ZNF845

Summary

ZNF845 (zinc finger protein 845, HGNC:25112) is a protein-coding gene on chromosome 19q13.42, encoding Zinc finger protein 845 (Q96IR2). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 91664 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 166 total
• MANE Select transcript: NM_138374

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25112
Approved symbol	ZNF845
Name	zinc finger protein 845
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000213799
Ensembl biotype	protein_coding
Entrez	91664

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000458035, ENST00000595091, ENST00000910593, ENST00000931103

RefSeq mRNA: 4 — MANE Select: NM_138374 NM_001321522, NM_001321523, NM_001321524, NM_138374

CCDS: CCDS46170

Canonical transcript exons

ENST00000458035 — 4 exons

Exon	Start	End
ENSE00002488982	53345506	53345632
ENSE00002508826	53341235	53341322
ENSE00002536420	53333749	53333792
ENSE00003024363	53350818	53356906

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 84.68.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.1044 / max 100.8505, expressed in 1549 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177323	5.1044	1549

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	84.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.01	gold quality
calcaneal tendon	UBERON:0003701	81.12	gold quality
cortical plate	UBERON:0005343	78.96	gold quality
islet of Langerhans	UBERON:0000006	77.38	gold quality
ganglionic eminence	UBERON:0004023	76.94	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.19	gold quality
granulocyte	CL:0000094	75.79	gold quality
endometrium	UBERON:0001295	75.11	gold quality
stromal cell of endometrium	CL:0002255	74.35	gold quality
lymph node	UBERON:0000029	74.13	gold quality
ventricular zone	UBERON:0003053	73.86	gold quality
rectum	UBERON:0001052	71.76	gold quality
bone marrow	UBERON:0002371	71.62	gold quality
adrenal tissue	UBERON:0018303	71.56	gold quality
tonsil	UBERON:0002372	71.40	gold quality
leukocyte	CL:0000738	70.81	gold quality
placenta	UBERON:0001987	70.57	gold quality
smooth muscle tissue	UBERON:0001135	70.52	gold quality
quadriceps femoris	UBERON:0001377	70.39	gold quality
pancreas	UBERON:0001264	70.35	gold quality
vermiform appendix	UBERON:0001154	70.20	gold quality
monocyte	CL:0000576	70.06	gold quality
urinary bladder	UBERON:0001255	69.86	gold quality
corpus callosum	UBERON:0002336	69.67	gold quality
duodenum	UBERON:0002114	69.60	gold quality
descending thoracic aorta	UBERON:0002345	69.26	gold quality
colonic epithelium	UBERON:0000397	68.94	silver quality
bone marrow cell	CL:0002092	68.53	silver quality
right coronary artery	UBERON:0001625	68.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

92 targeting ZNF845, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-12118	100.00	65.88	1270
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-10395-5P	99.86	67.35	676
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6515-3P	99.82	68.19	1933
HSA-MIR-4694-3P	99.79	69.53	2640

Cross-species orthologs

12 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp729a	ENSMUSG00000021510
mus_musculus	Zfp458	ENSMUSG00000055480
mus_musculus	Zfp459	ENSMUSG00000055560
mus_musculus	Zfp759	ENSMUSG00000057396
mus_musculus	Zfp729b	ENSMUSG00000058093
mus_musculus	Zfp712	ENSMUSG00000090641
mus_musculus	Zfp748	ENSMUSG00000095432
rattus_norvegicus	Zfp458	ENSRNOG00000017986
rattus_norvegicus	Zfp729	ENSRNOG00000047145
rattus_norvegicus	Zfp748	ENSRNOG00000049259
rattus_norvegicus	Zfp712	ENSRNOG00000068153
rattus_norvegicus	Zfp729b	ENSRNOG00000069921

Paralogs (36): ZNF302 (ENSG00000089335), ZNF184 (ENSG00000096654), CTCF (ENSG00000102974), ZNF574 (ENSG00000105732), ZBTB24 (ENSG00000112365), ZNF142 (ENSG00000115568), CTCFL (ENSG00000124092), ZNF473 (ENSG00000142528), ZNF827 (ENSG00000151612), ZNF689 (ENSG00000156853), ZNF208 (ENSG00000160321), ZNF91 (ENSG00000167232), ZNF526 (ENSG00000167625), ZNF764 (ENSG00000169951), ZNF747 (ENSG00000169955), ZNF282 (ENSG00000170265), ZNF160 (ENSG00000170949), ZNF497 (ENSG00000174586), ZBTB34 (ENSG00000177125), ZNF771 (ENSG00000179965), ZNF48 (ENSG00000180035), ZNF594 (ENSG00000180626), ZBTB37 (ENSG00000185278), ZFP92 (ENSG00000189420), ZNF107 (ENSG00000196247), ZNF729 (ENSG00000196350), ZNF569 (ENSG00000196437), ZNF420 (ENSG00000197050), ZNF785 (ENSG00000197162), ZNF665 (ENSG00000197497), ZNF181 (ENSG00000197841), ZNF347 (ENSG00000197937), ZNF84 (ENSG00000198040), ZBTB48 (ENSG00000204859), ZNF99 (ENSG00000213973), ZNF688 (ENSG00000229809)

Protein

Protein identifiers

Zinc finger protein 845 — Q96IR2 (reviewed: Q96IR2)

All UniProt accessions (1): Q96IR2

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (4): NP_001308451, NP_001308452, NP_001308453, NP_612383* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13465

UniProt features (34 total): zinc finger region 27, sequence conflict 4, chain 1, domain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96IR2-F1	70.47	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 205

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 33 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MODULE_49, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, ELF2_TARGET_GENES, MIR616_5P, MIR371B_5P, MIR373_5P, MIR335_3P, MIR6833_3P, MIR4768_5P, MIR155_5P, MIR3925_3P, MIR3064_3P, MIR19A_5P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

552 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF845	C8orf82	Q6P1X6	512
ZNF845	VN1R4	Q7Z5H5	449
ZNF845	RFC2	P32846	438
ZNF845	DNAAF8	Q8IYS4	418
ZNF845	RNF166	Q96A37	405
ZNF845	CELF1	Q92879	404
ZNF845	ZC3HC1	Q86WB0	399
ZNF845	MRM2	Q9UI43	398
ZNF845	MS4A15	Q8N5U1	397
ZNF845	EIF2B2	P49770	375
ZNF845	FGD4	Q96M96	373
ZNF845	DARS1	P14868	371
ZNF845	OR4N4	Q8N0Y3	371
ZNF845	MYOZ1	Q9NP98	370
ZNF845	SERGEF	Q9UGK8	368

IntAct

29 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
Set	ZKSCAN1	psi-mi:“MI:0914”(association)	0.350
MPHOSPH8	HCFC1	psi-mi:“MI:0914”(association)	0.350
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
SART3	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
GPATCH4	NOP56	psi-mi:“MI:0914”(association)	0.350
rl3_rl3l_human	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
PURG	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL36	GTPBP10	psi-mi:“MI:0914”(association)	0.350
ADARB1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
OASL	ZNF316	psi-mi:“MI:0914”(association)	0.350
GLI4	ZNF316	psi-mi:“MI:0914”(association)	0.350
PNMA8A	AP3B1	psi-mi:“MI:0914”(association)	0.350
LYAR	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
RSL1D1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
ZNF418	ZNF195	psi-mi:“MI:0914”(association)	0.350
	NVL	psi-mi:“MI:0914”(association)	0.350
CUL9	NVL	psi-mi:“MI:0914”(association)	0.350
CCDC137	NVL	psi-mi:“MI:0914”(association)	0.350
RBM4B	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL4	ZNF320	psi-mi:“MI:0914”(association)	0.350
PRKRA	GTPBP10	psi-mi:“MI:0914”(association)	0.350
NEIL1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL13	POLRMT	psi-mi:“MI:0914”(association)	0.350

BioGRID (36): ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-RNA), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS), ZNF845 (Affinity Capture-MS)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75820, P0CB33, P0CJ79, P0DKX0, P10755, P17032, P17035, P52738, Q02386, Q03923, Q03936, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586, Q14593, Q147U1, Q15928, Q3MIS6, Q3SXZ3, Q494X3, Q4R6C2, Q5HY98

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 34 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Major pathway of rRNA processing in the nucleolus and cytosol	5	15.4×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

166 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	153
Likely benign	9
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

476 predictions. Top by Δscore:

Variant	Effect	Δscore
19:53341230:TTCA:T	acceptor_loss	1.0000
19:53341231:TCAG:T	acceptor_loss	1.0000
19:53341233:AGGA:A	acceptor_loss	1.0000
19:53341234:G:A	acceptor_loss	1.0000
19:53341234:GGATT:G	acceptor_gain	1.0000
19:53345593:G:T	donor_gain	1.0000
19:53333789:AGCGG:A	donor_loss	0.9900
19:53333790:GCG:G	donor_gain	0.9900
19:53333790:GCGGT:G	donor_loss	0.9900
19:53333791:CGGTG:C	donor_loss	0.9900
19:53333792:GGT:G	donor_loss	0.9900
19:53333793:G:GG	donor_gain	0.9900
19:53333793:GTGA:G	donor_loss	0.9900
19:53333794:TGAG:T	donor_loss	0.9900
19:53341233:A:AG	acceptor_gain	0.9900
19:53341233:AG:A	acceptor_gain	0.9900
19:53341234:G:GA	acceptor_gain	0.9900
19:53341234:GG:G	acceptor_gain	0.9900
19:53341318:CTCAG:C	donor_loss	0.9900
19:53341319:TCAGG:T	donor_loss	0.9900
19:53341320:CAGGT:C	donor_loss	0.9900
19:53341321:AGG:A	donor_loss	0.9900
19:53341322:GGTG:G	donor_loss	0.9900
19:53341323:GTGA:G	donor_loss	0.9900
19:53341324:T:A	donor_loss	0.9900
19:53345501:TTCA:T	acceptor_loss	0.9900
19:53345502:TCAG:T	acceptor_loss	0.9900
19:53345503:CA:C	acceptor_loss	0.9900
19:53345504:AG:A	acceptor_gain	0.9900
19:53345505:GG:G	acceptor_gain	0.9900

AlphaMissense

6508 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:53353025:T:C	F784L	0.997
19:53353027:T:A	F784L	0.997
19:53353027:T:G	F784L	0.997
19:53352857:T:C	F728L	0.996
19:53352859:C:A	F728L	0.996
19:53352859:C:G	F728L	0.996
19:53353109:T:C	F812L	0.995
19:53353111:C:A	F812L	0.995
19:53353111:C:G	F812L	0.995
19:53353193:T:C	F840L	0.994
19:53353195:C:A	F840L	0.994
19:53353195:C:G	F840L	0.994
19:53352941:T:C	F756L	0.993
19:53352943:C:A	F756L	0.993
19:53352943:C:G	F756L	0.993
19:53353128:T:C	L818P	0.992
19:53353445:T:C	F924L	0.992
19:53353447:C:A	F924L	0.992
19:53353447:C:G	F924L	0.992
19:53352017:T:C	F448L	0.991
19:53352019:C:A	F448L	0.991
19:53352019:C:G	F448L	0.991
19:53352605:T:C	F644L	0.991
19:53352607:C:A	F644L	0.991
19:53352607:C:G	F644L	0.991
19:53352689:T:C	F672L	0.991
19:53352691:T:A	F672L	0.991
19:53352691:T:G	F672L	0.991
19:53352876:T:C	L734P	0.991
19:53352886:T:A	H737Q	0.991

dbSNP variants (sampled 300 via entrez): RS1000033558 (19:53353557 A>C,G), RS1000140526 (19:53351132 A>G,T), RS1000231534 (19:53346666 G>A,C), RS1000374760 (19:53343039 G>A), RS1000389940 (19:53342280 A>G), RS1000456886 (19:53342139 A>T), RS1000518687 (19:53347941 G>A), RS1000554602 (19:53348905 G>A), RS1000642323 (19:53343775 T>C), RS1000708103 (19:53346505 A>G), RS1000726513 (19:53343182 A>G), RS1000799951 (19:53343043 T>C), RS1000845538 (19:53332382 T>G), RS1000889229 (19:53344533 G>A), RS1000941390 (19:53345871 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation, increases expression	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Ozone	increases expression, affects expression, increases abundance	2
Cadmium Chloride	increases abundance, increases expression, decreases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
arsenite	decreases reaction, affects binding	1
butyraldehyde	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
jinfukang	decreases expression	1
Temozolomide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Coal	decreases expression, increases abundance	1
Smoke	decreases expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.