ZNF805

Summary

ZNF805 (zinc finger protein 805, HGNC:23272) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 805 (Q5CZA5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 390980 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 89 total
• MANE Select transcript: NM_001023563

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23272
Approved symbol	ZNF805
Name	zinc finger protein 805
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000204524
Ensembl biotype	protein_coding
Entrez	390980

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000354309, ENST00000414468

RefSeq mRNA: 2 — MANE Select: NM_001023563 NM_001023563, NM_001145078

CCDS: CCDS46207, CCDS46208

Canonical transcript exons

ENST00000414468 — 4 exons

Exon	Start	End
ENSE00002487809	57243923	57244049
ENSE00002998094	57253073	57262728
ENSE00003184276	57240632	57240921
ENSE00003575963	57248605	57248700

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 81.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.6124 / max 123.7550, expressed in 1755 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177747	3.9435	1573
177746	2.3961	1362
177749	1.1269	733
177748	0.1460	51

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	81.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.64	gold quality
adrenal tissue	UBERON:0018303	78.18	gold quality
corpus callosum	UBERON:0002336	76.39	gold quality
bone marrow	UBERON:0002371	76.27	gold quality
bone marrow cell	CL:0002092	76.04	gold quality
colonic epithelium	UBERON:0000397	75.37	gold quality
islet of Langerhans	UBERON:0000006	74.10	gold quality
tonsil	UBERON:0002372	73.94	gold quality
stromal cell of endometrium	CL:0002255	73.83	gold quality
skeletal muscle tissue	UBERON:0001134	72.44	gold quality
sural nerve	UBERON:0015488	71.39	gold quality
ventricular zone	UBERON:0003053	70.89	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.88	gold quality
muscle tissue	UBERON:0002385	70.83	gold quality
leukocyte	CL:0000738	70.52	gold quality
monocyte	CL:0000576	70.36	gold quality
endometrium	UBERON:0001295	70.13	gold quality
quadriceps femoris	UBERON:0001377	69.42	gold quality
adrenal gland	UBERON:0002369	68.87	gold quality
cortical plate	UBERON:0005343	68.79	gold quality
smooth muscle tissue	UBERON:0001135	68.56	gold quality
urinary bladder	UBERON:0001255	68.56	gold quality
ganglionic eminence	UBERON:0004023	68.37	gold quality
granulocyte	CL:0000094	68.04	gold quality
right adrenal gland cortex	UBERON:0035827	67.87	gold quality
muscle of leg	UBERON:0001383	67.79	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
gastrocnemius	UBERON:0001388	67.64	gold quality
lung	UBERON:0002048	67.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.27

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

298 targeting ZNF805, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4482-3P	99.98	72.50	3147

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 805 — Q5CZA5 (reviewed: Q5CZA5)

All UniProt accessions (1): Q5CZA5

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Miscellaneous. Gene prediction based on similarity to orthologs.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5CZA5-1	1	yes
Q5CZA5-2	2

RefSeq proteins (2): NP_001018857, NP_001138550 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13465

UniProt features (21 total): zinc finger region 13, region of interest 2, compositionally biased region 2, chain 1, domain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5CZA5-F1	68.54	0.18

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 81 (showing top): TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ZWANG_DOWN_BY_2ND_EGF_PULSE, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CBX7_TARGET_GENES, CEBPZ_TARGET_GENES, CHAF1B_TARGET_GENES, DIDO1_TARGET_GENES, TRIP13_TARGET_GENES, ZNF7_TARGET_GENES, ZNF711_TARGET_GENES, MIR616_5P, MIR371B_5P, MIR373_5P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

268 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF805	KATNBL1	Q9H079	509
ZNF805	C2CD2	Q9Y426	505
ZNF805	INTS2	Q9H0H0	478
ZNF805	N4BP2L2	Q92802	464
ZNF805	THEM5	Q8N1Q8	461
ZNF805	SLC25A51	Q9H1U9	454
ZNF805	TRAPPC1	Q9Y5R8	436
ZNF805	GTF2IRD2B	Q6EKJ0	434
ZNF805	GTF2IRD2	Q86UP8	432
ZNF805	PCNX1	Q96RV3	417
ZNF805	PARP11	Q9NR21	403
ZNF805	RNF149	Q8NC42	400
ZNF805	C2CD4B	A6NLJ0	400
ZNF805	PCDHA5	Q9Y5H7	391
ZNF805	ARHGAP6	O43182	387

IntAct

4 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
ZNF264	TRIM24	psi-mi:“MI:0914”(association)	0.350

BioGRID (9): ZNF805 (Affinity Capture-MS), ZNF805 (Proximity Label-MS), ZNF805 (Affinity Capture-RNA), ZNF805 (Affinity Capture-MS), ZNF805 (Affinity Capture-MS), ZNF805 (Affinity Capture-MS), ZNF805 (Affinity Capture-MS), ZNF805 (Affinity Capture-MS), ZNF805 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0JPL0, A2A761, A3KN32, A3KN36, A6NFI3, A6NM28, A6QLU5, A6QPT6, A7MBI1, A8MTY0, B2RXC5, B4DU55, E9PYI1, O14978, O60765, O75467, O75820, O95780, P0C7X2, P0DKX0, P0DPD5, P10072, P15622, P16374, P17014, P17023, P17032, P17098, P51523, P51786, P52738, P52742, Q02975, Q06732, Q08DG8, Q08ER8, Q0VCB0, Q14590, Q14929, Q29RZ4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	74
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

436 predictions. Top by Δscore:

Variant	Effect	Δscore
19:57243918:TTCA:T	acceptor_loss	1.0000
19:57243919:TCAG:T	acceptor_loss	1.0000
19:57243920:CAGGT:C	acceptor_loss	1.0000
19:57243921:A:AC	acceptor_loss	1.0000
19:57243922:GGT:G	acceptor_gain	1.0000
19:57244048:GG:G	donor_gain	1.0000
19:57244049:GG:G	donor_gain	1.0000
19:57244049:GGT:G	donor_loss	1.0000
19:57244050:G:GA	donor_loss	1.0000
19:57244051:TAA:T	donor_loss	1.0000
19:57240920:AGGTG:A	donor_loss	0.9900
19:57240922:GT:G	donor_loss	0.9900
19:57240923:T:G	donor_loss	0.9900
19:57243922:GGTGT:G	acceptor_gain	0.9900
19:57244010:G:GT	donor_gain	0.9900
19:57244050:G:GG	donor_gain	0.9900
19:57253067:TTTCA:T	acceptor_loss	0.9900
19:57253068:TTCA:T	acceptor_loss	0.9900
19:57253069:TCAG:T	acceptor_loss	0.9900
19:57253070:CA:C	acceptor_loss	0.9900
19:57253071:A:AG	acceptor_gain	0.9900
19:57253072:G:A	acceptor_loss	0.9900
19:57253072:G:GG	acceptor_gain	0.9900
19:57253072:GGT:G	acceptor_gain	0.9900
19:57240918:GCAG:G	donor_gain	0.9800
19:57240922:G:GG	donor_gain	0.9800
19:57243921:A:AG	acceptor_gain	0.9800
19:57243922:G:GG	acceptor_gain	0.9800
19:57248604:GGGT:G	acceptor_gain	0.9800
19:57243916:A:AG	acceptor_gain	0.9700

AlphaMissense

4169 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:57254228:T:C	L470P	1.000
19:57253705:T:C	F296L	0.999
19:57253707:C:A	F296L	0.999
19:57253707:C:G	F296L	0.999
19:57253957:T:C	F380L	0.999
19:57253959:C:A	F380L	0.999
19:57253959:C:G	F380L	0.999
19:57254041:T:C	F408L	0.999
19:57254043:C:A	F408L	0.999
19:57254043:C:G	F408L	0.999
19:57254068:C:G	H417D	0.999
19:57254075:G:C	R419P	0.999
19:57254125:T:C	F436L	0.999
19:57254127:C:A	F436L	0.999
19:57254127:C:G	F436L	0.999
19:57254209:T:C	F464L	0.999
19:57254211:T:A	F464L	0.999
19:57254211:T:G	F464L	0.999
19:57254234:G:C	R472P	0.999
19:57254238:C:A	H473Q	0.999
19:57254238:C:G	H473Q	0.999
19:57254293:T:C	F492L	0.999
19:57254295:C:A	F492L	0.999
19:57254295:C:G	F492L	0.999
19:57254327:G:C	R503P	0.999
19:57254377:T:C	F520L	0.999
19:57254379:T:A	F520L	0.999
19:57254379:T:G	F520L	0.999
19:57254396:T:C	L526P	0.999
19:57254461:T:C	F548L	0.999

dbSNP variants (sampled 300 via entrez): RS1000022801 (19:57246371 A>G), RS1000196582 (19:57249430 AT>A), RS1000223249 (19:57249731 A>T), RS1000379830 (19:57241283 C>G), RS1000386203 (19:57239529 C>CAT), RS1000399749 (19:57245515 C>G,T), RS1000467147 (19:57239690 A>G), RS1000654443 (19:57262940 A>G), RS1000668149 (19:57252430 A>C), RS1000684007 (19:57256373 G>GT), RS1000902854 (19:57259921 A>G), RS1000946660 (19:57246519 T>C), RS1001308238 (19:57239471 AAAATATATATAT>A,AAAATATATATATAAATATATATAT), RS1001383609 (19:57249606 A>T), RS1001519061 (19:57255807 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	4
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
Air Pollutants	increases abundance, increases expression, decreases expression	2
Cyclosporine	increases expression, increases methylation	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
beta-lapachone	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
NSC 689534	affects binding, increases expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Leflunomide	increases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Coal	decreases expression, increases abundance	1
Copper	increases expression, affects binding	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.