{"context":{"query":">>mesh>>pharmgkb_clinical","source_dataset":"mesh","target_dataset":"pharmgkb_clinical"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]D003865,43,D003865,194,0]["},"schema":"id|variant|gene|type|level_of_evidence|chemicals|phenotypes","mappings":[{"input":"D003865","source":"D003865|Depressive Disorder, Major","targets":["CYP2C19*1__CYP2C19*2__CYP2C19*3__CYP2C19*17_CYP2C19_10|CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17|CYP2C19|Efficacy|4|citalopram|Major Depressive Disorder;Obsessive-Compulsive Disorder","CYP2C19*1__CYP2C19*2__CYP2C19*3__CYP2C19*17_CYP2C19_5|CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17|CYP2C19|Metabolism/PK|1A|escitalopram|Major Depressive Disorder;Mental Disorders","CYP2C19*1__CYP2C19*2__CYP2C19*3__CYP2C19*17_CYP2C19_6|CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17|CYP2C19|Metabolism/PK|1A|imipramine|Depressive Disorder;Major Depressive Disorder","CYP2C19*1__CYP2C19*2__CYP2C19*3__CYP2C19*17_CYP2C19_7|CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17|CYP2C19|Metabolism/PK|1A|citalopram|Depressive Disorder;Major Depressive Disorder","CYP2C19*1__CYP2C19*2__CYP2C19*3__CYP2C19*17_CYP2C19_9|CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17|CYP2C19|Metabolism/PK|1A|amitriptyline|Major Depressive Disorder;Mental Disorders","CYP2D6*1__CYP2D6*1XN__CYP2D6*2__CYP2D6*2XN__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*6__CYP2D6*10__CYP2D6*17_CYP2D6_1|CYP2D6*1, CYP2D6*1xN, CYP2D6*2, CYP2D6*2xN, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*10, CYP2D6*17|CYP2D6|Metabolism/PK|1A|nortriptyline|Major Depressive Disorder","CYP2D6*1__CYP2D6*1XN__CYP2D6*2__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*6__CYP2D6*10__CYP2D6*41_CYP2D6_3|CYP2D6*1, CYP2D6*1xN, CYP2D6*2, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*10, CYP2D6*41|CYP2D6|Metabolism/PK|1A|clomipramine|Major Depressive Disorder;Mental Disorders","CYP2D6*1__CYP2D6*1XN__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*6__CYP2D6*10__CYP2D6*17_CYP2D6_1|CYP2D6*1, CYP2D6*1xN, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*10, CYP2D6*17|CYP2D6|Metabolism/PK|3|fluoxetine|Major Depressive Disorder;Mental Disorders","CYP2D6*1__CYP2D6*2__CYP2D6*2XN__CYP2D6*4__CYP2D6*5__CYP2D6*6__CYP2D6*9__CYP2D6*10_CYP2D6_1|CYP2D6*1, CYP2D6*2, CYP2D6*2xN, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*9, CYP2D6*10|CYP2D6|Metabolism/PK|1A|desipramine|Major Depressive Disorder;Mental Disorders","CYP2D6*1__CYP2D6*3__CYP2D6*4__CYP2D6*5_CYP2D6_1|CYP2D6*1, CYP2D6*3, CYP2D6*4, CYP2D6*5|CYP2D6|Metabolism/PK|1A|imipramine|Major Depressive Disorder;Mental Disorders","CYP2D6*1__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*10__CYP2D6*17__CYP2D6*41_CYP2D6_1|CYP2D6*1, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*10, CYP2D6*17, CYP2D6*41|CYP2D6|Toxicity|4|citalopram|Major Depressive Disorder","CYP2D6*1__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*6_CYP2D6_2|CYP2D6*1, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6|CYP2D6|Toxicity|1A|desipramine|Depressive Disorder;Major Depressive Disorder","CYP2D6*1__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*6_CYP2D6_3|CYP2D6*1, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6|CYP2D6|Toxicity|1A|clomipramine|Major Depressive Disorder","CYP2D6*1__CYP2D6*3__CYP2D6*4__CYP2D6*5__CYP2D6*6__CYP2D6*81_CYP2D6_1|CYP2D6*1, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*81|CYP2D6|Toxicity|1A|venlafaxine|Agitation;Alcohol-Related Disorders;Cardiotoxicity;Depression;Depressive Disorder;Drug Toxicity;dysphoria;Edema;Major Depressive Disorder;Nausea;Obsessive-Compulsive Disorder;Tachycardia;Vomiting","RS10007051_1|rs10007051||Efficacy|3|duloxetine|Major Depressive Disorder","RS10036156_GABRP_1|rs10036156|GABRP|Efficacy|3|antidepressants;Selective serotonin reuptake inhibitors;venlafaxine|Major Depressive Disorder","RS10042486_HTR1A_1|rs10042486|HTR1A|Efficacy|3|fluvoxamine;milnacipran;paroxetine|Major Depressive Disorder","RS1006737_CACNA1C_1|rs1006737|CACNA1C|Toxicity|3|citalopram|Major Depressive Disorder","RS10123866_INVS_1|rs10123866|INVS|Efficacy|3|duloxetine|Major Depressive Disorder","RS10124893_TEX10_1|rs10124893|TEX10|Efficacy|3|duloxetine|Major Depressive Disorder","RS1045642_ABCB1_7|rs1045642|ABCB1|Toxicity|3|nortriptyline|Depression;Depressive Disorder;Hypotensive disorder;Major Depressive Disorder","RS1065852_CYP2D6_3|rs1065852|CYP2D6|Efficacy|3|escitalopram|Major Depressive Disorder","RS10771997_1|rs10771997||Efficacy|3|duloxetine|Major Depressive Disorder","RS10771998_1|rs10771998||Efficacy|3|duloxetine|Major Depressive Disorder","RS10771999_1|rs10771999||Efficacy|3|duloxetine|Major Depressive Disorder","RS10848635_CACNA1C_1|rs10848635|CACNA1C|Toxicity|3|citalopram|Major Depressive Disorder","RS10879346_TPH2_1|rs10879346|TPH2|Efficacy|3|antidepressants;mirtazapine;venlafaxine|Major Depressive Disorder","RS10975641_GLDC_1|rs10975641|GLDC|Efficacy|3|citalopram;escitalopram|Major Depressive Disorder","RS10989064_TEX10_1|rs10989064|TEX10|Efficacy|3|duloxetine|Major Depressive Disorder","RS10997242_CTNNA3_1|rs10997242|CTNNA3|Efficacy|3|antidepressants|Major Depressive Disorder","RS11042725_ADM_1|rs11042725|ADM|Efficacy|3|paroxetine|Major Depressive Disorder","RS1128503_ABCB1_35|rs1128503|ABCB1|Metabolism/PK|3|aripiprazole|Major Depressive Disorder","RS1128503_ABCB1_36|rs1128503|ABCB1|Efficacy|3|antidepressants|Major Depressive Disorder","RS1160351_MDGA2_1|rs1160351|MDGA2|Toxicity|3|fluvoxamine;milnacipran;paroxetine|Major Depressive Disorder","RS11628713_PAPLN_1|rs11628713|PAPLN|Toxicity|3|citalopram|Major Depressive Disorder","RS117986340_KMT2E_1|rs117986340|KMT2E|Efficacy|3|duloxetine|Major Depressive Disorder","RS11933890_1|rs11933890||Efficacy|3|duloxetine|Major Depressive Disorder","RS12054895_1|rs12054895||Efficacy|4|citalopram;escitalopram|Major Depressive Disorder","RS12094644_1|rs12094644||Efficacy|3|duloxetine|Major Depressive Disorder","RS12502866_1|rs12502866||Efficacy|3|duloxetine|Major Depressive Disorder","RS12595802_ATP10A_1|rs12595802|ATP10A|Efficacy|3|duloxetine|Major Depressive Disorder","RS12603700_MIEF2_1|rs12603700|MIEF2|Efficacy|3|duloxetine|Major Depressive Disorder","RS12630569_ZNF385D_1|rs12630569|ZNF385D|Efficacy|3|duloxetine|Major Depressive Disorder","RS12657120_SKIC3_1|rs12657120|SKIC3|Efficacy|3|duloxetine|Major Depressive Disorder","RS13093500_ZNF385D_1|rs13093500|ZNF385D|Efficacy|3|duloxetine|Major Depressive Disorder","RS13204353_TREML4_1|rs13204353|TREML4|Efficacy|3|duloxetine|Major Depressive Disorder","RS13306278_COMT_1|rs13306278|COMT|Efficacy|3|Selective serotonin reuptake inhibitors|Major Depressive Disorder","RS13432159_1|rs13432159||Toxicity|3|sertraline|Major Depressive Disorder","RS1364043_HTR1A_1|rs1364043|HTR1A|Efficacy|3|fluvoxamine;milnacipran;paroxetine|Major Depressive Disorder","RS1439050_NTRK2_1|rs1439050|NTRK2|Toxicity|3|antidepressants|Major Depressive Disorder","RS153549_REEP5_1|rs153549|REEP5|Efficacy|3|citalopram;fluoxetine;paroxetine;sertraline|Major Depressive Disorder","RS153560_REEP5_1|rs153560|REEP5|Efficacy|3|citalopram;fluoxetine;paroxetine;sertraline|Major Depressive Disorder","RS16873129_RAPGEF5_1|rs16873129|RAPGEF5|Efficacy|3|antidepressants|Major Depressive Disorder","RS16965962_1|rs16965962||Toxicity|3|citalopram|Major Depressive Disorder","RS17135437_COL26A1_1|rs17135437|COL26A1|Toxicity|3|citalopram|Major Depressive Disorder","RS17614642_FKBP5_1|rs17614642|FKBP5|Efficacy|3|bupropion|Major Depressive Disorder","RS17724452_ANO2_1|rs17724452|ANO2|Efficacy|3|duloxetine|Major Depressive Disorder","RS17724464_ANO2_1|rs17724464|ANO2|Efficacy|3|duloxetine|Major Depressive Disorder","RS17724494_ANO2_1|rs17724494|ANO2|Efficacy|3|duloxetine|Major Depressive Disorder","RS17786394_ANO2_1|rs17786394|ANO2|Efficacy|3|duloxetine|Major Depressive Disorder","RS17786400_ANO2_1|rs17786400|ANO2|Efficacy|3|duloxetine|Major Depressive Disorder","RS17786412_ANO2_1|rs17786412|ANO2|Efficacy|3|duloxetine|Major Depressive Disorder","RS1799889_SERPINE1_1|rs1799889|SERPINE1|Efficacy|3|antidepressants;citalopram;fluoxetine|Major Depressive Disorder","RS1799971_OPRM1_10|rs1799971|OPRM1|Toxicity|3|tianeptine|Major Depressive Disorder;suicidal ideation","RS1800532_TPH1_2|rs1800532|TPH1|Efficacy|4|antidepressants;citalopram;escitalopram;fluoxetine;paroxetine|Major Depressive Disorder","RS1800544_ADRA2A_3|rs1800544|ADRA2A|Efficacy|3|Selective serotonin reuptake inhibitors|Major Depressive Disorder","RS1801131_MTHFR_5|rs1801131|MTHFR|Efficacy|3|l-methylfolate;Vitamin B-complex;Incl. Combinations|Major Depressive Disorder","RS1801133_MTHFR_8|rs1801133|MTHFR|Efficacy|3|l-methylfolate;Vitamin B-complex;Incl. Combinations|Major Depressive Disorder","RS1969624_SACM1L_1|rs1969624|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS1992647_GABRA6_1|rs1992647|GABRA6|Efficacy|3|antidepressants;Selective serotonin reuptake inhibitors;venlafaxine|Major Depressive Disorder","RS2032583_ABCB1_1|rs2032583|ABCB1|Efficacy|3|amitriptyline;antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxine|Depression;Depressive Disorder;Major Depressive Disorder","RS2069521_1|rs2069521||Toxicity|3|escitalopram|Major Depressive Disorder","RS2069526_CYP1A2_1|rs2069526|CYP1A2|Toxicity|3|escitalopram|Major Depressive Disorder","RS2112460_CACNA1A_1|rs2112460|CACNA1A|Efficacy|3|antidepressants|Major Depressive Disorder","RS2216711_GDNF_1|rs2216711|GDNF|Efficacy|3|paroxetine|Major Depressive Disorder","RS2227631_SERPINE1_1|rs2227631|SERPINE1|Efficacy|3|antidepressants;citalopram;fluoxetine|Major Depressive Disorder","RS2228478_MC1R_1|rs2228478|MC1R|Efficacy|3|desipramine|Major Depressive Disorder","RS2228479_MC1R_1|rs2228479|MC1R|Efficacy|3|desipramine|Major Depressive Disorder","RS2235015_ABCB1_1|rs2235015|ABCB1|Efficacy|3|amitriptyline;antidepressants;citalopram;paroxetine;venlafaxine|Depression;Depressive Disorder;Major Depressive Disorder","RS2235067_ABCB1_1|rs2235067|ABCB1|Efficacy|3|amitriptyline;citalopram;paroxetine;venlafaxine|Major Depressive Disorder","RS2242446_SLC6A2_1|rs2242446|SLC6A2|Efficacy|3|venlafaxine|Major Depressive Disorder","RS2245705_SACM1L_1|rs2245705|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS2251954_SACM1L_1|rs2251954|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS2270007_CRHR2_1|rs2270007|CRHR2|Efficacy|3|citalopram|Major Depressive Disorder","RS2299267_PON2_1|rs2299267|PON2|Efficacy|3|antidepressants|Major Depressive Disorder","RS2303377_NCAM1_1|rs2303377|NCAM1|Efficacy|3|duloxetine|Major Depressive Disorder","RS2419128_1|rs2419128||Efficacy|3|duloxetine|Major Depressive Disorder","RS242941_CRHR1_1|rs242941|CRHR1|Efficacy|3|fluoxetine|Anxiety Disorders;Major Depressive Disorder","RS2433320_1|rs2433320||Efficacy|3|fluoxetine|Major Depressive Disorder","RS2470890_CYP1A2_1|rs2470890|CYP1A2|Efficacy|3|paroxetine|Major Depressive Disorder","RS2472304_CYP1A2_1|rs2472304|CYP1A2|Efficacy|3|paroxetine|Major Depressive Disorder","RS2500535_UST_1|rs2500535|UST|Efficacy|3|nortriptyline|Major Depressive Disorder","RS2532560_PARP11_1|rs2532560|PARP11|Efficacy|3|antidepressants|Major Depressive Disorder","RS25531_SLC6A4_3|rs25531|SLC6A4|Efficacy|4|fluoxetine|Major Depressive Disorder","RS2734833_DRD2_1|rs2734833|DRD2|Efficacy|3|Selective serotonin reuptake inhibitors|Major Depressive Disorder","RS2742390_SACM1L_1|rs2742390|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS2742417_SACM1L_1|rs2742417|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS2742421_SACM1L_1|rs2742421|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS2742423_SACM1L_1|rs2742423|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder","RS2742435_SACM1L_1|rs2742435|SACM1L|Toxicity|3|bupropion|Major Depressive Disorder"]}]}