ZNNT1

Summary

ZNNT1 (ZNF706 neighboring transcript 1, HGNC:54438) is a long non-coding RNA gene on chromosome 8q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54438
Approved symbol	ZNNT1
Name	ZNF706 neighboring transcript 1
Location	8q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AP003469.4
Ensembl gene	ENSG00000261087
Ensembl biotype	lncRNA
Entrez	115830329
RNAcentral	URS000194B0FA — lncRNA, 3435 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000565617

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000565617 — 1 exons

Exon	Start	End
ENSE00002623035	101166805	101169629

Expression profiles

Bgee: expression breadth ubiquitous, 221 present calls, max score 91.25.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7648 / max 325.6449, expressed in 218 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94217	0.7648	218

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar cortex	UBERON:0002129	91.25	gold quality
cerebellar hemisphere	UBERON:0002245	91.25	gold quality
cerebellum	UBERON:0002037	90.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.67	gold quality
cerebellar vermis	UBERON:0004720	89.51	gold quality
medial globus pallidus	UBERON:0002477	87.41	gold quality
amygdala	UBERON:0001876	86.82	gold quality
tendon of biceps brachii	UBERON:0008188	86.53	gold quality
globus pallidus	UBERON:0001875	86.32	gold quality
nucleus accumbens	UBERON:0001882	85.87	gold quality
cingulate cortex	UBERON:0003027	85.47	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.45	gold quality
anterior cingulate cortex	UBERON:0009835	85.40	gold quality
putamen	UBERON:0001874	84.94	gold quality
right frontal lobe	UBERON:0002810	84.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.74	gold quality
Ammon’s horn	UBERON:0001954	84.56	gold quality
caudate nucleus	UBERON:0001873	84.09	gold quality
substantia nigra	UBERON:0002038	83.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.74	gold quality
spinal cord	UBERON:0002240	83.55	gold quality
midbrain	UBERON:0001891	83.36	gold quality
primary visual cortex	UBERON:0002436	83.21	gold quality
lower esophagus mucosa	UBERON:0035834	82.98	gold quality
telencephalon	UBERON:0001893	82.66	gold quality
central nervous system	UBERON:0001017	82.60	gold quality
hypothalamus	UBERON:0001898	82.58	gold quality
brain	UBERON:0000955	82.57	gold quality
Brodmann (1909) area 23	UBERON:0013554	82.46	gold quality
temporal lobe	UBERON:0001871	82.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.87

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression. (PMID:31462126)
• METTL3/16-mediated m[6]A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells. (PMID:38310994)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.