ZSCAN18

Summary

ZSCAN18 (zinc finger and SCAN domain containing 18, HGNC:21037) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger and SCAN domain-containing protein 18 (Q8TBC5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 65982 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_001145543

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21037
Approved symbol	ZSCAN18
Name	zinc finger and SCAN domain containing 18
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12895
Ensembl gene	ENSG00000121413
Ensembl biotype	protein_coding
Entrez	65982

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 33 protein_coding, 5 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000240727, ENST00000421612, ENST00000433686, ENST00000594191, ENST00000594567, ENST00000595721, ENST00000595784, ENST00000595944, ENST00000596372, ENST00000598497, ENST00000600318, ENST00000600404, ENST00000600522, ENST00000600845, ENST00000600897, ENST00000601063, ENST00000601144, ENST00000861637, ENST00000861638, ENST00000861639, ENST00000861640, ENST00000861641, ENST00000861642, ENST00000861643, ENST00000861644, ENST00000861645, ENST00000861646, ENST00000861647, ENST00000861648, ENST00000861649, ENST00000861650, ENST00000861651, ENST00000861652, ENST00000861653, ENST00000932259, ENST00000932260, ENST00000932261, ENST00000941784, ENST00000941785

RefSeq mRNA: 4 — MANE Select: NM_001145543 NM_001145542, NM_001145543, NM_001145544, NM_023926

CCDS: CCDS12971, CCDS46214, CCDS46215

Canonical transcript exons

ENST00000601144 — 7 exons

Exon	Start	End
ENSE00000822507	58087316	58087404
ENSE00003004982	58098174	58098231
ENSE00003127539	58083856	58085379
ENSE00003592705	58086906	58087008
ENSE00003602144	58089865	58090386
ENSE00003679515	58086174	58086266
ENSE00003788930	58088688	58088837

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 98.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.8075 / max 146.6726, expressed in 1557 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182932	14.4257	1556
182933	0.2770	100
182931	0.1047	42

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	98.44	gold quality
pituitary gland	UBERON:0000007	97.66	gold quality
adenohypophysis	UBERON:0002196	97.65	gold quality
nucleus accumbens	UBERON:0001882	97.16	gold quality
postcentral gyrus	UBERON:0002581	97.13	gold quality
hypothalamus	UBERON:0001898	97.10	gold quality
right frontal lobe	UBERON:0002810	97.05	gold quality
right lobe of thyroid gland	UBERON:0001119	97.03	gold quality
left lobe of thyroid gland	UBERON:0001120	96.94	gold quality
thyroid gland	UBERON:0002046	96.73	gold quality
caudate nucleus	UBERON:0001873	96.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.67	gold quality
cerebellar hemisphere	UBERON:0002245	96.65	gold quality
cingulate cortex	UBERON:0003027	96.64	gold quality
anterior cingulate cortex	UBERON:0009835	96.64	gold quality
cerebellar cortex	UBERON:0002129	96.62	gold quality
parietal lobe	UBERON:0001872	96.54	gold quality
left ovary	UBERON:0002119	96.41	gold quality
putamen	UBERON:0001874	96.37	gold quality
cerebellum	UBERON:0002037	96.33	gold quality
amygdala	UBERON:0001876	96.32	gold quality
cardiac muscle of right atrium	UBERON:0003379	96.26	gold quality
forebrain	UBERON:0001890	96.23	gold quality
Ammon’s horn	UBERON:0001954	96.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	96.21	gold quality
superior frontal gyrus	UBERON:0002661	96.20	gold quality
lower esophagus	UBERON:0013473	96.19	gold quality
temporal lobe	UBERON:0001871	96.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.24

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
CDKN2A

miRNA regulators (miRDB)

21 targeting ZSCAN18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-1324	99.46	66.57	1302
HSA-MIR-3922-3P	99.25	64.96	1136
HSA-MIR-3176	99.25	64.35	954
HSA-MIR-4774-3P	98.90	67.82	737
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-1178-3P	98.57	67.09	890
HSA-MIR-550A-3P	98.37	69.61	632
HSA-MIR-1262	98.17	66.52	757
HSA-MIR-4701-3P	98.17	66.25	788
HSA-MIR-6736-5P	98.17	66.43	760
HSA-MIR-200C-5P	97.71	67.73	596
HSA-MIR-3127-5P	97.52	65.24	786
HSA-MIR-3121-5P	97.30	66.62	1146
HSA-MIR-3152-5P	96.98	66.88	819
HSA-MIR-4474-5P	94.23	67.95	568
HSA-MIR-5090	93.28	60.86	94
HSA-MIR-6775-5P	92.43	61.00	132
HSA-MIR-6090	91.01	62.65	222

Literature-anchored findings (GeneRIF, showing 3)

• A high negative correlation between promoter DNA methylation and gene expression was observed for CDO1, ZNF331 and ZSCAN18 in gastrointestinal tumors. (PMID:24948044)
• Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells. (PMID:36650573)
• Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer. (PMID:37223020)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	plagx	ENSDARG00000036855
danio_rerio	ovol1a	ENSDARG00000076472
danio_rerio	plagl2	ENSDARG00000076657
danio_rerio	ovol1b	ENSDARG00000078256
mus_musculus	Zscan18	ENSMUSG00000070822
rattus_norvegicus	Zscan18	ENSRNOG00000026861
drosophila_melanogaster	hb	FBGN0001180
drosophila_melanogaster	CG12391	FBGN0033581
caenorhabditis_elegans		WBGENE00001824
caenorhabditis_elegans		WBGENE00003033
caenorhabditis_elegans		WBGENE00012385

Paralogs (29): ZNF446 (ENSG00000083838), REST (ENSG00000084093), ZNF174 (ENSG00000103343), OVOL3 (ENSG00000105261), PLAGL1 (ENSG00000118495), ZNF576 (ENSG00000124444), OVOL2 (ENSG00000125850), PLAGL2 (ENSG00000126003), ZSCAN5A (ENSG00000131848), ZSCAN29 (ENSG00000140265), ZSCAN32 (ENSG00000140987), ZSCAN1 (ENSG00000152467), ZNF18 (ENSG00000154957), ZKSCAN2 (ENSG00000155592), ZNF496 (ENSG00000162714), ZNF202 (ENSG00000166261), ZNF641 (ENSG00000167528), ZNF444 (ENSG00000167685), SCAND1 (ENSG00000171222), ZNF274 (ENSG00000171606), ZNF131 (ENSG00000172262), OVOL1 (ENSG00000172818), ZNF518A (ENSG00000177853), ZNF518B (ENSG00000178163), PLAG1 (ENSG00000181690), ZSCAN5B (ENSG00000197213), ZNF770 (ENSG00000198146), PEG3 (ENSG00000198300), ZSCAN5C (ENSG00000204532)

Protein

Protein identifiers

Zinc finger and SCAN domain-containing protein 18 — Q8TBC5 (reviewed: Q8TBC5)

Alternative names: Zinc finger protein 447

All UniProt accessions (8): A0A0C4DG78, Q8TBC5, M0QXJ0, M0QZ65, M0R111, M0R1U9, M0R364, M0R3C6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8TBC5-1	1	yes
Q8TBC5-2	2
Q8TBC5-3	3
Q8TBC5-4	4

RefSeq proteins (4): NP_001139014, NP_001139015, NP_001139016, NP_076415 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily
IPR050916	SCAN-C2H2_zinc_finger	Family

Pfam: PF02023

UniProt features (19 total): compositionally biased region 5, region of interest 5, splice variant 3, zinc finger region 2, chain 1, domain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TBC5-F1	53.99	0.01

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 85 (showing top): SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5, ROSS_LEUKEMIA_WITH_MLL_FUSIONS, GATA1_01, BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP, ACEVEDO_LIVER_CANCER_UP, TGCCTTA_MIR124A, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN, HUTTMANN_B_CLL_POOR_SURVIVAL_UP, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN, LIM_MAMMARY_LUMINAL_MATURE_UP, ONKEN_UVEAL_MELANOMA_DN, EGFR_UP.V1_DN, WINTER_HYPOXIA_DN

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

670 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZSCAN18	CDO1	P78513	678
ZSCAN18	DCLK1	O15075	613
ZSCAN18	SFRP1	Q8N474	570
ZSCAN18	KLHL35	Q6PF15	507
ZSCAN18	ZNF331	Q9NQX6	423
ZSCAN18	ATP5MC2	Q06055	403
ZSCAN18	CNRIP1	Q96F85	399
ZSCAN18	CORO6	Q6QEF8	392
ZSCAN18	CCDC8	Q9H0W5	391
ZSCAN18	FOXI2	Q6ZQN5	391
ZSCAN18	ANKUB1	A6NFN9	369
ZSCAN18	SCUBE3	Q8IX30	367
ZSCAN18	RUBCNL	Q9H714	348
ZSCAN18	SCAND1	P57086	342
ZSCAN18	WDR17	Q8IZU2	336

IntAct

67 interactions, top by confidence:

A	B	Type	Score
MSH2	MSH3	psi-mi:“MI:0914”(association)	0.920
CSNK1A1	FAM83G	psi-mi:“MI:0914”(association)	0.900
PGBD1	ZNF24	psi-mi:“MI:0914”(association)	0.900
ZSCAN18	PGBD1	psi-mi:“MI:0915”(physical association)	0.740
SCAND1	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.740
ZSCAN18	SCAND1	psi-mi:“MI:0914”(association)	0.740
EPM2AIP1	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.670
ZSCAN18	SUFU	psi-mi:“MI:0915”(physical association)	0.670
ZNF397	ZNF213	psi-mi:“MI:0914”(association)	0.640
ZSCAN18	FDXACB1	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN22	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.560
ZNF174	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN18	ZNF446	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN32	ZNF197	psi-mi:“MI:0914”(association)	0.530
PGBD1	ZNF213	psi-mi:“MI:0914”(association)	0.530
ZNF396	ZNF24	psi-mi:“MI:0914”(association)	0.530
ZNF213	ZNF24	psi-mi:“MI:0914”(association)	0.530
ZSCAN18	ZNF24	psi-mi:“MI:0914”(association)	0.530
ZNF215	SCAND1	psi-mi:“MI:0914”(association)	0.530
ZKSCAN4	FN1	psi-mi:“MI:0914”(association)	0.530
ZSCAN9	SCAND1	psi-mi:“MI:0914”(association)	0.530
HOXD4	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.370
LIG4	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.370
SAFB2	ZSCAN18	psi-mi:“MI:0915”(physical association)	0.370
MAPT	MEX3A	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
GLI2	SPOP	psi-mi:“MI:0914”(association)	0.350
FGFR2	LANCL1	psi-mi:“MI:0914”(association)	0.350
ZKSCAN8	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (68): ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Affinity Capture-MS), ZSCAN18 (Two-hybrid), ZSCAN18 (Two-hybrid), ZSCAN18 (Two-hybrid), PGBD1 (Two-hybrid), SCAND1 (Two-hybrid)

ESM2 similar proteins: A0A0U1RRK4, A0A1W2PR82, A1YGK1, A2T7E6, A4D1S0, A6NEL2, A6QP24, A6QPM6, O43593, O43918, O94850, O95873, P0C7X2, P50617, P97609, Q3B7M4, Q3UM83, Q5FWE3, Q5JPB2, Q5M844, Q5XJV6, Q61645, Q64322, Q6GQX2, Q6NZ36, Q6PE13, Q6UWD8, Q6ZMS7, Q6ZW13, Q76NI1, Q7Z6P3, Q8BWG4, Q8BZW2, Q8IWN7, Q8NBB4, Q8NDX1, Q8NHY3, Q8TBC5, Q8TER5, Q91XA5

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 64 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Hedgehog ‘on’ state	5	24.0×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	84
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1360 predictions. Top by Δscore:

Variant	Effect	Δscore
19:58086168:CCTCA:C	donor_loss	1.0000
19:58086169:CTCA:C	donor_loss	1.0000
19:58086170:TCA:T	donor_loss	1.0000
19:58086171:CAC:C	donor_loss	1.0000
19:58086187:T:TA	donor_gain	1.0000
19:58086262:ATACC:A	acceptor_gain	1.0000
19:58086263:TACC:T	acceptor_gain	1.0000
19:58086264:ACC:A	acceptor_gain	1.0000
19:58086264:ACCC:A	acceptor_loss	1.0000
19:58086265:CC:C	acceptor_gain	1.0000
19:58086265:CCC:C	acceptor_gain	1.0000
19:58086266:CC:C	acceptor_gain	1.0000
19:58086267:C:CC	acceptor_gain	1.0000
19:58086267:C:T	acceptor_gain	1.0000
19:58086271:G:C	acceptor_gain	1.0000
19:58086271:G:GC	acceptor_gain	1.0000
19:58086276:G:C	acceptor_gain	1.0000
19:58086276:G:GC	acceptor_gain	1.0000
19:58086277:T:C	acceptor_gain	1.0000
19:58086277:T:TC	acceptor_gain	1.0000
19:58086285:C:CT	acceptor_gain	1.0000
19:58086905:CCCCA:C	donor_gain	1.0000
19:58086921:T:TA	donor_gain	1.0000
19:58087311:CCCA:C	donor_loss	1.0000
19:58087313:CAC:C	donor_loss	1.0000
19:58087315:C:CA	donor_loss	1.0000
19:58087400:CCAGG:C	acceptor_gain	1.0000
19:58087401:CAGG:C	acceptor_gain	1.0000
19:58087401:CAGGC:C	acceptor_gain	1.0000
19:58087402:AGG:A	acceptor_gain	1.0000

AlphaMissense

3282 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:58084952:G:C	F422L	0.999
19:58084952:G:T	F422L	0.999
19:58084954:A:G	F422L	0.999
19:58084868:G:C	F450L	0.998
19:58084868:G:T	F450L	0.998
19:58084870:A:G	F450L	0.998
19:58084935:A:G	L428P	0.997
19:58089977:G:C	F97L	0.995
19:58089977:G:T	F97L	0.995
19:58089979:A:G	F97L	0.995
19:58090059:A:G	L70P	0.995
19:58090101:A:T	V56D	0.995
19:58084841:G:C	H459Q	0.994
19:58084841:G:T	H459Q	0.994
19:58084891:A:G	C443R	0.994
19:58084953:A:G	F422S	0.994
19:58084975:A:G	C415R	0.994
19:58089987:A:G	L94P	0.994
19:58089996:A:G	L91P	0.994
19:58090113:A:G	F52S	0.994
19:58084869:A:G	F450S	0.993
19:58084880:G:C	C446W	0.993
19:58084882:A:G	C446R	0.993
19:58089978:A:G	F97S	0.993
19:58084881:C:T	C446Y	0.992
19:58084925:G:C	H431Q	0.992
19:58084925:G:T	H431Q	0.992
19:58084964:G:C	C418W	0.992
19:58084965:C:G	C418S	0.992
19:58084966:A:T	C418S	0.992

dbSNP variants (sampled 300 via entrez): RS1000049058 (19:58105744 T>C), RS1000158585 (19:58088238 A>G), RS1000202331 (19:58112861 G>C), RS1000313220 (19:58091212 A>G), RS1000324608 (19:58118028 G>C), RS1000357595 (19:58116583 C>G,T), RS1000378340 (19:58118233 C>A), RS1000399095 (19:58105522 G>A), RS1000811893 (19:58116852 T>C,G), RS1000824719 (19:58085504 C>A,G,T), RS1000841590 (19:58112607 C>T), RS1000893946 (19:58112758 T>C), RS1000900323 (19:58098195 C>A,G), RS1000949850 (19:58113990 C>T), RS1000955570 (19:58098308 A>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, decreases expression	5
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, decreases expression, affects cotreatment	2
aristolochic acid I	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
pirinixic acid	increases expression, affects binding, increases activity	1
bisphenol A	affects cotreatment, decreases methylation	1
geraniol	increases expression	1
arsenite	decreases expression, increases methylation	1
sodium arsenite	decreases expression	1
potassium chromate(VI)	increases expression	1
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	1
pentabromodiphenyl ether	increases expression	1
CGP 52608	affects binding, increases reaction	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	increases methylation	1
LDN 193189	affects cotreatment, increases expression	1
NSC 689534	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Fluorouracil	affects response to substance	1
Mitoxantrone	affects response to substance	1
Ozone	increases oxidation, increases abundance, affects cotreatment	1
Polychlorinated Biphenyls	affects expression	1
Smoke	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW90	HEK293 eGFP-ZSCAN18	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.