ZNF841

Summary

ZNF841 (zinc finger protein 841, HGNC:27611) is a protein-coding gene on chromosome 19q13.41, encoding Zinc finger protein 841 (Q6ZN19). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 284371 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_001136499

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27611
Approved symbol	ZNF841
Name	zinc finger protein 841
Location	19q13.41
Locus type	gene with protein product
Status	Approved
Aliases	LOC284371
Ensembl gene	ENSG00000197608
Ensembl biotype	protein_coding
Entrez	284371

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 2 retained_intron

ENST00000389534, ENST00000426391, ENST00000594295, ENST00000594440, ENST00000595599, ENST00000599430, ENST00000601738, ENST00000902211, ENST00000913200, ENST00000913201, ENST00000913202, ENST00000913203, ENST00000949293

RefSeq mRNA: 10 — MANE Select: NM_001136499 NM_001136499, NM_001321349, NM_001352298, NM_001352299, NM_001369825, NM_001369826, NM_001369827, NM_001369828, NM_001369829, NM_001369830

CCDS: CCDS46161, CCDS82388

Canonical transcript exons

ENST00000594440 — 7 exons

Exon	Start	End
ENSE00002254850	52088937	52089002
ENSE00002256902	52095575	52095765
ENSE00002302269	52093846	52093971
ENSE00002530599	52076958	52077084
ENSE00003519140	52084787	52084878
ENSE00003786455	52076044	52076172
ENSE00003922304	52064465	52067610

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 91.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.1273 / max 201.2012, expressed in 1720 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182516	10.1273	1720

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	91.75	gold quality
corpus callosum	UBERON:0002336	87.55	gold quality
adrenal tissue	UBERON:0018303	87.38	gold quality
endometrium	UBERON:0001295	85.80	gold quality
uterine cervix	UBERON:0000002	85.34	gold quality
sural nerve	UBERON:0015488	85.27	gold quality
ectocervix	UBERON:0012249	85.22	gold quality
left ovary	UBERON:0002119	85.00	gold quality
ovary	UBERON:0000992	84.81	gold quality
tonsil	UBERON:0002372	84.81	gold quality
bone marrow cell	CL:0002092	84.66	gold quality
right ovary	UBERON:0002118	84.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.22	gold quality
lower esophagus mucosa	UBERON:0035834	84.16	gold quality
body of uterus	UBERON:0009853	84.09	gold quality
prostate gland	UBERON:0002367	83.83	gold quality
cerebellar cortex	UBERON:0002129	83.76	gold quality
cerebellar hemisphere	UBERON:0002245	83.74	gold quality
cerebellum	UBERON:0002037	83.67	gold quality
stromal cell of endometrium	CL:0002255	83.58	gold quality
endocervix	UBERON:0000458	83.48	gold quality
colonic epithelium	UBERON:0000397	83.38	gold quality
myometrium	UBERON:0001296	83.27	gold quality
right uterine tube	UBERON:0001302	83.24	gold quality
pituitary gland	UBERON:0000007	83.15	gold quality
adenohypophysis	UBERON:0002196	82.99	gold quality
tibial nerve	UBERON:0001323	82.95	gold quality
vagina	UBERON:0000996	82.87	gold quality
body of pancreas	UBERON:0001150	82.15	gold quality
bone marrow	UBERON:0002371	82.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.06

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2590.1	ZNF841	More than 3 adjacent zinc fingers
MA2691.1	ZNF841	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605530

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 841 — Q6ZN19 (reviewed: Q6ZN19)

All UniProt accessions (3): Q6ZN19, M0QYV6, M0R0F3

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6ZN19-1	1	yes
Q6ZN19-2	2
Q6ZN19-3	3

RefSeq proteins (10): NP_001129971, NP_001308278, NP_001339227, NP_001339228, NP_001356754, NP_001356755, NP_001356756, NP_001356757, NP_001356758, NP_001356759 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050331	Zinc_finger_PRDM4/PRDM1/PRDM14	Family

Pfam: PF00096, PF13912

UniProt features (32 total): zinc finger region 23, cross-link 4, splice variant 2, sequence conflict 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZN19-F1	69.52	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 137, 554, 579, 791

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 67 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, ZNF350_TARGET_GENES, MIR300, MIR381_3P, MIR7151_3P, MIR583, MIR544B, GSE11924_TFH_VS_TH17_CD4_TCELL_UP, GSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_UP, GSE14308_TH1_VS_NAIVE_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE17721_CTRL_VS_LPS_1H_BMDC_UP, GSE17721_CTRL_VS_POLYIC_6H_BMDC_UP

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nuclear lumen (GO:0031981)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nucleus	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

248 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF841	ZMYM6	O95789	561
ZNF841	CACHD1	Q5VU97	543
ZNF841	SPDYE2	Q495Y8	542
ZNF841	TADA3	O75528	469
ZNF841	DMAP1	Q9NPF5	464
ZNF841	SETDB2	Q96T68	462
ZNF841	PSMB1	P20618	454
ZNF841	CALHM5	Q8N5C1	446
ZNF841	SUPT5H	O00267	443
ZNF841	KCTD1	Q719H9	433
ZNF841	ELF3	P78545	427
ZNF841	DACT1	Q9NYF0	425
ZNF841	DCTPP1	Q9H773	413
ZNF841	APMAP	Q9HDC9	400
ZNF841	CYB5D1	Q6P9G0	399

IntAct

4 interactions, top by confidence:

A	B	Type	Score
M		psi-mi:“MI:0914”(association)	0.350
CUL9	NVL	psi-mi:“MI:0914”(association)	0.350
USP25	ZNF841	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (4): ZNF841 (Affinity Capture-RNA), ZNF841 (Affinity Capture-MS), ZNF841 (Two-hybrid), ZNF841 (Affinity Capture-MS)

ESM2 similar proteins: A2RRD8, A6NHJ4, A6NK75, B4DU55, O75346, P0DPD5, P15621, P17030, P17039, P52737, Q0VGE8, Q14588, Q147U1, Q15928, Q2M3X9, Q3KNS6, Q494X3, Q4R6C2, Q5HYK9, Q5R5Q6, Q5R5S6, Q5REA0, Q5REK1, Q60585, Q61751, Q6ECI4, Q6P9Y7, Q6ZN19, Q6ZNA1, Q7Z3V5, Q86T29, Q86WZ6, Q8N141, Q8N7K0, Q8N9F8, Q8NA42, Q8NCK3, Q8NDQ6, Q8NEM1, Q8WV37

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MTY0, A8MUV8, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0CJ79, P0DKX0, P10755, P16373, P16374, P17019, P17035, P17038, P35789, P51522, P52738, Q03923, Q03936, Q03938, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

491 predictions. Top by Δscore:

Variant	Effect	Δscore
19:52076951:T:A	donor_gain	1.0000
19:52076953:CTCA:C	donor_loss	1.0000
19:52076955:CACCC:C	donor_loss	1.0000
19:52076956:A:C	donor_loss	1.0000
19:52076956:AC:A	donor_gain	1.0000
19:52076957:CC:C	donor_gain	1.0000
19:52076957:CCCAG:C	donor_loss	1.0000
19:52077080:GATCC:G	acceptor_gain	1.0000
19:52077082:TCC:T	acceptor_gain	1.0000
19:52077083:CC:C	acceptor_gain	1.0000
19:52077083:CCC:C	acceptor_gain	1.0000
19:52077084:CC:C	acceptor_gain	1.0000
19:52077084:CCTGA:C	acceptor_loss	1.0000
19:52067608:TAC:T	acceptor_gain	0.9900
19:52067611:C:CC	acceptor_gain	0.9900
19:52067611:C:CG	acceptor_loss	0.9900
19:52067612:T:G	acceptor_loss	0.9900
19:52075746:T:TA	donor_gain	0.9900
19:52076933:A:C	donor_gain	0.9900
19:52076956:A:AC	donor_gain	0.9900
19:52076957:C:CC	donor_gain	0.9900
19:52076973:T:TA	donor_gain	0.9900
19:52076997:C:A	donor_gain	0.9900
19:52077081:ATCC:A	acceptor_gain	0.9900
19:52077085:C:CC	acceptor_gain	0.9900
19:52077090:A:AC	acceptor_gain	0.9900
19:52084782:TTTAC:T	donor_loss	0.9900
19:52084783:TTA:T	donor_loss	0.9900
19:52084784:TACCT:T	donor_loss	0.9900
19:52084786:C:CA	donor_loss	0.9900

AlphaMissense

589 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000174767 (19:52076977 G>A,T), RS1000234411 (19:52072055 T>C), RS1000260745 (19:52072351 A>C), RS1000434793 (19:52091194 C>T), RS1000486826 (19:52065313 C>G,T), RS1000528655 (19:52090788 G>C,T), RS1000541119 (19:52090736 T>G), RS1000582165 (19:52078563 G>A), RS1000923211 (19:52060575 C>G,T), RS1001009535 (19:52060302 C>G), RS1001042527 (19:52096982 T>C), RS1001225527 (19:52079539 T>C,G), RS1001293514 (19:52096529 T>C), RS1001558737 (19:52073026 C>G,T), RS1001662695 (19:52096232 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002291_1	Bronchodilator response in asthma (inhaled corticosteroid treatment interaction)	1.000000e-09
GCST002291_2	Bronchodilator response in asthma (inhaled corticosteroid treatment interaction)	2.000000e-09
GCST005566_28	Insomnia	3.000000e-07
GCST007277_24	Tourette syndrome	9.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
beta-lapachone	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Niclosamide	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Aflatoxin B1	increases methylation	1
Okadaic Acid	increases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.