ZNF865

Summary

ZNF865 (zinc finger protein 865, HGNC:38705) is a protein-coding gene on chromosome 19q13.42, encoding Zinc finger protein 865 (P0CJ78). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 100507290 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 150 total
• MANE Select transcript: NM_001195605

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38705
Approved symbol	ZNF865
Name	zinc finger protein 865
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000261221
Ensembl biotype	protein_coding
Entrez	100507290

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000568956, ENST00000870148, ENST00000870149

RefSeq mRNA: 1 — MANE Select: NM_001195605 NM_001195605

CCDS: CCDS58681

Canonical transcript exons

ENST00000568956 — 2 exons

Exon	Start	End
ENSE00002576951	55613593	55617269
ENSE00002610416	55605647	55605732

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 89.30.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.9106 / max 371.8702, expressed in 1793 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177651	12.6447	1783
177650	1.0105	590
177652	0.7662	510
177649	0.2648	100
177648	0.2245	85

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	89.30	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.50	gold quality
left ventricle myocardium	UBERON:0006566	88.13	gold quality
apex of heart	UBERON:0002098	87.58	gold quality
muscle of leg	UBERON:0001383	87.38	gold quality
granulocyte	CL:0000094	85.17	gold quality
cardiac atrium	UBERON:0002081	83.23	gold quality
heart left ventricle	UBERON:0002084	83.23	gold quality
right atrium auricular region	UBERON:0006631	83.11	gold quality
cardiac ventricle	UBERON:0002082	82.84	gold quality
sural nerve	UBERON:0015488	82.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.16	gold quality
lower esophagus	UBERON:0013473	82.12	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.88	gold quality
muscle layer of sigmoid colon	UBERON:0035805	81.60	gold quality
popliteal artery	UBERON:0002250	80.65	gold quality
tibial artery	UBERON:0007610	80.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.45	gold quality
upper arm skin	UBERON:0004263	80.43	gold quality
aorta	UBERON:0000947	80.39	gold quality
heart	UBERON:0000948	80.39	gold quality
thoracic aorta	UBERON:0001515	80.17	gold quality
ascending aorta	UBERON:0001496	80.14	gold quality
body of uterus	UBERON:0009853	80.01	gold quality
right ovary	UBERON:0002118	79.91	gold quality
descending thoracic aorta	UBERON:0002345	79.84	gold quality
blood	UBERON:0000178	79.62	gold quality
left uterine tube	UBERON:0001303	79.45	gold quality
mucosa of transverse colon	UBERON:0004991	79.42	gold quality
mucosa of stomach	UBERON:0001199	79.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.68

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2515.1	ZNF865	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

miRNA regulators (miRDB)

50 targeting ZNF865, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-548AV-3P	99.43	68.50	1721
HSA-MIR-2392	99.43	67.50	708
HSA-MIR-584-3P	99.35	67.69	1082
HSA-MIR-6504-3P	99.17	69.31	2891
HSA-MIR-4478	99.07	65.16	2320
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-4324	99.04	70.14	1569
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-4755-3P	98.77	65.59	1915
HSA-MIR-198	98.70	67.32	920
HSA-MIR-423-5P	98.69	67.48	1522
HSA-MIR-2467-3P	98.65	67.18	1969

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkeyp-69b9.6	ENSDARG00000014825
danio_rerio	znf865	ENSDARG00000036698
mus_musculus	Zfp865	ENSMUSG00000074405
rattus_norvegicus	Znf865	ENSRNOG00000028628
drosophila_melanogaster	CG11902	FBGN0028647
drosophila_melanogaster	CG11696	FBGN0030314
drosophila_melanogaster	CG10631	FBGN0032817

Paralogs (7): ZNF671 (ENSG00000083814), ZNF710 (ENSG00000140548), ZNF212 (ENSG00000170260), ZNF366 (ENSG00000178175), ZNF662 (ENSG00000182983), ZNF667 (ENSG00000198046), ZNF783 (ENSG00000204946)

Protein

Protein identifiers

Zinc finger protein 865 — P0CJ78 (reviewed: P0CJ78)

All UniProt accessions (1): P0CJ78

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001182534* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050636	C2H2-ZF_domain-containing	Family

Pfam: PF00096, PF13912

UniProt features (39 total): zinc finger region 20, compositionally biased region 10, region of interest 6, cross-link 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CJ78-F1	58.96	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 802, 1040

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 38 (showing top): SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, PKCA_DN.V1_UP, ESC_V6.5_UP_EARLY.V1_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ATF6_TARGET_GENES, ZFP91_TARGET_GENES, ZNF407_TARGET_GENES, ZNF563_TARGET_GENES, ZNF664_TARGET_GENES, ZSCAN21_TARGET_GENES, GSE10239_NAIVE_VS_MEMORY_CD8_TCELL_DN, GSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_UP, MIR7151_3P, MIR619_5P

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

664 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF865	SNAPC2	Q13487	377
ZNF865	WDR90	Q96KV7	369
ZNF865	ATAD3B	Q5T9A4	340
ZNF865	GTF3C5	Q9Y5Q8	339
ZNF865	ZC3H3	Q8IXZ2	329
ZNF865	L3MBTL4	Q8NA19	325
ZNF865	PDAP1	Q13442	323
ZNF865	SLF2	Q8IX21	323
ZNF865	F5GXR3	F5GXR3	323
ZNF865	ADTRP	Q96IZ2	322
ZNF865	PTOV1	Q86YD1	321
ZNF865	RDH13	Q8NBN7	301
ZNF865	GARIN5A	Q6IPT2	271
ZNF865	C15orf40	Q8WUR7	270
ZNF865	ILDR1	Q86SU0	254

IntAct

60 interactions, top by confidence:

A	B	Type	Score
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
CACNG5	ZNF316	psi-mi:“MI:0914”(association)	0.530
LTBR	ZNF724	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
TEX28	NBAS	psi-mi:“MI:0914”(association)	0.350
NXF2B	MEIOC	psi-mi:“MI:0914”(association)	0.350
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.350
CCDC136	CCDC85C	psi-mi:“MI:0914”(association)	0.350
SIRT6	HDAC3	psi-mi:“MI:0914”(association)	0.350
RPL28	SDCBP	psi-mi:“MI:0914”(association)	0.350
TNFRSF19	NOP56	psi-mi:“MI:0914”(association)	0.350
TNFRSF1A	KHNYN	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
PIPSL	C1orf226	psi-mi:“MI:0914”(association)	0.350
FTL	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350
LURAP1	CIBAR1	psi-mi:“MI:0914”(association)	0.350
MCC	CIBAR1	psi-mi:“MI:0914”(association)	0.350
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
PNMA2	TARS3	psi-mi:“MI:0914”(association)	0.350

BioGRID (61): ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS), ZNF865 (Affinity Capture-MS)

ESM2 similar proteins: A2CE44, A6NFI3, A6NM28, A8K8V0, O15370, O70218, O95201, P0CJ78, P10075, P10754, P28698, P70338, Q04890, Q07120, Q14V87, Q19A40, Q569E7, Q58DK7, Q5DWN0, Q5FWU5, Q5RJR4, Q5T619, Q5TEC3, Q6DD87, Q6IQX8, Q6PD29, Q6PGE4, Q6ZMY9, Q7Z7K2, Q80VM4, Q8BIF9, Q8JZL0, Q8N8E2, Q8NAF0, Q8NCA9, Q8TD94, Q8WUU4, Q96C55, Q96H86, Q96MX3

Diamond homologs: A0A9P4XV22, A2ANX9, B1H2Q6, O62836, P08048, P0CJ78, P10925, P17010, P17012, P20662, P27705, P28698, P52288, P80944, Q01611, Q03081, Q03125, Q0VDT2, Q29419, Q3U3I9, Q52V16, Q567C6, Q5U2Z0, Q6B4Z5, Q7RTV3, Q95LI3, Q966L8, Q96EG3, Q9UDV6, Q9UL36, Q9Y462, A2A761, O60315, P56270, P56670, P56671, Q14119, Q9R0G7, P39943, P25490

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 70 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Major pathway of rRNA processing in the nucleolus and cytosol	5	8.3×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

150 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	146
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

248 predictions. Top by Δscore:

Variant	Effect	Δscore
19:55605733:G:GG	donor_gain	0.9800
19:55605733:GT:G	donor_loss	0.9800
19:55605734:TGAGT:T	donor_loss	0.9800
19:55605735:GAGTG:G	donor_loss	0.9800
19:55605736:AGTGA:A	donor_loss	0.9800
19:55605729:GCCG:G	donor_gain	0.9700
19:55613591:AG:A	acceptor_gain	0.9700
19:55613592:GG:G	acceptor_gain	0.9700
19:55613587:TCACA:T	acceptor_loss	0.9600
19:55613588:CACAG:C	acceptor_loss	0.9600
19:55613591:AGGGT:A	acceptor_loss	0.9600
19:55613592:G:GT	acceptor_loss	0.9600
19:55613592:GGGT:G	acceptor_gain	0.9500
19:55613591:A:AG	acceptor_gain	0.9400
19:55613592:G:GG	acceptor_gain	0.9400
19:55605737:G:C	donor_loss	0.8900
19:55606665:G:T	donor_gain	0.8800
19:55613589:ACAG:A	acceptor_gain	0.8800
19:55613591:AGG:A	acceptor_gain	0.8600
19:55613592:GGG:G	acceptor_gain	0.8600
19:55605742:GGG:G	donor_gain	0.8500
19:55605743:GGG:G	donor_gain	0.8500
19:55613589:A:AG	acceptor_gain	0.8400
19:55613592:GGGTC:G	acceptor_gain	0.8300
19:55605730:CCG:C	donor_gain	0.8000
19:55605743:GG:G	donor_gain	0.7900
19:55605744:GG:G	donor_gain	0.7900
19:55606665:G:GT	donor_gain	0.7700
19:55606424:T:TA	donor_gain	0.7600
19:55606425:A:AA	donor_gain	0.7600

AlphaMissense

6800 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:55614288:T:C	F224L	1.000
19:55614290:C:A	F224L	1.000
19:55614290:C:G	F224L	1.000
19:55614294:T:C	C226R	1.000
19:55614295:G:A	C226Y	1.000
19:55614296:C:G	C226W	1.000
19:55614303:T:A	C229S	1.000
19:55614303:T:C	C229R	1.000
19:55614304:G:A	C229Y	1.000
19:55614304:G:C	C229S	1.000
19:55614305:C:G	C229W	1.000
19:55614315:T:C	F233L	1.000
19:55614316:T:C	F233S	1.000
19:55614317:C:A	F233L	1.000
19:55614317:C:G	F233L	1.000
19:55614334:T:C	L239P	1.000
19:55614342:C:A	H242N	1.000
19:55614342:C:G	H242D	1.000
19:55614343:A:C	H242P	1.000
19:55614343:A:G	H242R	1.000
19:55614344:C:A	H242Q	1.000
19:55614344:C:G	H242Q	1.000
19:55614349:T:C	L244P	1.000
19:55614354:C:G	H246D	1.000
19:55614378:T:C	C254R	1.000
19:55614387:T:C	C257R	1.000
19:55614388:G:A	C257Y	1.000
19:55614399:T:G	Y261D	1.000
19:55614414:A:C	S266R	1.000
19:55614416:C:A	S266R	1.000

dbSNP variants (sampled 300 via entrez): RS1000067108 (19:55615857 A>G), RS1000418745 (19:55616132 C>T), RS1000712384 (19:55607276 A>G), RS1000823903 (19:55607540 G>A,T), RS1001177067 (19:55604123 G>A), RS1001263299 (19:55607783 C>T), RS1001427745 (19:55609894 A>G), RS1001473141 (19:55613031 G>A), RS1001587674 (19:55604802 G>T), RS1001638814 (19:55605205 T>C), RS1001754299 (19:55610226 A>G), RS1002203449 (19:55614300 G>A), RS1002991416 (19:55617746 T>C), RS1003030958 (19:55611513 T>A), RS1003049222 (19:55610495 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation	2
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	decreases expression	1
sodium arsenite	increases expression	1
butyraldehyde	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
pentanal	decreases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
Air Pollutants	affects expression, increases abundance	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Thiram	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.