ZSWIM8

Summary

ZSWIM8 (zinc finger SWIM-type containing 8, HGNC:23528) is a protein-coding gene on chromosome 10q22.2, encoding Zinc finger SWIM domain-containing protein 8 (A7E2V4). Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs).

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of macromolecule metabolic process; protein ubiquitination; and proteolysis involved in protein catabolic process. Part of Cul3-RING ubiquitin ligase complex.

Source: NCBI Gene 23053 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 114 total
• MANE Select transcript: NM_001367799

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23528
Approved symbol	ZSWIM8
Name	zinc finger SWIM-type containing 8
Location	10q22.2
Locus type	gene with protein product
Status	Approved
Aliases	4832404P21Rik
Ensembl gene	ENSG00000214655
Ensembl biotype	protein_coding
OMIM	619213
Entrez	23053

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 11 protein_coding_CDS_not_defined, 9 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000398706, ENST00000412198, ENST00000425051, ENST00000431225, ENST00000433366, ENST00000446546, ENST00000451629, ENST00000466354, ENST00000466568, ENST00000487278, ENST00000489234, ENST00000492395, ENST00000603114, ENST00000603187, ENST00000603195, ENST00000603309, ENST00000603409, ENST00000603840, ENST00000604165, ENST00000604524, ENST00000604729, ENST00000604754, ENST00000605216

RefSeq mRNA: 4 — MANE Select: NM_001367799 NM_001242487, NM_001242488, NM_001367799, NM_015037

CCDS: CCDS44440, CCDS60560, CCDS91266

Canonical transcript exons

ENST00000604729 — 26 exons

Exon	Start	End
ENSE00001534587	73797377	73797605
ENSE00001534615	73794541	73794639
ENSE00001534646	73791859	73792852
ENSE00001534648	73791324	73791499
ENSE00001534649	73790975	73791176
ENSE00001534651	73790172	73790292
ENSE00001558487	73789096	73789190
ENSE00001559353	73789367	73789539
ENSE00001561830	73788670	73788823
ENSE00003458535	73793588	73793719
ENSE00003459821	73794147	73794330
ENSE00003463348	73796774	73797014
ENSE00003470122	73797781	73798070
ENSE00003477654	73800011	73800170
ENSE00003488564	73798230	73798453
ENSE00003493517	73789956	73790037
ENSE00003524227	73801017	73801195
ENSE00003546674	73800296	73800472
ENSE00003546711	73799002	73799490
ENSE00003569739	73797113	73797271
ENSE00003608443	73795539	73795663
ENSE00003612567	73793865	73794044
ENSE00003637955	73801316	73801793
ENSE00003653266	73800640	73800759
ENSE00003660193	73789717	73789824
ENSE00003676025	73785606	73786086

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 99.26.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.8211 / max 437.8199, expressed in 1817 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105550	20.5248	1815
105551	3.2054	1512
105549	0.0908	15

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	99.26	gold quality
adenohypophysis	UBERON:0002196	99.19	gold quality
pituitary gland	UBERON:0000007	98.95	gold quality
left testis	UBERON:0004533	98.80	gold quality
right testis	UBERON:0004534	98.78	gold quality
right lobe of thyroid gland	UBERON:0001119	98.64	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.59	gold quality
left lobe of thyroid gland	UBERON:0001120	98.49	gold quality
right lobe of liver	UBERON:0001114	98.33	gold quality
cerebellar hemisphere	UBERON:0002245	98.32	gold quality
right adrenal gland cortex	UBERON:0035827	98.32	gold quality
metanephros cortex	UBERON:0010533	98.28	gold quality
right adrenal gland	UBERON:0001233	98.25	gold quality
skin of leg	UBERON:0001511	98.24	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	98.21	gold quality
cerebellar cortex	UBERON:0002129	98.18	gold quality
lower esophagus	UBERON:0013473	98.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.18	gold quality
skin of abdomen	UBERON:0001416	98.13	gold quality
muscle layer of sigmoid colon	UBERON:0035805	98.11	gold quality
minor salivary gland	UBERON:0001830	98.07	gold quality
endocervix	UBERON:0000458	98.02	gold quality
ectocervix	UBERON:0012249	98.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	97.96	gold quality
right frontal lobe	UBERON:0002810	97.95	gold quality
left adrenal gland cortex	UBERON:0035825	97.94	gold quality
right ovary	UBERON:0002118	97.89	gold quality
left adrenal gland	UBERON:0001234	97.87	gold quality
mucosa of stomach	UBERON:0001199	97.85	gold quality
right uterine tube	UBERON:0001302	97.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.44

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting ZSWIM8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-449B-3P	99.20	67.24	1047
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-5008-3P	98.73	67.50	1433
HSA-MIR-198	98.70	67.32	920
HSA-MIR-7113-5P	97.88	67.33	1735
HSA-MIR-2278	97.30	66.19	1130
HSA-MIR-6849-3P	97.25	64.57	1371
HSA-MIR-874-5P	96.93	63.92	1014
HSA-MIR-3651	95.62	64.67	287
HSA-MIR-6753-5P	94.70	64.08	470

Literature-anchored findings (GeneRIF, showing 4)

• A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. (PMID:33184234)
• The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. (PMID:33184237)
• ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. (PMID:34686700)
• The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization. (PMID:35940847)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zswim8	ENSDARG00000069397
mus_musculus	Zswim8	ENSMUSG00000021819
rattus_norvegicus	Zswim8	ENSRNOG00000056617
drosophila_melanogaster	Dora	FBGN0085430
caenorhabditis_elegans		WBGENE00004140

Paralogs (3): ZSWIM6 (ENSG00000130449), ZSWIM4 (ENSG00000132003), ZSWIM5 (ENSG00000162415)

Protein

Protein identifiers

Zinc finger SWIM domain-containing protein 8 — A7E2V4 (reviewed: A7E2V4)

All UniProt accessions (10): A7E2V4, H0YCW2, H7BZ52, H7C453, S4R393, S4R3B3, S4R3H3, S4R3S6, S4R3U7, S4R410

UniProt curated annotations — full annotation on UniProt →

Function. Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation. Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target. May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation. Plays an essential role for proper embryonic development of heart and lung. Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated. (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation.

Subunit / interactions. Component of the SCF-like E3 ubiquitin-protein ligase complex which contains CUL3, RBX1, ELOB, ELOC and ZSWIM8. (Microbial infection) Interacts with Zika virus protein NS5; this interaction allows STAT2 binding and subsequent proteasomal degradation.

Subcellular location. Cytoplasm. Cytosol.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the ZSWIM8 family.

Isoforms (5)

UniProt ID	Names	Canonical?
A7E2V4-1	1	yes
A7E2V4-2	2
A7E2V4-3	3
A7E2V4-4	4
A7E2V4-5	5

RefSeq proteins (4): NP_001229416, NP_001229417, NP_001354728, NP_055852 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007527	Znf_SWIM	Domain
IPR048370	ZSWIM4-8_C	Domain
IPR057945	TPR_ZSWIM8	Domain

Pfam: PF21055, PF25572

UniProt features (43 total): modified residue 11, compositionally biased region 10, sequence conflict 10, region of interest 6, splice variant 4, chain 1, zinc finger region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9RWZ	ELECTRON MICROSCOPY	3.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A7E2V4-F1	63.33	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (11): 36, 48, 53, 437, 567, 1139, 1153, 1156, 1160, 1267, 1836

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9010553	Regulation of expression of SLITs and ROBOs

MSigDB gene sets: 153 (showing top): GOBP_MACROMOLECULE_CATABOLIC_PROCESS, AP4_Q6, CAGCTG_AP4_Q5, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, CAIRO_HEPATOBLASTOMA_CLASSES_DN, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, NF1_Q6_01, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, TCF11_01, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, ATF3_Q6, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, HAND1E47_01

GO Biological Process (6): protein quality control for misfolded or incompletely synthesized proteins (GO:0006515), protein ubiquitination (GO:0016567), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161), target-directed miRNA degradation (GO:0140958), positive regulation of miRNA catabolic process (GO:2000627), type I interferon-mediated signaling pathway (GO:0060337)

GO Molecular Function (3): zinc ion binding (GO:0008270), ubiquitin-like ligase-substrate adaptor activity (GO:1990756), metal ion binding (GO:0046872)

GO Cellular Component (5): cytosol (GO:0005829), Cul2-RING ubiquitin ligase complex (GO:0031462), Cul3-RING ubiquitin ligase complex (GO:0031463), cytoplasm (GO:0005737), cullin-RING ubiquitin ligase complex (GO:0031461)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Signaling by ROBO receptors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
miRNA catabolic process	2
cellular anatomical structure	2
cullin-RING ubiquitin ligase complex	2
protein catabolic process	1
protein modification by small protein conjugation	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
post-transcriptional gene silencing	1
negative regulation of miRNA-mediated gene silencing	1
positive regulation of catabolic process	1
regulation of miRNA catabolic process	1
positive regulation of miRNA metabolic process	1
cellular response to type I interferon	1
interferon-mediated signaling pathway	1
transition metal ion binding	1
enzyme-substrate adaptor activity	1
cation binding	1
cytoplasm	1
intracellular anatomical structure	1
ubiquitin ligase complex	1

Protein interactions and networks

STRING

845 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZSWIM8	MRPS14	O60783	535
ZSWIM8	ZBTB44	Q8NCP5	528
ZSWIM8	CAAP1	Q9H8G2	513
ZSWIM8	CLEC17A	Q6ZS10	483
ZSWIM8	TAF9B	Q9HBM6	476
ZSWIM8	BMS1	Q14692	475
ZSWIM8	DDX52	Q9Y2R4	474
ZSWIM8	SLC39A13	Q96H72	447
ZSWIM8	SLC15A2	Q16348	433
ZSWIM8	CUL2	Q13617	418
ZSWIM8	ZSWIM2	Q8NEG5	410
ZSWIM8	ZNRF2	Q8NHG8	407
ZSWIM8	ECM1	Q16610	407
ZSWIM8	ROBO2	Q9HCK4	405
ZSWIM8	CEACAM1	P13688	396

IntAct

66 interactions, top by confidence:

A	B	Type	Score
CSNK1E	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
CUL3	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
ZSWIM8	SURF6	psi-mi:“MI:0915”(physical association)	0.400
ZSWIM8	CTDSP1	psi-mi:“MI:0915”(physical association)	0.370
ZSWIM8	SPG11	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
STING1	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
NUAK1	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
CSNK1D	TMEM131L	psi-mi:“MI:0914”(association)	0.350
CSNK1G2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
DYRK2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
AURKB	TARS3	psi-mi:“MI:0914”(association)	0.350
MAST1	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
ARRDC2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
TXNIP	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
DUSP16	MEIOC	psi-mi:“MI:0914”(association)	0.350
RPL15	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
MRPL4	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
OLFM2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
TULP2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
ASB3	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
FGF11	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
TSPYL6	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
PRG2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
SOCS1	ZSWIM8	psi-mi:“MI:0914”(association)	0.350

BioGRID (100): ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Proximity Label-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS), ZSWIM8 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8HBI7, A0A1L8HJK9, A0A1L8HTT5, A6NP61, A7E2V4, B2RVL6, C0SPG1, C3VD30, K7SGN7, P56163, P56198, P62932, Q1XFL1, Q29RJ0, Q32L09, Q3UHH1, Q3V0J4, Q497M3, Q4R739, Q58D79, Q5EA86, Q5R8D5, Q5TKR9, Q5VWQ0, Q5XI33, Q6DMN8, Q768S4, Q7T3T8, Q7T3T9, Q7T3U0, Q80T69, Q8BV79, Q8BZ21, Q8CAK3, Q8CDN1, Q8HXK7, Q8K3Y6, Q8N2G6, Q8N9V6, Q8ND61

Diamond homologs: A7E2V4, A7E305, Q3UHH1, Q80TC6, Q8C7B8, Q9H7M6, Q9P217, Q9VWN9, Q80TB7, Q9HCJ5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

114 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4537 predictions. Top by Δscore:

Variant	Effect	Δscore
10:73786084:GAGG:G	donor_loss	1.0000
10:73786085:AG:A	donor_loss	1.0000
10:73786087:GTGA:G	donor_loss	1.0000
10:73788646:T:TA	acceptor_gain	1.0000
10:73788657:ATT:A	acceptor_gain	1.0000
10:73788659:T:A	acceptor_gain	1.0000
10:73788667:A:G	acceptor_gain	1.0000
10:73789088:A:AG	acceptor_gain	1.0000
10:73789089:C:G	acceptor_gain	1.0000
10:73789091:CCCAG:C	acceptor_loss	1.0000
10:73789092:CCA:C	acceptor_loss	1.0000
10:73789094:A:AG	acceptor_gain	1.0000
10:73789094:A:T	acceptor_loss	1.0000
10:73789094:AG:A	acceptor_gain	1.0000
10:73789094:AGGCT:A	acceptor_gain	1.0000
10:73789095:G:GC	acceptor_gain	1.0000
10:73789095:GG:G	acceptor_gain	1.0000
10:73789095:GGC:G	acceptor_gain	1.0000
10:73789095:GGCT:G	acceptor_gain	1.0000
10:73789095:GGCTG:G	acceptor_gain	1.0000
10:73789186:GATAG:G	donor_gain	1.0000
10:73789187:A:G	donor_gain	1.0000
10:73789187:ATAGG:A	donor_loss	1.0000
10:73789189:AGG:A	donor_loss	1.0000
10:73789191:G:GG	donor_gain	1.0000
10:73789192:T:G	donor_loss	1.0000
10:73789365:AG:A	acceptor_gain	1.0000
10:73789366:GG:G	acceptor_gain	1.0000
10:73789469:GCT:G	donor_gain	1.0000
10:73789540:G:GG	donor_gain	1.0000

AlphaMissense

11838 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:73785924:T:C	F16L	1.000
10:73785926:C:A	F16L	1.000
10:73785926:C:G	F16L	1.000
10:73785942:T:C	F22L	1.000
10:73785944:T:A	F22L	1.000
10:73785944:T:G	F22L	1.000
10:73785999:T:A	W41R	1.000
10:73785999:T:C	W41R	1.000
10:73786000:G:C	W41S	1.000
10:73786001:G:C	W41C	1.000
10:73786001:G:T	W41C	1.000
10:73786008:T:A	W44R	1.000
10:73786008:T:C	W44R	1.000
10:73786010:G:C	W44C	1.000
10:73786010:G:T	W44C	1.000
10:73788688:T:G	L76W	1.000
10:73788697:T:C	L79P	1.000
10:73788702:G:C	A81P	1.000
10:73788724:T:A	I88N	1.000
10:73788729:T:A	F90I	1.000
10:73788729:T:C	F90L	1.000
10:73788730:T:C	F90S	1.000
10:73788730:T:G	F90C	1.000
10:73788731:T:A	F90L	1.000
10:73788731:T:G	F90L	1.000
10:73788742:A:T	E94V	1.000
10:73788772:T:C	L104P	1.000
10:73788778:T:C	L106P	1.000
10:73788784:T:A	I108N	1.000
10:73788784:T:G	I108S	1.000

dbSNP variants (sampled 300 via entrez): RS1000017397 (10:73798973 C>A,T), RS1000035989 (10:73793182 G>A), RS1000108319 (10:73799875 T>C), RS1000176467 (10:73798183 TG>T), RS1000419857 (10:73786457 A>G), RS1001247176 (10:73784802 A>G), RS1001388694 (10:73786625 A>C,G), RS1001635100 (10:73791557 G>A,C,T), RS1001689150 (10:73797237 G>A), RS1001899799 (10:73794014 G>C), RS1002055580 (10:73796219 C>T), RS1002609522 (10:73802195 T>A,C), RS1002907182 (10:73789938 C>T), RS1002923266 (10:73788877 T>G), RS1002958959 (10:73795248 T>C)

Disease associations

OMIM: gene MIM:619213 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004132_74	Crohn’s disease	2.000000e-09
GCST007656_13	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy)	2.000000e-10

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
bisphenol A	decreases expression, decreases methylation	2
sodium arsenite	increases expression, affects cotreatment, decreases expression, increases abundance	2
(+)-JQ1 compound	increases expression	2
Resveratrol	affects cotreatment, decreases expression	2
Air Pollutants	affects expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
abrine	increases expression	1
Arsenic	decreases expression, increases abundance, affects cotreatment	1
Coumestrol	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Folic Acid	increases expression	1
Formaldehyde	decreases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Mustard Gas	increases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Dihydrotestosterone	increases expression	1
Urethane	increases expression	1
Antirheumatic Agents	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.