ZNF843

Summary

ZNF843 (zinc finger protein 843, HGNC:28710) is a protein-coding gene on chromosome 16p11.2, encoding Zinc finger protein 843 (Q8N446).

Predicted to enable zinc ion binding activity.

Source: NCBI Gene 283933 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 71 total
• MANE Select transcript: NM_001136509

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28710
Approved symbol	ZNF843
Name	zinc finger protein 843
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	MGC46336
Ensembl gene	ENSG00000176723
Ensembl biotype	protein_coding
Entrez	283933

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000315678, ENST00000564218, ENST00000618063, ENST00000857608, ENST00000857609, ENST00000958242

RefSeq mRNA: 2 — MANE Select: NM_001136509 NM_001136509, NM_001353381

CCDS: CCDS45471

Canonical transcript exons

ENST00000315678 — 2 exons

Exon	Start	End
ENSE00003841495	31442636	31442789
ENSE00003846735	31435434	31437184

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 79.65.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4229 / max 8.4168, expressed in 247 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157160	0.4229	247

Top tissues by expression

225 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	79.65	silver quality
gingival epithelium	UBERON:0001949	78.97	gold quality
parietal pleura	UBERON:0002400	77.54	gold quality
secondary oocyte	CL:0000655	77.53	silver quality
gingiva	UBERON:0001828	73.74	gold quality
tibia	UBERON:0000979	71.61	gold quality
upper leg skin	UBERON:0004262	71.26	gold quality
germinal epithelium of ovary	UBERON:0001304	71.13	gold quality
superficial temporal artery	UBERON:0001614	70.22	gold quality
sperm	CL:0000019	69.11	gold quality
stromal cell of endometrium	CL:0002255	68.82	gold quality
mucosa of paranasal sinus	UBERON:0005030	67.90	gold quality
cortical plate	UBERON:0005343	67.68	gold quality
islet of Langerhans	UBERON:0000006	67.42	gold quality
thymus	UBERON:0002370	67.37	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	67.03	gold quality
cerebellar vermis	UBERON:0004720	66.90	gold quality
ventral tegmental area	UBERON:0002691	66.69	gold quality
cardia of stomach	UBERON:0001162	66.50	gold quality
superior surface of tongue	UBERON:0007371	66.37	silver quality
pericardium	UBERON:0002407	66.33	gold quality
tendon of biceps brachii	UBERON:0008188	66.30	gold quality
vena cava	UBERON:0004087	66.07	gold quality
tongue	UBERON:0001723	66.03	gold quality
body of tongue	UBERON:0011876	65.97	gold quality
myocardium	UBERON:0002349	65.88	gold quality
pharyngeal mucosa	UBERON:0000355	65.83	gold quality
substantia nigra pars reticulata	UBERON:0001966	65.76	gold quality
substantia nigra pars compacta	UBERON:0001965	65.65	gold quality
lateral globus pallidus	UBERON:0002476	65.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.90

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting ZNF843, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-605-5P	98.79	68.24	1161
HSA-MIR-6761-5P	98.71	68.03	1504
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-188-5P	97.89	67.01	756
HSA-MIR-6866-3P	97.38	66.94	748
HSA-MIR-6892-5P	97.27	68.60	847
HSA-MIR-3943	95.87	64.57	523

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Zinc finger protein 843 — Q8N446 (reviewed: Q8N446)

All UniProt accessions (2): Q8N446, H3BQN5

RefSeq proteins (2): NP_001129981, NP_001340310 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

UniProt features (7 total): zinc finger region 2, region of interest 2, chain 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N446-F1	47.13	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): chr16p11, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN, CBX7_TARGET_GENES, ID2_TARGET_GENES, ZNF7_TARGET_GENES, MIR605_5P, MIR6817_5P, MIR4769_3P, MIR188_5P, MIR6866_3P, GSE13485_DAY1_VS_DAY3_YF17D_VACCINE_PBMC_UP, DESCARTES_MAIN_FETAL_ENS_NEURONS, DESCARTES_FETAL_PANCREAS_ENS_NEURONS, MEF2C_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (4): zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transition metal ion binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
binding	1
cation binding	1

Protein interactions and networks

STRING

270 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF843	ZNF646	O15015	540
ZNF843	PPP1R17	O96001	419
ZNF843	ARMC5	Q96C12	403
ZNF843	RUSF1	Q96GQ5	370
ZNF843	CHKB	Q9Y259	307
ZNF843	ITGAD	Q13349	303
ZNF843	COX6A2	Q02221	301
ZNF843	TRIM72	Q6ZMU5	294
ZNF843	SGO1	Q5FBB7	257
ZNF843	TGFB1I1	O43294	248
ZNF843	LRRC10	Q5BKY1	235
ZNF843	HIPK3	Q9H422	230
ZNF843	COQ10A	Q96MF6	222
ZNF843	KAT8	Q9H7Z6	221
ZNF843	HIPK2	Q9H2X6	200

IntAct

17 interactions, top by confidence:

A	B	Type	Score
CDC37	ZNF843	psi-mi:“MI:0915”(physical association)	0.590
CYSRT1	ZNF843	psi-mi:“MI:0915”(physical association)	0.560
KRTAP6-2	ZNF843	psi-mi:“MI:0915”(physical association)	0.560
HOXA1	ZNF843	psi-mi:“MI:0915”(physical association)	0.560
HSP90AB1	ZNF843	psi-mi:“MI:0915”(physical association)	0.400
ZNF843	GNAQ	psi-mi:“MI:0914”(association)	0.350
ZNF843	CAMK2B	psi-mi:“MI:0914”(association)	0.350
ZNF843	AMY2A	psi-mi:“MI:0914”(association)	0.350
ZNF843	PMPCA	psi-mi:“MI:0914”(association)	0.350
ZNF843	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000
ZNF843	KRTAP6-2	psi-mi:“MI:0915”(physical association)	0.000
ZNF843	HOXA1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (16): LIMD1 (Affinity Capture-MS), CAMK2D (Affinity Capture-MS), CAMK2B (Affinity Capture-MS), PSMG3 (Affinity Capture-MS), GNAQ (Affinity Capture-MS), ZNF843 (Two-hybrid), KRTAP6-2 (Two-hybrid), CYSRT1 (Two-hybrid), CAMK2B (Affinity Capture-MS), LIMD1 (Affinity Capture-MS), CAMK2D (Affinity Capture-MS), AMY2B (Affinity Capture-MS), AMY2A (Affinity Capture-MS), NME2 (Affinity Capture-MS), CELA3A (Affinity Capture-MS)

ESM2 similar proteins: A5PL33, A6NHQ4, B2KGE5, B2RW88, C0HM98, H3BQW9, H7C350, I3L1E1, O60393, P0CAT3, P0DPF6, P43359, P70331, Q0VFX4, Q2M3A8, Q32LI1, Q3C1V9, Q3SXR2, Q3ZCQ2, Q5SWP3, Q5SWW7, Q5W5W9, Q63003, Q6NXZ1, Q6Q795, Q6UXR6, Q6UXR8, Q6UXU0, Q6UXV3, Q6ZSR3, Q71F78, Q8BT88, Q8N446, Q8N5N4, Q8N616, Q8N6K4, Q8NBC4, Q8NBF4, Q8NEQ6, Q8TBC5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

281 predictions. Top by Δscore:

Variant	Effect	Δscore
16:31442662:T:TA	donor_gain	0.9400
16:31437140:TTCC:T	acceptor_loss	0.9300
16:31437141:TCC:T	acceptor_loss	0.9300
16:31437142:CCTG:C	acceptor_loss	0.9300
16:31437143:C:A	acceptor_loss	0.9300
16:31437144:TG:T	acceptor_loss	0.9300
16:31437145:G:C	acceptor_loss	0.9300
16:31437181:CTCT:C	acceptor_gain	0.9300
16:31442663:C:A	donor_gain	0.9200
16:31437143:C:CC	acceptor_gain	0.9100
16:31437183:CT:C	acceptor_gain	0.9100
16:31437185:C:CC	acceptor_gain	0.9000
16:31437180:TCTCT:T	acceptor_gain	0.8600
16:31437181:CTCTC:C	acceptor_gain	0.8600
16:31437182:TCTCT:T	acceptor_gain	0.8600
16:31437183:CTCTA:C	acceptor_loss	0.8400
16:31437184:TC:T	acceptor_loss	0.8400
16:31437185:CTAGA:C	acceptor_loss	0.8400
16:31437186:T:A	acceptor_loss	0.8400
16:31442629:CTCT:C	donor_loss	0.8400
16:31442630:TCTT:T	donor_loss	0.8400
16:31442631:CTTAC:C	donor_loss	0.8400
16:31442632:TTAC:T	donor_loss	0.8400
16:31442633:TA:T	donor_loss	0.8400
16:31442634:ACC:A	donor_loss	0.8400
16:31442635:C:CA	donor_loss	0.8400
16:31442634:AC:A	donor_gain	0.8300
16:31442635:CC:C	donor_gain	0.8300
16:31437185:C:G	acceptor_gain	0.8200
16:31441960:G:A	donor_gain	0.7900

AlphaMissense

2204 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:31436724:A:C	F42L	0.991
16:31436724:A:T	F42L	0.991
16:31436726:A:G	F42L	0.991
16:31435851:A:C	F333L	0.957
16:31435851:A:T	F333L	0.957
16:31435853:A:G	F333L	0.957
16:31436725:A:G	F42S	0.952
16:31436697:G:C	H51Q	0.940
16:31436697:G:T	H51Q	0.940
16:31436725:A:C	F42C	0.936
16:31436415:G:C	F145L	0.927
16:31436415:G:T	F145L	0.927
16:31436417:A:G	F145L	0.927
16:31436190:G:C	F220L	0.922
16:31436190:G:T	F220L	0.922
16:31436192:A:G	F220L	0.922
16:31436772:G:C	F26L	0.908
16:31436772:G:T	F26L	0.908
16:31436774:A:G	F26L	0.908
16:31436475:A:C	F125L	0.906
16:31436475:A:T	F125L	0.906
16:31436477:A:G	F125L	0.906
16:31436699:G:C	H51D	0.903
16:31435839:C:A	K337N	0.894
16:31435839:C:G	K337N	0.894
16:31436235:G:C	F205L	0.889
16:31436235:G:T	F205L	0.889
16:31436237:A:G	F205L	0.889
16:31435842:C:A	W336C	0.886
16:31435842:C:G	W336C	0.886

dbSNP variants (sampled 300 via entrez): RS1000047593 (16:31435348 G>A,T), RS1000665144 (16:31442896 G>A), RS1000682370 (16:31435950 C>A,G,T), RS1000905548 (16:31442635 C>A,G), RS1001087595 (16:31441552 A>G,T), RS1001324105 (16:31440043 C>T), RS1001564169 (16:31439759 G>A), RS1002221597 (16:31435750 C>A,G), RS1002331382 (16:31442164 C>T), RS1002445819 (16:31442511 G>A), RS1002705722 (16:31443773 C>A,T), RS1002772989 (16:31444033 A>ACCC), RS1002963590 (16:31436978 A>C,G), RS1002999437 (16:31438581 C>G,T), RS1003225340 (16:31444809 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
sodium arsenite	increases expression	1
ferrous chloride	decreases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Sunitinib	increases expression	1
Benzo(a)pyrene	decreases expression	1
Lead	affects expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases methylation	1
Okadaic Acid	decreases expression	1
Acrylamide	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW89	HEK293 eGFP-ZNF843	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.