ZNF891

Summary

ZNF891 (zinc finger protein 891, HGNC:38709) is a protein-coding gene on chromosome 12q24.33, encoding Zinc finger protein 891 (A8MT65). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 101060200 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_001277291

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38709
Approved symbol	ZNF891
Name	zinc finger protein 891
Location	12q24.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000214029
Ensembl biotype	protein_coding
Entrez	101060200

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000537226, ENST00000650709, ENST00000913536, ENST00000913537, ENST00000913538, ENST00000913539, ENST00000942568

RefSeq mRNA: 1 — MANE Select: NM_001277291 NM_001277291

CCDS: CCDS59238

Canonical transcript exons

ENST00000537226 — 2 exons

Exon	Start	End
ENSE00002243826	133104779	133122024
ENSE00002255373	133130227	133130274

Expression profiles

Bgee: expression breadth ubiquitous, 196 present calls, max score 80.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.2232 / max 52.3081, expressed in 1198 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134267	1.5617	772
134269	1.0450	513
134268	0.6165	323

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.22	gold quality
calcaneal tendon	UBERON:0003701	76.87	gold quality
tendon of biceps brachii	UBERON:0008188	76.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.27	gold quality
tendon	UBERON:0000043	76.14	gold quality
ileal mucosa	UBERON:0000331	75.39	silver quality
pancreatic ductal cell	CL:0002079	74.69	silver quality
buccal mucosa cell	CL:0002336	74.67	gold quality
oviduct epithelium	UBERON:0004804	74.24	gold quality
cortical plate	UBERON:0005343	73.20	gold quality
ganglionic eminence	UBERON:0004023	72.12	gold quality
ventricular zone	UBERON:0003053	70.27	gold quality
medial globus pallidus	UBERON:0002477	70.16	gold quality
corpus callosum	UBERON:0002336	70.14	gold quality
colonic epithelium	UBERON:0000397	69.21	silver quality
adrenal tissue	UBERON:0018303	69.18	gold quality
thymus	UBERON:0002370	69.03	gold quality
popliteal artery	UBERON:0002250	68.90	gold quality
tibial artery	UBERON:0007610	68.89	gold quality
skin of hip	UBERON:0001554	68.76	gold quality
islet of Langerhans	UBERON:0000006	68.67	gold quality
stromal cell of endometrium	CL:0002255	67.94	gold quality
smooth muscle tissue	UBERON:0001135	67.86	gold quality
tibialis anterior	UBERON:0001385	67.75	silver quality
left ovary	UBERON:0002119	67.33	gold quality
aorta	UBERON:0000947	67.23	gold quality
ovary	UBERON:0000992	67.23	gold quality
gastrocnemius	UBERON:0001388	67.04	gold quality
right ovary	UBERON:0002118	67.04	gold quality
muscle of leg	UBERON:0001383	67.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.80

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

13 targeting ZNF891, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-1303	99.65	69.77	1662
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-3123	99.47	67.15	2693
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312
HSA-MIR-6857-3P	96.70	65.43	915

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 891 — A8MT65 (reviewed: A8MT65)

All UniProt accessions (2): A0A494C1V2, A8MT65

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001264220* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050589	Ikaros_C2H2-ZF	Family

Pfam: PF00096, PF01352, PF13465

UniProt features (10 total): zinc finger region 8, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MT65-F1	56.14	0.12

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 26 (showing top): chr12q24, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, RATTENBACHER_BOUND_BY_CELF1, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CEBPZ_TARGET_GENES, PAX3_TARGET_GENES, PCGF1_TARGET_GENES, SKIL_TARGET_GENES, ZNF407_TARGET_GENES, ZNF610_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR3925_5P, GSE14000_TRANSLATED_RNA_VS_MRNA_16H_LPS_DC_UP, ZNF549_TARGET_GENES, MYOCD_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

270 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF891	FBXO33	Q7Z6M2	479
ZNF891	CTAGE8	P0CG41	474
ZNF891	ZCCHC2	Q9C0B9	473
ZNF891	FAM86B2	P0C5J1	449
ZNF891	GLYCTK	Q8IVS8	434
ZNF891	DPH5	Q9H2P9	433
ZNF891	GPR27	Q9NS67	400
ZNF891	BRWD3	Q6RI45	396
ZNF891	USP27X	A6NNY8	373
ZNF891	CEP250	Q9BV73	370
ZNF891	WNK3	Q9BYP7	359
ZNF891	EIF3I	Q13347	325
ZNF891	TRIM38	O00635	322
ZNF891	SNRNP35	Q16560	313
ZNF891	WDR38	Q5JTN6	311

IntAct

6 interactions, top by confidence:

A	B	Type	Score
ZNF891	GAPDH	psi-mi:“MI:0915”(physical association)	0.400
ZNF891	ECE1	psi-mi:“MI:0915”(physical association)	0.370
PSME3	ZNF891	psi-mi:“MI:0914”(association)	0.350

BioGRID (4): ZNF891 (Affinity Capture-MS), ZNF891 (Affinity Capture-MS), ZNF891 (Affinity Capture-RNA), GAPDH (Proximity Label-MS)

ESM2 similar proteins: A0JPL0, A3KN36, A7MBI1, A8MT65, B2RXC5, D3ZVT0, P08042, P21506, P51508, P52738, Q02525, Q06730, Q12901, Q2KI58, Q2M218, Q2M3W8, Q2M3X9, Q2VY69, Q49AA0, Q4R6J4, Q4V8A8, Q5FWF6, Q5HY98, Q5RB33, Q5RC79, Q5REF1, Q5T5D7, Q5VIY5, Q61967, Q6P2D0, Q6ZN11, Q86XU0, Q86Y25, Q8N782, Q8N859, Q8NB42, Q8TF39, Q8TF47, Q8WXB4, Q95K49

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

579 predictions. Top by Δscore:

Variant	Effect	Δscore
12:133105508:A:AG	acceptor_gain	1.0000
12:133105509:G:GG	acceptor_gain	1.0000
12:133130128:C:CA	donor_gain	1.0000
12:133105506:TCA:T	acceptor_loss	0.9900
12:133105508:A:C	acceptor_loss	0.9900
12:133130112:C:CA	donor_gain	0.9900
12:133130162:G:C	donor_gain	0.9900
12:133130222:CTCA:C	donor_loss	0.9900
12:133130223:TCACC:T	donor_loss	0.9900
12:133130224:CACCC:C	donor_loss	0.9900
12:133130225:A:AC	donor_gain	0.9900
12:133130225:AC:A	donor_gain	0.9900
12:133130226:C:CC	donor_gain	0.9900
12:133130226:CC:C	donor_gain	0.9900
12:133130226:CCCGT:C	donor_gain	0.9900
12:133130230:T:TA	donor_gain	0.9900
12:133130235:AGTG:A	donor_gain	0.9900
12:133130288:C:CT	donor_gain	0.9900
12:133130289:T:TT	donor_gain	0.9900
12:133130123:AGACT:A	donor_gain	0.9800
12:133130238:G:A	donor_gain	0.9800
12:133130242:G:A	donor_gain	0.9800
12:133130072:C:CA	donor_gain	0.9700
12:133130129:C:A	donor_gain	0.9700
12:133130141:C:A	donor_gain	0.9700
12:133105509:GT:G	acceptor_gain	0.9600
12:133105509:GTTTC:G	acceptor_gain	0.9600
12:133105509:GTTT:G	acceptor_gain	0.9400
12:133120286:A:AC	donor_gain	0.9300
12:133120287:C:CC	donor_gain	0.9300

AlphaMissense

3665 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:133120428:G:C	F497L	0.998
12:133120428:G:T	F497L	0.998
12:133120430:A:G	F497L	0.998
12:133120344:G:C	F525L	0.997
12:133120344:G:T	F525L	0.997
12:133120346:A:G	F525L	0.997
12:133120764:G:C	F385L	0.997
12:133120764:G:T	F385L	0.997
12:133120766:A:G	F385L	0.997
12:133121763:G:C	F52L	0.996
12:133121763:G:T	F52L	0.996
12:133121764:A:G	F52S	0.996
12:133121765:A:G	F52L	0.996
12:133120680:A:C	F413L	0.995
12:133120680:A:T	F413L	0.995
12:133120682:A:G	F413L	0.995
12:133121717:A:C	Y68D	0.993
12:133120512:G:C	F469L	0.992
12:133120512:G:T	F469L	0.992
12:133120514:A:G	F469L	0.992
12:133120596:G:C	F441L	0.992
12:133120596:G:T	F441L	0.992
12:133120598:A:G	F441L	0.992
12:133120725:G:C	H398Q	0.992
12:133120725:G:T	H398Q	0.992
12:133121683:A:G	L79P	0.991
12:133121784:G:C	F45L	0.991
12:133121784:G:T	F45L	0.991
12:133121786:A:G	F45L	0.991
12:133120389:G:C	H510Q	0.990

dbSNP variants (sampled 300 via entrez): RS1000033140 (12:133125116 G>T), RS1000047427 (12:133131470 ATACTGT>A), RS1000080748 (12:133130706 T>G), RS1000134559 (12:133130550 A>C), RS1000161299 (12:133113425 A>G), RS1000261700 (12:133107249 A>T), RS1000314593 (12:133106947 C>A,T), RS1000332757 (12:133107629 C>T), RS1000393154 (12:133112011 T>C), RS1000466612 (12:133112377 A>C), RS1000499975 (12:133106968 A>G), RS1000572596 (12:133125858 A>G), RS1000803356 (12:133113709 G>C), RS1000977796 (12:133107272 A>G), RS1001082659 (12:133132034 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005580_126	Intraocular pressure	4.000000e-08
GCST010002_179	Refractive error	1.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
Air Pollutants	affects expression, increases abundance	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Valproic Acid	increases expression	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.