ZNF836

Summary

ZNF836 (zinc finger protein 836, HGNC:34333) is a protein-coding gene on chromosome 19q13.33, encoding Zinc finger protein 836 (Q6ZNA1). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 162962 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 131 total
• MANE Select transcript: NM_001102657

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34333
Approved symbol	ZNF836
Name	zinc finger protein 836
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ16287
Ensembl gene	ENSG00000196267
Ensembl biotype	protein_coding
Entrez	162962

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000596428, ENST00000597065, ENST00000597252, ENST00000599618, ENST00000602187, ENST00000682614, ENST00000884043, ENST00000938682

RefSeq mRNA: 1 — MANE Select: NM_001102657 NM_001102657

CCDS: CCDS46162

Canonical transcript exons

ENST00000682614 — 5 exons

Exon	Start	End
ENSE00003103547	52171336	52171621
ENSE00003491791	52168058	52168152
ENSE00003518295	52160465	52160591
ENSE00003531094	52169648	52169781
ENSE00003920872	52154107	52157540

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 95.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6511 / max 100.4753, expressed in 1669 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182518	3.3133	1174
182519	2.0433	1165
182520	1.2944	867

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.84	gold quality
adrenal tissue	UBERON:0018303	93.15	gold quality
calcaneal tendon	UBERON:0003701	89.73	gold quality
right adrenal gland cortex	UBERON:0035827	88.37	gold quality
right adrenal gland	UBERON:0001233	87.36	gold quality
left adrenal gland cortex	UBERON:0035825	87.31	gold quality
adrenal gland	UBERON:0002369	87.23	gold quality
left adrenal gland	UBERON:0001234	86.91	gold quality
ganglionic eminence	UBERON:0004023	86.53	gold quality
adrenal cortex	UBERON:0001235	86.28	gold quality
tendon	UBERON:0000043	85.47	gold quality
colonic epithelium	UBERON:0000397	85.42	gold quality
lower esophagus mucosa	UBERON:0035834	84.99	gold quality
cortical plate	UBERON:0005343	84.86	gold quality
left ovary	UBERON:0002119	84.69	gold quality
sperm	CL:0000019	83.86	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.94	gold quality
right ovary	UBERON:0002118	82.59	gold quality
right lung	UBERON:0002167	81.95	gold quality
adenohypophysis	UBERON:0002196	81.79	gold quality
ovary	UBERON:0000992	81.23	gold quality
popliteal artery	UBERON:0002250	80.93	gold quality
tibial artery	UBERON:0007610	80.92	gold quality
granulocyte	CL:0000094	80.81	gold quality
descending thoracic aorta	UBERON:0002345	80.78	gold quality
body of uterus	UBERON:0009853	80.42	gold quality
aorta	UBERON:0000947	80.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	80.31	gold quality
ectocervix	UBERON:0012249	80.23	gold quality
sural nerve	UBERON:0015488	80.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.17

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2573.1	ZNF836	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605368

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 836 — Q6ZNA1 (reviewed: Q6ZNA1)

All UniProt accessions (4): M0QYS4, M0QZ88, M0R1N4, Q6ZNA1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001096127* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352

UniProt features (33 total): zinc finger region 25, sequence conflict 4, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZNA1-F1	70.23	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, GOCC_NUCLEOLUS, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, ID1_TARGET_GENES, SKIL_TARGET_GENES, TFEB_TARGET_GENES, ZNF274_TARGET_GENES, ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_DN, GAUTAM_EYE_CHOROID_SCLERA_ACTIVATED_T_CELLS, GSE2706_R848_VS_LPS_2H_STIM_DC_UP, GSE2706_LPS_VS_R848_AND_LPS_2H_STIM_DC_DN, GOBP_NEGATIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS, chr19q13

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), nucleolus (GO:0005730), microtubule cytoskeleton (GO:0015630)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular membraneless organelle	1
cytoskeleton	1

Protein interactions and networks

STRING

254 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF836	IPP	Q9Y573	524
ZNF836	ZNG1F	Q4V339	430
ZNF836	DTWD1	Q8N5C7	378
ZNF836	TMEM240	Q5SV17	373
ZNF836	ZMAT1	Q5H9K5	367
ZNF836	SLC25A30	Q5SVS4	367
ZNF836	SERPINB12	Q96P63	360
ZNF836	KCTD17	Q8N5Z5	322
ZNF836	ABRA	Q8N0Z2	302
ZNF836	RABGAP1	Q9Y3P9	294
ZNF836	SDK2	Q58EX2	290
ZNF836	STXBP4	Q6ZWJ1	289
ZNF836	MYRFL	Q96LU7	289
ZNF836	LCMT1	Q9UIC8	288
ZNF836	KCNG4	Q8TDN1	287

IntAct

6 interactions, top by confidence:

A	B	Type	Score
ZNF562	MDM2	psi-mi:“MI:0914”(association)	0.350
ZNF836	TBCD	psi-mi:“MI:0915”(physical association)	0.000
ZNF836	TCP11L1	psi-mi:“MI:0915”(physical association)	0.000
APP	ZNF836	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (6): TBCD (Affinity Capture-MS), TCP11L1 (Affinity Capture-MS), ZNF836 (Affinity Capture-MS), ZNF836 (Affinity Capture-MS), ZNF836 (Two-hybrid), ZNF836 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDP4, A6NHJ4, O94892, P0CJ79, P17014, P17021, P17025, P17032, P17035, P18733, P51508, P51814, Q06730, Q06732, Q09FC8, Q0VGE8, Q14586, Q32M78, Q3MIS6, Q5JVG2, Q5R4K8, Q5R9S5, Q5RBQ3, Q5RCJ2, Q5RER9, Q5TYW1, Q5VIY5, Q6P560, Q6PDB4, Q6ZMW2, Q6ZN06, Q6ZNA1, Q76KX8, Q7L2R6, Q86Y25, Q8N184, Q8N823, Q8N883, Q8N8J6, Q8NEP9

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75820, P0CB33, P0CJ79, P0DKX0, P10755, P17032, P17035, P52738, Q02386, Q03923, Q03936, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586, Q14593, Q147U1, Q15928, Q3MIS6, Q3SXZ3, Q494X3, Q4R6C2, Q5HY98

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

131 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	119
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

716 predictions. Top by Δscore:

Variant	Effect	Δscore
19:52160460:CTTA:C	donor_loss	1.0000
19:52160462:TACCC:T	donor_loss	1.0000
19:52160463:A:AC	donor_gain	1.0000
19:52160463:AC:A	donor_gain	1.0000
19:52160463:ACCCA:A	donor_loss	1.0000
19:52160464:C:CC	donor_gain	1.0000
19:52160464:CC:C	donor_gain	1.0000
19:52160587:GGTCC:G	acceptor_gain	1.0000
19:52160588:GTCC:G	acceptor_gain	1.0000
19:52160589:TCC:T	acceptor_gain	1.0000
19:52160590:CC:C	acceptor_gain	1.0000
19:52160590:CCC:C	acceptor_gain	1.0000
19:52160591:CC:C	acceptor_gain	1.0000
19:52160592:C:A	acceptor_loss	1.0000
19:52160592:C:CC	acceptor_gain	1.0000
19:52160593:T:C	acceptor_loss	1.0000
19:52168152:TCTG:T	acceptor_loss	1.0000
19:52168153:C:CA	acceptor_loss	1.0000
19:52171332:TTA:T	donor_loss	1.0000
19:52171333:TA:T	donor_loss	1.0000
19:52171334:A:AC	donor_gain	1.0000
19:52171335:C:CT	donor_gain	1.0000
19:52171335:CTTG:C	donor_gain	1.0000
19:52160463:ACC:A	donor_gain	0.9900
19:52160464:CCC:C	donor_gain	0.9900
19:52160589:TCCC:T	acceptor_gain	0.9900
19:52160592:C:T	acceptor_gain	0.9900
19:52160597:A:AC	acceptor_gain	0.9900
19:52168052:TTTTA:T	donor_loss	0.9900
19:52168053:TTTA:T	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000094793 (19:52168660 C>G,T), RS1000143487 (19:52163497 G>A,C), RS1000381772 (19:52157908 T>C), RS1000441395 (19:52169607 CA>C,CAA,CAAA), RS1000494228 (19:52163595 A>C), RS1000830694 (19:52159731 T>C), RS1000871211 (19:52168776 G>A), RS1001179777 (19:52160040 G>A), RS1001454600 (19:52165760 C>A,G,T), RS1001717412 (19:52170764 T>C), RS1002025081 (19:52172641 A>G), RS1002106118 (19:52171014 A>G), RS1002211638 (19:52164152 G>A), RS1002363407 (19:52169473 T>C,G), RS1002422457 (19:52169199 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Particulate Matter	increases expression	2
urushiol	decreases expression	1
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
pentabromodiphenyl ether	increases expression	1
torcetrapib	increases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	increases expression	1
Succimer	affects cotreatment, decreases expression	1
Nickel	decreases expression	1
Ozone	affects expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	decreases expression	1
Fluorescein-5-isothiocyanate	affects binding	1
Lactic Acid	decreases expression	1
Magnetite Nanoparticles	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.