{"context":{"query":">>ensembl>>reactome","source_dataset":"ensembl","target_dataset":"reactome"},"stats":{"queried":1,"total":46,"mapped":1},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"ENSG00000141510","source":"ENSG00000141510|TP53","targets":["R-HSA-111448|Activation of NOXA and translocation to mitochondria|9606|false","R-HSA-139915|Activation of PUMA and translocation to mitochondria|9606|false","R-HSA-1912408|Pre-NOTCH Transcription and Translation|9606|false","R-HSA-2559580|Oxidative Stress Induced Senescence|9606|false","R-HSA-2559584|Formation of Senescence-Associated Heterochromatin Foci (SAHF)|9606|false","R-HSA-2559585|Oncogene Induced Senescence|9606|false","R-HSA-2559586|DNA Damage/Telomere Stress Induced Senescence|9606|false","R-HSA-3232118|SUMOylation of transcription factors|9606|false","R-HSA-349425|Autodegradation of the E3 ubiquitin ligase COP1|9606|false","R-HSA-390471|Association of TriC/CCT with target proteins during biosynthesis|9606|false","R-HSA-5620971|Pyroptosis|9606|false","R-HSA-5628897|TP53 Regulates Metabolic Genes|9606|false","R-HSA-5689880|Ub-specific processing proteases|9606|false","R-HSA-5689896|Ovarian tumor domain proteases|9606|false","R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-6803204|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|9606|false","R-HSA-6803205|TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain|9606|false","R-HSA-6803207|TP53 Regulates Transcription of Caspase Activators and Caspases|9606|false","R-HSA-6803211|TP53 Regulates Transcription of Death Receptors and Ligands|9606|false","R-HSA-6804114|TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest|9606|false","R-HSA-6804115|TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain|9606|false","R-HSA-6804116|TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest|9606|false","R-HSA-6804754|Regulation of TP53 Expression|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804758|Regulation of TP53 Activity through Acetylation|9606|false","R-HSA-6804759|Regulation of TP53 Activity through Association with Co-factors|9606|false","R-HSA-6804760|Regulation of TP53 Activity through Methylation|9606|false","R-HSA-6811555|PI5P Regulates TP53 Acetylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-69481|G2/M Checkpoints|9606|false","R-HSA-69541|Stabilization of p53|9606|false","R-HSA-69895|Transcriptional  activation of  cell cycle inhibitor p21 |9606|false","R-HSA-70635|Urea cycle|9606|false","R-HSA-8852276|The role of GTSE1 in G2/M progression after G2 checkpoint|9606|false","R-HSA-8853884|Transcriptional Regulation by VENTX|9606|false","R-HSA-8941855|RUNX3 regulates CDKN1A transcription|9606|false","R-HSA-8943724|Regulation of PTEN gene transcription|9606|false","R-HSA-9723905|Loss of function of TP53 in cancer due to loss of tetramerization ability|9606|true","R-HSA-9725370|Signaling by ALK fusions and activated point mutants|9606|true","R-HSA-9758274|Regulation of NF-kappa B signaling|9606|false","R-HSA-9819196|Zygotic genome activation (ZGA)|9606|false","R-HSA-983231|Factors involved in megakaryocyte development and platelet production|9606|false","R-HSA-9833482|PKR-mediated signaling|9606|false"]}]}