ZNF792

Summary

ZNF792 (zinc finger protein 792, HGNC:24751) is a protein-coding gene on chromosome 19q13.11, encoding Zinc finger protein 792 (Q3KQV3). May be involved in transcriptional regulation.

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 126375 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 116 total
• MANE Select transcript: NM_175872

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24751
Approved symbol	ZNF792
Name	zinc finger protein 792
Location	19q13.11
Locus type	gene with protein product
Status	Approved
Aliases	FLJ38451
Ensembl gene	ENSG00000180884
Ensembl biotype	protein_coding
Entrez	126375

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000404801, ENST00000605484, ENST00000886076

RefSeq mRNA: 1 — MANE Select: NM_175872 NM_175872

CCDS: CCDS12440

Canonical transcript exons

ENST00000404801 — 4 exons

Exon	Start	End
ENSE00001280059	34956354	34959571
ENSE00002281843	34960235	34960357
ENSE00002300045	34963630	34964229
ENSE00002446473	34960868	34960994

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 81.94.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5362 / max 37.7626, expressed in 1139 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180463	1.5016	840
180464	0.7818	444
180462	0.2529	121

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.94	gold quality
granulocyte	CL:0000094	73.41	gold quality
right lung	UBERON:0002167	73.29	gold quality
islet of Langerhans	UBERON:0000006	72.94	gold quality
leukocyte	CL:0000738	72.76	gold quality
monocyte	CL:0000576	72.26	gold quality
cortical plate	UBERON:0005343	71.97	gold quality
stromal cell of endometrium	CL:0002255	71.93	gold quality
palpebral conjunctiva	UBERON:0001812	71.42	gold quality
ganglionic eminence	UBERON:0004023	71.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.21	gold quality
visceral pleura	UBERON:0002401	71.14	gold quality
smooth muscle tissue	UBERON:0001135	70.99	gold quality
parietal pleura	UBERON:0002400	70.80	gold quality
upper lobe of left lung	UBERON:0008952	70.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.38	gold quality
lymph node	UBERON:0000029	70.18	gold quality
upper lobe of lung	UBERON:0008948	70.18	gold quality
ventricular zone	UBERON:0003053	69.97	gold quality
lung	UBERON:0002048	69.93	gold quality
apex of heart	UBERON:0002098	69.49	gold quality
omental fat pad	UBERON:0010414	68.48	gold quality
peritoneum	UBERON:0002358	68.40	gold quality
adipose tissue of abdominal region	UBERON:0007808	68.05	gold quality
rectum	UBERON:0001052	68.03	gold quality
adipose tissue	UBERON:0001013	67.82	gold quality
spleen	UBERON:0002106	67.81	gold quality
vermiform appendix	UBERON:0001154	67.61	gold quality
pancreas	UBERON:0001264	66.83	gold quality
bone marrow cell	CL:0002092	66.70	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

108 targeting ZNF792, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zfx	ENSDARG00000074453
danio_rerio		ENSDARG00000098424
mus_musculus	Zfy2	ENSMUSG00000000103
mus_musculus	Zfy1	ENSMUSG00000053211
rattus_norvegicus	Zfy1	ENSRNOG00000053042

Paralogs (38): ZFX (ENSG00000005889), ZBTB11 (ENSG00000066422), ZFAT (ENSG00000066827), ZFY (ENSG00000067646), ZNF586 (ENSG00000083828), IKZF5 (ENSG00000095574), ZNF419 (ENSG00000105136), ZNF549 (ENSG00000121406), ZSCAN20 (ENSG00000121903), ZNF304 (ENSG00000131845), PRDM15 (ENSG00000141956), ZNF660 (ENSG00000144792), ZNF711 (ENSG00000147180), ZNF773 (ENSG00000152439), ZNF256 (ENSG00000152454), ZNF837 (ENSG00000152475), ZNF691 (ENSG00000164011), ZNF610 (ENSG00000167554), E4F1 (ENSG00000167967), ZNF562 (ENSG00000171466), ZNF561 (ENSG00000171469), ZNF584 (ENSG00000171574), ZIK1 (ENSG00000171649), ZNF570 (ENSG00000171827), ZSCAN2 (ENSG00000176371), ZNF552 (ENSG00000178935), ZNF154 (ENSG00000179909), ZNF793 (ENSG00000188227), ZNF548 (ENSG00000188785), ZNF79 (ENSG00000196152), ZNF418 (ENSG00000196724), ZNF772 (ENSG00000197128), ZNF583 (ENSG00000198440), ZNF480 (ENSG00000198464), ZNF551 (ENSG00000204519), ZNF134 (ENSG00000213762), ZNF587B (ENSG00000269343), ZNF8 (ENSG00000278129)

Protein

Protein identifiers

Zinc finger protein 792 — Q3KQV3 (reviewed: Q3KQV3)

All UniProt accessions (2): Q3KQV3, S4R3B8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_787068* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050636	C2H2-ZF_domain-containing	Family

Pfam: PF00096, PF01352

UniProt features (19 total): zinc finger region 13, sequence variant 2, chain 1, domain 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3KQV3-F1	64.47	0.16

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 196

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 63 (showing top): HNF4_01, AACTTT_UNKNOWN, HNF4ALPHA_Q6, VECCHI_GASTRIC_CANCER_EARLY_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ZWANG_DOWN_BY_2ND_EGF_PULSE, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, LMTK3_TARGET_GENES, RLF_TARGET_GENES, TAFAZZIN_TARGET_GENES, ZFP91_TARGET_GENES, ZNF2_TARGET_GENES, ZNF223_TARGET_GENES, ZSCAN31_TARGET_GENES, MIR559

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), identical protein binding (GO:0042802), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
protein binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

280 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF792	RPP38	P78345	401
ZNF792	LRIF1	Q5T3J3	385
ZNF792	PRSS33	Q8NF86	340
ZNF792	KAZN	Q674X7	330
ZNF792	LSM11	P83369	327
ZNF792	ZNF277	Q9NRM2	324
ZNF792	CDCA4	Q9BXL8	311
ZNF792	MAST4	O15021	309
ZNF792	NABP1	Q96AH0	309
ZNF792	ZNF207	O43670	297
ZNF792	MIER3	Q7Z3K6	294
ZNF792	SH3TC2	Q8TF17	294
ZNF792	ZFHX2	Q9C0A1	285
ZNF792	PRDM11	Q9NQV5	270
ZNF792	ARID3B	Q8IVW6	269

IntAct

173 interactions, top by confidence:

A	B	Type	Score
KRTAP10-9	ZNF792	psi-mi:“MI:0915”(physical association)	0.720
ZNF408	ZNF792	psi-mi:“MI:0915”(physical association)	0.720
MID2	ZNF792	psi-mi:“MI:0915”(physical association)	0.720
ZNF792	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.720
ZNF792	ZNF408	psi-mi:“MI:0915”(physical association)	0.720
ZNF792	MID2	psi-mi:“MI:0915”(physical association)	0.720
ZNF792	ZNF473	psi-mi:“MI:0915”(physical association)	0.670
ZNF792	ZNF792	psi-mi:“MI:0915”(physical association)	0.670
ZNF473	ZNF792	psi-mi:“MI:0915”(physical association)	0.670
ZNF792	KRTAP10-5	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF792	psi-mi:“MI:0915”(physical association)	0.560
HNRNPK	ZNF792	psi-mi:“MI:0915”(physical association)	0.560
KRT40	ZNF792	psi-mi:“MI:0915”(physical association)	0.560
ZNF792	SSX2IP	psi-mi:“MI:0915”(physical association)	0.560
	ZNF792	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-5	ZNF792	psi-mi:“MI:0915”(physical association)	0.560
ZNF792	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
ZNF792	KRT40	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (66): ZNF792 (Two-hybrid), ZNF792 (Two-hybrid), ZNF792 (Two-hybrid), ZNF792 (Two-hybrid), ZNF792 (Two-hybrid), ZNF792 (Two-hybrid), ZNF792 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-5 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZNF792 (Affinity Capture-RNA), ZNF792 (Affinity Capture-RNA), ZNF792 (Two-hybrid), ZNF792 (Two-hybrid)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A6QLU5, B2RUI1, D3ZVT0, O14709, O43296, O75123, P10072, P15621, P17020, P17097, P51814, P85977, Q08ER8, Q0VGE8, Q14590, Q32KN0, Q3KQV3, Q4V8A8, Q5CZA5, Q5RBX0, Q5RCD9, Q5VIY5, Q61116, Q61967, Q6GQR8, Q6P9A3, Q6ZMS4, Q7TSH9, Q7TSI0, Q7Z3I7, Q86UD4, Q86WZ6, Q8BFS8, Q8IZ26, Q8N9F8, Q8TAF7

Diamond homologs: A0JPL0, A2VDP4, A3KN32, A6NFI3, A6NM28, A6QLU5, B2RXC5, B4DU55, O43296, O60765, O75290, O75467, P10072, P15622, P17014, P17023, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P52736, P52738, Q02975, Q06730, Q06732, Q14590, Q14929, Q16587, Q29RZ4, Q2TL60, Q3KNS6, Q3KQV3, Q49AA0, Q4R8H9, Q4V8A8, Q4V8E9, Q5FWF6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 50 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	7	14.4×	3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	101
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

693 predictions. Top by Δscore:

Variant	Effect	Δscore
19:34960866:AC:A	donor_gain	1.0000
19:34960867:CC:C	donor_gain	1.0000
19:34960867:CCCAG:C	donor_gain	1.0000
19:34959572:CT:C	acceptor_loss	0.9900
19:34960862:CCTT:C	donor_loss	0.9900
19:34960863:CTT:C	donor_loss	0.9900
19:34960864:TTA:T	donor_loss	0.9900
19:34960865:TACCC:T	donor_loss	0.9900
19:34960866:A:AC	donor_gain	0.9900
19:34960867:C:A	donor_loss	0.9900
19:34960867:C:CC	donor_gain	0.9900
19:34960998:CCA:C	acceptor_gain	0.9900
19:34960999:C:T	acceptor_gain	0.9900
19:34960999:CATGA:C	acceptor_gain	0.9900
19:34961000:A:C	acceptor_gain	0.9900
19:34961003:A:AC	acceptor_gain	0.9900
19:34963625:CTCA:C	donor_loss	0.9900
19:34963626:TCAC:T	donor_loss	0.9900
19:34963627:CACC:C	donor_loss	0.9900
19:34963629:C:G	donor_loss	0.9900
19:34959572:C:CC	acceptor_gain	0.9800
19:34960353:AAGTC:A	acceptor_gain	0.9800
19:34960990:CAGCC:C	acceptor_gain	0.9800
19:34960993:CC:C	acceptor_gain	0.9800
19:34960994:CC:C	acceptor_gain	0.9800
19:34960995:C:CA	acceptor_loss	0.9800
19:34960995:C:CC	acceptor_gain	0.9800
19:34961000:A:AC	acceptor_gain	0.9800
19:34961003:A:C	acceptor_gain	0.9800
19:34963628:A:AC	donor_gain	0.9800

AlphaMissense

4258 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:34958226:G:C	F543L	0.999
19:34958226:G:T	F543L	0.999
19:34958228:A:G	F543L	0.999
19:34958394:A:C	F487L	0.999
19:34958394:A:T	F487L	0.999
19:34958396:A:G	F487L	0.999
19:34958478:G:C	F459L	0.999
19:34958478:G:T	F459L	0.999
19:34958480:A:G	F459L	0.999
19:34958142:G:C	F571L	0.998
19:34958142:G:T	F571L	0.998
19:34958144:A:G	F571L	0.998
19:34958283:G:C	H524Q	0.998
19:34958283:G:T	H524Q	0.998
19:34958285:G:C	H524D	0.998
19:34958310:A:C	F515L	0.998
19:34958310:A:T	F515L	0.998
19:34958312:A:G	F515L	0.998
19:34958369:G:C	H496D	0.998
19:34958199:G:C	H552Q	0.997
19:34958199:G:T	H552Q	0.997
19:34958209:A:G	L549P	0.997
19:34958227:A:G	F543S	0.997
19:34958285:G:T	H524N	0.997
19:34958293:A:G	L521P	0.997
19:34958367:A:C	H496Q	0.997
19:34958367:A:T	H496Q	0.997
19:34958377:A:G	L493P	0.997
19:34958446:C:G	R470P	0.997
19:34958451:A:C	H468Q	0.997

dbSNP variants (sampled 300 via entrez): RS1000110588 (19:34962156 G>A), RS1000544584 (19:34961873 T>C), RS1000877421 (19:34959998 C>T), RS1001200612 (19:34958999 T>A), RS1001211933 (19:34958773 G>A,T), RS1001213788 (19:34961179 C>T), RS1001701327 (19:34964374 C>A,T), RS1002044839 (19:34963248 G>T), RS1002111151 (19:34964213 G>A), RS1002438268 (19:34963448 T>C), RS1003207882 (19:34956662 C>T), RS1003238878 (19:34956251 C>A,T), RS1003553482 (19:34959956 G>A), RS1003707704 (19:34962028 G>A), RS1003976506 (19:34956696 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006993_14	Hippocampal volume in Alzheimer’s disease dementia	6.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005035	hippocampal volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects expression, affects cotreatment, increases expression	2
Cyclosporine	decreases expression, increases methylation	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
zinc chromate	increases abundance, increases expression	1
microcystin RR	increases expression	1
chromium hexavalent ion	increases abundance, increases expression	1
2-palmitoylglycerol	increases expression	1
abrine	decreases expression	1
licochalcone B	decreases expression	1
jinfukang	increases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	increases expression	1
Decitabine	affects expression	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Doxorubicin	increases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Tunicamycin	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases expression	1
Antirheumatic Agents	increases expression	1
Thapsigargin	decreases expression	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW88	HEK293 eGFP-ZNF792	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.