ZSCAN26

Summary

ZSCAN26 (zinc finger and SCAN domain containing 26, HGNC:12978) is a protein-coding gene on chromosome 6p22.1, encoding Zinc finger and SCAN domain-containing protein 26 (Q16670). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm.

Source: NCBI Gene 7741 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 22 total
• MANE Select transcript: NM_001023560

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12978
Approved symbol	ZSCAN26
Name	zinc finger and SCAN domain containing 26
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	SRE-ZBP
Ensembl gene	ENSG00000197062
Ensembl biotype	protein_coding
OMIM	616474
Entrez	7741

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 protein_coding

ENST00000316606, ENST00000421553, ENST00000611552, ENST00000614088, ENST00000617168, ENST00000619937, ENST00000623276, ENST00000854327, ENST00000854328, ENST00000854329, ENST00000854330, ENST00000934901, ENST00000934902, ENST00000934903, ENST00000951043, ENST00000951044, ENST00000951045, ENST00000951046, ENST00000951047

RefSeq mRNA: 5 — MANE Select: NM_001023560 NM_001023560, NM_001111039, NM_001287421, NM_001287422, NM_152736

CCDS: CCDS75414, CCDS75415, CCDS78119

Canonical transcript exons

ENST00000421553 — 4 exons

Exon	Start	End
ENSE00001752123	28271854	28272339
ENSE00003572600	28272670	28272787
ENSE00003741860	28267143	28267213
ENSE00003915554	28276195	28278204

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 89.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.9827 / max 473.6693, expressed in 1755 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66623	13.2130	1725
66622	0.7595	405
66625	0.6058	337
66624	0.4045	204

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	89.44	gold quality
cerebellar hemisphere	UBERON:0002245	88.53	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.51	gold quality
cerebellar cortex	UBERON:0002129	88.35	gold quality
ganglionic eminence	UBERON:0004023	87.92	gold quality
left ovary	UBERON:0002119	87.51	gold quality
body of uterus	UBERON:0009853	87.16	gold quality
secondary oocyte	CL:0000655	86.92	gold quality
right ovary	UBERON:0002118	86.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.63	gold quality
ventricular zone	UBERON:0003053	86.52	gold quality
oocyte	CL:0000023	86.45	gold quality
cerebellum	UBERON:0002037	86.34	gold quality
right uterine tube	UBERON:0001302	86.27	gold quality
descending thoracic aorta	UBERON:0002345	86.19	gold quality
endocervix	UBERON:0000458	86.10	gold quality
ovary	UBERON:0000992	85.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	85.27	gold quality
right coronary artery	UBERON:0001625	85.16	gold quality
gall bladder	UBERON:0002110	85.04	gold quality
right frontal lobe	UBERON:0002810	85.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.92	gold quality
calcaneal tendon	UBERON:0003701	84.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.53	gold quality
lower esophagus	UBERON:0013473	84.50	gold quality
apex of heart	UBERON:0002098	84.37	gold quality
thoracic aorta	UBERON:0001515	84.32	gold quality
ascending aorta	UBERON:0001496	84.12	gold quality
mucosa of stomach	UBERON:0001199	84.08	gold quality
aorta	UBERON:0000947	84.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.21

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
FOS	Repression

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zscan26	ENSMUSG00000022228
rattus_norvegicus	Zscan26	ENSRNOG00000053518

Paralogs (30): ZNF263 (ENSG00000006194), ZNF213 (ENSG00000085644), ZNF500 (ENSG00000103199), ZKSCAN1 (ENSG00000106261), ZNF205 (ENSG00000122386), ZSCAN9 (ENSG00000137185), PGBD1 (ENSG00000137338), ZNF215 (ENSG00000149054), ZSCAN12 (ENSG00000158691), ZNF394 (ENSG00000160908), ZNF75A (ENSG00000162086), ZSCAN21 (ENSG00000166529), ZNF232 (ENSG00000167840), ZNF24 (ENSG00000172466), ZNF449 (ENSG00000173275), ZSCAN4 (ENSG00000180532), ZSCAN22 (ENSG00000182318), ZNF75D (ENSG00000186376), ZNF396 (ENSG00000186496), ZNF397 (ENSG00000186812), ZSCAN30 (ENSG00000186814), ZKSCAN4 (ENSG00000187626), ZSCAN23 (ENSG00000187987), ZKSCAN3 (ENSG00000189298), ZSCAN16 (ENSG00000196812), ZSCAN25 (ENSG00000197037), ZNF165 (ENSG00000197279), ZKSCAN8 (ENSG00000198315), ZSCAN31 (ENSG00000235109), ZNF853 (ENSG00000236609)

Protein

Protein identifiers

Zinc finger and SCAN domain-containing protein 26 — Q16670 (reviewed: Q16670)

Alternative names: Protein SRE-ZBP, Zinc finger protein 187

All UniProt accessions (5): A0A024RCN4, A0A087WXH0, A0A087X2F1, B4DMT1, Q16670

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Induction. By serum stimulation.

Isoforms (2)

UniProt ID	Names	Canonical?
Q16670-1	1	yes
Q16670-2	2

RefSeq proteins (5): NP_001018854, NP_001104509, NP_001274350, NP_001274351, NP_689949 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003309	SCAN_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR038269	SCAN_sf	Homologous_superfamily

Pfam: PF00096, PF02023

UniProt features (22 total): zinc finger region 8, sequence variant 4, region of interest 2, compositionally biased region 2, sequence conflict 2, chain 1, domain 1, cross-link 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q16670-F1	64.03	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 17

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 157 (showing top): MORF_ITGA2, MORF_MSH3, MORF_BRCA1, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1, MORF_RAD51L3, BROWNE_HCMV_INFECTION_48HR_DN, MARTINEZ_RB1_TARGETS_DN, MORF_CTSB, MORF_IL4, MORF_PRKCA, MORF_THPO, MORF_ATF2, MORF_BCL2L11, MORF_PPP2R5B

GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
cellular anatomical structure	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1

Protein interactions and networks

STRING

736 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZSCAN26	NKAPL	Q5M9Q1	574
ZSCAN26	VSIG10L	Q86VR7	453
ZSCAN26	NPEPL1	Q8NDH3	424
ZSCAN26	TMEM151A	Q8N4L1	418
ZSCAN26	GPALPP1	Q8IXQ4	377
ZSCAN26	QNG1	Q5T6V5	374
ZSCAN26	C2CD4D	B7Z1M9	357
ZSCAN26	SLC35G3	Q8N808	348
ZSCAN26	STPG1	Q5TH74	341
ZSCAN26	DHRS7B	Q6IAN0	321
ZSCAN26	XRRA1	Q6P2D8	320
ZSCAN26	CCDC144NL	Q6NUI1	314
ZSCAN26	FBN3	Q75N90	293
ZSCAN26	HOMEZ	Q8IX15	292
ZSCAN26	KIZ	Q2M2Z5	281

IntAct

75 interactions, top by confidence:

A	B	Type	Score
KRTAP10-7	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.740
ZSCAN26	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.740
ZSCAN26	FSD2	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN26	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN26	KRTAP10-5	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-4	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN26	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN26	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
PDE4DIP	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
TRIM41	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
CCDC136	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
KRTAP4-12	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
ZSCAN26		psi-mi:“MI:0915”(physical association)	0.560
FSD2	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-5	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-9	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560
	ZSCAN26	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (67): PDE4DIP (Two-hybrid), MTUS2 (Two-hybrid), CCNDBP1 (Two-hybrid), CCDC136 (Two-hybrid), KRTAP4-12 (Two-hybrid), TRIM41 (Two-hybrid), FSD2 (Two-hybrid), KRTAP10-4 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-1 (Two-hybrid), KRTAP10-5 (Two-hybrid), KRTAP10-3 (Two-hybrid), RPL26L1 (Affinity Capture-MS), LRP4 (Affinity Capture-MS)

ESM2 similar proteins: A1YEP8, A1YEV9, A1YFW2, A1YG26, A1YG48, A1YG60, A2T6E3, A2T6V8, A2T712, A2T736, A2T7D2, A2T7F4, A2T7L7, A2T812, A6QNZ0, O14709, O15535, O43296, O43309, P10073, P17023, P17097, P49910, Q07231, Q12901, Q15776, Q16670, Q1LZ87, Q3MJ62, Q53GI3, Q571J5, Q5JNZ3, Q5RAE6, Q5RBX0, Q5RCD9, Q5RJ54, Q7Z7L9, Q86W11, Q8IZ26, Q8NF99

Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

22 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	11
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

860 predictions. Top by Δscore:

Variant	Effect	Δscore
6:28267165:C:G	donor_gain	1.0000
6:28271845:T:G	acceptor_gain	1.0000
6:28271846:A:AG	acceptor_gain	1.0000
6:28271847:A:G	acceptor_gain	1.0000
6:28271849:TTTAG:T	acceptor_loss	1.0000
6:28271850:TTAG:T	acceptor_loss	1.0000
6:28271851:TAG:T	acceptor_loss	1.0000
6:28271852:A:G	acceptor_loss	1.0000
6:28271852:A:T	acceptor_loss	1.0000
6:28271853:G:A	acceptor_loss	1.0000
6:28271853:GGAGT:G	acceptor_gain	1.0000
6:28272783:GAAGG:G	donor_gain	1.0000
6:28272786:GG:G	donor_gain	1.0000
6:28272787:GG:G	donor_gain	1.0000
6:28272788:G:GG	donor_gain	1.0000
6:28267210:CCAGG:C	donor_loss	0.9900
6:28267211:CAGGT:C	donor_loss	0.9900
6:28267213:GGTG:G	donor_loss	0.9900
6:28267214:GTGAG:G	donor_loss	0.9900
6:28267215:T:A	donor_loss	0.9900
6:28271844:A:AG	acceptor_gain	0.9900
6:28271850:TTAGG:T	acceptor_gain	0.9900
6:28271851:TAGG:T	acceptor_gain	0.9900
6:28271852:A:AG	acceptor_gain	0.9900
6:28271852:AG:A	acceptor_gain	0.9900
6:28271852:AGGA:A	acceptor_gain	0.9900
6:28271853:G:GA	acceptor_gain	0.9900
6:28271853:G:GG	acceptor_gain	0.9900
6:28271853:GG:G	acceptor_gain	0.9900
6:28271853:GGA:G	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000041417 (6:28271488 A>C), RS1000139158 (6:28278264 A>G), RS1000293759 (6:28270239 T>C), RS1000407622 (6:28277956 A>G), RS1001041105 (6:28273241 C>G), RS1001496692 (6:28269915 T>G), RS1001772429 (6:28273627 T>A), RS1002301685 (6:28273435 G>A), RS1002625135 (6:28275168 T>C), RS1002864858 (6:28268379 G>GT), RS1003033073 (6:28275638 G>A,C), RS1003472702 (6:28269838 A>G,T), RS1003549990 (6:28267694 G>T), RS1003579352 (6:28270104 C>T), RS1003808297 (6:28269461 G>C)

Disease associations

OMIM: gene MIM:616474 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST004521_112	Autism spectrum disorder or schizophrenia	3.000000e-26
GCST004521_115	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_166	Autism spectrum disorder or schizophrenia	4.000000e-24
GCST004521_212	Autism spectrum disorder or schizophrenia	5.000000e-14
GCST004521_23	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_43	Autism spectrum disorder or schizophrenia	2.000000e-27
GCST004521_6	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_7	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_73	Autism spectrum disorder or schizophrenia	8.000000e-11
GCST004521_77	Autism spectrum disorder or schizophrenia	1.000000e-19
GCST008921_4	Asthma and major depressive disorder	2.000000e-11
GCST008921_6	Asthma and major depressive disorder	1.000000e-09
GCST010002_50	Refractive error	4.000000e-34

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects expression, affects cotreatment	6
sodium arsenite	decreases expression, increases expression	3
Nickel	decreases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
avobenzone	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases expression	1
Copper	affects binding, decreases expression	1
Disulfiram	affects binding, decreases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Methyl Methanesulfonate	increases expression	1
Quercetin	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW93	HEK293 eGFP-ZSCAN26	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.