ZNF852

Summary

ZNF852 (zinc finger protein 852, HGNC:27713) is a protein-coding gene on chromosome 3p21.31, encoding Zinc finger protein 852 (Q6ZMS4). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 285346 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27713
Approved symbol	ZNF852
Name	zinc finger protein 852
Location	3p21.31
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000178917
Ensembl biotype	protein_coding
Entrez	285346

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000436261, ENST00000463067, ENST00000489411, ENST00000650400, ENST00000710690, ENST00000710691, ENST00000715584

RefSeq mRNA: 4 — MANE Select: None NM_001287349, NM_001423469, NM_001423470, NM_001423484

Canonical transcript exons

ENST00000436261 — 5 exons

Exon	Start	End
ENSE00001212659	44510553	44510617
ENSE00001778354	44491766	44499299
ENSE00002298771	44502965	44503056
ENSE00003608120	44502542	44502668
ENSE00004027288	44499302	44500634

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 80.69.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.6124 / max 116.6307, expressed in 1431 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41859	4.3594	1416
41858	0.2077	76
41857	0.0453	15

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.69	gold quality
colonic epithelium	UBERON:0000397	79.84	gold quality
tonsil	UBERON:0002372	79.45	gold quality
islet of Langerhans	UBERON:0000006	77.87	gold quality
monocyte	CL:0000576	77.27	gold quality
bone marrow cell	CL:0002092	77.21	gold quality
endometrium	UBERON:0001295	76.96	gold quality
leukocyte	CL:0000738	76.90	gold quality
pancreas	UBERON:0001264	76.77	gold quality
body of pancreas	UBERON:0001150	76.25	gold quality
bone marrow	UBERON:0002371	75.08	gold quality
rectum	UBERON:0001052	74.79	gold quality
lymph node	UBERON:0000029	74.20	gold quality
vermiform appendix	UBERON:0001154	73.72	gold quality
ganglionic eminence	UBERON:0004023	73.53	gold quality
calcaneal tendon	UBERON:0003701	73.32	gold quality
smooth muscle tissue	UBERON:0001135	73.08	gold quality
cortical plate	UBERON:0005343	72.59	gold quality
stomach	UBERON:0000945	72.46	gold quality
duodenum	UBERON:0002114	72.28	gold quality
sural nerve	UBERON:0015488	71.95	gold quality
urinary bladder	UBERON:0001255	71.94	gold quality
adrenal tissue	UBERON:0018303	71.81	gold quality
body of stomach	UBERON:0001161	71.79	gold quality
skeletal muscle tissue	UBERON:0001134	71.76	gold quality
stromal cell of endometrium	CL:0002255	71.71	gold quality
muscle tissue	UBERON:0002385	71.64	gold quality
ovary	UBERON:0000992	70.99	gold quality
saliva-secreting gland	UBERON:0001044	70.84	gold quality
myometrium	UBERON:0001296	70.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells. (PMID:34957631)

Cross-species orthologs

0 orthologs

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

Zinc finger protein 852 — Q6ZMS4 (reviewed: Q6ZMS4)

All UniProt accessions (5): A0A3B3ISA9, A0AA34QVT6, A0AAQ5BIJ2, A0AAQ5BIJ6, Q6ZMS4

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (4): NP_001274278, NP_001410398, NP_001410399, NP_001410413 (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (16 total): zinc finger region 12, chain 1, domain 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZMS4-F1	70.85	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 145

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): OSMAN_BLADDER_CANCER_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, chr3p21, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, RBM34_TARGET_GENES, MIR3685, GSE11864_UNTREATED_VS_CSF1_IFNG_PAM3CYS_IN_MAC_UP, MIR1248, MIR7973, DESCARTES_FETAL_KIDNEY_MEGAKARYOCYTES, HDGF_TARGET_GENES, ZNF394_TARGET_GENES, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_DN, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

136 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF852	CDCP2	Q5VXM1	697
ZNF852	NKAPL	Q5M9Q1	396
ZNF852	METTL6	Q8TCB7	349
ZNF852	CMTM8	Q8IZV2	348
ZNF852	KAT8	Q9H7Z6	316
ZNF852	CAPN7	Q9Y6W3	311
ZNF852	VENTX	O95231	307
ZNF852	SLC25A38	Q96DW6	298
ZNF852	PGBD1	Q96JS3	283
ZNF852	RPE65	Q16518	281
ZNF852	GZMK	P49863	262
ZNF852	BBOF1	Q8ND07	248
ZNF852	SNRK	Q9NRH2	245
ZNF852	LIMD1	Q9UGP4	224
ZNF852	AADACL3	Q5VUY0	223
ZNF852	SH3BP5	O60239	223

IntAct

14 interactions, top by confidence:

A	B	Type	Score
PRICKLE3	SIAH2	psi-mi:“MI:0914”(association)	0.530
ARIH1	SPOP	psi-mi:“MI:0914”(association)	0.530
DRICH1	CSNK1E	psi-mi:“MI:0914”(association)	0.530
TIMM50	ZNF724	psi-mi:“MI:0914”(association)	0.530
TIMM50	ZNF724	psi-mi:“MI:0914”(association)	0.350
CD6	CIBAR1	psi-mi:“MI:0914”(association)	0.350
SHISA3	ZNF316	psi-mi:“MI:0914”(association)	0.350
PTX3	POLRMT	psi-mi:“MI:0914”(association)	0.350
ARIH1	PHGDH	psi-mi:“MI:0914”(association)	0.350
OR52B2	PCCA	psi-mi:“MI:0914”(association)	0.350
TIMM50	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS), ZNF852 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A2T7D2, Q01793, Q49A33, Q6GQR8, Q6ZMS4, Q86XU0, Q9P0L1, Q9Y2L8, O14709, P51523, Q32M78, Q4R6J4, Q5T5D7, A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14771, O14978, O15535, O43309

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

630 predictions. Top by Δscore:

Variant	Effect	Δscore
3:44502536:CATTA:C	donor_loss	0.9900
3:44502537:ATTAC:A	donor_loss	0.9900
3:44502538:TTACC:T	donor_loss	0.9900
3:44502539:TACC:T	donor_loss	0.9900
3:44502540:ACCC:A	donor_loss	0.9900
3:44502556:C:CT	donor_gain	0.9900
3:44502557:T:TT	donor_gain	0.9900
3:44503823:CAG:C	donor_gain	0.9900
3:44510552:CCGA:C	donor_gain	0.9900
3:44500642:C:CT	acceptor_gain	0.9800
3:44500643:A:T	acceptor_gain	0.9800
3:44503052:TTGAG:T	acceptor_gain	0.9800
3:44503057:C:CC	acceptor_gain	0.9800
3:44510551:A:AC	donor_gain	0.9800
3:44510552:C:CC	donor_gain	0.9800
3:44500635:CTG:C	acceptor_gain	0.9700
3:44500642:C:T	acceptor_gain	0.9700
3:44502540:AC:A	donor_gain	0.9700
3:44502541:CC:C	donor_gain	0.9700
3:44502568:T:A	donor_gain	0.9700
3:44503054:GAGC:G	acceptor_loss	0.9600
3:44503055:AGC:A	acceptor_loss	0.9600
3:44503056:GC:G	acceptor_loss	0.9600
3:44503057:CTGA:C	acceptor_loss	0.9600
3:44503058:T:G	acceptor_loss	0.9600
3:44503053:TGAG:T	acceptor_gain	0.9500
3:44507877:G:C	donor_gain	0.9500
3:44510485:CCTCA:C	donor_loss	0.9400
3:44510486:CTCAC:C	donor_loss	0.9400
3:44510487:TCAC:T	donor_loss	0.9400

AlphaMissense

3644 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:44499349:A:C	F476L	0.997
3:44499349:A:T	F476L	0.997
3:44499351:A:G	F476L	0.997
3:44499433:G:C	F448L	0.995
3:44499433:G:T	F448L	0.995
3:44499435:A:G	F448L	0.995
3:44499517:G:C	F420L	0.995
3:44499517:G:T	F420L	0.995
3:44499519:A:G	F420L	0.995
3:44499601:G:C	F392L	0.995
3:44499601:G:T	F392L	0.995
3:44499603:A:G	F392L	0.995
3:44500021:A:C	F252L	0.995
3:44500021:A:T	F252L	0.995
3:44500023:A:G	F252L	0.995
3:44499769:G:C	F336L	0.994
3:44499769:G:T	F336L	0.994
3:44499771:A:G	F336L	0.994
3:44500189:G:C	F196L	0.994
3:44500189:G:T	F196L	0.994
3:44500191:A:G	F196L	0.994
3:44499488:T:G	Q430P	0.993
3:44499685:G:C	F364L	0.993
3:44499685:G:T	F364L	0.993
3:44499687:A:G	F364L	0.993
3:44499404:T:G	Q458P	0.991
3:44499500:A:G	L426P	0.991
3:44499937:A:C	F280L	0.991
3:44499937:A:T	F280L	0.991
3:44499939:A:G	F280L	0.991

dbSNP variants (sampled 300 via entrez): RS1000038171 (3:44508155 T>G), RS1000159271 (3:44495139 A>C,G), RS1000269225 (3:44501876 G>A), RS1000414583 (3:44512365 A>G), RS1000543185 (3:44493756 G>A), RS1000866969 (3:44507286 T>C), RS1000973999 (3:44500726 A>C), RS1001005130 (3:44500318 TA>T), RS1001007372 (3:44499827 T>A,C), RS1001154068 (3:44511703 G>A), RS1001164411 (3:44493401 G>A,T), RS1001394809 (3:44505035 A>G), RS1001915218 (3:44510736 C>A,G), RS1001958231 (3:44498353 G>A), RS1002185539 (3:44491889 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	increases abundance, increases expression, affects cotreatment	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
Leflunomide	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Urethane	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.