ZNF844

Summary

ZNF844 (zinc finger protein 844, HGNC:25932) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 844 (Q08AG5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 284391 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 118 total
• MANE Select transcript: NM_001136501

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25932
Approved symbol	ZNF844
Name	zinc finger protein 844
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14959
Ensembl gene	ENSG00000223547
Ensembl biotype	protein_coding
Entrez	284391

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000439326, ENST00000441304, ENST00000550826

RefSeq mRNA: 1 — MANE Select: NM_001136501 NM_001136501

CCDS: CCDS45985

Canonical transcript exons

ENST00000439326 — 4 exons

Exon	Start	End
ENSE00001612204	12074031	12074157
ENSE00001620841	12075312	12081565
ENSE00001741226	12074361	12074421
ENSE00002245132	12064731	12064876

Expression profiles

Bgee: expression breadth ubiquitous, 238 present calls, max score 86.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2096 / max 1056.3810, expressed in 1227 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173980	6.5928	1162
173979	0.7146	371
173981	0.5137	257
173982	0.3884	204

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	86.84	silver quality
calcaneal tendon	UBERON:0003701	85.98	gold quality
cardiac muscle of right atrium	UBERON:0003379	85.87	silver quality
left ventricle myocardium	UBERON:0006566	85.36	silver quality
buccal mucosa cell	CL:0002336	85.01	gold quality
oviduct epithelium	UBERON:0004804	83.79	gold quality
amniotic fluid	UBERON:0000173	81.90	gold quality
pigmented layer of retina	UBERON:0001782	79.95	gold quality
ventricular zone	UBERON:0003053	79.66	gold quality
colonic epithelium	UBERON:0000397	79.52	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.18	gold quality
tendon	UBERON:0000043	78.46	gold quality
islet of Langerhans	UBERON:0000006	78.01	gold quality
myocardium	UBERON:0002349	77.35	silver quality
bone marrow cell	CL:0002092	77.26	gold quality
ileal mucosa	UBERON:0000331	77.07	silver quality
upper arm skin	UBERON:0004263	76.85	gold quality
esophagus squamous epithelium	UBERON:0006920	76.84	gold quality
ganglionic eminence	UBERON:0004023	76.56	gold quality
bronchial epithelial cell	CL:0002328	76.28	gold quality
adult mammalian kidney	UBERON:0000082	75.78	gold quality
bronchus	UBERON:0002185	75.45	gold quality
cortical plate	UBERON:0005343	75.36	gold quality
kidney	UBERON:0002113	75.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.73	gold quality
stromal cell of endometrium	CL:0002255	74.73	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.30	gold quality
fallopian tube	UBERON:0003889	74.19	gold quality
corpus epididymis	UBERON:0004359	73.98	gold quality
endometrium	UBERON:0001295	73.86	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6379	no	3.17
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting ZNF844, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-3156-3P	99.76	66.72	939

Cross-species orthologs

0 orthologs

Paralogs (15): ZNF14 (ENSG00000105708), ZNF57 (ENSG00000171970), ZNF791 (ENSG00000173875), ZNF443 (ENSG00000180855), ZNF101 (ENSG00000181896), ZNF563 (ENSG00000188868), ZNF799 (ENSG00000196466), ZNF700 (ENSG00000196757), ZNF441 (ENSG00000197044), ZNF433 (ENSG00000197647), ZNF44 (ENSG00000197857), ZNF823 (ENSG00000197933), ZNF442 (ENSG00000198342), ZNF709 (ENSG00000242852), ZNF878 (ENSG00000257446)

Protein

Protein identifiers

Zinc finger protein 844 — Q08AG5 (reviewed: Q08AG5)

All UniProt accessions (3): Q08AG5, F8VS19, F8WE48

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001129973* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (22 total): zinc finger region 9, sequence variant 9, chain 1, domain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q08AG5-F1	57.43	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 59 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, VECCHI_GASTRIC_CANCER_EARLY_DN, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, DODD_NASOPHARYNGEAL_CARCINOMA_DN, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP, KIM_MYCN_AMPLIFICATION_TARGETS_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ZNF184_TARGET_GENES, MIR4262, MIR6809_3P, MIR181A_5P_MIR181B_5P, MIR181D_5P, MIR181C_5P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

478 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF844	WDR93	Q6P2C0	474
ZNF844	MIDEAS	Q6PJG2	373
ZNF844	PHYHD1	Q5SRE7	368
ZNF844	GBX1	Q14549	322
ZNF844	FBXO38	Q6PIJ6	306
ZNF844	PSD3	Q9NYI0	295
ZNF844	ATP6V0B	Q99437	293
ZNF844	TRIT1	Q9H3H1	292
ZNF844	SH2D2A	Q9NP31	269
ZNF844	SMC1B	Q8NDV3	236
ZNF844	KCNF1	Q9H3M0	232
ZNF844	TMEM131L	A2VDJ0	220
ZNF844	ZNF646	O15015	217
ZNF844	PCDH9	Q9HC56	213
ZNF844	ZNF438	Q7Z4V0	211

IntAct

47 interactions, top by confidence:

A	B	Type	Score
ZNF844	KRT40	psi-mi:“MI:0915”(physical association)	0.720
MDFI	ZNF844	psi-mi:“MI:0915”(physical association)	0.720
ZNF844	NDEL1	psi-mi:“MI:0915”(physical association)	0.720
NDEL1	ZNF844	psi-mi:“MI:0915”(physical association)	0.720
KRT40	ZNF844	psi-mi:“MI:0915”(physical association)	0.720
ZNF844	MDFI	psi-mi:“MI:0915”(physical association)	0.720
ZNF844	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZNF844	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-9	ZNF844	psi-mi:“MI:0915”(physical association)	0.560
ZNF844	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
CABP5	ZNF844	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	ZNF844	psi-mi:“MI:0915”(physical association)	0.560
ZNF844	TRAF1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF844	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	ZNF844	psi-mi:“MI:0915”(physical association)	0.560
ZNF844	HOOK2	psi-mi:“MI:0915”(physical association)	0.560
ZNF844	CABP5	psi-mi:“MI:0915”(physical association)	0.560
ZNF844	MESD	psi-mi:“MI:0915”(physical association)	0.560
ZNF844	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ZNF844	GOLGA6L9	psi-mi:“MI:0915”(physical association)	0.000
ZNF844	TRAF1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (17): ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), KRTAP10-9 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), ZNF844 (Two-hybrid), KRTAP10-7 (Two-hybrid)

ESM2 similar proteins: A0A087WUL8, A0A0J9YWL9, A0A0J9YY54, A0A0U1RQI7, A6NJ88, A6QL64, B4DH59, D3ZVV1, E9Q6E9, F1LWT0, O04492, O88799, P0DKJ7, P0DKJ8, P0DKL2, P0DPF3, P18583, P53353, Q08AG5, Q0P6D6, Q2EG98, Q3BBV2, Q4ZJZ1, Q5HY64, Q5JPF3, Q5QGU6, Q5TAG4, Q5TI25, Q5XHX6, Q6P3W6, Q6P902, Q6XPR3, Q6ZQX7, Q86T75, Q86VE3, Q86VQ3, Q8N2N9, Q8N660, Q8N693, Q96EQ9

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

118 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	100
Likely benign	8
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

655 predictions. Top by Δscore:

Variant	Effect	Δscore
19:12064881:GT:G	donor_gain	1.0000
19:12074015:ATGT:A	acceptor_gain	1.0000
19:12074015:ATGTG:A	acceptor_gain	1.0000
19:12074016:T:G	acceptor_gain	1.0000
19:12074018:T:TA	acceptor_gain	1.0000
19:12074019:G:A	acceptor_gain	1.0000
19:12074026:TTCAG:T	acceptor_loss	1.0000
19:12074030:GGAC:G	acceptor_gain	1.0000
19:12074158:G:GA	donor_loss	1.0000
19:12074158:G:GG	donor_gain	1.0000
19:12074159:T:A	donor_loss	1.0000
19:12075309:CA:C	acceptor_loss	1.0000
19:12075310:A:AG	acceptor_gain	1.0000
19:12075311:G:A	acceptor_loss	1.0000
19:12075311:G:GA	acceptor_gain	1.0000
19:12075311:GA:G	acceptor_gain	1.0000
19:12075311:GAA:G	acceptor_gain	1.0000
19:12075311:GAAGT:G	acceptor_gain	1.0000
19:12064875:TG:T	donor_gain	0.9900
19:12064876:GG:G	donor_gain	0.9900
19:12064877:G:GG	donor_gain	0.9900
19:12064877:GTGA:G	donor_loss	0.9900
19:12074013:ACAT:A	acceptor_gain	0.9900
19:12074015:AT:A	acceptor_gain	0.9900
19:12074023:T:TA	acceptor_gain	0.9900
19:12074029:A:AG	acceptor_gain	0.9900
19:12074029:AG:A	acceptor_gain	0.9900
19:12074030:G:GA	acceptor_gain	0.9900
19:12074030:GG:G	acceptor_gain	0.9900
19:12074030:GGA:G	acceptor_gain	0.9900

AlphaMissense

4471 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:12075904:T:C	F262L	0.994
19:12075906:C:A	F262L	0.994
19:12075906:C:G	F262L	0.994
19:12075988:T:C	F290L	0.994
19:12075990:C:A	F290L	0.994
19:12075990:C:G	F290L	0.994
19:12074065:T:C	F13S	0.993
19:12075820:T:C	F234L	0.993
19:12075822:T:A	F234L	0.993
19:12075822:T:G	F234L	0.993
19:12074064:T:C	F13L	0.990
19:12074066:C:A	F13L	0.990
19:12074066:C:G	F13L	0.990
19:12074079:T:A	W18R	0.990
19:12074079:T:C	W18R	0.990
19:12074089:T:C	L21P	0.988
19:12074102:G:C	Q25H	0.985
19:12074102:G:T	Q25H	0.985
19:12074146:T:C	L40P	0.985
19:12074110:T:C	L28P	0.984
19:12074081:G:C	W18C	0.983
19:12074081:G:T	W18C	0.983
19:12074105:G:C	K26N	0.983
19:12074105:G:T	K26N	0.983
19:12074112:T:G	Y29D	0.983
19:12075945:C:A	H275Q	0.983
19:12075945:C:G	H275Q	0.983
19:12075770:G:C	R217P	0.982
19:12075933:T:A	H271Q	0.982
19:12075933:T:G	H271Q	0.982

dbSNP variants (sampled 300 via entrez): RS1000057260 (19:12064483 C>G), RS1000123913 (19:12065536 T>C), RS1000260636 (19:12081029 A>G), RS1000312411 (19:12081428 A>G), RS1000645555 (19:12080145 A>G), RS1001004838 (19:12062843 C>G,T), RS1001035787 (19:12063365 G>A), RS1001204316 (19:12074973 C>T), RS1001299543 (19:12069232 G>C), RS1001308909 (19:12068933 T>C), RS1001351354 (19:12069475 G>A), RS1001508133 (19:12072276 C>T), RS1001677861 (19:12065570 A>G), RS1001709097 (19:12065854 T>C,G), RS1001807158 (19:12080641 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008163_111	Height	7.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, affects cotreatment, increases abundance	3
Nickel	decreases expression	2
Tobacco Smoke Pollution	decreases expression, increases expression	2
Valproic Acid	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
bisphenol A	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
butyraldehyde	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
nickel sulfate	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
avobenzone	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
Leflunomide	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Doxorubicin	decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Urethane	increases expression	1
Vanadates	decreases expression	1
Aflatoxin M1	decreases expression	1
Acrylamide	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.