{"context":{"query":">>ensembl>>reactome","source_dataset":"ensembl","target_dataset":"reactome"},"stats":{"queried":1,"total":59,"mapped":1},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"ENSG00000012048","source":"ENSG00000012048|BRCA1","targets":["R-HSA-1221632|Meiotic synapsis|9606|false","R-HSA-3108214|SUMOylation of DNA damage response and repair proteins|9606|false","R-HSA-5685938|HDR through Single Strand Annealing (SSA)|9606|false","R-HSA-5685942|HDR through Homologous Recombination (HRR)|9606|false","R-HSA-5689901|Metalloprotease DUBs|9606|false","R-HSA-5693554|Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)|9606|false","R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-5693568|Resolution of D-loop Structures through Holliday Junction Intermediates|9606|false","R-HSA-5693571|Nonhomologous End-Joining (NHEJ)|9606|false","R-HSA-5693579|Homologous DNA Pairing and Strand Exchange|9606|false","R-HSA-5693607|Processing of DNA double-strand break ends|9606|false","R-HSA-5693616|Presynaptic phase of homologous DNA pairing and strand exchange|9606|false","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-8951664|Neddylation|9606|false","R-HSA-8953750|Transcriptional Regulation by E2F6|9606|false","R-HSA-912446|Meiotic recombination|9606|false","R-HSA-9663199|Defective DNA double strand break response due to BRCA1 loss of function|9606|true","R-HSA-9699150|Defective DNA double strand break response due to BARD1 loss of function|9606|true","R-HSA-9701192|Defective homologous recombination repair (HRR) due to BRCA1 loss of function|9606|true","R-HSA-9704331|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function|9606|true","R-HSA-9704646|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function|9606|true","R-HSA-9709570|Impaired BRCA2 binding to RAD51|9606|true","R-HSA-9709603|Impaired BRCA2 binding to PALB2|9606|true","R-HSA-9755511|KEAP1-NFE2L2 pathway|9606|false","R-HSA-9825895|Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence|9606|false","R-HSA-1266738|Developmental Biology|9606|false","R-HSA-1474165|Reproduction|9606|false","R-HSA-1500620|Meiosis|9606|false","R-HSA-1640170|Cell Cycle|9606|false","R-HSA-1643685|Disease|9606|true","R-HSA-212436|Generic Transcription Pathway|9606|false","R-HSA-2262752|Cellular responses to stress|9606|false","R-HSA-2990846|SUMOylation|9606|false","R-HSA-3108232|SUMO E3 ligases SUMOylate target proteins|9606|false","R-HSA-3700989|Transcriptional Regulation by TP53|9606|false","R-HSA-392499|Metabolism of proteins|9606|false","R-HSA-5633007|Regulation of TP53 Activity|9606|false","R-HSA-5688426|Deubiquitination|9606|false","R-HSA-5693532|DNA Double-Strand Break Repair|9606|false","R-HSA-5693537|Resolution of D-Loop Structures|9606|false","R-HSA-5693538|Homology Directed Repair|9606|false","R-HSA-5693567|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|9606|false","R-HSA-5693606|DNA Double Strand Break Response|9606|false","R-HSA-597592|Post-translational protein modification|9606|false","R-HSA-69481|G2/M Checkpoints|9606|false","R-HSA-69620|Cell Cycle Checkpoints|9606|false","R-HSA-73857|RNA Polymerase II Transcription|9606|false","R-HSA-73894|DNA Repair|9606|false","R-HSA-74160|Gene expression (Transcription)|9606|false","R-HSA-8953897|Cellular responses to stimuli|9606|false","R-HSA-9675135|Diseases of DNA repair|9606|true","R-HSA-9675136|Diseases of DNA Double-Strand Break Repair|9606|true","R-HSA-9701190|Defective homologous recombination repair (HRR) due to BRCA2 loss of function|9606|true","R-HSA-9701193|Defective homologous recombination repair (HRR) due to PALB2 loss of function|9606|true","R-HSA-9711123|Cellular response to chemical stress|9606|false","R-HSA-9730414|MITF-M-regulated melanocyte development|9606|false","R-HSA-9856651|MITF-M-dependent gene expression|9606|false"]}]}