{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:11998,10,HGNC:11998,174,2]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:11998","source":"HGNC:11998|tumor protein p53","targets":["1000372|NM_000546.6(TP53):c.376-3C>G|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1001614|NM_000546.6(TP53):c.880G>A (p.Glu294Lys)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1002444|NM_000546.6(TP53):c.1176_1177insCCCTGGGGCGACTCTCAGGTGAGCACCACCCCCACACAGAGCTGCTCAGCTACTCAGACCGCGCATTCTGCAAATGCAGGCTCTGGAACGTTGGAGGCTATNNNNNNNNNNAAAAAAAAAAGAAGGGCCTGACTCA (p.Asp393delinsProTrpGlyAspSerGlnValSerThrThrProThrGlnSerCysSerAlaThrGlnThrAlaHisSerAlaAsnAlaGlySerGlyThrLeuGluAlaXaaXaaXaaXaaLysLysLysArgArgAlaTer)|Insertion|Uncertain significance|TP53|criteria provided, single submitter|17","1004021|NM_000546.6(TP53):c.598_636dup (p.Asn200_Phe212dup)|Duplication|Uncertain significance|TP53|criteria provided, single submitter|17","1005517|NM_000546.6(TP53):c.795G>A (p.Leu265=)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1005829|NM_000546.6(TP53):c.409C>G (p.Leu137Val)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1005876|NM_000546.6(TP53):c.464C>T (p.Thr155Ile)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1006477|NM_000546.6(TP53):c.874A>G (p.Lys292Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1006876|NC_000017.10:g.(?_7589449)_(7591611_?)dup|Duplication|Uncertain significance|TP53|criteria provided, single submitter|17","100814|NM_000546.6(TP53):c.587G>T (p.Arg196Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","100815|NM_000546.6(TP53):c.736A>G (p.Met246Val)|single nucleotide variant|Pathogenic/Likely pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","100816|NM_000546.6(TP53):c.887A>G (p.His296Arg)|single nucleotide variant|Likely pathogenic|TP53|no assertion criteria provided|17","1008811|NM_000546.6(TP53):c.842_844dup (p.Asp281_Arg282insHis)|Duplication|Uncertain significance|TP53|criteria provided, single submitter|17","1009024|NM_000546.6(TP53):c.313_360dup (p.Gly105_Lys120dup)|Duplication|Likely pathogenic|TP53|criteria provided, single submitter|17","1009427|NM_000546.6(TP53):c.944C>T (p.Ser315Phe)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1011474|NM_000546.6(TP53):c.340T>G (p.Leu114Val)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1012210|NM_000546.6(TP53):c.825T>A (p.Cys275Ter)|single nucleotide variant|Pathogenic|TP53|criteria provided, single submitter|17","1013724|NM_000546.6(TP53):c.96+6G>A|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1014638|NC_000017.10:g.(?_7578129)_(7593029_?)dup|Duplication|Uncertain significance|TP53|criteria provided, single submitter|17","1015039|NM_000546.6(TP53):c.595G>A (p.Gly199Arg)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1015453|NM_000546.6(TP53):c.1027G>C (p.Glu343Gln)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1016947|NM_000546.6(TP53):c.43A>C (p.Ser15Arg)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1018290|NM_000546.6(TP53):c.402T>G (p.Phe134Leu)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1019369|NM_000546.6(TP53):c.632C>G (p.Thr211Ser)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1019612|NM_000546.6(TP53):c.1009C>A (p.Arg337Ser)|single nucleotide variant|Likely pathogenic|TP53|reviewed by expert panel|17","1020042|NM_000546.6(TP53):c.559+3G>A|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1020154|NM_000546.6(TP53):c.1020G>A (p.Met340Ile)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1020758|NM_000546.6(TP53):c.911C>T (p.Thr304Ile)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1021578|NM_000546.6(TP53):c.371G>C (p.Cys124Ser)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1021579|NM_000546.6(TP53):c.244C>T (p.Pro82Ser)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1021706|NM_000546.6(TP53):c.875A>C (p.Lys292Thr)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1021810|NM_000546.6(TP53):c.978A>T (p.Glu326Asp)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1021934|NM_000546.6(TP53):c.568C>G (p.Pro190Ala)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1023582|NM_000546.6(TP53):c.919+5G>A|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1023676|NM_000546.6(TP53):c.1135del (p.Arg379fs)|Deletion|Uncertain significance|TP53|criteria provided, single submitter|17","1024017|NM_000546.6(TP53):c.571C>T (p.Pro191Ser)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1024056|NM_000546.6(TP53):c.687_695del (p.Thr230_Ile232del)|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1024359|NM_000546.6(TP53):c.909C>G (p.Ser303Arg)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1024481|NM_000546.6(TP53):c.375+3_375+11del|Deletion|Uncertain significance|TP53|criteria provided, single submitter|17","1024800|NM_000546.6(TP53):c.988C>T (p.Leu330Phe)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1024822|NM_000546.6(TP53):c.862A>G (p.Asn288Asp)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1026335|NM_000546.6(TP53):c.476C>A (p.Ala159Asp)|single nucleotide variant|Pathogenic/Likely pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","1026336|NM_000546.6(TP53):c.289G>A (p.Val97Ile)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1026463|NM_000546.6(TP53):c.1179C>G (p.Asp393Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1026715|NM_000546.6(TP53):c.685T>G (p.Cys229Gly)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1027110|NM_000546.6(TP53):c.434T>G (p.Leu145Arg)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1035024|NM_000546.6(TP53):c.115G>A (p.Ala39Thr)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1035039|NM_000546.6(TP53):c.74+3G>A|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1036023|NM_000546.6(TP53):c.623A>T (p.Asp208Val)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1036209|NM_000546.6(TP53):c.575A>C (p.Gln192Pro)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1036853|NM_000546.6(TP53):c.719G>T (p.Ser240Ile)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1039474|NM_000546.6(TP53):c.292C>G (p.Pro98Ala)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1041303|NC_000017.10:g.(?_7571752)_(7579912_?)dup|Duplication|Uncertain significance|TP53|criteria provided, single submitter|17","1041304|NC_000017.10:g.(?_7576843)_(7593029_?)dup|Duplication|Uncertain significance|TP53|criteria provided, single submitter|17","1042468|NM_000546.6(TP53):c.838_840delinsCTC (p.Arg280Leu)|Indel|Uncertain significance|TP53|criteria provided, single submitter|17","1043464|NM_000546.6(TP53):c.97T>A (p.Ser33Thr)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1045295|NM_000546.6(TP53):c.653_655del (p.Val218_Pro219delinsAla)|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1046409|NM_000546.6(TP53):c.1100+3G>A|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1046623|NM_000546.6(TP53):c.1064C>G (p.Ala355Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1047514|NM_000546.6(TP53):c.904G>A (p.Gly302Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|TP53|criteria provided, conflicting classifications|17","1050359|NM_000546.6(TP53):c.731del (p.Gly244fs)|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1051765|NM_000546.6(TP53):c.559+6C>T|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1052035|NM_000546.6(TP53):c.737_745del (p.Met246_Arg248del)|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1052297|NM_000546.6(TP53):c.1118del (p.Lys373fs)|Deletion|Uncertain significance|TP53|reviewed by expert panel|17","1053218|NM_000546.6(TP53):c.412G>A (p.Ala138Thr)|single nucleotide variant|Uncertain significance|TP53|reviewed by expert panel|17","1053765|NM_000546.6(TP53):c.754C>T (p.Leu252Phe)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1053808|NM_000546.6(TP53):c.640C>T (p.His214Tyr)|single nucleotide variant|Uncertain significance|TP53|reviewed by expert panel|17","1054035|NM_000546.6(TP53):c.326T>A (p.Phe109Tyr)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1054765|NM_000546.6(TP53):c.377A>C (p.Tyr126Ser)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1055289|NM_000546.6(TP53):c.350G>C (p.Gly117Ala)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1055894|NM_000546.6(TP53):c.1025G>T (p.Arg342Leu)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1056982|NM_000546.6(TP53):c.782+5G>A|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1057941|NM_000546.6(TP53):c.392A>G (p.Asn131Ser)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1058186|NM_000546.6(TP53):c.522G>C (p.Arg174Ser)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1058730|NM_000546.6(TP53):c.455C>A (p.Pro152Gln)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1059163|NM_000546.6(TP53):c.301A>G (p.Lys101Glu)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1059222|NM_000546.6(TP53):c.1113del (p.Lys373fs)|Deletion|Uncertain significance|TP53|criteria provided, single submitter|17","1059527|NM_000546.6(TP53):c.1118A>T (p.Lys373Met)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1060593|NM_000546.6(TP53):c.672+3C>T|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1061283|NM_000546.6(TP53):c.1060C>G (p.Gln354Glu)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1061526|NM_000546.6(TP53):c.871A>C (p.Lys291Gln)|single nucleotide variant|Uncertain significance|TP53|criteria provided, single submitter|17","1061739|NM_000546.6(TP53):c.598A>G (p.Asn200Asp)|single nucleotide variant|Uncertain significance|TP53|criteria provided, multiple submitters, no conflicts|17","1066203|NM_000546.6(TP53):c.934_992dup (p.Ile332fs)|Duplication|Likely pathogenic|TP53|criteria provided, single submitter|17","1066207|NM_000546.6(TP53):c.1052del (p.Lys351fs)|Deletion|Likely pathogenic|TP53|criteria provided, single submitter|17","1066819|NC_000017.10:g.(?_7571752)_(7574043_?)del|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1066930|NM_000546.6(TP53):c.1043del (p.Leu348fs)|Deletion|Likely pathogenic|TP53|criteria provided, single submitter|17","1067373|NM_000546.6(TP53):c.96+1del|Deletion|Likely pathogenic|TP53|criteria provided, single submitter|17","1067825|NM_000546.6(TP53):c.509_520del (p.Thr170_Val173del)|Deletion|Pathogenic/Likely pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","1067910|NM_000546.6(TP53):c.472C>A (p.Arg158Ser)|single nucleotide variant|Pathogenic|TP53|criteria provided, single submitter|17","1068266|NM_000546.6(TP53):c.75-1G>A|single nucleotide variant|Likely pathogenic|TP53|criteria provided, single submitter|17","1068484|NM_000546.6(TP53):c.919+1del|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1068801|NM_000546.6(TP53):c.801del (p.Asn268fs)|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1068830|NM_000546.6(TP53):c.872_890dup (p.His297fs)|Duplication|Pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","1069164|NC_000017.10:g.(?_7571752)_(7579912_?)del|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1069165|NC_000017.10:g.(?_7579291)_(7579404_?)del|Deletion|Pathogenic|TP53|criteria provided, single submitter|17","1069225|NM_000546.6(TP53):c.425del (p.Pro142fs)|Deletion|Pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","1069253|NM_000546.6(TP53):c.268_269insGCCCCTCCTGGCCCCTGCCCCTGCCCCT (p.Ser90fs)|Microsatellite|Pathogenic|TP53|criteria provided, single submitter|17","1069265|NM_000546.6(TP53):c.403del (p.Cys135fs)|Deletion|Pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","1069305|NM_000546.6(TP53):c.702C>G (p.Tyr234Ter)|single nucleotide variant|Pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17","1070469|NM_000546.6(TP53):c.205del (p.Ala69fs)|Deletion|Pathogenic|TP53|criteria provided, multiple submitters, no conflicts|17"]}]}