ZSCAN16-AS1

Summary

ZSCAN16-AS1 (ZSCAN16 antisense RNA 1, HGNC:48982) is a long non-coding RNA gene on chromosome 6p22.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 100129195 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48982
Approved symbol	ZSCAN16-AS1
Name	ZSCAN16 antisense RNA 1
Location	6p22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000269293
Ensembl biotype	lncRNA
Entrez	100129195
RNAcentral	URS000075F0C3 — lncRNA, 2186 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 67 — 67 lncRNA

ENST00000600652, ENST00000602810, ENST00000605945, ENST00000660873, ENST00000667674, ENST00000671586, ENST00000716089, ENST00000716090, ENST00000716091, ENST00000733323, ENST00000733324, ENST00000733325, ENST00000733326, ENST00000733327, ENST00000733328, ENST00000733329, ENST00000733330, ENST00000733331, ENST00000733332, ENST00000733333, ENST00000733334, ENST00000733335, ENST00000733336, ENST00000733337, ENST00000733338, ENST00000733339, ENST00000733340, ENST00000733341, ENST00000733342, ENST00000733343, ENST00000733344, ENST00000733345, ENST00000733346, ENST00000733347, ENST00000733348, ENST00000733349, ENST00000733350, ENST00000733351, ENST00000733352, ENST00000733353, ENST00000733354, ENST00000733355, ENST00000733356, ENST00000733357, ENST00000733358, ENST00000733359, ENST00000733360, ENST00000733361, ENST00000733362, ENST00000733363, ENST00000733364, ENST00000733365, ENST00000733366, ENST00000733367, ENST00000733368, ENST00000733369, ENST00000733370, ENST00000733371, ENST00000733372, ENST00000733373, ENST00000733374, ENST00000733375, ENST00000733376, ENST00000733377, ENST00000733378, ENST00000733379, ENST00000733380

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000600652 — 3 exons

Exon	Start	End
ENSE00003001653	28125623	28125819
ENSE00003148252	28136745	28137293
ENSE00003198704	28121795	28123211

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 93.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.2054 / max 258.3651, expressed in 1783 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72398	12.9857	1780
72401	0.4639	91
72397	0.3518	181
72399	0.2457	106
72400	0.1584	61

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	93.51	silver quality
buccal mucosa cell	CL:0002336	91.32	gold quality
medial globus pallidus	UBERON:0002477	87.56	silver quality
apex of heart	UBERON:0002098	85.76	gold quality
right atrium auricular region	UBERON:0006631	85.07	gold quality
gastrocnemius	UBERON:0001388	84.81	gold quality
muscle of leg	UBERON:0001383	84.79	gold quality
cardiac atrium	UBERON:0002081	84.67	gold quality
heart left ventricle	UBERON:0002084	84.50	gold quality
cardiac ventricle	UBERON:0002082	84.34	gold quality
nucleus accumbens	UBERON:0001882	83.92	gold quality
putamen	UBERON:0001874	83.73	gold quality
globus pallidus	UBERON:0001875	83.60	silver quality
cardiac muscle of right atrium	UBERON:0003379	83.37	gold quality
heart right ventricle	UBERON:0002080	83.21	silver quality
heart	UBERON:0000948	83.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.75	gold quality
amygdala	UBERON:0001876	82.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.00	gold quality
adenohypophysis	UBERON:0002196	81.98	gold quality
caudate nucleus	UBERON:0001873	81.88	gold quality
skeletal muscle tissue	UBERON:0001134	81.63	gold quality
anterior cingulate cortex	UBERON:0009835	81.38	gold quality
hypothalamus	UBERON:0001898	81.34	gold quality
spinal cord	UBERON:0002240	81.34	gold quality
muscle tissue	UBERON:0002385	81.24	gold quality
pituitary gland	UBERON:0000007	80.92	gold quality
biceps brachii	UBERON:0001507	80.88	silver quality
islet of Langerhans	UBERON:0000006	80.81	gold quality
adult mammalian kidney	UBERON:0000082	80.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• ZSCAN16-AS1 expedites hepatocellular carcinoma progression via modulating the miR-181c-5p/SPAG9 axis to activate the JNK pathway. (PMID:34097562)
• Long noncoding RNA ZSCAN16AS1 promotes the malignant properties of hepatocellular carcinoma by decoying microRNA451a and consequently increasing ATF2 expression. (PMID:34498716)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.