{"context":{"query":">>hgnc>>clinvar[germline_classification==\"Pathogenic\"]","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":62,"mapped":1},"pagination":{"has_next":false},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:1097","source":"HGNC:1097|B-Raf proto-oncogene, serine/threonine kinase","targets":["1210729|NM_004333.6(BRAF):c.2125C>G (p.Gln709Glu)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","1317489|NM_004333.6(BRAF):c.1738A>G (p.Asn580Asp)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","1325840|NM_004333.6(BRAF):c.1454T>G (p.Leu485Trp)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","13962|NM_004333.6(BRAF):c.1385G>T (p.Arg462Ile)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7","13963|NM_004333.6(BRAF):c.1388T>G (p.Ile463Ser)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7","13964|NM_004333.6(BRAF):c.1391G>A (p.Gly464Glu)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","13965|NM_004333.6(BRAF):c.736G>C (p.Ala246Pro)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","13966|NM_004333.6(BRAF):c.1801A>G (p.Lys601Glu)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","13967|NM_004333.6(BRAF):c.1397G>T (p.Gly466Val)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7","13968|NM_004333.6(BRAF):c.1790T>G (p.Leu597Arg)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7","13969|NM_004333.6(BRAF):c.1789C>G (p.Leu597Val)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","13971|NM_004333.6(BRAF):c.1406G>C (p.Gly469Ala)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","13972|NM_004333.6(BRAF):c.1781A>G (p.Asp594Gly)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","13973|NM_004333.6(BRAF):c.770A>G (p.Gln257Arg)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","13974|NM_004333.6(BRAF):c.1406G>A (p.Gly469Glu)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","13975|NM_004333.6(BRAF):c.1455G>C (p.Leu485Phe)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","13979|NM_004333.6(BRAF):c.1741A>G (p.Asn581Asp)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","162793|NM_004333.6(BRAF):c.1794_1796dup (p.Thr599dup)|Duplication|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","162797|NM_004333.6(BRAF):c.1914T>G (p.Asp638Glu)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","1685577|NM_004333.6(BRAF):c.1591T>C (p.Trp531Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","177672|NM_004333.6(BRAF):c.1785T>G (p.Phe595Leu)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","177844|NM_004333.6(BRAF):c.1455G>T (p.Leu485Phe)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","180784|NM_004333.6(BRAF):c.739T>C (p.Phe247Leu)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","180788|NM_004333.6(BRAF):c.1722C>A (p.His574Gln)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","180789|NM_004333.6(BRAF):c.1785T>A (p.Phe595Leu)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","223138|NM_004333.6(BRAF):c.1399T>G (p.Ser467Ala)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","2430770|NM_004333.6(BRAF):c.1591T>A (p.Trp531Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","2501901|NM_004333.6(BRAF):c.1396G>C (p.Gly466Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","265358|NM_004333.6(BRAF):c.1593G>T (p.Trp531Cys)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","2664272|NM_004333.6(BRAF):c.1799_1810delinsATG (p.Val600_Trp604delinsAspGly)|Indel|Pathogenic|BRAF|no assertion criteria provided|7","2674585|NM_004333.6(BRAF):c.741T>A (p.Phe247Leu)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7","2691256|NM_004333.6(BRAF):c.1455_1469del (p.Leu485_Pro490delinsPhe)|Deletion|Pathogenic|BRAF|no assertion criteria provided|7","279992|NM_004333.6(BRAF):c.1390G>C (p.Gly464Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","280033|NM_004333.6(BRAF):c.1796C>G (p.Thr599Arg)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","29806|NM_004333.6(BRAF):c.722C>G (p.Thr241Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","29808|NM_004333.6(BRAF):c.1593G>C (p.Trp531Cys)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","3373467|NM_004333.6(BRAF):c.721A>G (p.Thr241Ala)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","3572914|NM_004333.6(BRAF):c.2126A>G (p.Gln709Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","372572|NM_004333.6(BRAF):c.1390G>A (p.Gly464Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","372626|NM_004333.6(BRAF):c.1574T>G (p.Leu525Arg)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","375946|NM_004333.6(BRAF):c.1781A>T (p.Asp594Val)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","40346|NM_004333.6(BRAF):c.730A>C (p.Thr244Pro)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","40347|NM_004333.6(BRAF):c.735A>C (p.Leu245Phe)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","40348|NM_004333.6(BRAF):c.735A>T (p.Leu245Phe)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","40372|NM_004333.6(BRAF):c.1497A>T (p.Lys499Asn)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","40373|NM_004333.6(BRAF):c.1502A>C (p.Glu501Ala)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","40375|NM_004333.6(BRAF):c.1513C>T (p.Leu505Phe)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","40387|NM_004333.6(BRAF):c.1787G>T (p.Gly596Val)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","40388|NM_004333.6(BRAF):c.1796C>T (p.Thr599Ile)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","40389|NM_004333.6(BRAF):c.1799T>G (p.Val600Gly)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","41446|NM_004333.6(BRAF):c.1801A>C (p.Lys601Gln)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","430737|NM_004333.6(BRAF):c.2128-4_2129del|Deletion|Pathogenic|BRAF|criteria provided, single submitter|7","44802|NM_004333.6(BRAF):c.1405_1407del (p.Gly469del)|Deletion|Pathogenic|BRAF|no assertion criteria provided|7","44803|NM_004333.6(BRAF):c.1406G>T (p.Gly469Val)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","44810|NM_004333.6(BRAF):c.1720C>T (p.His574Tyr)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","44818|NM_004333.6(BRAF):c.1802A>C (p.Lys601Thr)|single nucleotide variant|Pathogenic|BRAF|criteria provided, multiple submitters, no conflicts|7","44829|NM_004333.6(BRAF):c.722C>A (p.Thr241Lys)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","55793|NM_004333.6(BRAF):c.741T>G (p.Phe247Leu)|single nucleotide variant|Pathogenic|BRAF|reviewed by expert panel|7","666412|NM_004333.6(BRAF):c.1448A>C (p.Lys483Thr)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","666569|NM_004333.6(BRAF):c.1592G>C (p.Trp531Ser)|single nucleotide variant|Pathogenic|BRAF|criteria provided, single submitter|7","690297|NM_004333.6(BRAF):c.1906C>T (p.Gln636Ter)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7","977765|NM_004333.6(BRAF):c.1277G>C (p.Arg426Thr)|single nucleotide variant|Pathogenic|BRAF|no assertion criteria provided|7"]}]}