ZNF823

Summary

ZNF823 (zinc finger protein 823, HGNC:30936) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 823 (P16415). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 55552 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 74 total
• MANE Select transcript: NM_001080493

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30936
Approved symbol	ZNF823
Name	zinc finger protein 823
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	HSZFP36
Ensembl gene	ENSG00000197933
Ensembl biotype	protein_coding
Entrez	55552

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000341191, ENST00000431998, ENST00000440527, ENST00000586121, ENST00000890454

RefSeq mRNA: 3 — MANE Select: NM_001080493 NM_001080493, NM_001297610, NM_017507

CCDS: CCDS45981

Canonical transcript exons

ENST00000341191 — 4 exons

Exon	Start	End
ENSE00001367353	11721265	11723342
ENSE00003512656	11725201	11725327
ENSE00003526306	11738817	11738946
ENSE00003643376	11724194	11724254

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 89.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.9333 / max 100.8505, expressed in 1441 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179281	4.9333	1441

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	89.46	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.02	gold quality
calcaneal tendon	UBERON:0003701	87.29	gold quality
epithelial cell of pancreas	CL:0000083	87.24	gold quality
parotid gland	UBERON:0001831	86.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.28	gold quality
lower esophagus mucosa	UBERON:0035834	84.96	gold quality
esophagus squamous epithelium	UBERON:0006920	83.29	gold quality
colonic mucosa	UBERON:0000317	82.10	gold quality
mucosa of sigmoid colon	UBERON:0004993	81.82	gold quality
oral cavity	UBERON:0000167	81.68	gold quality
endothelial cell	CL:0000115	81.16	silver quality
oviduct epithelium	UBERON:0004804	79.92	gold quality
esophagus mucosa	UBERON:0002469	78.88	gold quality
ileal mucosa	UBERON:0000331	78.44	gold quality
colonic epithelium	UBERON:0000397	78.38	gold quality
mucosa of transverse colon	UBERON:0004991	78.32	gold quality
placenta	UBERON:0001987	77.72	gold quality
islet of Langerhans	UBERON:0000006	77.25	gold quality
skin of hip	UBERON:0001554	77.19	gold quality
rectum	UBERON:0001052	76.74	gold quality
gingiva	UBERON:0001828	76.53	gold quality
jejunal mucosa	UBERON:0000399	76.00	gold quality
amniotic fluid	UBERON:0000173	75.98	gold quality
gingival epithelium	UBERON:0001949	75.77	gold quality
ventricular zone	UBERON:0003053	75.29	gold quality
endometrium	UBERON:0001295	75.21	gold quality
metanephros cortex	UBERON:0010533	75.15	gold quality
transverse colon	UBERON:0001157	75.12	gold quality
right lobe of liver	UBERON:0001114	75.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

53 targeting ZNF823, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp961	ENSMUSG00000052446
rattus_norvegicus	Zfp617	ENSRNOG00000049856

Paralogs (15): ZNF14 (ENSG00000105708), ZNF57 (ENSG00000171970), ZNF791 (ENSG00000173875), ZNF443 (ENSG00000180855), ZNF101 (ENSG00000181896), ZNF563 (ENSG00000188868), ZNF799 (ENSG00000196466), ZNF700 (ENSG00000196757), ZNF441 (ENSG00000197044), ZNF433 (ENSG00000197647), ZNF44 (ENSG00000197857), ZNF442 (ENSG00000198342), ZNF844 (ENSG00000223547), ZNF709 (ENSG00000242852), ZNF878 (ENSG00000257446)

Protein

Protein identifiers

Zinc finger protein 823 — P16415 (reviewed: P16415)

Alternative names: Zinc finger protein ZFP-36

All UniProt accessions (4): C9J2N8, C9JU45, P16415, K7EN93

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
P16415-1	1	yes
P16415-2	2

RefSeq proteins (3): NP_001073962, NP_001284539, NP_059977 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13912

UniProt features (20 total): zinc finger region 16, chain 1, domain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P16415-F1	72.77	0.10

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 59 (showing top): TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, chr19p13, GEORGES_TARGETS_OF_MIR192_AND_MIR215, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, TURASHVILI_BREAST_NORMAL_DUCTAL_VS_LOBULAR_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, BARX1_TARGET_GENES, CEBPZ_TARGET_GENES, E2F2_TARGET_GENES, GREB1_TARGET_GENES, PRKDC_TARGET_GENES, SFMBT1_TARGET_GENES, ZBTB12_TARGET_GENES, ZNF407_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

396 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF823	EIF3G	O75821	568
ZNF823	C3orf49	Q96BT1	521
ZNF823	FTCDNL1	E5RQL4	477
ZNF823	SAFB	Q15424	459
ZNF823	SPEN	Q96T58	436
ZNF823	SLC39A8	Q9C0K1	429
ZNF823	LBR	Q14739	418
ZNF823	SAFB2	Q14151	411
ZNF823	FXR1	P51114	408
ZNF823	ACTMAP	Q5BKX5	396
ZNF823	XKR5	Q6UX68	374
ZNF823	CWF19L2	Q2TBE0	370
ZNF823	ZNF414	Q96IQ9	370
ZNF823	CACNA1D	Q01668	353
ZNF823	ARC	Q7LC44	353

IntAct

6 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
CDK6	ZNF823	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
DDX6	EIF3CL	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF823	PAK1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): ZNF823 (Proximity Label-MS), ZNF823 (Affinity Capture-MS), ZNF823 (Affinity Capture-MS), ZNF823 (Affinity Capture-MS), ZNF823 (Two-hybrid)

ESM2 similar proteins: A6NK75, C9JN71, O75820, O94892, P08043, P0CJ79, P16415, P17017, P17021, P17035, P17039, P35789, P52737, Q08AN1, Q3KP31, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R9F0, Q5RB30, Q5RDX1, Q5REA0, Q5REI6, Q5REK1, Q6P3V2, Q6ZN19, Q6ZNA1, Q6ZNG1, Q76KX8, Q80W31, Q86T29, Q86YE8, Q8C827, Q8N4W9, Q8N7K0, Q8NB50, Q8NDQ6, Q8NEP9, Q8TBZ8

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

698 predictions. Top by Δscore:

Variant	Effect	Δscore
19:11723340:CTT:C	acceptor_gain	1.0000
19:11723341:TT:T	acceptor_gain	1.0000
19:11723343:C:CC	acceptor_gain	1.0000
19:11725339:CACA:C	acceptor_gain	1.0000
19:11725342:A:C	acceptor_gain	1.0000
19:11723338:GACTT:G	acceptor_gain	0.9900
19:11723342:TC:T	acceptor_loss	0.9900
19:11723343:CTGTA:C	acceptor_loss	0.9900
19:11723344:T:C	acceptor_loss	0.9900
19:11725338:CCACA:C	acceptor_gain	0.9900
19:11725339:C:T	acceptor_gain	0.9900
19:11725344:G:C	acceptor_gain	0.9900
19:11738812:CTCA:C	donor_loss	0.9900
19:11738813:TCACC:T	donor_loss	0.9900
19:11738815:ACCAT:A	donor_loss	0.9900
19:11725341:CA:C	acceptor_gain	0.9800
19:11738810:CACT:C	donor_loss	0.9800
19:11738811:ACTC:A	donor_loss	0.9800
19:11738815:A:AC	donor_gain	0.9800
19:11738815:AC:A	donor_gain	0.9800
19:11738816:C:CC	donor_gain	0.9800
19:11738816:CC:C	donor_gain	0.9800
19:11738829:T:TA	donor_gain	0.9800
19:11731572:C:T	acceptor_gain	0.9700
19:11738816:CCA:C	donor_gain	0.9700
19:11725328:C:A	acceptor_loss	0.9600
19:11725329:T:A	acceptor_loss	0.9600
19:11725344:G:GC	acceptor_gain	0.9600
19:11722836:C:CC	acceptor_gain	0.9500
19:11725195:CCTTA:C	donor_loss	0.9500

AlphaMissense

4075 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:11722679:G:C	F285L	0.992
19:11722679:G:T	F285L	0.992
19:11722681:A:G	F285L	0.992
19:11722847:A:C	F229L	0.989
19:11722847:A:T	F229L	0.989
19:11722849:A:G	F229L	0.989
19:11721926:G:C	F536L	0.987
19:11721926:G:T	F536L	0.987
19:11721928:A:G	F536L	0.987
19:11722763:A:C	F257L	0.987
19:11722763:A:T	F257L	0.987
19:11722765:A:G	F257L	0.987
19:11721842:G:C	F564L	0.985
19:11721842:G:T	F564L	0.985
19:11721844:A:G	F564L	0.985
19:11722568:G:C	H322Q	0.985
19:11722568:G:T	H322Q	0.985
19:11722931:A:C	F201L	0.984
19:11722931:A:T	F201L	0.984
19:11722933:A:G	F201L	0.984
19:11722595:A:C	F313L	0.983
19:11722595:A:T	F313L	0.983
19:11722597:A:G	F313L	0.983
19:11722010:G:C	F508L	0.982
19:11722010:G:T	F508L	0.982
19:11722012:A:G	F508L	0.982
19:11722178:A:C	F452L	0.982
19:11722178:A:T	F452L	0.982
19:11722180:A:G	F452L	0.982
19:11722259:G:C	F425L	0.982

dbSNP variants (sampled 300 via entrez): RS1000042601 (19:11737869 T>C), RS1000203227 (19:11721080 G>T), RS1000876596 (19:11725530 A>G), RS1000892316 (19:11737821 TAGG>T), RS1001093263 (19:11724589 C>G,T), RS1001243604 (19:11738115 A>G), RS1001366442 (19:11730859 G>A,C), RS1001495957 (19:11725844 C>T), RS1001529505 (19:11725396 A>G), RS1001550776 (19:11728147 G>A), RS1001863360 (19:11730761 C>T), RS1001916137 (19:11733383 G>A), RS1002102064 (19:11727340 C>T), RS1002282591 (19:11727041 G>A), RS1002414323 (19:11737492 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004521_294	Autism spectrum disorder or schizophrenia	5.000000e-08
GCST008595_224	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy)	5.000000e-09
GCST012335_31	Hodgkin’s lymphoma	9.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence
EFO:0004784	self reported educational attainment

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects expression, increases expression	2
Cadmium Chloride	decreases expression, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
bisphenol A	increases expression, affects cotreatment	1
sodium arsenite	increases abundance, increases expression, affects cotreatment	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
vanadyl sulfate	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
abrine	decreases expression	1
Temozolomide	increases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Vorinostat	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Curcumin	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Formaldehyde	decreases expression	1
Glucose	increases expression	1
Indomethacin	increases expression, affects cotreatment	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Silver	increases expression	1
Smoke	decreases expression	1
Urethane	increases expression	1
Vincristine	decreases expression	1
1-Methyl-3-isobutylxanthine	increases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.