{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:3430,10,HGNC:3430,14,3]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:3430","source":"HGNC:3430|erb-b2 receptor tyrosine kinase 2","targets":["1000168|NM_004448.4(ERBB2):c.688C>T (p.Pro230Ser)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1001093|NM_004448.4(ERBB2):c.856G>C (p.Glu286Gln)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1002037|NM_004448.4(ERBB2):c.3521C>G (p.Ser1174Cys)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1006720|NM_004448.4(ERBB2):c.641G>T (p.Ser214Ile)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1008875|NM_004448.4(ERBB2):c.3763G>T (p.Val1255Leu)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1023323|NM_004448.4(ERBB2):c.298C>T (p.Arg100Trp)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1034543|NM_004448.4(ERBB2):c.3332G>A (p.Arg1111Gln)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1034734|NM_004448.4(ERBB2):c.1138A>G (p.Ser380Gly)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17","1037902|NM_004448.4(ERBB2):c.3662A>G (p.Tyr1221Cys)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1038878|NM_004448.4(ERBB2):c.1990G>T (p.Val664Phe)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1040825|NM_004448.4(ERBB2):c.3308C>T (p.Thr1103Ile)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17","1041144|NM_004448.4(ERBB2):c.3430G>C (p.Asp1144His)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1042421|NM_004448.4(ERBB2):c.874G>A (p.Gly292Ser)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1043905|NM_004448.4(ERBB2):c.3086G>C (p.Gly1029Ala)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1047031|NC_000017.10:g.(?_37856492)_(37884297_?)dup|Duplication|Uncertain significance|ERBB2|criteria provided, single submitter|17","1050529|NM_004448.4(ERBB2):c.1607G>A (p.Arg536Gln)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1052661|NM_004448.4(ERBB2):c.1366C>T (p.Arg456Cys)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1055517|NM_004448.4(ERBB2):c.343G>A (p.Ala115Thr)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1055879|NM_004448.4(ERBB2):c.1738-7C>A|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1060583|NM_004448.4(ERBB2):c.2431C>T (p.Arg811Trp)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1060897|NM_004448.4(ERBB2):c.3436C>T (p.Arg1146Trp)|single nucleotide variant|Conflicting classifications of pathogenicity|ERBB2|criteria provided, conflicting classifications|17","1063270|NM_004448.4(ERBB2):c.2493+5G>A|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1078249|NM_004448.4(ERBB2):c.1713T>C (p.Asn571=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1083155|NM_004448.4(ERBB2):c.3453G>A (p.Ser1151=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","1087913|NM_004448.4(ERBB2):c.1898+10A>G|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1088543|NM_004448.4(ERBB2):c.1065A>G (p.Ala355=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1094869|NM_004448.4(ERBB2):c.3081G>A (p.Gln1027=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1095139|NM_004448.4(ERBB2):c.2724T>C (p.Tyr908=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1095140|NM_004448.4(ERBB2):c.3036T>C (p.Asp1012=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1096647|NM_004448.4(ERBB2):c.3651C>T (p.Phe1217=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1096756|NM_004448.4(ERBB2):c.3268C>T (p.Leu1090=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1097100|NM_004448.4(ERBB2):c.3540C>T (p.Val1180=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1098011|NM_004448.4(ERBB2):c.226-5C>T|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1098250|NM_004448.4(ERBB2):c.1646+10G>A|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1101353|NM_004448.4(ERBB2):c.2914T>C (p.Leu972=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1102360|NM_004448.4(ERBB2):c.3160-8G>A|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1104608|NM_004448.4(ERBB2):c.1659G>A (p.Glu553=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1104738|NM_004448.4(ERBB2):c.1317C>T (p.Gly439=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1105229|NM_004448.4(ERBB2):c.816C>A (p.Val272=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1108038|NM_004448.4(ERBB2):c.3591G>A (p.Leu1197=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1113820|NM_004448.4(ERBB2):c.717G>A (p.Gln239=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1114576|NM_004448.4(ERBB2):c.81C>T (p.Thr27=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1114683|NM_004448.4(ERBB2):c.111C>A (p.Ala37=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1115477|NM_004448.4(ERBB2):c.1269C>T (p.Ser423=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1116809|NM_004448.4(ERBB2):c.2769C>T (p.Tyr923=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1117006|NM_004448.4(ERBB2):c.2307+7C>T|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1121686|NM_004448.4(ERBB2):c.768C>T (p.Leu256=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1124069|NM_004448.4(ERBB2):c.2172G>A (p.Lys724=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1124151|NM_004448.4(ERBB2):c.1389T>C (p.Ser463=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1126287|NM_004448.4(ERBB2):c.1746C>T (p.Asp582=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1127418|NM_004448.4(ERBB2):c.3396C>T (p.Thr1132=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1127936|NM_004448.4(ERBB2):c.808G>T (p.Ala270Ser)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1128796|NM_004448.4(ERBB2):c.2400T>C (p.Leu800=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1129456|NM_004448.4(ERBB2):c.3741G>A (p.Glu1247=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1131250|NM_004448.4(ERBB2):c.675C>G (p.Ala225=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1132112|NM_004448.4(ERBB2):c.3441C>T (p.Pro1147=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1133563|NM_004448.4(ERBB2):c.3156C>G (p.Thr1052=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1138756|NM_004448.4(ERBB2):c.2786G>A (p.Arg929Gln)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1139316|NM_004448.4(ERBB2):c.760-10G>T|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1148678|NM_004448.4(ERBB2):c.2472C>T (p.Asn824=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1149226|NM_004448.4(ERBB2):c.2688C>T (p.Arg896=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","1149932|NM_004448.4(ERBB2):c.2536T>C (p.Leu846=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1150935|NM_004448.4(ERBB2):c.498G>C (p.Thr166=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1152158|NM_004448.4(ERBB2):c.735G>C (p.Thr245=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1153185|NM_004448.4(ERBB2):c.1947-8G>A|single nucleotide variant|Likely benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","1153702|NM_004448.4(ERBB2):c.74-5G>T|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1156898|NM_004448.4(ERBB2):c.2541C>T (p.Ala847=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","1159119|NM_004448.4(ERBB2):c.1725C>T (p.Thr575=)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","1164704|NM_004448.4(ERBB2):c.1416C>T (p.Thr472=)|single nucleotide variant|Benign|ERBB2|criteria provided, single submitter|17","1165633|NM_004448.4(ERBB2):c.1932C>T (p.Ala644=)|single nucleotide variant|Benign|ERBB2|criteria provided, single submitter|17","1166261|NM_004448.4(ERBB2):c.2379G>A (p.Thr793=)|single nucleotide variant|Benign|ERBB2|criteria provided, single submitter|17","1166658|NM_004448.4(ERBB2):c.3403C>T (p.Pro1135Ser)|single nucleotide variant|Benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","1167074|NM_004448.4(ERBB2):c.1467G>A (p.Pro489=)|single nucleotide variant|Benign|ERBB2|criteria provided, single submitter|17","1168005|NM_004448.4(ERBB2):c.1371A>G (p.Ser457=)|single nucleotide variant|Benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","1168696|NM_004448.4(ERBB2):c.3070C>T (p.Leu1024=)|single nucleotide variant|Benign|ERBB2|criteria provided, single submitter|17","1169362|NM_004448.4(ERBB2):c.3108C>T (p.Ala1036=)|single nucleotide variant|Benign|ERBB2|criteria provided, single submitter|17","1188812|NM_004448.4(ERBB2):c.2129C>T (p.Ala710Val)|single nucleotide variant|Pathogenic|ERBB2|no assertion criteria provided|17","1319104|NM_004448.4(ERBB2):c.760-5C>T|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","1319105|NM_004448.4(ERBB2):c.563G>A (p.Arg188His)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17","1319106|NM_004448.4(ERBB2):c.3149C>T (p.Ser1050Leu)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17","132944|NM_004448.4(ERBB2):c.2494-3C>T|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","132945|NM_004448.4(ERBB2):c.2506C>T (p.Leu836=)|single nucleotide variant|not provided|ERBB2|no classification provided|17","132946|NM_004448.4(ERBB2):c.2520G>A (p.Arg840=)|single nucleotide variant|not provided|ERBB2|no classification provided|17","132947|NM_004448.4(ERBB2):c.2568C>T (p.Pro856=)|single nucleotide variant|not provided|ERBB2|no classification provided|17","132948|NM_004448.4(ERBB2):c.2605C>T (p.Leu869=)|single nucleotide variant|not provided|ERBB2|no classification provided|17","132963|NM_004448.4(ERBB2):c.3146G>A (p.Ser1049Asn)|single nucleotide variant|not provided|ERBB2|no classification provided|17","133279|NM_004448.4(ERBB2):c.2535C>T (p.Asp845=)|single nucleotide variant|not provided|ERBB2|no classification provided|17","134067|NM_004448.4(ERBB2):c.43C>T (p.Leu15Phe)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","134068|NM_004448.4(ERBB2):c.1157C>A (p.Ala386Asp)|single nucleotide variant|Benign/Likely benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","134069|NM_004448.4(ERBB2):c.1169C>T (p.Ala390Val)|single nucleotide variant|not provided|ERBB2|no classification provided|17","134070|NM_004448.4(ERBB2):c.1231T>G (p.Tyr411Asp)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, single submitter|17","134071|NM_004448.4(ERBB2):c.1466C>T (p.Pro489Leu)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17","134072|NM_004448.4(ERBB2):c.1356G>T (p.Trp452Cys)|single nucleotide variant|Benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","134073|NM_004448.4(ERBB2):c.1793C>A (p.Ala598Asp)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17","134074|NM_004448.4(ERBB2):c.133A>G (p.Met45Val)|single nucleotide variant|not provided|ERBB2|no classification provided|17","134075|NM_004448.4(ERBB2):c.140G>A (p.Arg47His)|single nucleotide variant|Benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","134076|NM_004448.4(ERBB2):c.93G>T (p.Met31Ile)|single nucleotide variant|Likely benign|ERBB2|criteria provided, single submitter|17","134077|NM_004448.4(ERBB2):c.2440C>T (p.Arg814Cys)|single nucleotide variant|not provided|ERBB2|no classification provided|17","134078|NM_004448.4(ERBB2):c.2790G>T (p.Glu930Asp)|single nucleotide variant|Benign/Likely benign|ERBB2|criteria provided, multiple submitters, no conflicts|17","134079|NM_004448.4(ERBB2):c.3182T>C (p.Leu1061Pro)|single nucleotide variant|Uncertain significance|ERBB2|criteria provided, multiple submitters, no conflicts|17"]}]}