{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:11364,10,HGNC:11364,128,3]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:11364","source":"HGNC:11364|signal transducer and activator of transcription 3","targets":["1005984|NM_139276.3(STAT3):c.2141C>T (p.Thr714Ile)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1012305|NM_139276.3(STAT3):c.1699A>G (p.Asn567Asp)|single nucleotide variant|Likely pathogenic|STAT3|criteria provided, single submitter|17","1021039|NM_139276.3(STAT3):c.1757T>C (p.Met586Thr)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, multiple submitters, no conflicts|17","1024431|NM_139276.3(STAT3):c.1264G>A (p.Gly422Ser)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1027740|NM_139276.3(STAT3):c.1129G>A (p.Ala377Thr)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1034544|NM_139276.3(STAT3):c.1925AGC[2] (p.Gln644del)|Microsatellite|Uncertain significance|STAT3|criteria provided, single submitter|17","1035701|NM_139276.3(STAT3):c.1066C>A (p.Pro356Thr)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1036929|NM_139276.3(STAT3):c.1110-10_1110-9del|Microsatellite|Likely benign|STAT3|criteria provided, single submitter|17","1039785|NM_139276.3(STAT3):c.1228C>T (p.His410Tyr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1041284|NM_139276.3(STAT3):c.1084C>T (p.Leu362Phe)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1044262|NM_139276.3(STAT3):c.406G>T (p.Val136Leu)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1045933|NM_139276.3(STAT3):c.2303C>T (p.Ser768Phe)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1046071|NM_139276.3(STAT3):c.377G>A (p.Gly126Glu)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1055052|NM_139276.3(STAT3):c.2271T>G (p.Phe757Leu)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1056747|NM_139276.3(STAT3):c.195C>A (p.Asp65Glu)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1057969|NM_139276.3(STAT3):c.1827A>T (p.Arg609Ser)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1058933|NM_139276.3(STAT3):c.618G>A (p.Met206Ile)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1060656|NM_139276.3(STAT3):c.1120G>T (p.Asp374Tyr)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1063518|NM_139276.3(STAT3):c.2138T>C (p.Val713Ala)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1067042|NM_139276.3(STAT3):c.1182G>A (p.Met394Ile)|single nucleotide variant|Likely pathogenic|STAT3|criteria provided, single submitter|17","1067430|NM_139276.3(STAT3):c.1924A>G (p.Lys642Glu)|single nucleotide variant|Likely pathogenic|STAT3|criteria provided, single submitter|17","1068485|NM_139276.3(STAT3):c.1859C>G (p.Thr620Ser)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1078676|NM_139276.3(STAT3):c.627G>A (p.Ala209=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1085703|NM_139276.3(STAT3):c.1749-12C>G|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1086778|NM_139276.3(STAT3):c.1366-4G>A|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1094945|NM_139276.3(STAT3):c.129-13T>C|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1096355|NM_139276.3(STAT3):c.366G>A (p.Ala122=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1098258|NM_139276.3(STAT3):c.1365+8C>G|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1099997|NM_139276.3(STAT3):c.551-77ATTCCCTCAGGTCAAGGAGT[2]|Microsatellite|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1102900|NM_139276.3(STAT3):c.1059C>T (p.Val353=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1104899|NM_139276.3(STAT3):c.1110-6T>C|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1108326|NM_139276.3(STAT3):c.327G>A (p.Leu109=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1113558|NM_139276.3(STAT3):c.129-4C>G|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1122248|NM_139276.3(STAT3):c.247C>T (p.Leu83=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1122406|NM_139276.3(STAT3):c.27G>A (p.Gln9=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1123951|NM_139276.3(STAT3):c.1234-7C>T|single nucleotide variant|Benign/Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1124567|NM_139276.3(STAT3):c.1230C>T (p.His410=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1125665|NM_139276.3(STAT3):c.2145-5dup|Duplication|Likely benign|STAT3|criteria provided, single submitter|17","1127477|NM_139276.3(STAT3):c.303T>C (p.Ile101=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1131787|NM_139276.3(STAT3):c.537C>T (p.Leu179=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1133829|NM_139276.3(STAT3):c.51G>A (p.Gln17=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1139892|NM_139276.3(STAT3):c.990C>T (p.Pro330=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1140484|NM_139276.3(STAT3):c.2064G>A (p.Arg688=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1141937|NM_139276.3(STAT3):c.128+20C>T|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1143403|NM_139276.3(STAT3):c.1122C>T (p.Asp374=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1149916|NM_139276.3(STAT3):c.312T>C (p.Ile104=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1152705|NM_139276.3(STAT3):c.2298T>C (p.Ala766=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1152953|NM_139276.3(STAT3):c.1888+7G>A|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1155302|NM_139276.3(STAT3):c.1601-8_1601-7insG|Insertion|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1158024|NM_139276.3(STAT3):c.1377G>A (p.Leu459=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1159249|NM_139276.3(STAT3):c.1917A>G (p.Pro639=)|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1165995|NM_139276.3(STAT3):c.551-137_551-18del|Deletion|Benign|STAT3|criteria provided, single submitter|17","1166806|NM_139276.3(STAT3):c.1049+452C>A|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1169481|NM_139276.3(STAT3):c.513C>T (p.Asp171=)|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1170478|NM_139276.3(STAT3):c.1743C>T (p.Asn581=)|single nucleotide variant|Benign/Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1172909|NM_139276.3(STAT3):c.1229A>G (p.His410Arg)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1176687|NM_139276.3(STAT3):c.1177G>T (p.Val393Leu)|single nucleotide variant|Likely pathogenic|STAT3|criteria provided, single submitter|17","1179307|NM_139276.3(STAT3):c.797+156C>A|single nucleotide variant|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1179517|NM_139276.3(STAT3):c.1888+205A>G|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1192236|NM_139276.3(STAT3):c.1852G>C (p.Gly618Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|STAT3|criteria provided, conflicting classifications|17","1192237|NM_139276.3(STAT3):c.1840A>C (p.Ser614Arg)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, multiple submitters, no conflicts|17","1196369|NM_139276.3(STAT3):c.273+22A>G|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1197563|NM_139276.3(STAT3):c.551-84_551-25del|Deletion|Likely benign|STAT3|criteria provided, single submitter|17","1205076|NM_139276.3(STAT3):c.551-84C>A|single nucleotide variant|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1208667|NM_139276.3(STAT3):c.128+64T>C|single nucleotide variant|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1212941|NM_139276.3(STAT3):c.2144+1G>A|single nucleotide variant|Conflicting classifications of pathogenicity|STAT3|criteria provided, conflicting classifications|17","1213392|NM_139276.3(STAT3):c.273+145T>C|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1216553|NM_139276.3(STAT3):c.2144+74T>C|single nucleotide variant|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1217055|NM_139276.3(STAT3):c.2102-79G>A|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1219373|NM_139276.3(STAT3):c.2257+31A>G|single nucleotide variant|Likely benign|STAT3|criteria provided, single submitter|17","1220339|NM_139276.3(STAT3):c.274-128C>G|single nucleotide variant|Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1223138|NM_139276.3(STAT3):c.468+58del|Deletion|Benign/Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1224098|NM_139276.3(STAT3):c.274-165C>T|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1230307|NM_139276.3(STAT3):c.1282-21G>A|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1233827|NM_139276.3(STAT3):c.1233+43C>G|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1233989|NM_139276.3(STAT3):c.273+314A>G|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1238352|NM_139276.3(STAT3):c.274-160G>C|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1239006|NM_139276.3(STAT3):c.1281+258T>A|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1241822|NM_139276.3(STAT3):c.372+147dup|Duplication|Benign|STAT3|criteria provided, single submitter|17","1241894|NM_139276.3(STAT3):c.645+40C>G|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1245407|NM_139276.3(STAT3):c.1282-93C>T|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1245519|NM_139276.3(STAT3):c.2257+318C>T|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1246460|NM_139276.3(STAT3):c.468+42dup|Duplication|Benign|STAT3|criteria provided, single submitter|17","1246980|NM_139276.3(STAT3):c.1600+191G>A|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1250621|NM_139276.3(STAT3):c.1282-253C>T|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1252217|NM_139276.3(STAT3):c.1282-162T>A|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1253696|NM_139276.3(STAT3):c.1600+62G>C|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1266273|NM_139276.3(STAT3):c.274-234_274-233dup|Duplication|Benign|STAT3|criteria provided, single submitter|17","1266337|NM_139276.3(STAT3):c.274-234dup|Duplication|Benign|STAT3|criteria provided, single submitter|17","1269237|NM_139276.3(STAT3):c.1281+33del|Deletion|Benign|STAT3|criteria provided, single submitter|17","1292777|NM_139276.3(STAT3):c.274-234_274-232dup|Duplication|Benign|STAT3|criteria provided, single submitter|17","1292786|NM_139276.3(STAT3):c.1600+162G>A|single nucleotide variant|Benign|STAT3|criteria provided, single submitter|17","1294243|NM_139276.3(STAT3):c.274-164C>G|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1294245|NM_139276.3(STAT3):c.274-153G>A|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1294247|NM_139276.3(STAT3):c.1109+24G>T|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1294248|NM_139276.3(STAT3):c.1464+35A>T|single nucleotide variant|Benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1300285|NM_139276.3(STAT3):c.1365+143_1365+146del|Deletion|Benign/Likely benign|STAT3|criteria provided, multiple submitters, no conflicts|17","1305948|NM_139276.3(STAT3):c.1303G>A (p.Glu435Lys)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17","1307011|NM_139276.3(STAT3):c.82A>G (p.Met28Val)|single nucleotide variant|Conflicting classifications of pathogenicity|STAT3|criteria provided, conflicting classifications|17","1307644|NM_139276.3(STAT3):c.2248G>C (p.Gly750Arg)|single nucleotide variant|Uncertain significance|STAT3|criteria provided, single submitter|17"]}]}