRNA: 1 — MANE Select: NM_153358 NM_153358

CCDS: CCDS12273

Canonical transcript exons

ENST00000343325 — 4 exons

Exon	Start	End
ENSE00001402263	12627721	12633834
ENSE00003593031	12610920	12611082
ENSE00003644188	12624650	12624710
ENSE00003661491	12623700	12623826

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 95.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.1223 / max 355.6993, expressed in 1804 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173995	18.7167	1797
173997	3.4453	1193
173996	2.8374	1375
173999	0.1230	47

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nipple	UBERON:0002030	95.82	gold quality
pylorus	UBERON:0001166	94.54	gold quality
pericardium	UBERON:0002407	94.25	gold quality
superior surface of tongue	UBERON:0007371	93.75	gold quality
renal medulla	UBERON:0000362	93.67	gold quality
calcaneal tendon	UBERON:0003701	93.61	gold quality
trachea	UBERON:0003126	93.50	gold quality
trigeminal ganglion	UBERON:0001675	93.41	gold quality
inferior vagus X ganglion	UBERON:0005363	93.28	gold quality
cardiac muscle of right atrium	UBERON:0003379	92.65	gold quality
cardia of stomach	UBERON:0001162	92.57	gold quality
ventral tegmental area	UBERON:0002691	92.26	gold quality
left ventricle myocardium	UBERON:0006566	91.98	gold quality
saphenous vein	UBERON:0007318	91.69	gold quality
pancreatic ductal cell	CL:0002079	91.60	gold quality
medulla oblongata	UBERON:0001896	91.57	gold quality
dorsal root ganglion	UBERON:0000044	91.36	gold quality
ileal mucosa	UBERON:0000331	91.34	gold quality
seminal vesicle	UBERON:0000998	91.21	gold quality
layer of synovial tissue	UBERON:0007616	91.10	gold quality
mammary duct	UBERON:0001765	90.94	gold quality
subthalamic nucleus	UBERON:0001906	90.93	gold quality
kidney epithelium	UBERON:0004819	90.93	gold quality
epithelium of mammary gland	UBERON:0003244	90.92	gold quality
superior vestibular nucleus	UBERON:0007227	90.88	gold quality
urethra	UBERON:0000057	90.61	gold quality
dorsal plus ventral thalamus	UBERON:0001897	90.56	gold quality
cartilage tissue	UBERON:0002418	90.27	gold quality
sural nerve	UBERON:0015488	90.19	gold quality
corpus callosum	UBERON:0002336	90.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting ZNF791, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-6515-3P	99.82	68.19	1933
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-3944-5P	98.50	67.55	997
HSA-MIR-628-5P	98.36	67.74	844
HSA-MIR-6742-3P	97.95	64.50	1490
HSA-MIR-193B-5P	97.91	65.88	837
HSA-MIR-15B-3P	97.85	66.68	974
HSA-MIR-1226-3P	97.51	66.32	1063
HSA-MIR-194-3P	97.36	65.96	1027
HSA-MIR-643	97.35	67.91	805
HSA-MIR-4793-3P	94.87	65.85	896
HSA-MIR-4315	94.78	64.86	112
HSA-MIR-4694-5P	94.62	65.39	532
HSA-MIR-6890-5P	92.89	65.83	442

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA KCNQ1OT1 contributes to hydrogen peroxide-induced apoptosis, inflammation, and oxidative stress of cardiomyocytes via miR-130a-3p/ZNF791 axis. (PMID:35989482)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp791	ENSMUSG00000074194
rattus_norvegicus	Zfp791	ENSRNOG00000023920

Paralogs (15): ZNF14 (ENSG00000105708), ZNF57 (ENSG00000171970), ZNF443 (ENSG00000180855), ZNF101 (ENSG00000181896), ZNF563 (ENSG00000188868), ZNF799 (ENSG00000196466), ZNF700 (ENSG00000196757), ZNF441 (ENSG00000197044), ZNF433 (ENSG00000197647), ZNF44 (ENSG00000197857), ZNF823 (ENSG00000197933), ZNF442 (ENSG00000198342), ZNF844 (ENSG00000223547), ZNF709 (ENSG00000242852), ZNF878 (ENSG00000257446)

Protein

Protein identifiers

Zinc finger protein 791 — Q3KP31 (reviewed: Q3KP31)

All UniProt accessions (5): Q3KP31, C9JU55, M0QYQ0, M0R0E8, M0R2N1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q3KP31-1	1	yes
Q3KP31-2	2

RefSeq proteins (1): NP_699189* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050589	Ikaros_C2H2-ZF	Family

Pfam: PF00096, PF01352

UniProt features (21 total): zinc finger region 17, chain 1, domain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3KP31-F1	81.26	0.40

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 53 (showing top): ACEVEDO_LIVER_CANCER_UP, OSMAN_BLADDER_CANCER_DN, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ALKBH3_TARGET_GENES, CIITA_TARGET_GENES, DIDO1_TARGET_GENES, ELF2_TARGET_GENES, HES4_TARGET_GENES, PAX3_TARGET_GENES, RORA_TARGET_GENES, ZNF146_TARGET_GENES, ZNF274_TARGET_GENES, ZNF30_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

578 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF791	OR4F21	O95013	444
ZNF791	ZNF487	B1APH4	431
ZNF791	GARIN5A	Q6IPT2	418
ZNF791	TMCO6	Q96DC7	401
ZNF791	RNF208	Q9H0X6	348
ZNF791	PAXBP1	Q9Y5B6	313
ZNF791	POGZ	Q7Z3K3	310
ZNF791	EIF4E1B	A6NMX2	310
ZNF791	HUS1B	Q8NHY5	310
ZNF791	ZGLP1	P0C6A0	297
ZNF791	OR51B4	Q9Y5P0	290
ZNF791	ETFBKMT	Q8IXQ9	289
ZNF791	MRPS11	P82912	287
ZNF791	WFDC5	Q8TCV5	284
ZNF791	KLHDC7B	Q96G42	278

IntAct

30 interactions, top by confidence:

A	B	Type	Score
GRN	ZNF791	psi-mi:“MI:0915”(physical association)	0.560
ZNF791	WFS1	psi-mi:“MI:0915”(physical association)	0.560
HRC	ZNF791	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
EFEMP1	ZNF316	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
PURG	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL36	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL13A	GTPBP10	psi-mi:“MI:0914”(association)	0.350
TEX19	ZNF316	psi-mi:“MI:0914”(association)	0.350
GLI4	ZNF316	psi-mi:“MI:0914”(association)	0.350
KRT40	ANKRD36	psi-mi:“MI:0914”(association)	0.350
SURF6		psi-mi:“MI:0914”(association)	0.350
APP	ZNF724	psi-mi:“MI:0914”(association)	0.350
PRKRA	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
PRKRA	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL13	POLRMT	psi-mi:“MI:0914”(association)	0.350
	ZNF791	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (24): ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS), ZNF791 (Affinity Capture-MS)

ESM2 similar proteins: A6NK75, C9JN71, O75820, O94892, P08043, P0CJ79, P16415, P17017, P17021, P17035, P17039, P35789, P52737, Q08AN1, Q3KP31, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R9F0, Q5RB30, Q5RDX1, Q5REA0, Q5REI6, Q5REK1, Q6P3V2, Q6ZN19, Q6ZNA1, Q6ZNG1, Q76KX8, Q80W31, Q86T29, Q86YE8, Q8C827, Q8N4W9, Q8N7K0, Q8NB50, Q8NDQ6, Q8NEP9, Q8TBZ8

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 28 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Major pathway of rRNA processing in the nucleolus and cytosol	5	15.4×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

507 predictions. Top by Δscore:

Variant	Effect	Δscore
19:12611080:ATGG:A	donor_loss	1.0000
19:12611081:TGG:T	donor_loss	1.0000
19:12611084:T:A	donor_loss	1.0000
19:12623684:ATATT:A	acceptor_gain	1.0000
19:12623685:T:G	acceptor_gain	1.0000
19:12623686:A:AG	acceptor_gain	1.0000
19:12623686:ATT:A	acceptor_gain	1.0000
19:12623686:ATTG:A	acceptor_gain	1.0000
19:12623687:T:G	acceptor_gain	1.0000
19:12623688:T:TA	acceptor_gain	1.0000
19:12623689:G:A	acceptor_gain	1.0000
19:12623692:T:A	acceptor_gain	1.0000
19:12623695:TTCA:T	acceptor_loss	1.0000
19:12623696:TCA:T	acceptor_loss	1.0000
19:12623696:TCAGG:T	acceptor_gain	1.0000
19:12623697:CAGGA:C	acceptor_gain	1.0000
19:12623698:A:AG	acceptor_gain	1.0000
19:12623698:AG:A	acceptor_gain	1.0000
19:12623699:G:GC	acceptor_gain	1.0000
19:12623699:GG:G	acceptor_gain	1.0000
19:12623699:GGA:G	acceptor_gain	1.0000
19:12623699:GGAC:G	acceptor_gain	1.0000
19:12623699:GGACT:G	acceptor_gain	1.0000
19:12623822:TATAG:T	donor_gain	1.0000
19:12623823:ATAG:A	donor_gain	1.0000
19:12623823:ATAGG:A	donor_loss	1.0000
19:12623824:TAG:T	donor_gain	1.0000
19:12623824:TAGGT:T	donor_loss	1.0000
19:12623825:AG:A	donor_gain	1.0000
19:12623825:AGG:A	donor_loss	1.0000

AlphaMissense

3855 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:12628202:T:C	F225L	0.993
19:12628204:C:A	F225L	0.993
19:12628204:C:G	F225L	0.993
19:12628622:T:C	F365L	0.990
19:12628624:T:A	F365L	0.990
19:12628624:T:G	F365L	0.990
19:12628958:T:C	F477L	0.990
19:12628960:T:A	F477L	0.990
19:12628960:T:G	F477L	0.990
19:12629042:T:C	F505L	0.989
19:12629044:T:A	F505L	0.989
19:12629044:T:G	F505L	0.989
19:12628538:T:C	F337L	0.988
19:12628540:C:A	F337L	0.988
19:12628540:C:G	F337L	0.988
19:12628286:T:C	F253L	0.986
19:12628288:C:A	F253L	0.986
19:12628288:C:G	F253L	0.986
19:12629126:T:C	F533L	0.985
19:12629128:T:A	F533L	0.985
19:12629128:T:G	F533L	0.985
19:12628370:T:C	F281L	0.984
19:12628372:C:A	F281L	0.984
19:12628372:C:G	F281L	0.984
19:12628874:T:C	F449L	0.984
19:12628876:C:A	F449L	0.984
19:12628876:C:G	F449L	0.984
19:12628706:T:C	F393L	0.983
19:12628708:C:A	F393L	0.983
19:12628708:C:G	F393L	0.983

dbSNP variants (sampled 300 via entrez): RS1000134915 (19:12620024 C>A,T), RS1000362989 (19:12611378 C>T), RS1000786455 (19:12631551 G>A), RS1000966271 (19:12631849 G>A,C,T), RS1001103957 (19:12616043 T>C), RS1001225814 (19:12617073 A>G), RS1001248729 (19:12627876 C>G,T), RS1001276630 (19:12616828 T>A,G), RS1001353668 (19:12610334 G>A), RS1001414251 (19:12622156 A>G), RS1001519110 (19:12615280 C>T), RS1001545035 (19:12618915 T>G), RS1001613450 (19:12622717 A>C), RS1001635176 (19:12615556 G>A), RS1001876381 (19:12633174 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, decreases expression, increases abundance, affects expression	4
sodium arsenite	increases abundance, increases expression	2
Ozone	decreases expression, increases abundance, affects expression, affects cotreatment	2
Smoke	decreases expression, increases abundance	2
Tobacco Smoke Pollution	affects expression, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	decreases expression, increases abundance, affects cotreatment	1
bisphenol A	affects expression	1
potassium chromate(VI)	increases expression, affects cotreatment	1
methacrylaldehyde	increases abundance, affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
K 7174	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acrolein	decreases expression, increases abundance, affects cotreatment	1
Arsenic	increases expression, increases abundance	1
Cisplatin	affects cotreatment, decreases expression	1
Coal	decreases expression, increases abundance	1
Dietary Carbohydrates	decreases expression	1
Doxorubicin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Urethane	increases expression	1
Valproic Acid	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Aflatoxin M1	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW87	HEK293 eGFP-ZNF791	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.