ZNF892

Summary

ZNF892 (zinc finger protein 892, HGNC:38707) is a protein-coding gene on chromosome 2q11.1, encoding Zinc finger protein 892 (A0A087WUV0). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 344065 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001395961

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38707
Approved symbol	ZNF892
Name	zinc finger protein 892
Location	2q11.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000233757
Ensembl biotype	protein_coding
Entrez	344065

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000425953, ENST00000610384, ENST00000614286

RefSeq mRNA: 1 — MANE Select: NM_001395961 NM_001395961

CCDS: CCDS92807

Canonical transcript exons

ENST00000425953 — 5 exons

Exon	Start	End
ENSE00001603138	95212193	95212282
ENSE00001684987	95211618	95211720
ENSE00001794633	95208648	95208736
ENSE00003978129	95207521	95207834
ENSE00003978130	95214336	95223839

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 84.27.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	84.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.00	silver quality
cortical plate	UBERON:0005343	76.64	gold quality
sural nerve	UBERON:0015488	74.14	gold quality
calcaneal tendon	UBERON:0003701	71.67	gold quality
ganglionic eminence	UBERON:0004023	70.77	gold quality
urinary bladder	UBERON:0001255	69.72	gold quality
ventricular zone	UBERON:0003053	68.69	gold quality
smooth muscle tissue	UBERON:0001135	68.53	gold quality
colonic epithelium	UBERON:0000397	68.40	silver quality
stromal cell of endometrium	CL:0002255	68.30	gold quality
islet of Langerhans	UBERON:0000006	66.62	gold quality
testis	UBERON:0000473	66.14	gold quality
right testis	UBERON:0004534	66.10	gold quality
lower esophagus	UBERON:0013473	65.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.84	gold quality
body of uterus	UBERON:0009853	65.68	gold quality
left testis	UBERON:0004533	65.24	gold quality
tonsil	UBERON:0002372	64.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.05	gold quality
mucosa of stomach	UBERON:0001199	63.70	gold quality
primary visual cortex	UBERON:0002436	63.64	gold quality
popliteal artery	UBERON:0002250	63.48	gold quality
tibial artery	UBERON:0007610	63.47	gold quality
adrenal tissue	UBERON:0018303	63.13	gold quality
endometrium	UBERON:0001295	62.77	gold quality
skeletal muscle tissue	UBERON:0001134	62.47	gold quality
pancreas	UBERON:0001264	62.43	gold quality
myometrium	UBERON:0001296	62.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.39

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp954	ENSMUSG00000062116
mus_musculus	Zfp773	ENSMUSG00000063535
mus_musculus	Zfp772	ENSMUSG00000066838
rattus_norvegicus	Zfp418l1	ENSRNOG00000066094

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 892 — A0A087WUV0 (reviewed: A0A087WUV0)

All UniProt accessions (2): A0A087WUV0, A0A087WZK3

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001382890* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF13465

UniProt features (14 total): zinc finger region 10, region of interest 2, chain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A087WUV0-F1	66.74	0.29

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 21 (showing top): chr2q11, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_DNA_BINDING_TRANSCRIPTION_REPRESSOR_ACTIVITY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, HOXB4_TARGET_GENES, KLF7_TARGET_GENES, SKIL_TARGET_GENES, UBN1_TARGET_GENES, ZNF10_TARGET_GENES, ZNF331_TARGET_GENES, ZNF610_TARGET_GENES, ZSCAN30_TARGET_GENES, ZNF134_TARGET_GENES

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
regulation of DNA-templated transcription	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transition metal ion binding	1
DNA binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

68 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF892	TBC1D2	Q9BYX2	306
ZNF892	PLAGL2	Q9UPG8	254
ZNF892	C19orf53	Q9UNZ5	203
ZNF892	MBNL1	Q9NR56	198
ZNF892	NOX3	Q9HBY0	194
ZNF892	NOX5	Q96PH1	178
ZNF892	HRG	P04196	166
ZNF892	MIER2	Q8N344	166
ZNF892	HES7	Q9BYE0	165
ZNF892	GPR137B	O60478	158
ZNF892	ZNF19	P17023	153
ZNF892	DUOX2	Q9NRD8	152
ZNF892	DUOX1	Q9NRD9	141
ZNF892	PQBP1	O60828	136
ZNF892	MVK	Q03426	64

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0A087WUV0, Q96K75, Q99676, Q9HBT8, Q9UJL9, Q9UJN7, A0A2Z4LIS9, A2A761, A6NP11, A6QLU5, A6QPT6, A7MBI1, A8MQ14, A8MT65, A8MTY0, B2RXC5, B4DU55, B4DX44, B4DXR9, E9PYI1, O43296, O60765, O75290, O75346, O95780, P0CG31, P10078, P17014, P17032, P17098, P21506, P51508, P51786, P51814, P52738, P52742, P59923, Q03936, Q06730, Q06732

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

621 predictions. Top by Δscore:

Variant	Effect	Δscore
2:95208731:TCCC:T	donor_gain	1.0000
2:95208737:G:GG	donor_gain	1.0000
2:95211486:TGGCC:T	donor_gain	1.0000
2:95207611:G:GT	donor_gain	0.9900
2:95208641:C:G	acceptor_gain	0.9900
2:95208642:TTTTA:T	acceptor_loss	0.9900
2:95208643:TTTA:T	acceptor_loss	0.9900
2:95208645:TA:T	acceptor_loss	0.9900
2:95208646:A:AG	acceptor_gain	0.9900
2:95208646:A:C	acceptor_loss	0.9900
2:95208646:AG:A	acceptor_gain	0.9900
2:95208647:G:A	acceptor_loss	0.9900
2:95208647:G:GG	acceptor_gain	0.9900
2:95208647:GG:G	acceptor_gain	0.9900
2:95208647:GGATC:G	acceptor_gain	0.9900
2:95208734:CAA:C	donor_gain	0.9900
2:95208734:CAAG:C	donor_loss	0.9900
2:95208735:AA:A	donor_gain	0.9900
2:95208736:AGT:A	donor_loss	0.9900
2:95208737:G:A	donor_loss	0.9900
2:95208738:T:G	donor_loss	0.9900
2:95211487:GGCCA:G	donor_gain	0.9900
2:95211718:TGGGT:T	donor_loss	0.9900
2:95211719:GG:G	donor_gain	0.9900
2:95211719:GGGT:G	donor_loss	0.9900
2:95211720:GG:G	donor_gain	0.9900
2:95211721:G:GT	donor_loss	0.9900
2:95211722:T:TT	donor_loss	0.9900
2:95212281:GC:G	donor_gain	0.9900
2:95212379:TTG:T	donor_gain	0.9900

AlphaMissense

3468 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:95215058:T:C	F342L	0.999
2:95215060:C:A	F342L	0.999
2:95215060:C:G	F342L	0.999
2:95215310:T:C	F426L	0.999
2:95215312:C:A	F426L	0.999
2:95215312:C:G	F426L	0.999
2:95215394:T:C	F454L	0.999
2:95215396:C:A	F454L	0.999
2:95215396:C:G	F454L	0.999
2:95214806:T:C	F258L	0.998
2:95214808:T:A	F258L	0.998
2:95214808:T:G	F258L	0.998
2:95215142:T:C	F370L	0.998
2:95215144:T:A	F370L	0.998
2:95215144:T:G	F370L	0.998
2:95215226:T:C	F398L	0.998
2:95215228:T:A	F398L	0.998
2:95215228:T:G	F398L	0.998
2:95214890:T:C	F286L	0.997
2:95214892:C:A	F286L	0.997
2:95214892:C:G	F286L	0.997
2:95214974:T:C	F314L	0.997
2:95214976:T:A	F314L	0.997
2:95214976:T:G	F314L	0.997
2:95215008:G:C	R325P	0.996
2:95215339:T:A	H435Q	0.996
2:95215339:T:G	H435Q	0.996
2:95215413:T:C	L460P	0.996
2:95215478:T:C	F482L	0.996
2:95215480:T:A	F482L	0.996

dbSNP variants (sampled 300 via entrez): RS1000106668 (2:95214869 T>C), RS1000170195 (2:95255328 C>T), RS1000175862 (2:95207500 G>C), RS1000302877 (2:95255551 T>A,C,G), RS1000334888 (2:95248178 C>T), RS1000439757 (2:95221932 C>G), RS1000526252 (2:95241260 C>G), RS1000581582 (2:95241627 A>G), RS1000598856 (2:95234300 TAGA>T), RS1000609956 (2:95262641 C>G,T), RS1000698467 (2:95207634 G>A,C), RS1000749520 (2:95227303 G>GT), RS1000885609 (2:95227653 G>T), RS1000950984 (2:95212233 G>A), RS1001046623 (2:95220352 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.