ZSCAN9
gene geneOn this page
Also known as PRD51
Summary
ZSCAN9 (zinc finger and SCAN domain containing 9, HGNC:12984) is a protein-coding gene on chromosome 6p22.1, encoding Zinc finger and SCAN domain-containing protein 9 (O15535). May be involved in transcriptional regulation.
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
Source: NCBI Gene 7746 — RefSeq curated summary.
At a glance
- GWAS associations: 24
- Clinical variants (ClinVar): 65 total
- MANE Select transcript:
NM_006299
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:12984 |
| Approved symbol | ZSCAN9 |
| Name | zinc finger and SCAN domain containing 9 |
| Location | 6p22.1 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | PRD51 |
| Ensembl gene | ENSG00000137185 |
| Ensembl biotype | protein_coding |
| OMIM | 602246 |
| Entrez | 7746 |
Gene structure
Transcript identifiers
Ensembl transcripts: 16 — 15 protein_coding, 1 nonsense_mediated_decay
ENST00000252207, ENST00000425468, ENST00000526391, ENST00000527436, ENST00000527844, ENST00000531941, ENST00000531979, ENST00000531981, ENST00000647743, ENST00000866168, ENST00000919061, ENST00000919062, ENST00000950585, ENST00000950586, ENST00000950587, ENST00000950588
RefSeq mRNA: 4 — MANE Select: NM_006299
NM_001199479, NM_001199480, NM_001410841, NM_006299
CCDS: CCDS4646, CCDS56407, CCDS93875
Canonical transcript exons
ENST00000252207 — 4 exons
| Exon | Start | End |
|---|---|---|
| ENSE00002189816 | 28225275 | 28225366 |
| ENSE00003699286 | 28227012 | 28227504 |
| ENSE00003701738 | 28227690 | 28227837 |
| ENSE00003903506 | 28232562 | 28233487 |
Expression profiles
Bgee: expression breadth ubiquitous, 212 present calls, max score 89.51.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.0034 / max 139.8894, expressed in 1751 samples.
FANTOM5 promoters (1 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 66619 | 9.0034 | 1751 |
Top tissues by expression
277 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| ganglionic eminence | UBERON:0004023 | 89.51 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 89.32 | gold quality |
| oocyte | CL:0000023 | 87.19 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 86.91 | gold quality |
| right testis | UBERON:0004534 | 86.04 | gold quality |
| left testis | UBERON:0004533 | 85.90 | gold quality |
| cortical plate | UBERON:0005343 | 85.73 | gold quality |
| cerebellar hemisphere | UBERON:0002245 | 84.90 | gold quality |
| rectum | UBERON:0001052 | 84.89 | gold quality |
| embryo | UBERON:0000922 | 84.78 | gold quality |
| cerebellar cortex | UBERON:0002129 | 84.66 | gold quality |
| testis | UBERON:0000473 | 84.40 | gold quality |
| right hemisphere of cerebellum | UBERON:0014890 | 84.30 | gold quality |
| mucosa of transverse colon | UBERON:0004991 | 84.23 | gold quality |
| ventricular zone | UBERON:0003053 | 84.16 | gold quality |
| adrenal tissue | UBERON:0018303 | 84.07 | gold quality |
| muscle layer of sigmoid colon | UBERON:0035805 | 83.92 | gold quality |
| body of uterus | UBERON:0009853 | 83.84 | gold quality |
| metanephros cortex | UBERON:0010533 | 83.70 | gold quality |
| lower esophagus muscularis layer | UBERON:0035833 | 83.66 | gold quality |
| lower esophagus | UBERON:0013473 | 83.65 | gold quality |
| adenohypophysis | UBERON:0002196 | 83.37 | gold quality |
| esophagogastric junction muscularis propria | UBERON:0035841 | 83.23 | gold quality |
| right ovary | UBERON:0002118 | 83.12 | gold quality |
| apex of heart | UBERON:0002098 | 83.07 | gold quality |
| body of pancreas | UBERON:0001150 | 82.97 | gold quality |
| left ovary | UBERON:0002119 | 82.97 | gold quality |
| small intestine Peyer’s patch | UBERON:0003454 | 82.91 | gold quality |
| right lobe of thyroid gland | UBERON:0001119 | 82.90 | gold quality |
| transverse colon | UBERON:0001157 | 82.86 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 3.64 |
Regulation
Is transcription factor: yes
Downstream targets (CollecTRI)
1 targets.
| Target | Regulation |
|---|---|
| CDKN2A |
Upstream regulators (CollecTRI, top): MYC
miRNA regulators (miRDB)
23 targeting ZSCAN9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3613-3P | 100.00 | 76.36 | 7965 |
| HSA-MIR-656-3P | 100.00 | 72.15 | 2788 |
| HSA-MIR-126-5P | 100.00 | 72.71 | 3180 |
| HSA-MIR-4795-3P | 100.00 | 74.62 | 4024 |
| HSA-MIR-5692A | 100.00 | 74.40 | 6850 |
| HSA-MIR-371B-5P | 99.99 | 75.34 | 4759 |
| HSA-MIR-3662 | 99.99 | 73.82 | 5684 |
| HSA-MIR-4531 | 99.99 | 69.70 | 3181 |
| HSA-MIR-373-5P | 99.98 | 75.36 | 4753 |
| HSA-MIR-616-5P | 99.98 | 75.58 | 4775 |
| HSA-MIR-875-3P | 99.63 | 69.47 | 2548 |
| HSA-MIR-372-5P | 99.41 | 69.11 | 2299 |
| HSA-MIR-4311 | 99.31 | 70.47 | 3041 |
| HSA-MIR-4758-3P | 99.12 | 63.96 | 869 |
| HSA-MIR-371A-5P | 99.08 | 66.51 | 1914 |
| HSA-MIR-3154 | 98.94 | 66.55 | 1455 |
| HSA-MIR-3124-3P | 98.87 | 68.95 | 2123 |
| HSA-MIR-583 | 98.71 | 67.44 | 1791 |
| HSA-MIR-4483 | 98.09 | 64.12 | 1642 |
| HSA-MIR-1913 | 97.07 | 66.20 | 1417 |
| HSA-MIR-3126-5P | 96.87 | 65.83 | 912 |
| HSA-MIR-6875-5P | 96.87 | 65.49 | 958 |
| HSA-MIR-490-5P | 96.75 | 65.81 | 661 |
Cross-species orthologs
0 orthologs
Paralogs (30): ZNF263 (ENSG00000006194), ZNF213 (ENSG00000085644), ZNF500 (ENSG00000103199), ZKSCAN1 (ENSG00000106261), ZNF205 (ENSG00000122386), PGBD1 (ENSG00000137338), ZNF215 (ENSG00000149054), ZSCAN12 (ENSG00000158691), ZNF394 (ENSG00000160908), ZNF75A (ENSG00000162086), ZSCAN21 (ENSG00000166529), ZNF232 (ENSG00000167840), ZNF24 (ENSG00000172466), ZNF449 (ENSG00000173275), ZSCAN4 (ENSG00000180532), ZSCAN22 (ENSG00000182318), ZNF75D (ENSG00000186376), ZNF396 (ENSG00000186496), ZNF397 (ENSG00000186812), ZSCAN30 (ENSG00000186814), ZKSCAN4 (ENSG00000187626), ZSCAN23 (ENSG00000187987), ZKSCAN3 (ENSG00000189298), ZSCAN16 (ENSG00000196812), ZSCAN25 (ENSG00000197037), ZSCAN26 (ENSG00000197062), ZNF165 (ENSG00000197279), ZKSCAN8 (ENSG00000198315), ZSCAN31 (ENSG00000235109), ZNF853 (ENSG00000236609)
Protein
Protein identifiers
Zinc finger and SCAN domain-containing protein 9 — O15535 (reviewed: O15535)
Alternative names: Cell proliferation-inducing gene 12 protein, PRD51, Zinc finger protein 193
All UniProt accessions (6): A0A0B4J224, O15535, E9PLJ4, E9PQL7, U3KQB2, U3KQV4
UniProt curated annotations — full annotation on UniProt →
Function. May be involved in transcriptional regulation.
Subcellular location. Nucleus.
Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.
Isoforms (2)
| UniProt ID | Names | Canonical? |
|---|---|---|
| O15535-1 | 1 | yes |
| O15535-2 | 2 |
RefSeq proteins (4): NP_001186408, NP_001186409, NP_001397770, NP_006290* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR003309 | SCAN_dom | Domain |
| IPR013087 | Znf_C2H2_type | Domain |
| IPR036236 | Znf_C2H2_sf | Homologous_superfamily |
| IPR038269 | SCAN_sf | Homologous_superfamily |
Pfam: PF00096, PF02023
UniProt features (13 total): zinc finger region 5, cross-link 3, chain 1, domain 1, splice variant 1, sequence variant 1, sequence conflict 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-O15535-F1 | 64.00 | 0.05 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Post-translational modifications (3): 26, 215, 238
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 80 (showing top):
NOUZOVA_TRETINOIN_AND_H4_ACETYLATION, DANG_BOUND_BY_MYC, SCHLOSSER_SERUM_RESPONSE_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN, PDGF_ERK_DN.V1_DN, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ALKBH3_TARGET_GENES, DIDO1_TARGET_GENES, E2F2_TARGET_GENES, GLI4_TARGET_GENES, GTF2E2_TARGET_GENES, HHEX_TARGET_GENES, HMG20B_TARGET_GENES
GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)
GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565), metal ion binding (GO:0046872)
GO Cellular Component (1): nucleus (GO:0005634)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | 2 |
| regulation of DNA-templated transcription | 1 |
| transcription by RNA polymerase II | 1 |
| cis-regulatory region sequence-specific DNA binding | 1 |
| chromatin | 1 |
| DNA-binding transcription factor activity | 1 |
| regulation of transcription by RNA polymerase II | 1 |
| transition metal ion binding | 1 |
| double-stranded DNA binding | 1 |
| sequence-specific DNA binding | 1 |
| nucleic acid binding | 1 |
| binding | 1 |
| DNA binding | 1 |
| cation binding | 1 |
| intracellular membrane-bounded organelle | 1 |
Protein interactions and networks
STRING
364 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| ZSCAN9 | NKAPL | Q5M9Q1 | 614 |
| ZSCAN9 | THUMPD2 | Q9BTF0 | 336 |
| ZSCAN9 | FAM180B | Q6P0A1 | 323 |
| ZSCAN9 | MEAK7 | Q6P9B6 | 321 |
| ZSCAN9 | HBG1 | P02096 | 320 |
| ZSCAN9 | GPR20 | Q99678 | 311 |
| ZSCAN9 | TRIM6 | Q9C030 | 308 |
| ZSCAN9 | NKAP | Q8N5F7 | 305 |
| ZSCAN9 | TMEM161B | Q8NDZ6 | 305 |
| ZSCAN9 | TM2D1 | Q9BX74 | 300 |
| ZSCAN9 | TRIM34 | Q9BYJ4 | 287 |
| ZSCAN9 | SMCHD1 | A6NHR9 | 274 |
| ZSCAN9 | PGBD1 | Q96JS3 | 271 |
| ZSCAN9 | LRRC37A | A6NMS7 | 271 |
| ZSCAN9 | CXorf38 | Q8TB03 | 269 |
| ZSCAN9 | STIMATE | Q86TL2 | 269 |
IntAct
105 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| ZNF446 | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.780 |
| ZSCAN9 | ZNF446 | psi-mi:“MI:0915”(physical association) | 0.780 |
| ZNF446 | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.750 |
| ZSCAN9 | ZNF446 | psi-mi:“MI:0915”(physical association) | 0.750 |
| SRPK2 | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.720 |
| ZSCAN9 | SRPK2 | psi-mi:“MI:0915”(physical association) | 0.720 |
| ZSCAN9 | LMO3 | psi-mi:“MI:0915”(physical association) | 0.720 |
| LMO3 | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.720 |
| ZSCAN9 | MAGEH1 | psi-mi:“MI:0915”(physical association) | 0.560 |
| MAGEH1 | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | AIRIM | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | FHL2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | ZSCAN22 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | ZSCAN23 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | FBXO17 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | GEM | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | GFAP | psi-mi:“MI:0915”(physical association) | 0.560 |
| GRN | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | NEFL | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZSCAN9 | PPIA | psi-mi:“MI:0915”(physical association) | 0.560 |
| PRKCA | ZSCAN9 | psi-mi:“MI:0915”(physical association) | 0.560 |
BioGRID (26): ZSCAN9 (Two-hybrid), MAGEH1 (Two-hybrid), ZNF446 (Two-hybrid), ZSCAN9 (Two-hybrid), ZNF24 (Affinity Capture-MS), ZNF446 (Two-hybrid), ZSCAN9 (Two-hybrid), TFF3 (Two-hybrid), ZSCAN9 (Affinity Capture-Western), ZSCAN9 (Two-hybrid), ZSCAN9 (Two-hybrid), ZSCAN9 (Two-hybrid), ZSCAN9 (Two-hybrid), ZSCAN9 (Two-hybrid), GEM (Two-hybrid)
ESM2 similar proteins: A1YEP8, A1YEV9, A1YFW2, A1YG26, A1YG48, A1YG60, A2T6E3, A2T6V8, A2T712, A2T736, A2T7D2, A2T7F4, A2T7L7, A2T812, A6QNZ0, O14709, O15535, O43296, O43309, P10073, P17023, P17097, P49910, Q07231, Q12901, Q15776, Q16670, Q1LZ87, Q3MJ62, Q53GI3, Q571J5, Q5JNZ3, Q5RAE6, Q5RBX0, Q5RCD9, Q5RJ54, Q7Z7L9, Q86W11, Q8IZ26, Q8NF99
Diamond homologs: A1YEP8, A1YEQ3, A1YEV9, A1YFW2, A1YFW6, A1YG26, A1YG48, A1YG60, A1YGJ4, A1YGK6, A2T6E3, A2T6V8, A2T6W2, A2T712, A2T736, A2T7D2, A2T7D7, A2T7F2, A2T7F4, A2T7L7, A2T812, A6QNZ0, A6QPT6, B2KFW1, O14709, O14771, O14978, O15535, O43309, O60304, O95125, P10073, P17022, P17028, P17029, P17040, P28698, P49910, P51815, P59923
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
65 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 61 |
| Likely benign | 2 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
763 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 6:28225367:G:GG | donor_gain | 1.0000 |
| 6:28227688:AGAT:A | acceptor_gain | 1.0000 |
| 6:28227689:GATG:G | acceptor_gain | 1.0000 |
| 6:28225362:GTCTC:G | donor_gain | 0.9900 |
| 6:28227117:G:A | acceptor_gain | 0.9900 |
| 6:28227687:CAGAT:C | acceptor_loss | 0.9900 |
| 6:28227688:A:AG | acceptor_gain | 0.9900 |
| 6:28227688:A:AT | acceptor_loss | 0.9900 |
| 6:28227689:G:GA | acceptor_loss | 0.9900 |
| 6:28227689:G:GG | acceptor_gain | 0.9900 |
| 6:28227689:GAT:G | acceptor_gain | 0.9900 |
| 6:28228161:G:GT | donor_gain | 0.9900 |
| 6:28232560:A:AG | acceptor_gain | 0.9900 |
| 6:28232561:G:GG | acceptor_gain | 0.9900 |
| 6:28227116:T:TA | acceptor_gain | 0.9800 |
| 6:28227500:ATGAG:A | donor_loss | 0.9800 |
| 6:28227501:TGAGG:T | donor_loss | 0.9800 |
| 6:28227503:AGG:A | donor_loss | 0.9800 |
| 6:28227505:G:C | donor_loss | 0.9800 |
| 6:28227506:T:G | donor_loss | 0.9800 |
| 6:28227688:AGATG:A | acceptor_gain | 0.9800 |
| 6:28227689:GATGG:G | acceptor_gain | 0.9800 |
| 6:28227834:ACAG:A | donor_loss | 0.9800 |
| 6:28227835:CAG:C | donor_loss | 0.9800 |
| 6:28227836:AGGT:A | donor_loss | 0.9800 |
| 6:28227837:GG:G | donor_loss | 0.9800 |
| 6:28227838:GTGAG:G | donor_loss | 0.9800 |
| 6:28227839:T:A | donor_loss | 0.9800 |
| 6:28227833:GACAG:G | donor_gain | 0.9700 |
| 6:28232556:TTTCA:T | acceptor_loss | 0.9700 |
AlphaMissense
2611 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 6:28232864:T:C | F291L | 0.998 |
| 6:28232866:C:A | F291L | 0.998 |
| 6:28232866:C:G | F291L | 0.998 |
| 6:28233116:T:C | F375L | 0.998 |
| 6:28233118:T:A | F375L | 0.998 |
| 6:28233118:T:G | F375L | 0.998 |
| 6:28232948:T:C | F319L | 0.997 |
| 6:28232950:C:A | F319L | 0.997 |
| 6:28232950:C:G | F319L | 0.997 |
| 6:28232780:T:C | F263L | 0.996 |
| 6:28232782:T:A | F263L | 0.996 |
| 6:28232782:T:G | F263L | 0.996 |
| 6:28233063:A:C | Q357P | 0.995 |
| 6:28232967:T:C | L325P | 0.994 |
| 6:28232977:T:A | H328Q | 0.994 |
| 6:28232977:T:G | H328Q | 0.994 |
| 6:28233061:T:A | H356Q | 0.994 |
| 6:28233061:T:G | H356Q | 0.994 |
| 6:28233135:T:C | L381P | 0.994 |
| 6:28232893:C:A | H300Q | 0.993 |
| 6:28232893:C:G | H300Q | 0.993 |
| 6:28233123:G:C | R377P | 0.993 |
| 6:28232949:T:C | F319S | 0.992 |
| 6:28233051:T:C | L353P | 0.992 |
| 6:28232865:T:C | F291S | 0.991 |
| 6:28232891:C:G | H300D | 0.991 |
| 6:28232975:C:G | H328D | 0.991 |
| 6:28233039:G:C | R349P | 0.991 |
| 6:28233073:C:A | H360Q | 0.991 |
| 6:28233073:C:G | H360Q | 0.991 |
dbSNP variants (sampled 300 via entrez): RS1000335920 (6:28232972 C>T), RS1000483708 (6:28226537 A>G), RS1000572502 (6:28226889 C>A,T), RS1001230493 (6:28228365 G>A), RS1001317540 (6:28223199 C>G), RS1001565029 (6:28233575 G>C), RS1002449375 (6:28230003 A>C,G), RS1002467234 (6:28231308 A>G), RS1002580500 (6:28230099 C>T), RS1002750158 (6:28231019 C>T), RS1003007135 (6:28225063 G>A,T), RS1004366295 (6:28228481 C>T), RS1004418705 (6:28228705 A>T), RS1004475826 (6:28230727 A>C), RS1004569345 (6:28231010 A>G)
Disease associations
OMIM: gene MIM:602246 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
24 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST004521_112 | Autism spectrum disorder or schizophrenia | 3.000000e-26 |
| GCST004521_115 | Autism spectrum disorder or schizophrenia | 3.000000e-16 |
| GCST004521_166 | Autism spectrum disorder or schizophrenia | 4.000000e-24 |
| GCST004521_212 | Autism spectrum disorder or schizophrenia | 5.000000e-14 |
| GCST004521_22 | Autism spectrum disorder or schizophrenia | 2.000000e-11 |
| GCST004521_23 | Autism spectrum disorder or schizophrenia | 2.000000e-11 |
| GCST004521_6 | Autism spectrum disorder or schizophrenia | 2.000000e-15 |
| GCST004521_73 | Autism spectrum disorder or schizophrenia | 8.000000e-11 |
| GCST004521_77 | Autism spectrum disorder or schizophrenia | 1.000000e-19 |
| GCST006088_38 | Familial squamous cell lung carcinoma | 5.000000e-07 |
| GCST008921_6 | Asthma and major depressive disorder | 1.000000e-09 |
| GCST010002_50 | Refractive error | 4.000000e-34 |
| GCST010142_16 | Fish- and plant-related diet | 2.000000e-10 |
| GCST010142_19 | Fish- and plant-related diet | 4.000000e-10 |
| GCST010142_34 | Fish- and plant-related diet | 7.000000e-09 |
| GCST010142_35 | Fish- and plant-related diet | 8.000000e-09 |
| GCST010142_42 | Fish- and plant-related diet | 1.000000e-08 |
| GCST010142_7 | Fish- and plant-related diet | 3.000000e-12 |
| GCST010702_75 | Subcortical volume (MOSTest) | 3.000000e-11 |
| GCST010703_272 | Brain morphology (MOSTest) | 7.000000e-16 |
| GCST011494_26 | Daytime nap | 3.000000e-18 |
| GCST012228_156 | Waist-hip index | 4.000000e-08 |
| GCST012230_279 | Waist-to-hip ratio adjusted for BMI | 2.000000e-08 |
| GCST90011898_139 | Alanine aminotransferase levels | 3.000000e-10 |
EFO canonical traits (5, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0006953 | family history of lung cancer |
| EFO:0008111 | diet measurement |
| EFO:0004346 | neuroimaging measurement |
| EFO:0007828 | daytime rest measurement |
| EFO:0007788 | BMI-adjusted waist-hip ratio |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
32 total (human), top 30 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Valproic Acid | affects cotreatment, decreases expression, affects expression, decreases methylation | 7 |
| bisphenol A | affects cotreatment, increases expression | 2 |
| aristolochic acid I | decreases expression | 1 |
| 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide | decreases expression | 1 |
| bisphenol F | affects cotreatment, increases expression | 1 |
| TAK-243 | increases sumoylation | 1 |
| dicrotophos | decreases expression | 1 |
| triphenyl phosphate | affects expression | 1 |
| trichostatin A | decreases expression | 1 |
| tris(1,3-dichloro-2-propyl)phosphate | increases expression | 1 |
| sodium arsenite | increases expression | 1 |
| potassium chromate(VI) | increases expression, affects cotreatment | 1 |
| beta-methylcholine | affects expression | 1 |
| epigallocatechin gallate | affects cotreatment, increases expression | 1 |
| di-n-butylphosphoric acid | affects expression | 1 |
| entinostat | decreases expression | 1 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | affects cotreatment, decreases expression | 1 |
| abrine | increases expression | 1 |
| Grape Seed Proanthocyanidins | affects cotreatment, decreases expression | 1 |
| dorsomorphin | decreases expression, affects cotreatment | 1 |
| bisphenol S | affects cotreatment, increases expression | 1 |
| Temozolomide | increases expression | 1 |
| Catechin | affects cotreatment, decreases expression | 1 |
| Dexamethasone | increases expression, affects cotreatment | 1 |
| Ethyl Methanesulfonate | increases expression | 1 |
| Indomethacin | affects cotreatment, increases expression | 1 |
| Methyl Methanesulfonate | increases expression | 1 |
| Thiram | increases expression | 1 |
| 1-Methyl-3-isobutylxanthine | affects cotreatment, increases expression | 1 |
| Cyclosporine | increases expression | 1 |
Cellosaurus cell lines
1 cell lines: 1 cancer cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_AW48 | K562 eGFP-ZSCAN9 | Cancer cell line | Female |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): squamous cell lung carcinoma