ZNF883

Summary

ZNF883 (zinc finger protein 883, HGNC:27271) is a protein-coding gene on chromosome 9q32, encoding Zinc finger protein 883 (P0CG24). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 169834 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_001101338

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27271
Approved symbol	ZNF883
Name	zinc finger protein 883
Location	9q32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000228623
Ensembl biotype	protein_coding
Entrez	169834

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000639662, ENST00000917919, ENST00000917920, ENST00000917921, ENST00000917922, ENST00000917923, ENST00000917924

RefSeq mRNA: 1 — MANE Select: NM_001101338 NM_001101338

Canonical transcript exons

ENST00000639662 — 5 exons

Exon	Start	End
ENSE00003805003	112988129	112999138
ENSE00003996463	112999665	112999814
ENSE00003996464	113001994	113002073
ENSE00003996465	113011141	113011227
ENSE00003996466	113012150	113012192

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 85.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.7246 / max 107.9373, expressed in 1016 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102077	5.7246	1016

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.66	gold quality
thymus	UBERON:0002370	83.26	silver quality
cortical plate	UBERON:0005343	83.08	gold quality
cerebellar vermis	UBERON:0004720	82.74	gold quality
nucleus accumbens	UBERON:0001882	80.98	gold quality
caudate nucleus	UBERON:0001873	80.29	gold quality
putamen	UBERON:0001874	80.07	gold quality
spinal cord	UBERON:0002240	79.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.15	gold quality
corpus callosum	UBERON:0002336	78.88	gold quality
ganglionic eminence	UBERON:0004023	78.36	gold quality
ventricular zone	UBERON:0003053	78.17	gold quality
primary visual cortex	UBERON:0002436	77.90	gold quality
Ammon’s horn	UBERON:0001954	77.11	gold quality
amygdala	UBERON:0001876	77.05	gold quality
temporal lobe	UBERON:0001871	76.90	gold quality
prefrontal cortex	UBERON:0000451	76.31	gold quality
anterior cingulate cortex	UBERON:0009835	76.22	gold quality
substantia nigra	UBERON:0002038	75.83	gold quality
cerebral cortex	UBERON:0000956	75.66	gold quality
brain	UBERON:0000955	75.54	gold quality
frontal cortex	UBERON:0001870	75.28	gold quality
superior frontal gyrus	UBERON:0002661	75.22	gold quality
hypothalamus	UBERON:0001898	75.05	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.77	gold quality
right frontal lobe	UBERON:0002810	73.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.74	gold quality
cerebellar cortex	UBERON:0002129	72.61	gold quality
cerebellar hemisphere	UBERON:0002245	72.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 883 — P0CG24 (reviewed: P0CG24)

All UniProt accessions (1): P0CG24

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001094808* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF13465, PF13912

UniProt features (14 total): zinc finger region 13, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CG24-F1	90.03	0.71

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 14 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, DESCARTES_MAIN_FETAL_SATB2_LRRC7_POSITIVE_CELLS, chr9q32, CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_UP, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE5099_DAY3_VS_DAY7_MCSF_TREATED_MACROPHAGE_UP, GSE5099_CLASSICAL_M1_VS_ALTERNATIVE_M2_MACROPHAGE_UP, GSE25088_CTRL_VS_IL4_STIM_MACROPHAGE_UP

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

76 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF883	ENPP4	Q9Y6X5	581
ZNF883	ATF7IP	Q6VMQ6	447
ZNF883	TMEM231	Q9H6L2	321
ZNF883	GTF2F1	P35269	295
ZNF883	KCNJ9	Q92806	271
ZNF883	GGCX	P38435	246
ZNF883	SLC39A1	Q9NY26	224
ZNF883	MBTPS2	O43462	203
ZNF883	KCNJ3	P48549	202
ZNF883	GABBR2	O75899	184
ZNF883	KDR	P35968	171
ZNF883	POLE	Q07864	165
ZNF883	CNST	Q6PJW8	137
ZNF883	KRAS	P01116	128
ZNF883	ERAS	Q7Z444	100

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ZNF883	CCDC125	psi-mi:“MI:0915”(physical association)	0.560
ZNF883	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ZNF883	CCDC125	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (1): ZNF883 (Two-hybrid)

ESM2 similar proteins: C9JN71, E9QAG8, O75820, P08043, P0CG24, P10751, P15620, P17017, P17039, P18716, P18718, P18732, P18735, P18736, P18744, P18746, P24399, Q14585, Q15072, Q28151, Q3KP31, Q3SYV7, Q3ZCT1, Q4R4C7, Q4VA44, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5RAM9, Q5RB30, Q5RDX1, Q5REI6, Q5RF70, Q5RFP4, Q60493, Q62513, Q62981, Q6AZW8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000218416 (9:113001884 T>G), RS1000307922 (9:113007048 G>A), RS1000438649 (9:113007270 T>C), RS1000611395 (9:113000073 C>G,T), RS1000786555 (9:113012678 G>A), RS1000855629 (9:113014146 T>C), RS1000938238 (9:113013527 C>T), RS1001446986 (9:113007705 C>A,T), RS1001605437 (9:113010716 G>A,T), RS1001944641 (9:113012307 C>A,T), RS1001957549 (9:113012640 CG>C,CGG,CGGGGGGGG), RS1001977947 (9:113005550 T>C,G), RS1002113988 (9:113005974 A>G), RS1002162126 (9:113001876 CATCTGTTTAGTACAGAA>C), RS1002205191 (9:113012179 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009302_6	Antipsychotic drug-induced weight gain in schizophrenia	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004567	antipsychotic drug related weight gain

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases methylation, increases mutagenesis	2
Nickel	decreases expression	2
Phenylmercuric Acetate	decreases expression, affects cotreatment	2
dicrotophos	decreases expression	1
aflatoxin B2	increases methylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Tretinoin	decreases expression	1
Propofol	increases expression	1
Okadaic Acid	decreases expression	1
Acrylamide	decreases expression	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.