{"context":{"query":">>hgnc>>clinvar[germline_classification==\"Pathogenic\"]","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":43,"mapped":1},"pagination":{"has_next":false},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:11364","source":"HGNC:11364|signal transducer and activator of transcription 3","targets":["1005984|NM_139276.3(STAT3):c.2141C>T (p.Thr714Ile)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1039785|NM_139276.3(STAT3):c.1228C>T (p.His410Tyr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1068485|NM_139276.3(STAT3):c.1859C>G (p.Thr620Ser)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1398166|NM_139276.3(STAT3):c.1110-2A>G|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1429110|NM_139276.3(STAT3):c.2116C>A (p.Leu706Met)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1429145|NM_139276.3(STAT3):c.1915C>G (p.Pro639Ala)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","144030|NM_139276.3(STAT3):c.1175A>G (p.Lys392Arg)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","144031|NM_139276.3(STAT3):c.1938C>G (p.Asn646Lys)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","144032|NM_139276.3(STAT3):c.1974G>C (p.Lys658Asn)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","1705748|NM_139276.3(STAT3):c.1910T>C (p.Val637Ala)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","1800571|NM_139276.3(STAT3):c.988C>T (p.Pro330Ser)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","1804642|NM_139276.3(STAT3):c.985A>G (p.Met329Val)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","1804643|NM_139276.3(STAT3):c.1858A>G (p.Thr620Ala)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","18303|NM_139276.3(STAT3):c.1384GTG[1] (p.Val463del)|Microsatellite|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","18304|NM_139276.3(STAT3):c.1144C>T (p.Arg382Trp)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","18305|NM_139276.3(STAT3):c.1145G>A (p.Arg382Gln)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","18306|NM_139276.3(STAT3):c.1268G>A (p.Arg423Gln)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","18307|NM_139276.3(STAT3):c.1145G>T (p.Arg382Leu)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","18308|NM_139276.3(STAT3):c.1909G>A (p.Val637Met)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","2099076|NM_139276.3(STAT3):c.1145G>C (p.Arg382Pro)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2138013|NM_139276.3(STAT3):c.1915C>A (p.Pro639Thr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2138015|NM_139276.3(STAT3):c.1907C>A (p.Ser636Tyr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2138016|NM_139276.3(STAT3):c.1865C>T (p.Thr622Ile)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2169593|NM_139276.3(STAT3):c.1934T>A (p.Leu645Gln)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","224843|NM_139276.3(STAT3):c.1032G>C (p.Gln344His)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","224846|NM_139276.3(STAT3):c.454C>T (p.Arg152Trp)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","224847|NM_139276.3(STAT3):c.1057G>T (p.Val353Phe)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","224848|NM_139276.3(STAT3):c.2147C>T (p.Thr716Met)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","224849|NM_139276.3(STAT3):c.1260T>G (p.Asn420Lys)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","224850|NM_139276.3(STAT3):c.2107G>A (p.Ala703Thr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2308162|NM_139276.3(STAT3):c.995A>T (p.His332Leu)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2925614|NM_139276.3(STAT3):c.1907C>T (p.Ser636Phe)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2925616|NM_139276.3(STAT3):c.1181T>C (p.Met394Thr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","2940006|NM_139276.3(STAT3):c.2137G>T (p.Val713Leu)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","3391073|NM_139276.3(STAT3):c.1309C>T (p.His437Tyr)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","3759433|NM_139276.3(STAT3):c.2137G>C (p.Val713Leu)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","418505|NM_139276.3(STAT3):c.1397A>G (p.Asn466Ser)|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","430904|NM_139276.3(STAT3):c.1853G>A (p.Gly618Asp)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","476197|NM_139276.3(STAT3):c.986T>A (p.Met329Lys)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","636714|NM_139276.3(STAT3):c.1139+1G>T|single nucleotide variant|Pathogenic|STAT3|criteria provided, multiple submitters, no conflicts|17","64689|NM_139276.3(STAT3):c.1166C>T (p.Thr389Ile)|single nucleotide variant|Pathogenic|STAT3|no assertion criteria provided|17","664121|NM_139276.3(STAT3):c.1311C>A (p.His437Gln)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17","850251|NM_139276.3(STAT3):c.833G>A (p.Arg278His)|single nucleotide variant|Pathogenic|STAT3|criteria provided, single submitter|17"]}]}