ZNF850

Summary

ZNF850 (zinc finger protein 850, HGNC:27994) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 850 (A8MQ14). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 342892 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 151 total
• MANE Select transcript: NM_001193552

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27994
Approved symbol	ZNF850
Name	zinc finger protein 850
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000267041
Ensembl biotype	protein_coding
Entrez	342892

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000589390, ENST00000591344, ENST00000614887

RefSeq mRNA: 2 — MANE Select: NM_001193552 NM_001193552, NM_001267779

CCDS: CCDS59379, CCDS74350

Canonical transcript exons

ENST00000591344 — 5 exons

Exon	Start	End
ENSE00002775885	36743480	36750804
ENSE00002835384	36762305	36762431
ENSE00002847836	36762595	36762675
ENSE00002852231	36761643	36761738
ENSE00003849122	36772725	36772807

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 90.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.1195 / max 163.2012, expressed in 1320 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180691	4.5101	1017
180692	1.6094	880

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	90.99	gold quality
secondary oocyte	CL:0000655	87.38	gold quality
ventricular zone	UBERON:0003053	72.87	gold quality
calcaneal tendon	UBERON:0003701	71.32	gold quality
bone marrow cell	CL:0002092	70.73	gold quality
adrenal tissue	UBERON:0018303	69.79	gold quality
germinal epithelium of ovary	UBERON:0001304	69.42	silver quality
ganglionic eminence	UBERON:0004023	68.17	gold quality
cortical plate	UBERON:0005343	66.84	gold quality
islet of Langerhans	UBERON:0000006	66.19	gold quality
stromal cell of endometrium	CL:0002255	65.93	gold quality
placenta	UBERON:0001987	65.75	gold quality
colonic epithelium	UBERON:0000397	65.00	silver quality
parietal pleura	UBERON:0002400	63.66	silver quality
ileal mucosa	UBERON:0000331	62.49	silver quality
sural nerve	UBERON:0015488	62.42	silver quality
visceral pleura	UBERON:0002401	61.88	silver quality
oviduct epithelium	UBERON:0004804	61.76	gold quality
leukocyte	CL:0000738	61.42	gold quality
smooth muscle tissue	UBERON:0001135	61.39	gold quality
bone marrow	UBERON:0002371	61.35	gold quality
monocyte	CL:0000576	61.23	gold quality
skin of hip	UBERON:0001554	60.69	gold quality
lower lobe of lung	UBERON:0008949	60.57	silver quality
right coronary artery	UBERON:0001625	60.25	gold quality
popliteal artery	UBERON:0002250	60.01	gold quality
tibial artery	UBERON:0007610	59.99	gold quality
adrenal gland	UBERON:0002369	59.97	gold quality
palpebral conjunctiva	UBERON:0001812	59.96	silver quality
pancreas	UBERON:0001264	59.94	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-76312	yes	102.56
E-ANND-3	yes	5.16
E-MTAB-6678	no	3.77

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2591.1	ZNF850	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605530

miRNA regulators (miRDB)

197 targeting ZNF850, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000091679
mus_musculus	Zfp619	ENSMUSG00000068959
rattus_norvegicus	Zfp788	ENSRNOG00000014380
rattus_norvegicus	Zfp619	ENSRNOG00000066986

Paralogs (4): PRDM5 (ENSG00000138738), ZNF668 (ENSG00000167394), ZNF358 (ENSG00000198816), ZNF579 (ENSG00000218891)

Protein

Protein identifiers

Zinc finger protein 850 — A8MQ14 (reviewed: A8MQ14)

All UniProt accessions (3): A0A087X0M6, A8MQ14, K7EJI8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001180481, NP_001254708 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (34 total): zinc finger region 32, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MQ14-F1	72.22	0.02

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 66 (showing top): GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT, GOBP_EMBRYO_DEVELOPMENT, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ARHGAP35_TARGET_GENES, DYRK1A_TARGET_GENES, IRF5_TARGET_GENES, SIPA1_TARGET_GENES, ZNF30_TARGET_GENES, ZNF561_TARGET_GENES, ZSCAN21_TARGET_GENES, MIR616_5P, MIR371B_5P, MIR373_5P, MIR6867_5P

GO Biological Process (3): in utero embryonic development (GO:0001701), regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (4): zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chordate embryonic development	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transition metal ion binding	1
DNA binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

368 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF850	MAGEB17	A8MXT2	507
ZNF850	SLC35E2A	P0CK97	507
ZNF850	SLC35E2B	P0CK96	480
ZNF850	OR2T4	Q8NH00	475
ZNF850	CYP20A1	Q6UW02	461
ZNF850	NOL9	Q5SY16	453
ZNF850	PLCXD1	Q9NUJ7	449
ZNF850	FAM47C	Q5HY64	446
ZNF850	GNL3L	Q9NVN8	433
ZNF850	ZBED5	Q49AG3	420
ZNF850	BEND2	Q8NDZ0	403
ZNF850	FAM186A	A6NE01	398
ZNF850	RBMS2	Q15434	391
ZNF850	SWT1	Q5T5J6	368
ZNF850	ASAH1	Q13510	365

IntAct

5 interactions, top by confidence:

A	B	Type	Score
KLF15		psi-mi:“MI:0914”(association)	0.350
KLF16		psi-mi:“MI:0914”(association)	0.350
ZNF850	IPO8	psi-mi:“MI:0914”(association)	0.350
FBL	ZNF850	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (7): ZNF850 (Affinity Capture-MS), ZNF850 (Proximity Label-MS), ZNF850 (Proximity Label-MS), ZNF850 (Affinity Capture-MS), ZNF850 (Affinity Capture-MS), ZNF850 (Affinity Capture-MS), ZNF850 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

151 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	137
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

941 predictions. Top by Δscore:

Variant	Effect	Δscore
19:36762596:T:TA	donor_gain	1.0000
19:36762671:TAGAG:T	acceptor_gain	1.0000
19:36718946:A:AG	acceptor_gain	0.9900
19:36718947:G:GA	acceptor_gain	0.9900
19:36718947:GAA:G	acceptor_gain	0.9900
19:36718947:GAAGA:G	acceptor_gain	0.9900
19:36762299:CCTTA:C	donor_loss	0.9900
19:36762300:CTTA:C	donor_loss	0.9900
19:36762301:TTACC:T	donor_loss	0.9900
19:36762302:TAC:T	donor_loss	0.9900
19:36762303:A:AC	donor_gain	0.9900
19:36762303:ACCTA:A	donor_loss	0.9900
19:36762304:C:CC	donor_gain	0.9900
19:36762304:C:T	donor_loss	0.9900
19:36762429:CCC:C	acceptor_gain	0.9900
19:36762430:CCC:C	acceptor_gain	0.9900
19:36762613:T:TA	donor_gain	0.9900
19:36762673:GAG:G	acceptor_gain	0.9900
19:36762674:AGCT:A	acceptor_loss	0.9900
19:36762675:GCT:G	acceptor_loss	0.9900
19:36762676:C:A	acceptor_loss	0.9900
19:36762676:C:CC	acceptor_gain	0.9900
19:36762677:T:A	acceptor_loss	0.9900
19:36772723:AC:A	donor_gain	0.9900
19:36772724:CC:C	donor_gain	0.9900
19:36718942:TTCTA:T	acceptor_loss	0.9800
19:36718943:TCTAG:T	acceptor_loss	0.9800
19:36718944:CTA:C	acceptor_loss	0.9800
19:36718945:TA:T	acceptor_loss	0.9800
19:36718946:AGA:A	acceptor_loss	0.9800

AlphaMissense

7157 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:36748070:A:C	F990L	0.996
19:36748070:A:T	F990L	0.996
19:36748072:A:G	F990L	0.996
19:36749246:A:C	F598L	0.996
19:36749246:A:T	F598L	0.996
19:36749248:A:G	F598L	0.996
19:36748154:G:C	F962L	0.995
19:36748154:G:T	F962L	0.995
19:36748156:A:G	F962L	0.995
19:36749498:A:C	F514L	0.995
19:36749498:A:T	F514L	0.995
19:36749500:A:G	F514L	0.995
19:36749330:A:C	F570L	0.994
19:36749330:A:T	F570L	0.994
19:36749332:A:G	F570L	0.994
19:36749582:A:C	F486L	0.994
19:36749582:A:T	F486L	0.994
19:36749584:A:G	F486L	0.994
19:36749666:A:C	F458L	0.994
19:36749666:A:T	F458L	0.994
19:36749668:A:G	F458L	0.994
19:36749750:A:C	F430L	0.994
19:36749750:A:T	F430L	0.994
19:36749752:A:G	F430L	0.994
19:36749414:A:C	F542L	0.993
19:36749414:A:T	F542L	0.993
19:36749416:A:G	F542L	0.993
19:36747986:A:C	F1018L	0.992
19:36747986:A:T	F1018L	0.992
19:36747988:A:G	F1018L	0.992

dbSNP variants (sampled 300 via entrez): RS1000427398 (19:36748850 A>G), RS1000479759 (19:36749087 C>A,T), RS1000698348 (19:36756193 C>G,T), RS1000714659 (19:36754993 T>G), RS1000815393 (19:36747372 C>A), RS1000824065 (19:36761075 G>A), RS1001004360 (19:36767054 T>C), RS1001106350 (19:36760821 C>T), RS1001324672 (19:36754701 G>A), RS1001456566 (19:36767339 T>C,G), RS1001494482 (19:36747014 G>A), RS1001583931 (19:36748628 C>G,T), RS1001674005 (19:36754436 A>G), RS1001817297 (19:36755633 T>G), RS1001886338 (19:36746675 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003074_22	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging)	5.000000e-07
GCST90002397_431	Mean spheric corpuscular volume	3.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007707	cerebral amyloid deposition measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctane sulfonic acid	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Valproic Acid	decreases expression, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
perfluorooctanoic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	increases expression	1
Folic Acid	decreases expression	1
Quercetin	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	increases expression	1
Okadaic Acid	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.