{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:12687,10,HGNC:12687,114,2]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:12687","source":"HGNC:12687|von Hippel-Lindau tumor suppressor","targets":["1000024|NM_000551.4(VHL):c.97T>A (p.Ser33Thr)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1002447|NM_000551.4(VHL):c.20A>G (p.Asn7Ser)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1004248|NM_000551.4(VHL):c.131G>A (p.Gly44Asp)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1005487|NM_000551.4(VHL):c.29A>G (p.Glu10Gly)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1006593|NM_000551.4(VHL):c.118C>G (p.Pro40Ala)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1008452|NM_000551.4(VHL):c.122A>T (p.Glu41Val)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1011133|NM_000551.4(VHL):c.230G>C (p.Cys77Ser)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1016980|NM_000551.4(VHL):c.106G>A (p.Glu36Lys)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1017783|NM_000551.4(VHL):c.40G>A (p.Gly14Ser)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1018990|NM_000551.4(VHL):c.146G>T (p.Gly49Val)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1019042|NM_000551.4(VHL):c.93_122dup (p.Ala35_Gly44dup)|Duplication|Uncertain significance|VHL|criteria provided, single submitter|3","1020108|NM_000551.4(VHL):c.211C>T (p.Pro71Ser)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1020685|NM_000551.4(VHL):c.132C>T (p.Gly44=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1023005|NM_000551.4(VHL):c.190C>A (p.Arg64Ser)|single nucleotide variant|Likely pathogenic|VHL|criteria provided, single submitter|3","1023630|NM_000551.4(VHL):c.228C>G (p.Phe76Leu)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1025348|NM_000551.4(VHL):c.98C>T (p.Ser33Leu)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1027008|NM_000551.4(VHL):c.288G>T (p.Gln96His)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1035305|NM_000551.4(VHL):c.22_27dup (p.Trp8_Asp9dup)|Duplication|Uncertain significance|VHL|criteria provided, single submitter|3","1035388|NM_000551.4(VHL):c.127T>C (p.Ser43Pro)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1035620|NM_000551.4(VHL):c.327C>G (p.Ile109Met)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1035825|NM_000551.4(VHL):c.7C>G (p.Arg3Gly)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1037470|NM_000551.4(VHL):c.295C>G (p.Pro99Ala)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1039427|NM_000551.4(VHL):c.176C>A (p.Pro59Gln)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1040271|NM_000551.4(VHL):c.124G>C (p.Glu42Gln)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1041174|NM_000551.4(VHL):c.64G>A (p.Glu22Lys)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1042098|NM_000551.4(VHL):c.28G>C (p.Glu10Gln)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1042895|NM_000551.4(VHL):c.145G>C (p.Gly49Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1043302|NM_000551.4(VHL):c.125A>G (p.Glu42Gly)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1043787|NM_000551.4(VHL):c.124G>A (p.Glu42Lys)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1046403|NM_000551.4(VHL):c.279C>T (p.Gly93=)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1046424|NC_000003.11:g.(?_10191461)_(10191719_?)dup|Duplication|Uncertain significance|VHL|criteria provided, single submitter|3","1047144|NM_000551.4(VHL):c.88G>C (p.Gly30Arg)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1052300|NM_000551.4(VHL):c.51G>T (p.Glu17Asp)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1052912|NM_000551.4(VHL):c.38_52del (p.Val13_Glu17del)|Deletion|Uncertain significance|VHL|criteria provided, single submitter|3","1054464|NM_000551.4(VHL):c.329A>G (p.His110Arg)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1055280|NM_000551.4(VHL):c.340+4C>T|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1055853|NM_000551.4(VHL):c.35A>G (p.Glu12Gly)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1056027|NC_000003.11:g.(?_10183522)_(10188330_?)dup|Duplication|Uncertain significance|VHL|criteria provided, single submitter|3","1057750|NM_000551.4(VHL):c.314C>T (p.Thr105Met)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1059402|NM_000551.4(VHL):c.205C>T (p.Arg69Cys)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1059764|NM_000551.4(VHL):c.16G>T (p.Glu6Ter)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1068142|NM_000551.4(VHL):c.241C>G (p.Pro81Ala)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1070179|NM_000551.4(VHL):c.239G>A (p.Ser80Asn)|single nucleotide variant|Pathogenic/Likely pathogenic|VHL|criteria provided, multiple submitters, no conflicts|3","1071196|NM_000551.4(VHL):c.244_259dup (p.Val87fs)|Duplication|Pathogenic|VHL|criteria provided, single submitter|3","1072069|NM_000551.4(VHL):c.241_244dup (p.Arg82fs)|Duplication|Pathogenic|VHL|criteria provided, single submitter|3","1073436|NC_000003.11:g.(?_10183532)_(10188330_?)del|Deletion|Pathogenic|VHL|criteria provided, single submitter|3","1076108|NM_000551.4(VHL):c.298del (p.Thr100fs)|Deletion|Pathogenic|VHL|criteria provided, single submitter|3","1077591|NM_000551.4(VHL):c.309T>C (p.Pro103=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1081013|NM_000551.4(VHL):c.177G>A (p.Pro59=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1081035|NM_000551.4(VHL):c.171G>C (p.Gly57=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1103013|NM_000551.4(VHL):c.306G>T (p.Pro102=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1103811|NM_000551.4(VHL):c.9G>T (p.Arg3=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1105331|NM_000551.4(VHL):c.303G>A (p.Leu101=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1107773|NM_000551.4(VHL):c.327C>A (p.Ile109=)|single nucleotide variant|Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1118561|NM_000551.4(VHL):c.45G>C (p.Ala15=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1119280|NM_000551.4(VHL):c.186_187delinsTT (p.Val62_Leu63=)|Indel|Likely benign|VHL|criteria provided, single submitter|3","1120822|NM_000551.4(VHL):c.222C>T (p.Val74=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1123324|NM_000551.4(VHL):c.180G>C (p.Arg60=)|single nucleotide variant|Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1123711|NM_000551.4(VHL):c.135G>C (p.Pro45=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1128655|NM_000551.4(VHL):c.315G>T (p.Thr105=)|single nucleotide variant|Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1133372|NM_000551.4(VHL):c.300G>A (p.Thr100=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1137865|NM_000551.4(VHL):c.207C>G (p.Arg69=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1138466|NM_000551.4(VHL):c.15G>A (p.Ala5=)|single nucleotide variant|Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1147379|NM_000551.4(VHL):c.237C>T (p.Arg79=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1148417|NM_000551.4(VHL):c.63A>G (p.Glu21=)|single nucleotide variant|Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1149942|NM_000551.4(VHL):c.300G>T (p.Thr100=)|single nucleotide variant|Benign/Likely benign|VHL|criteria provided, multiple submitters, no conflicts|3","1157043|NM_000551.4(VHL):c.18G>A (p.Glu6=)|single nucleotide variant|Likely benign|VHL|criteria provided, single submitter|3","1178859|NM_000551.4(VHL):c.-530G>C|single nucleotide variant|Benign|VHL|criteria provided, multiple submitters, no conflicts|3","1267817|NC_000003.12:g.10141569_10141571dup|Duplication|Benign|VHL|criteria provided, single submitter|3","1274684|NM_000551.4(VHL):c.-258C>T|single nucleotide variant|Benign|VHL|criteria provided, multiple submitters, no conflicts|3","1290627|NM_000551.4(VHL):c.-45C>A|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1292417|NC_000003.12:g.10141570_10141571dup|Duplication|Benign|VHL|criteria provided, single submitter|3","1297059|NM_000551.4(VHL):c.244C>G (p.Arg82Gly)|single nucleotide variant|Pathogenic|VHL|criteria provided, single submitter|3","1303980|NM_000551.4(VHL):c.111G>C (p.Glu37Asp)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1311090|NM_000551.4(VHL):c.-15_4delinsCGGCCCGGGTGGTCTGGTCTCCG (p.Met1fs)|Indel|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1311412|NM_000551.4(VHL):c.212C>T (p.Pro71Leu)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1313664|NM_000551.4(VHL):c.13_31dup (p.Ala11fs)|Duplication|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1314230|NM_000551.4(VHL):c.242C>A (p.Pro81Gln)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1326284|NM_000551.4(VHL):c.284C>G (p.Pro95Arg)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","132707|NM_000551.4(VHL):c.104C>A (p.Ala35Asp)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1337521|NM_000551.3(VHL):c.-122T>C|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1337837|NM_000551.3(VHL):c.-110C>G|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1346071|NM_000551.4(VHL):c.148G>C (p.Ala50Pro)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1350346|NM_000551.4(VHL):c.49G>A (p.Glu17Lys)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","135405|NM_000551.4(VHL):c.119C>T (p.Pro40Leu)|single nucleotide variant|Benign|VHL|reviewed by expert panel|3","135406|NM_000551.4(VHL):c.3G>A (p.Met1Ile)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","135951|NM_000551.4(VHL):c.183C>G (p.Pro61=)|single nucleotide variant|Benign|VHL|reviewed by expert panel|3","135952|NM_000551.4(VHL):c.191G>A (p.Arg64His)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","135953|NM_000551.4(VHL):c.25G>A (p.Asp9Asn)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","135954|NM_000551.4(VHL):c.274G>T (p.Asp92Tyr)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","135955|NM_000551.4(VHL):c.280G>A (p.Glu94Lys)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1371900|NM_000551.4(VHL):c.143T>A (p.Leu48Gln)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","1372717|NM_000551.4(VHL):c.70G>C (p.Gly24Arg)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1373310|NM_000551.4(VHL):c.118C>T (p.Pro40Ser)|single nucleotide variant|Uncertain significance|VHL|criteria provided, multiple submitters, no conflicts|3","1375111|NM_000551.4(VHL):c.163G>C (p.Glu55Gln)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1377127|NM_000551.4(VHL):c.159G>C (p.Glu53Asp)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","1378852|NM_000551.4(VHL):c.67T>C (p.Tyr23His)|single nucleotide variant|Uncertain significance|VHL|criteria provided, single submitter|3","137904|NM_000551.4(VHL):c.-35G>A|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3","137905|NM_000551.4(VHL):c.246C>T (p.Arg82=)|single nucleotide variant|Benign|VHL|reviewed by expert panel|3","1380616|NM_000551.4(VHL):c.158A>G (p.Glu53Gly)|single nucleotide variant|Conflicting classifications of pathogenicity|VHL|criteria provided, conflicting classifications|3"]}]}