{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:1100,10,HGNC:1100,27,1]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:1100","source":"HGNC:1100|BRCA1 DNA repair associated","targets":["1000183|NM_007294.4(BRCA1):c.4709T>C (p.Leu1570Pro)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1000551|NM_007294.4(BRCA1):c.3664G>A (p.Glu1222Lys)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1001081|NM_007294.4(BRCA1):c.353T>C (p.Leu118Pro)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1002154|NM_007294.4(BRCA1):c.1226T>G (p.Val409Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1002750|NM_007294.4(BRCA1):c.2614T>C (p.Phe872Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1003072|NM_007294.4(BRCA1):c.3017A>C (p.His1006Pro)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1003150|NM_007294.4(BRCA1):c.4328G>T (p.Arg1443Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1004428|NM_007294.4(BRCA1):c.1810A>G (p.Lys604Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1004775|NM_007294.4(BRCA1):c.1976C>G (p.Pro659Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1004786|NM_007294.4(BRCA1):c.3556C>G (p.Leu1186Val)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1005082|NM_007294.4(BRCA1):c.1930T>G (p.Cys644Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1005528|NM_007294.4(BRCA1):c.4685C>G (p.Pro1562Arg)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1005598|NM_007294.4(BRCA1):c.4333C>T (p.Pro1445Ser)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1005841|NM_007294.4(BRCA1):c.4652C>T (p.Ser1551Phe)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1005942|NM_007294.4(BRCA1):c.3660T>G (p.Asp1220Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1005980|NM_007294.4(BRCA1):c.4162C>A (p.Gln1388Lys)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1007698|NM_007294.4(BRCA1):c.1199A>T (p.Asp400Val)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1007721|NM_007294.4(BRCA1):c.3811A>G (p.Ser1271Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1007863|NC_000017.10:g.(?_41277268)_(41277500_?)del|Deletion|Uncertain significance|BRCA1|criteria provided, single submitter|17","1009121|NM_007294.4(BRCA1):c.778A>G (p.Lys260Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1009204|NM_007294.4(BRCA1):c.500C>T (p.Thr167Ile)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1009272|NM_007294.4(BRCA1):c.4445A>C (p.Asp1482Ala)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1009310|NM_007294.4(BRCA1):c.3673T>A (p.Cys1225Ser)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1009406|NM_007294.4(BRCA1):c.4586T>G (p.Ile1529Ser)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1009551|NM_007294.4(BRCA1):c.4001G>T (p.Gly1334Val)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1010063|NM_007294.4(BRCA1):c.641A>T (p.Asp214Val)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1010509|NM_007294.4(BRCA1):c.1328A>G (p.Lys443Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1010603|NM_007294.4(BRCA1):c.1331G>T (p.Ser444Ile)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1010631|NM_007294.4(BRCA1):c.547+5G>A|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1010734|NM_007294.4(BRCA1):c.4840C>G (p.Pro1614Ala)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1011036|NM_007294.4(BRCA1):c.3610A>G (p.Arg1204Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1011411|NC_000017.10:g.(?_41201132)_(41276119_?)dup|Duplication|Uncertain significance|BRCA1|criteria provided, single submitter|17","1012155|NM_007294.4(BRCA1):c.1728del (p.Glu577fs)|Deletion|Pathogenic|BRCA1|no assertion criteria provided|17","1012156|NM_007294.4(BRCA1):c.3982del (p.Ser1328fs)|Deletion|Pathogenic|BRCA1|no assertion criteria provided|17","1012905|NM_007294.4(BRCA1):c.1528T>G (p.Ser510Ala)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1013802|NM_007294.4(BRCA1):c.4595T>C (p.Val1532Ala)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1014065|NM_007294.4(BRCA1):c.4403A>C (p.Asn1468Thr)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1014279|NM_007294.4(BRCA1):c.1633G>T (p.Val545Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1014997|NM_007294.4(BRCA1):c.1709C>T (p.Pro570Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1015821|NM_007294.4(BRCA1):c.2907T>A (p.Asn969Lys)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1015826|NM_007294.4(BRCA1):c.4581G>T (p.Glu1527Asp)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1017178|NM_007294.4(BRCA1):c.968G>A (p.Gly323Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1018104|NM_007294.4(BRCA1):c.1657_1680dup (p.Asp560_Ser561insHisGluAsnLysThrLysGlyAsp)|Duplication|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1019393|NM_007294.4(BRCA1):c.2236G>A (p.Asp746Asn)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1019499|NM_007294.4(BRCA1):c.370ATC[1] (p.Ile125del)|Microsatellite|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1020068|NM_007294.4(BRCA1):c.498G>C (p.Arg166Ser)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1020506|NC_000017.10:g.(?_41242955)_(41276119_?)dup|Duplication|Uncertain significance|BRCA1|criteria provided, single submitter|17","1020675|NM_007294.4(BRCA1):c.4163A>G (p.Gln1388Arg)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1021564|NM_007294.4(BRCA1):c.829A>C (p.Asn277His)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1022148|NM_007294.4(BRCA1):c.4186-6T>C|single nucleotide variant|Likely benign|BRCA1|criteria provided, single submitter|17","1022166|NM_007294.4(BRCA1):c.4608G>T (p.Glu1536Asp)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1022202|NM_007294.4(BRCA1):c.302-3C>T|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1022374|NM_007294.4(BRCA1):c.4037A>G (p.Glu1346Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1022688|NM_007294.4(BRCA1):c.2306T>C (p.Ile769Thr)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1023503|NM_007294.4(BRCA1):c.2446C>A (p.His816Asn)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1024428|NM_007294.4(BRCA1):c.4477G>T (p.Val1493Leu)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1024907|NM_007294.4(BRCA1):c.3131T>C (p.Ile1044Thr)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1024990|NM_007294.4(BRCA1):c.4105G>A (p.Ala1369Thr)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1025124|NM_007294.4(BRCA1):c.1358A>C (p.Glu453Ala)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1025776|NM_007294.4(BRCA1):c.594-1G>C|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1026607|NM_007294.4(BRCA1):c.3645C>G (p.Asn1215Lys)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1026712|NM_007294.4(BRCA1):c.3025T>C (p.Ser1009Pro)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1026797|NM_007294.4(BRCA1):c.1304A>T (p.Asp435Val)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1026850|NM_007294.4(BRCA1):c.442-2A>G|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1027319|NM_007294.4(BRCA1):c.1163G>A (p.Arg388Lys)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1027595|NC_000017.10:g.(?_41196311)_(41203135_41209068)del|Deletion|Pathogenic|BRCA1|criteria provided, single submitter|17","1027624|NC_000017.10:g.(41203135_41209068)_(41209153_41215349)del|Deletion|Pathogenic|BRCA1|criteria provided, single submitter|17","1034478|NM_007294.4(BRCA1):c.3255A>T (p.Arg1085Ser)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1034479|NM_007294.4(BRCA1):c.3372C>A (p.Phe1124Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1034679|NM_007294.4(BRCA1):c.632G>C (p.Gly211Ala)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1034998|NM_007294.4(BRCA1):c.2321G>C (p.Gly774Ala)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1035284|NM_007294.4(BRCA1):c.4434G>T (p.Glu1478Asp)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1035312|NM_007294.4(BRCA1):c.1219G>A (p.Ala407Thr)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1035776|NM_007294.4(BRCA1):c.905C>T (p.Ala302Val)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1036207|NM_007294.4(BRCA1):c.3877G>A (p.Ala1293Thr)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1037303|NM_007294.4(BRCA1):c.4227_4229dup (p.Glu1410_Met1411insGlu)|Duplication|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1037513|NM_007294.4(BRCA1):c.643G>A (p.Glu215Lys)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1038775|NM_007294.4(BRCA1):c.1852A>T (p.Arg618Trp)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1038907|NM_007294.4(BRCA1):c.2089T>C (p.Phe697Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1039566|NM_007294.4(BRCA1):c.1473G>T (p.Gln491His)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1039705|NM_007294.4(BRCA1):c.1093A>G (p.Arg365Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1039797|NM_007294.4(BRCA1):c.1910C>G (p.Thr637Ser)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1039866|NM_007294.4(BRCA1):c.3789GAA[1] (p.Lys1264del)|Microsatellite|Uncertain significance|BRCA1|criteria provided, single submitter|17","1040071|NM_007294.4(BRCA1):c.662C>A (p.Ala221Glu)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1040298|NM_007294.4(BRCA1):c.2828A>G (p.Lys943Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1042273|NC_000017.10:g.(?_41276028)_(41276119_?)dup|Duplication|Uncertain significance|BRCA1|criteria provided, single submitter|17","1042860|NM_007294.4(BRCA1):c.3959C>G (p.Ser1320Cys)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1043747|NM_007294.4(BRCA1):c.4884G>A (p.Met1628Ile)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1044289|NM_007294.4(BRCA1):c.2595G>C (p.Lys865Asn)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1044675|NM_007294.4(BRCA1):c.4502G>A (p.Cys1501Tyr)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1044787|NM_007294.4(BRCA1):c.3551_3553del (p.Gly1184del)|Deletion|Uncertain significance|BRCA1|criteria provided, multiple submitters, no conflicts|17","1044896|NM_007294.4(BRCA1):c.428A>G (p.Glu143Gly)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1045169|NM_007294.4(BRCA1):c.449C>G (p.Thr150Ser)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1045652|NM_007294.4(BRCA1):c.2501G>C (p.Gly834Ala)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1046087|NM_007294.4(BRCA1):c.3653G>A (p.Ser1218Asn)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1046490|NM_007294.4(BRCA1):c.3565A>C (p.Ser1189Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1047210|NM_007294.4(BRCA1):c.1031C>G (p.Ala344Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17","1047334|NC_000017.10:g.(?_41256133)_(41276119_?)dup|Duplication|Uncertain significance|BRCA1|criteria provided, single submitter|17","1047505|NM_007294.4(BRCA1):c.404A>C (p.Lys135Thr)|single nucleotide variant|Uncertain significance|BRCA1|criteria provided, single submitter|17","1047709|NM_007294.4(BRCA1):c.1751C>T (p.Ala584Val)|single nucleotide variant|Conflicting classifications of pathogenicity|BRCA1|criteria provided, conflicting classifications|17"]}]}