ZSCAN25

Summary

ZSCAN25 (zinc finger and SCAN domain containing 25, HGNC:21961) is a protein-coding gene on chromosome 7q22.1, encoding Zinc finger and SCAN domain-containing protein 25 (Q6NSZ9). May be involved in transcriptional regulation.

This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined.

Source: NCBI Gene 221785 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 84 total
• MANE Select transcript: NM_145115

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21961
Approved symbol	ZSCAN25
Name	zinc finger and SCAN domain containing 25
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ32468
Ensembl gene	ENSG00000197037
Ensembl biotype	protein_coding
Entrez	221785

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 16 protein_coding, 3 retained_intron, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000394150, ENST00000394152, ENST00000431485, ENST00000466948, ENST00000473646, ENST00000481424, ENST00000485586, ENST00000493443, ENST00000873815, ENST00000873816, ENST00000873817, ENST00000873818, ENST00000873819, ENST00000873820, ENST00000873821, ENST00000873822, ENST00000873823, ENST00000873824, ENST00000873825, ENST00000919726, ENST00000919727, ENST00000964553

RefSeq mRNA: 9 — MANE Select: NM_145115 NM_001350979, NM_001350980, NM_001350981, NM_001350982, NM_001350983, NM_001350984, NM_001350985, NM_001350986, NM_145115

CCDS: CCDS5671

Canonical transcript exons

ENST00000394152 — 8 exons

Exon	Start	End
ENSE00001517630	99619561	99619993
ENSE00001517631	99619048	99619132
ENSE00001517632	99618525	99618651
ENSE00001854753	99616946	99617016
ENSE00003467099	99621373	99621574
ENSE00003484736	99622549	99622640
ENSE00003500678	99624057	99624180
ENSE00003849931	99629191	99632408

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 93.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.5256 / max 103.8722, expressed in 1793 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79897	13.5256	1793

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	93.09	silver quality
tibialis anterior	UBERON:0001385	86.40	silver quality
secondary oocyte	CL:0000655	83.81	gold quality
ileal mucosa	UBERON:0000331	82.21	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.77	gold quality
bone marrow cell	CL:0002092	81.60	gold quality
granulocyte	CL:0000094	80.79	gold quality
oviduct epithelium	UBERON:0004804	80.49	gold quality
oocyte	CL:0000023	80.46	gold quality
colonic epithelium	UBERON:0000397	80.35	gold quality
sural nerve	UBERON:0015488	80.12	gold quality
ventricular zone	UBERON:0003053	80.04	gold quality
left ventricle myocardium	UBERON:0006566	79.82	gold quality
calcaneal tendon	UBERON:0003701	79.80	gold quality
cortical plate	UBERON:0005343	79.74	gold quality
adrenal tissue	UBERON:0018303	78.89	gold quality
ganglionic eminence	UBERON:0004023	78.78	gold quality
tonsil	UBERON:0002372	78.37	gold quality
ovary	UBERON:0000992	78.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.00	gold quality
leukocyte	CL:0000738	77.70	gold quality
deltoid	UBERON:0001476	77.47	silver quality
smooth muscle tissue	UBERON:0001135	77.45	gold quality
monocyte	CL:0000576	77.38	gold quality
vermiform appendix	UBERON:0001154	77.26	gold quality
stromal cell of endometrium	CL:0002255	77.25	gold quality
left ovary	UBERON:0002119	77.20	gold quality
fallopian tube	UBERON:0003889	77.06	gold quality
skin of leg	UBERON:0001511	77.00	gold quality
right ovary	UBERON:0002118	77.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.80

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2517.1	ZSCAN25	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

78 targeting ZSCAN25, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-320A-3P	99.77	69.73	2107
HSA-MIR-320B	99.77	69.73	2107
HSA-MIR-320C	99.77	69.73	2107
HSA-MIR-320D	99.77	69.73	2107
HSA-MIR-4429	99.77	69.62	2111
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-378A-5P	99.65	66.33	1311

Literature-anchored findings (GeneRIF, showing 2)

• ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation. (PMID:35227287)
• ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome. (PMID:38166538)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zscan25	ENSMUSG00000070420
rattus_norvegicus	Zscan25	ENSRNOG00000042213

Paralogs (30): ZNF263 (ENSG00000006194), ZNF213 (ENSG00000085644), ZNF500 (ENSG00000103199), ZKSCAN1 (ENSG00000106261), ZNF205 (ENSG00000122386), ZSCAN9 (ENSG00000137185), PGBD1 (ENSG00000137338), ZNF215 (ENSG00000149054), ZSCAN12 (ENSG00000158691), ZNF394 (ENSG00000160908), ZNF75A (ENSG00000162086), ZSCAN21 (ENSG00000166529), ZNF232 (ENSG00000167840), ZNF24 (ENSG00000172466), ZNF449 (ENSG00000173275), ZSCAN4 (ENSG00000180532), ZSCAN22 (ENSG00000182318), ZNF75D (ENSG00000186376), ZNF396 (ENSG00000186496), ZNF397 (ENSG00000186812), ZSCAN30 (ENSG00000186814), ZKSCAN4 (ENSG00000187626), ZSCAN23 (ENSG00000187987), ZKSCAN3 (ENSG00000189298), ZSCAN16 (ENSG00000196812), ZSCAN26 (ENSG00000197062), ZNF165 (ENSG00000197279), ZKSCAN8 (ENSG00000198315), ZSCAN31 (ENSG00000235109), ZNF853 (ENSG00000236609)

Protein

Protein identifiers

Zinc finger and SCAN domain-containing protein 25 — Q6NSZ9 (reviewed: Q6NSZ9)

Alternative names: Zinc finger protein 498

All UniProt accessions (2): C9K079, Q6NSZ9

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6NSZ9-1	1	yes
Q6NSZ9-2	2
Q6NSZ9-3	3
Q6NSZ9-4	4

RefSeq proteins (9): NP_001337908, NP_001337909, NP_001337910, NP_001337911, NP_001337912, NP_001337913, NP_001337914, NP_001337915, NP_660090* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF02023

UniProt features (19 total): zinc finger region 7, cross-link 5, splice variant 3, chain 1, domain 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6NSZ9-F1	63.26	0.19

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 3, 22, 128, 278, 285

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 68 (showing top): GCANCTGNY_MYOD_Q6, SCGGAAGY_ELK1_02, YOSHIMURA_MAPK8_TARGETS_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, DIDO1_TARGET_GENES, DYRK1A_TARGET_GENES, E2F2_TARGET_GENES, ELF2_TARGET_GENES, GLI4_TARGET_GENES, SNAI1_TARGET_GENES, SNIP1_TARGET_GENES, TEAD2_TARGET_GENES, ZFP3_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

946 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZSCAN25	ZBED8L	Q8TCP9	506
ZSCAN25	CYP3A5	P20815	447
ZSCAN25	SSC4D	Q8WTU2	391
ZSCAN25	THEMIS2	Q5TEJ8	388
ZSCAN25	CYP3A7	P24462	363
ZSCAN25	TRMT1L	Q7Z2T5	356
ZSCAN25	CLEC18A	A5D8T8	355
ZSCAN25	SLC35E1	Q96K37	328
ZSCAN25	RNF217	Q8TC41	322
ZSCAN25	RBM19	Q9Y4C8	317
ZSCAN25	MAFF	Q9ULX9	313
ZSCAN25	SH2D1B	O14796	312
ZSCAN25	PTCD1	O75127	301
ZSCAN25	RBPMS2	Q6ZRY4	298
ZSCAN25	CEP85L	Q5SZL2	290

IntAct

84 interactions, top by confidence:

A	B	Type	Score
LARP7	CCNT1	psi-mi:“MI:0914”(association)	0.850
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF483	ZNF197	psi-mi:“MI:0914”(association)	0.530
PGBD1	ZNF213	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL7A	NVL	psi-mi:“MI:0914”(association)	0.530
H1-1	SURF6	psi-mi:“MI:0914”(association)	0.530
WTAP	DDX39A	psi-mi:“MI:0914”(association)	0.350
ZSCAN20	ZNF197	psi-mi:“MI:0914”(association)	0.350
PPAN	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
SART3	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350

BioGRID (92): ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS), ZSCAN25 (Affinity Capture-MS)

ESM2 similar proteins: A1YEQ3, A1YEV9, A1YFW6, A1YG26, A2T6W2, A2T712, A2T7G6, A2T7L7, A6NGD5, A6NJL1, A6QPT6, D2HQI1, O14771, O60304, O95125, O95201, P0CG00, P10754, P17022, P17029, P51815, Q15697, Q3B7M4, Q3URR7, Q4KLI1, Q4R8H9, Q58DK7, Q5DTZ0, Q5R670, Q5SXI5, Q5T619, Q642B9, Q6NSZ9, Q6P9G9, Q6ZMS7, Q810A1, Q8BGS3, Q8BZ34, Q8CF60, Q91VW9

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 89 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	7	42.4×	3e-09
Cap-dependent Translation Initiation	7	42.4×	3e-09
SARS-CoV-1 modulates host translation machinery	7	42.4×	3e-09
Eukaryotic Translation Elongation	7	38.2×	5e-09
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	7	37.3×	6e-09
Peptide chain elongation	14	34.8×	9e-17
Viral mRNA Translation	14	34.8×	9e-17
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	14	34.5×	9e-17

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	15	34.3×	6e-17
ribosomal small subunit biogenesis	8	22.5×	3e-07
translation	13	16.5×	2e-10
rRNA processing	8	14.0×	8e-06
nucleosome assembly	5	8.7×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

84 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	75
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1148 predictions. Top by Δscore:

Variant	Effect	Δscore
7:99619128:GGAGG:G	donor_gain	1.0000
7:99619129:GAGGG:G	donor_gain	1.0000
7:99619556:A:AG	acceptor_gain	1.0000
7:99619556:AAAAG:A	acceptor_gain	1.0000
7:99619557:AAAG:A	acceptor_gain	1.0000
7:99619558:AAG:A	acceptor_gain	1.0000
7:99619559:A:G	acceptor_gain	1.0000
7:99619559:AG:A	acceptor_gain	1.0000
7:99619560:G:A	acceptor_gain	1.0000
7:99619990:GGCG:G	donor_gain	1.0000
7:99619991:GCGG:G	donor_gain	1.0000
7:99621878:G:GG	donor_gain	1.0000
7:99618650:CT:C	donor_gain	0.9900
7:99618652:G:GG	donor_gain	0.9900
7:99619130:A:T	donor_gain	0.9900
7:99619131:GG:G	donor_gain	0.9900
7:99619132:GG:G	donor_gain	0.9900
7:99619557:A:G	acceptor_gain	0.9900
7:99619557:AAAGG:A	acceptor_gain	0.9900
7:99619558:A:G	acceptor_gain	0.9900
7:99619560:G:GG	acceptor_gain	0.9900
7:99619936:C:T	donor_gain	0.9900
7:99619956:TG:T	donor_gain	0.9900
7:99619957:GG:G	donor_gain	0.9900
7:99619961:G:GT	donor_gain	0.9900
7:99619971:A:T	donor_gain	0.9900
7:99619982:G:GT	donor_gain	0.9900
7:99619994:GTGG:G	donor_gain	0.9900
7:99624055:AGG:A	acceptor_gain	0.9900
7:99624056:GGG:G	acceptor_gain	0.9900

AlphaMissense

3565 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:99629454:T:C	F357L	1.000
7:99629456:C:A	F357L	1.000
7:99629456:C:G	F357L	1.000
7:99629535:T:C	F384L	1.000
7:99629537:T:A	F384L	1.000
7:99629537:T:G	F384L	1.000
7:99629619:T:C	F412L	1.000
7:99629621:C:A	F412L	1.000
7:99629621:C:G	F412L	1.000
7:99629703:T:C	F440L	1.000
7:99629705:C:A	F440L	1.000
7:99629705:C:G	F440L	1.000
7:99629784:T:C	F467L	1.000
7:99629786:C:A	F467L	1.000
7:99629786:C:G	F467L	1.000
7:99629868:T:C	F495L	1.000
7:99629870:C:A	F495L	1.000
7:99629870:C:G	F495L	1.000
7:99629455:T:C	F357S	0.999
7:99629785:T:C	F467S	0.999
7:99629869:T:C	F495S	0.999
7:99629895:C:A	H504N	0.999
7:99629897:C:A	H504Q	0.999
7:99629897:C:G	H504Q	0.999
7:99629952:T:C	F523L	0.999
7:99629954:C:A	F523L	0.999
7:99629954:C:G	F523L	0.999
7:99629536:T:C	F384S	0.998
7:99629653:G:C	R423P	0.998
7:99629660:C:A	H425Q	0.998

dbSNP variants (sampled 300 via entrez): RS1000006168 (7:99642880 T>C), RS1000093241 (7:99683083 A>T), RS1000111953 (7:99680238 C>T), RS1000123857 (7:99634865 C>G), RS1000188828 (7:99654881 T>C), RS1000189515 (7:99723701 A>T), RS1000192281 (7:99698266 C>G,T), RS1000203154 (7:99654534 A>G), RS1000240401 (7:99686821 G>A), RS1000298793 (7:99663016 C>G,T), RS1000318792 (7:99735367 T>C,G), RS1000335541 (7:99691751 A>G), RS1000385372 (7:99647557 G>A), RS1000472813 (7:99722816 A>G), RS1000500743 (7:99629918 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000327_12	Anthropometric traits	6.000000e-06
GCST000327_3	Anthropometric traits	5.000000e-06
GCST000327_4	Anthropometric traits	4.000000e-06
GCST006249_46	Serum metabolite levels	4.000000e-21
GCST006249_47	Serum metabolite levels	1.000000e-45

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004302	anthropometric measurement
EFO:0004338	body weight

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

5 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs15524	Toxicity	3	opioids	Opioid-Related Disorders
rs4646450	Metabolism/PK	3	tacrolimus	Kidney Transplantation;Liver transplantation
rs776746	Metabolism/PK	3	lumefantrine	Malaria
rs776746	Metabolism/PK	3	lopinavir	HIV infectious disease
rs776746	Toxicity	3	opioids	Opioid-Related Disorders

PharmGKB variants

28 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs15524	CYP3A5, ZSCAN25	3	4.00	3	tacrolimus;carbamazepine;opioids
rs776746	CYP3A5, ZSCAN25	3	6.25	62	sunitinib;atorvastatin;carbamazepine;lumefantrine;lovastatin;simvastatin;nifedipine;ondansetron;apixaban;tacrolimus
rs2257401	CYP3A7, ZSCAN25		0.00	0
rs4646457	ZSCAN25		0.00	0
rs4646458	ZSCAN25		0.00	0
rs10242455	ZSCAN25		0.00	0
rs10264272	CYP3A5, ZSCAN25	3	0.00	8	lumefantrine
rs17161788	CYP3A5, ZSCAN25	3	1.75	1	atorvastatin
rs28383479	CYP3A5, ZSCAN25		0.00	0
rs41279854	CYP3A5, ZSCAN25		0.00	0
rs41303343	CYP3A5, ZSCAN25	4	-1.25	7	lumefantrine
rs55817950	CYP3A5, ZSCAN25		0.00	0
rs56244447	CYP3A5, ZSCAN25		0.00	0
rs72552791	CYP3A5, ZSCAN25		0.00	0
rs10211	CYP3A7, ZSCAN25		0.00	0
rs4646450	CYP3A5, ZSCAN25	3	4.75	1	tacrolimus
rs3800959	CYP3A5, ZSCAN25		0.00	0
rs45446698	CYP3A7, ZSCAN25		0.00	1
rs4646453	CYP3A5, ZSCAN25		0.00	0
rs11568824	CYP3A7, ZSCAN25		0.00	1
rs45494802	CYP3A7, ZSCAN25		0.00	1
rs45575938	CYP3A7, ZSCAN25		0.00	1
rs45467892	CYP3A7, ZSCAN25		0.00	1
rs11568825	CYP3A7, ZSCAN25		0.00	1
rs11568826	CYP3A7, ZSCAN25		0.00	1
rs6977165	CYP3A5, ZSCAN25		0.00	0
rs4646449	CYP3A5, ZSCAN25		0.00	0
rs776744	ZSCAN25		0.00	0

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Doxorubicin	decreases expression, decreases response to substance	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	affects sumoylation	1
butyraldehyde	decreases expression	1
manganese chloride	increases abundance, increases expression	1
ferrous chloride	decreases expression	1
pentanal	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Leflunomide	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Manganese	increases abundance, increases expression	1
Valproic Acid	affects expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.