{"context":{"query":">>ensembl>>reactome","source_dataset":"ensembl","target_dataset":"reactome"},"stats":{"queried":1,"total":61,"mapped":1},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"ENSG00000149311","source":"ENSG00000149311|ATM","targets":["R-HSA-2559586|DNA Damage/Telomere Stress Induced Senescence|9606|false","R-HSA-3371453|Regulation of HSF1-mediated heat shock response|9606|false","R-HSA-349425|Autodegradation of the E3 ubiquitin ligase COP1|9606|false","R-HSA-5685938|HDR through Single Strand Annealing (SSA)|9606|false","R-HSA-5685942|HDR through Homologous Recombination (HRR)|9606|false","R-HSA-5693548|Sensing of DNA Double Strand Breaks|9606|false","R-HSA-5693554|Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)|9606|false","R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-5693568|Resolution of D-loop Structures through Holliday Junction Intermediates|9606|false","R-HSA-5693571|Nonhomologous End-Joining (NHEJ)|9606|false","R-HSA-5693579|Homologous DNA Pairing and Strand Exchange|9606|false","R-HSA-5693607|Processing of DNA double-strand break ends|9606|false","R-HSA-5693616|Presynaptic phase of homologous DNA pairing and strand exchange|9606|false","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-6803204|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|9606|false","R-HSA-6803207|TP53 Regulates Transcription of Caspase Activators and Caspases|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804760|Regulation of TP53 Activity through Methylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-69541|Stabilization of p53|9606|false","R-HSA-912446|Meiotic recombination|9606|false","R-HSA-9664873|Pexophagy|9606|false","R-HSA-9701192|Defective homologous recombination repair (HRR) due to BRCA1 loss of function|9606|true","R-HSA-9704331|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function|9606|true","R-HSA-9704646|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function|9606|true","R-HSA-9709570|Impaired BRCA2 binding to RAD51|9606|true","R-HSA-9709603|Impaired BRCA2 binding to PALB2|9606|true","R-HSA-1474165|Reproduction|9606|false","R-HSA-1500620|Meiosis|9606|false","R-HSA-1632852|Macroautophagy|9606|false","R-HSA-1640170|Cell Cycle|9606|false","R-HSA-1643685|Disease|9606|true","R-HSA-212436|Generic Transcription Pathway|9606|false","R-HSA-2262752|Cellular responses to stress|9606|false","R-HSA-2559583|Cellular Senescence|9606|false","R-HSA-3371556|Cellular response to heat stress|9606|false","R-HSA-3700989|Transcriptional Regulation by TP53|9606|false","R-HSA-5633007|Regulation of TP53 Activity|9606|false","R-HSA-5633008|TP53 Regulates Transcription of Cell Death Genes|9606|false","R-HSA-5693532|DNA Double-Strand Break Repair|9606|false","R-HSA-5693537|Resolution of D-Loop Structures|9606|false","R-HSA-5693538|Homology Directed Repair|9606|false","R-HSA-5693567|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|9606|false","R-HSA-5693606|DNA Double Strand Break Response|9606|false","R-HSA-6806003|Regulation of TP53 Expression and Degradation|9606|false","R-HSA-69481|G2/M Checkpoints|9606|false","R-HSA-69563|p53-Dependent G1 DNA Damage Response|9606|false","R-HSA-69580|p53-Dependent G1/S DNA damage checkpoint|9606|false","R-HSA-69615|G1/S DNA Damage Checkpoints|9606|false","R-HSA-69620|Cell Cycle Checkpoints|9606|false","R-HSA-73857|RNA Polymerase II Transcription|9606|false","R-HSA-73894|DNA Repair|9606|false","R-HSA-74160|Gene expression (Transcription)|9606|false","R-HSA-8953897|Cellular responses to stimuli|9606|false","R-HSA-9612973|Autophagy|9606|false","R-HSA-9663891|Selective autophagy|9606|false","R-HSA-9675135|Diseases of DNA repair|9606|true","R-HSA-9675136|Diseases of DNA Double-Strand Break Repair|9606|true","R-HSA-9701190|Defective homologous recombination repair (HRR) due to BRCA2 loss of function|9606|true","R-HSA-9701193|Defective homologous recombination repair (HRR) due to PALB2 loss of function|9606|true"]}]}