ZNF837

Summary

ZNF837 (zinc finger protein 837, HGNC:25164) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 837 (Q96EG3). May be involved in transcriptional regulation.

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 116412 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_138466

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25164
Approved symbol	ZNF837
Name	zinc finger protein 837
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000152475
Ensembl biotype	protein_coding
Entrez	116412

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000427624, ENST00000597582, ENST00000851403, ENST00000851404, ENST00000851405, ENST00000851406, ENST00000923608

RefSeq mRNA: 1 — MANE Select: NM_138466 NM_138466

CCDS: CCDS46216

Canonical transcript exons

ENST00000597582 — 3 exons

Exon	Start	End
ENSE00003058273	58369819	58369928
ENSE00003189223	58367623	58369361
ENSE00003199590	58380941	58381030

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 77.26.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2389 / max 23.8964, expressed in 764 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182955	1.2389	764

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	77.26	gold quality
right lobe of liver	UBERON:0001114	71.78	gold quality
left lobe of thyroid gland	UBERON:0001120	69.30	gold quality
right lobe of thyroid gland	UBERON:0001119	69.19	gold quality
stromal cell of endometrium	CL:0002255	68.58	gold quality
metanephros cortex	UBERON:0010533	68.28	gold quality
left ovary	UBERON:0002119	67.94	gold quality
right ovary	UBERON:0002118	67.49	gold quality
right adrenal gland	UBERON:0001233	67.44	gold quality
right adrenal gland cortex	UBERON:0035827	67.30	gold quality
thyroid gland	UBERON:0002046	67.28	gold quality
left adrenal gland	UBERON:0001234	67.12	gold quality
lower esophagus mucosa	UBERON:0035834	66.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.70	gold quality
mucosa of transverse colon	UBERON:0004991	66.66	gold quality
body of uterus	UBERON:0009853	66.58	gold quality
left adrenal gland cortex	UBERON:0035825	66.56	gold quality
ventricular zone	UBERON:0003053	66.55	gold quality
skin of leg	UBERON:0001511	66.51	gold quality
skin of abdomen	UBERON:0001416	66.40	gold quality
left uterine tube	UBERON:0001303	66.18	gold quality
endocervix	UBERON:0000458	66.01	gold quality
granulocyte	CL:0000094	65.29	gold quality
body of stomach	UBERON:0001161	65.13	gold quality
body of pancreas	UBERON:0001150	65.03	gold quality
adrenal cortex	UBERON:0001235	64.87	gold quality
adenohypophysis	UBERON:0002196	64.79	gold quality
ganglionic eminence	UBERON:0004023	64.62	gold quality
ectocervix	UBERON:0012249	64.42	gold quality
minor salivary gland	UBERON:0001830	64.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.07

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting ZNF837, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-520G-3P	98.91	67.38	1914
HSA-MIR-520H	98.91	67.38	1914
HSA-MIR-6769B-5P	98.73	64.91	1092
HSA-MIR-6769A-5P	97.99	64.16	851
HSA-MIR-4497	92.25	64.06	134

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zfx	ENSDARG00000074453
danio_rerio		ENSDARG00000098424
mus_musculus	Zfy2	ENSMUSG00000000103
mus_musculus	Zfy1	ENSMUSG00000053211
rattus_norvegicus	Zfy1	ENSRNOG00000053042

Paralogs (38): ZFX (ENSG00000005889), ZBTB11 (ENSG00000066422), ZFAT (ENSG00000066827), ZFY (ENSG00000067646), ZNF586 (ENSG00000083828), IKZF5 (ENSG00000095574), ZNF419 (ENSG00000105136), ZNF549 (ENSG00000121406), ZSCAN20 (ENSG00000121903), ZNF304 (ENSG00000131845), PRDM15 (ENSG00000141956), ZNF660 (ENSG00000144792), ZNF711 (ENSG00000147180), ZNF773 (ENSG00000152439), ZNF256 (ENSG00000152454), ZNF691 (ENSG00000164011), ZNF610 (ENSG00000167554), E4F1 (ENSG00000167967), ZNF562 (ENSG00000171466), ZNF561 (ENSG00000171469), ZNF584 (ENSG00000171574), ZIK1 (ENSG00000171649), ZNF570 (ENSG00000171827), ZSCAN2 (ENSG00000176371), ZNF552 (ENSG00000178935), ZNF154 (ENSG00000179909), ZNF792 (ENSG00000180884), ZNF793 (ENSG00000188227), ZNF548 (ENSG00000188785), ZNF79 (ENSG00000196152), ZNF418 (ENSG00000196724), ZNF772 (ENSG00000197128), ZNF583 (ENSG00000198440), ZNF480 (ENSG00000198464), ZNF551 (ENSG00000204519), ZNF134 (ENSG00000213762), ZNF587B (ENSG00000269343), ZNF8 (ENSG00000278129)

Protein

Protein identifiers

Zinc finger protein 837 — Q96EG3 (reviewed: Q96EG3)

All UniProt accessions (1): Q96EG3

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_612475* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (13 total): zinc finger region 8, sequence variant 2, chain 1, compositionally biased region 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96EG3-F1	58.92	0.02

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 27 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MODULE_49, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES, CEBPZ_TARGET_GENES, ELF2_TARGET_GENES, FOXJ2_TARGET_GENES, HOXB7_TARGET_GENES, NAB2_TARGET_GENES, PRKDC_TARGET_GENES, RBM34_TARGET_GENES, MIR520G_3P_MIR520H, BLANCO_MELO_HUMAN_PARAINFLUENZA_VIRUS_3_INFECTION_A594_CELLS_DN, EWSR1_TARGET_GENES

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), identical protein binding (GO:0042802), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
protein binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

394 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF837	WDR97	A6NE52	549
ZNF837	LRRC24	Q50LG9	469
ZNF837	TEX14	Q8IWB6	446
ZNF837	RFPL2	O75678	413
ZNF837	SHROOM1	Q2M3G4	393
ZNF837	GTF2IRD2B	Q6EKJ0	370
ZNF837	GTF2IRD2	Q86UP8	368
ZNF837	VPS37B	Q9H9H4	359
ZNF837	RUSC1	Q9BVN2	350
ZNF837	MRPL23	Q16540	349
ZNF837	GET1	O00258	303
ZNF837	ZFTA	C9JLR9	295
ZNF837	ADAMTS10	Q9H324	254
ZNF837	RYR1	P21817	253
ZNF837	CYTH2	Q99418	251

IntAct

257 interactions, top by confidence:

A	B	Type	Score
ZNF837	ZNF317	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	BEGAIN	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	VASN	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	ZNF121	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	UBE2I	psi-mi:“MI:0915”(physical association)	0.560
TNS2	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
ZNF124	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
VASN	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
PHF19	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	ZNF835	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	CHIC2	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
SPRED2	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
MYO15B	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
CCNDBP1	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
BAHD1	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	ZNF330	psi-mi:“MI:0915”(physical association)	0.560
FSD2	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-9	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-9	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
CCDC125	ZNF837	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (79): ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid), ZNF837 (Two-hybrid)

ESM2 similar proteins: A6NM28, A6QPT6, A8K8V0, B2KFW1, E9PYI1, O14771, O60304, O75467, O95201, P10075, P10078, P10754, P17098, P28698, P30373, P59923, Q14929, Q16587, Q3KNW1, Q3URR7, Q4KLI1, Q58DK7, Q5RJR4, Q5T619, Q62396, Q68H95, Q6AW86, Q6PGE4, Q6ZMS7, Q6ZMY9, Q7Z398, Q7Z7K2, Q86UQ0, Q8BGS3, Q8BI73, Q8BZ34, Q8JZL0, Q8N393, Q91VW9, Q969J2

Diamond homologs: A0A9P4XV22, A2ANX9, B1H2Q6, O62836, P08048, P0CJ78, P10925, P17010, P17012, P20662, P27705, P28698, P52288, P80944, Q01611, Q03081, Q03125, Q0VDT2, Q29419, Q3U3I9, Q52V16, Q567C6, Q5U2Z0, Q6B4Z5, Q7RTV3, Q95LI3, Q966L8, Q96EG3, Q9UDV6, Q9UL36, Q9Y462, P17041, P18732, Q08AN1, Q3US17, Q80V23, Q86T29, Q8CF60, Q8TBZ5, Q96BV0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 77 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	9	12.5×	3e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

329 predictions. Top by Δscore:

Variant	Effect	Δscore
19:58380939:A:AC	donor_gain	1.0000
19:58380940:C:CC	donor_gain	1.0000
19:58380940:CT:C	donor_gain	1.0000
19:58380940:CTCT:C	donor_gain	1.0000
19:58369358:GGAT:G	acceptor_gain	0.9900
19:58369359:GAT:G	acceptor_gain	0.9900
19:58369361:TC:T	acceptor_loss	0.9900
19:58369362:C:CC	acceptor_gain	0.9900
19:58369362:CT:C	acceptor_loss	0.9900
19:58369363:T:C	acceptor_loss	0.9900
19:58369715:A:AC	donor_gain	0.9900
19:58369715:ACT:A	donor_gain	0.9900
19:58369716:C:CC	donor_gain	0.9900
19:58369716:CTC:C	donor_gain	0.9900
19:58369716:CT:C	donor_gain	0.9800
19:58380934:CACTT:C	donor_loss	0.9800
19:58380935:ACTTA:A	donor_loss	0.9800
19:58380937:TTA:T	donor_loss	0.9800
19:58380938:TA:T	donor_loss	0.9800
19:58380939:ACT:A	donor_gain	0.9800
19:58380940:CTC:C	donor_gain	0.9800
19:58369357:AGGAT:A	acceptor_gain	0.9700
19:58369372:A:T	acceptor_gain	0.9700
19:58369926:CAT:C	acceptor_gain	0.9700
19:58369929:C:CC	acceptor_gain	0.9700
19:58380933:CCACT:C	donor_loss	0.9700
19:58380939:ACTCT:A	donor_gain	0.9700
19:58380940:CTCTC:C	donor_gain	0.9700
19:58369360:AT:A	acceptor_gain	0.9600
19:58369371:C:CT	acceptor_gain	0.9600

AlphaMissense

3400 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:58367797:G:C	F512L	1.000
19:58367797:G:T	F512L	1.000
19:58367799:A:G	F512L	1.000
19:58367881:G:C	F484L	0.999
19:58367881:G:T	F484L	0.999
19:58367883:A:G	F484L	0.999
19:58367965:G:C	F456L	0.999
19:58367965:G:T	F456L	0.999
19:58367967:A:G	F456L	0.999
19:58368133:G:C	F400L	0.999
19:58368133:G:T	F400L	0.999
19:58368135:A:G	F400L	0.999
19:58368217:G:C	F372L	0.999
19:58368217:G:T	F372L	0.999
19:58368219:A:G	F372L	0.999
19:58368409:G:C	F308L	0.999
19:58368409:G:T	F308L	0.999
19:58368411:A:G	F308L	0.999
19:58368493:G:C	F280L	0.999
19:58368493:G:T	F280L	0.999
19:58368495:A:G	F280L	0.999
19:58367798:A:G	F512S	0.998
19:58367854:G:C	H493Q	0.998
19:58367854:G:T	H493Q	0.998
19:58367842:G:C	H497Q	0.997
19:58367842:G:T	H497Q	0.997
19:58367856:G:C	H493D	0.997
19:58367856:G:T	H493N	0.997
19:58367882:A:G	F484S	0.997
19:58367883:A:T	F484I	0.997

dbSNP variants (sampled 300 via entrez): RS1000096586 (19:58381908 T>A), RS1000539931 (19:58371164 C>A), RS1000550874 (19:58381168 A>C), RS1000596390 (19:58376354 C>G), RS1000642632 (19:58370328 C>T), RS1000739533 (19:58367336 A>G), RS1000918224 (19:58367502 G>A,C), RS1001142254 (19:58371440 T>C), RS1001267225 (19:58374728 G>A), RS1001393585 (19:58368703 G>A,C,T), RS1001424853 (19:58368975 G>A,T), RS1001485720 (19:58381056 A>C), RS1001548030 (19:58382917 G>A), RS1001678494 (19:58380776 C>G,T), RS1001743360 (19:58369950 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, increases methylation	3
(+)-JQ1 compound	increases expression	2
Particulate Matter	increases abundance, increases expression	2
GSK-J4	decreases expression	1
OTX015	increases expression	1
mivebresib	increases expression	1
methylmercuric chloride	decreases expression	1
beta-lapachone	decreases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects methylation	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Estradiol	decreases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD46	HEK293 eGFP-ZNF837	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.