ZNF835

Summary

ZNF835 (zinc finger protein 835, HGNC:34332) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 835 (Q9Y2P0). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 90485 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 95 total
• MANE Select transcript: NM_001005850

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34332
Approved symbol	ZNF835
Name	zinc finger protein 835
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	BC37295_3
Ensembl gene	ENSG00000127903
Ensembl biotype	protein_coding
Entrez	90485

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000537055, ENST00000601659, ENST00000890488, ENST00000890489

RefSeq mRNA: 1 — MANE Select: NM_001005850 NM_001005850

CCDS: CCDS56105

Canonical transcript exons

ENST00000537055 — 2 exons

Exon	Start	End
ENSE00002262872	56671576	56671757
ENSE00002439124	56661980	56665245

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 96.50.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2481 / max 32.0520, expressed in 394 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182885	1.2481	394

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	96.50	gold quality
oocyte	CL:0000023	83.16	silver quality
diaphragm	UBERON:0001103	81.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.27	gold quality
mucosa of urinary bladder	UBERON:0001259	77.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.55	gold quality
secondary oocyte	CL:0000655	75.83	silver quality
cortical plate	UBERON:0005343	75.32	gold quality
apex of heart	UBERON:0002098	75.24	gold quality
ventricular zone	UBERON:0003053	74.28	gold quality
ganglionic eminence	UBERON:0004023	74.01	gold quality
endothelial cell	CL:0000115	72.66	gold quality
prefrontal cortex	UBERON:0000451	72.10	gold quality
cerebellar hemisphere	UBERON:0002245	69.79	gold quality
cerebellar cortex	UBERON:0002129	69.75	gold quality
olfactory bulb	UBERON:0002264	69.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.50	gold quality
cerebellum	UBERON:0002037	68.59	gold quality
right frontal lobe	UBERON:0002810	68.04	gold quality
type B pancreatic cell	CL:0000169	67.32	gold quality
oviduct epithelium	UBERON:0004804	67.21	gold quality
neocortex	UBERON:0001950	66.22	gold quality
frontal cortex	UBERON:0001870	66.03	gold quality
cingulate cortex	UBERON:0003027	65.97	gold quality
primary visual cortex	UBERON:0002436	65.96	gold quality
anterior cingulate cortex	UBERON:0009835	65.96	gold quality
heart left ventricle	UBERON:0002084	65.66	gold quality
medial globus pallidus	UBERON:0002477	65.62	silver quality
Brodmann (1909) area 9	UBERON:0013540	65.50	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

24 targeting ZNF835, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-377-5P	99.70	65.28	712
HSA-MIR-6086	99.70	65.38	699
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-940	99.37	66.14	2064
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-6893-5P	99.31	66.25	2119
HSA-MIR-6768-3P	99.14	67.38	1319
HSA-MIR-6799-5P	99.14	65.72	2093
HSA-MIR-4478	99.07	65.16	2320
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-670-3P	99.03	68.88	2404
HSA-MIR-1294	98.91	69.26	1030
HSA-MIR-9986	98.91	69.28	1024
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-3158-3P	98.45	64.25	560
HSA-MIR-340-3P	98.11	68.25	679
HSA-MIR-6827-3P	98.08	72.27	651
HSA-MIR-3189-5P	97.55	66.71	655
HSA-MIR-4486	96.96	60.61	931
HSA-MIR-3194-5P	96.80	64.90	1027
HSA-MIR-1258	96.08	67.74	700
HSA-MIR-6078	75.68	58.05	34

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 835 — Q9Y2P0 (reviewed: Q9Y2P0)

All UniProt accessions (2): Q9Y2P0, M0QYX0

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001005850* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (23 total): zinc finger region 14, compositionally biased region 3, region of interest 2, sequence variant 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2P0-F1	76.91	0.62

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 30 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MARTENS_TRETINOIN_RESPONSE_UP, KRAS.AMP.LUNG_UP.V1_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ZNF711_TARGET_GENES, MIR670_3P, MIR1294, MIR9986, MIR6868_5P, MIR6827_3P, MIR340_3P, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_DN, GSE1460_CD4_THYMOCYTE_VS_NAIVE_CD4_TCELL_CORD_BLOOD_DN, WP_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_DN

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

296 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF835	OR13A1	Q8NGR1	447
ZNF835	OR5P3	Q8WZ94	447
ZNF835	MAPDA	Q6DHV7	440
ZNF835	PHF3	Q92576	417
ZNF835	CYP4Z1	Q86W10	405
ZNF835	VSIG10L	Q86VR7	403
ZNF835	JHY	Q6NUN7	400
ZNF835	ANKRD36B	Q8N2N9	392
ZNF835	MOGAT3	Q86VF5	391
ZNF835	BLTP1	Q2LD37	375
ZNF835	TRIM49	P0CI25	370
ZNF835	IGF2R	P11717	353
ZNF835	CALHM2	Q9HA72	348
ZNF835	WRAP73	Q9P2S5	348
ZNF835	OR1J2	Q8NGS2	348
ZNF835	BTBD10	Q9BSF8	348

IntAct

205 interactions, top by confidence:

A	B	Type	Score
GUCD1	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
ZNF835	TEX12	psi-mi:“MI:0915”(physical association)	0.560
ZNF835	ZNF343	psi-mi:“MI:0915”(physical association)	0.560
MKRN3	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
POLR1C	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
BYSL	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
ZNF121	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
CABP5	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
CIB3	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
TEX12	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
OSBPL3	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
RINT1	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
GOLGA2	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
TSPYL2	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
ZNF526	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
KRT31	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
KRTAP12-3	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
RUNDC3A	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
TRIM23	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
ZNF835	IKBKG	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
KRTAP4-5	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
CEP70	ZNF835	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (68): ZNF835 (Affinity Capture-MS), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid), ZNF835 (Two-hybrid)

ESM2 similar proteins: A3KN32, A6NM28, A8K8V0, E9PYI1, O75467, O95201, P10072, P10075, P10078, P10754, P28698, P30373, P52736, Q0VCC5, Q14929, Q16587, Q17QR7, Q29RZ4, Q3KNW1, Q3TDE8, Q3US17, Q58DK7, Q5RJR4, Q5T619, Q5TEC3, Q5U4E2, Q62396, Q68H95, Q6AW86, Q6PGE4, Q6ZMY9, Q7Z398, Q7Z7K2, Q8BI73, Q8BIF9, Q8BIQ3, Q8BKK5, Q8JZL0, Q8N393, Q8R0T2

Diamond homologs: O88553, P0CG23, P17141, P21506, Q02526, Q3ZCX4, Q6ZSS3, Q8N8Y5, Q9UDV6, Q9Y2P0, Q9Y6Q3, A8MQ14, P17097, Q03936, Q15937, Q29RZ4, Q3KNS6, Q3V080, Q5RBX0, Q5RBY9, Q5T619, Q6DD87, Q6J6I6, Q6PG37, Q6ZMV8, Q7TNU6, Q7TSH9, Q8BIF9, Q8NEM1, Q8NHY6, Q8TBZ5, Q969W8, Q96EG3, Q96N77, Q96NG8, Q9BSG1, Q9UJL9, Q9Y2G7, A6QLU5, Q96N95

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

95 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	89
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

379 predictions. Top by Δscore:

Variant	Effect	Δscore
19:56665241:TGGGT:T	acceptor_gain	1.0000
19:56665242:GGGT:G	acceptor_gain	1.0000
19:56665243:GGT:G	acceptor_gain	1.0000
19:56665244:GT:G	acceptor_gain	1.0000
19:56665246:C:CC	acceptor_gain	1.0000
19:56671629:AG:A	donor_gain	0.9900
19:56665242:GGGTC:G	acceptor_gain	0.9700
19:56665243:GGTC:G	acceptor_gain	0.9700
19:56665244:GTC:G	acceptor_gain	0.9700
19:56665245:TCTGA:T	acceptor_gain	0.9700
19:56665246:C:CA	acceptor_gain	0.9700
19:56665247:T:A	acceptor_gain	0.9700
19:56665260:A:C	acceptor_gain	0.9700
19:56665260:A:AC	acceptor_gain	0.9500
19:56671630:G:A	donor_gain	0.9400
19:56671590:C:A	donor_gain	0.9200
19:56671659:A:AC	donor_gain	0.9200
19:56671702:T:TA	donor_gain	0.9200
19:56671659:AGT:A	donor_gain	0.9000
19:56671625:T:TA	donor_gain	0.8900
19:56671589:T:TA	donor_gain	0.8800
19:56671660:G:C	donor_gain	0.8800
19:56671586:G:A	donor_gain	0.8700
19:56665248:G:C	acceptor_gain	0.8600
19:56671659:AGTCT:A	donor_gain	0.8500
19:56671698:T:TA	donor_gain	0.8300
19:56666799:A:AC	donor_gain	0.8200
19:56666800:C:CC	donor_gain	0.8200
19:56671630:G:C	donor_gain	0.8000
19:56671208:TGC:T	donor_gain	0.7900

AlphaMissense

3531 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:56663750:G:C	F483L	0.999
19:56663750:G:T	F483L	0.999
19:56663752:A:G	F483L	0.999
19:56663834:G:C	F455L	0.999
19:56663834:G:T	F455L	0.999
19:56663836:A:G	F455L	0.999
19:56663918:G:C	F427L	0.999
19:56663918:G:T	F427L	0.999
19:56663920:A:G	F427L	0.999
19:56664170:G:C	F343L	0.999
19:56664170:G:T	F343L	0.999
19:56664172:A:G	F343L	0.999
19:56664674:G:C	F175L	0.999
19:56664674:G:T	F175L	0.999
19:56664676:A:G	F175L	0.999
19:56664758:G:C	F147L	0.999
19:56664758:G:T	F147L	0.999
19:56664760:A:G	F147L	0.999
19:56663817:A:G	L461P	0.998
19:56663886:C:G	R438P	0.998
19:56664002:G:C	F399L	0.998
19:56664002:G:T	F399L	0.998
19:56664004:A:G	F399L	0.998
19:56664338:G:C	F287L	0.998
19:56664338:G:T	F287L	0.998
19:56664340:A:G	F287L	0.998
19:56664422:G:C	F259L	0.998
19:56664422:G:T	F259L	0.998
19:56664424:A:G	F259L	0.998
19:56664506:G:C	F231L	0.998

dbSNP variants (sampled 300 via entrez): RS1000052771 (19:56672060 G>A,T), RS1000287737 (19:56667135 G>A,C), RS1000666060 (19:56670948 C>G,T), RS1000710102 (19:56663193 C>A,T), RS1000889838 (19:56668085 C>A,G), RS1000991691 (19:56662899 C>A), RS1001014856 (19:56673234 A>C), RS1001070295 (19:56673426 G>A), RS1001327800 (19:56666626 G>C), RS1002014810 (19:56665660 A>T), RS1002129250 (19:56665988 G>C), RS1002166924 (19:56672523 T>C), RS1002387416 (19:56671342 G>A), RS1002799708 (19:56662754 G>A), RS1002841415 (19:56670484 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004640_13	Western dietary pattern	5.000000e-06
GCST011386_2	Vaginal microbiome composition (G. vaginalis)	7.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0011013	vaginal microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
arsenite	increases methylation	1
tebuconazole	decreases expression	1
2-palmitoylglycerol	increases expression	1
bisphenol S	decreases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1
Acrylamide	decreases expression	1
Particulate Matter	increases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.