{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:427,10,HGNC:427,43,4]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:427","source":"HGNC:427|ALK receptor tyrosine kinase","targets":["1000122|NM_004304.5(ALK):c.4649T>C (p.Leu1550Pro)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1000590|NM_004304.5(ALK):c.2129T>G (p.Leu710Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1000602|NM_004304.5(ALK):c.4571A>G (p.Lys1524Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1000849|NM_004304.5(ALK):c.3260C>G (p.Thr1087Ser)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1000852|NM_004304.5(ALK):c.3154T>G (p.Phe1052Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1000895|NM_004304.5(ALK):c.2144G>A (p.Gly715Glu)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1001113|NM_004304.5(ALK):c.1118G>T (p.Arg373Ile)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1001211|NM_004304.5(ALK):c.1634G>A (p.Ser545Asn)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1001467|NM_004304.5(ALK):c.2192C>A (p.Thr731Asn)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1001771|NM_004304.5(ALK):c.4729T>C (p.Phe1577Leu)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002031|NM_004304.5(ALK):c.1027G>A (p.Glu343Lys)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1002096|NM_004304.5(ALK):c.2323G>T (p.Val775Phe)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002333|NM_004304.5(ALK):c.2032G>C (p.Asp678His)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002387|NM_004304.5(ALK):c.3055G>T (p.Val1019Phe)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002636|NM_004304.5(ALK):c.1375C>G (p.Gln459Glu)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1002687|NM_004304.5(ALK):c.1249del (p.Val417fs)|Deletion|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1002763|NM_004304.5(ALK):c.2032G>T (p.Asp678Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002785|NM_004304.5(ALK):c.3937T>C (p.Trp1313Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002872|NM_004304.5(ALK):c.4483T>A (p.Ser1495Thr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1002998|NM_004304.5(ALK):c.725C>T (p.Thr242Ile)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1003120|NM_004304.5(ALK):c.1825C>G (p.Leu609Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1003201|NM_004304.5(ALK):c.3067+9G>T|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1003664|NM_004304.5(ALK):c.4109C>G (p.Pro1370Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1003730|NM_004304.5(ALK):c.772C>T (p.His258Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1004009|NM_004304.5(ALK):c.3859G>A (p.Gly1287Ser)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1004608|NM_004304.5(ALK):c.3688G>A (p.Ala1230Thr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1004726|NM_004304.5(ALK):c.2488-6G>C|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1004861|NM_004304.5(ALK):c.3310T>A (p.Ser1104Thr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1005268|NM_004304.5(ALK):c.3938+3A>G|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1005283|NM_004304.5(ALK):c.3106A>G (p.Ile1036Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1005484|NM_004304.5(ALK):c.2543C>T (p.Ala848Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1005559|NM_004304.5(ALK):c.1085T>C (p.Ile362Thr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006044|NM_004304.5(ALK):c.844G>A (p.Asp282Asn)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006051|NM_004304.5(ALK):c.2731A>C (p.Lys911Gln)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006113|NM_004304.5(ALK):c.1690G>C (p.Val564Leu)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006168|NM_004304.5(ALK):c.1150C>T (p.His384Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006263|NM_004304.5(ALK):c.3653C>G (p.Pro1218Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1006268|NM_004304.5(ALK):c.2710C>T (p.His904Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006584|NM_004304.5(ALK):c.3743+3G>T|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006689|NM_004304.5(ALK):c.4652C>T (p.Pro1551Leu)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1006706|NM_004304.5(ALK):c.2881C>G (p.Pro961Ala)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1006725|NM_004304.5(ALK):c.487G>A (p.Val163Met)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1006905|NM_004304.5(ALK):c.4826T>C (p.Leu1609Pro)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1007159|NM_004304.5(ALK):c.474dup (p.Gly159fs)|Duplication|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1007209|NM_004304.5(ALK):c.1589A>G (p.Glu530Gly)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1007264|NM_004304.5(ALK):c.4844T>C (p.Met1615Thr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1007469|NM_004304.5(ALK):c.2281G>A (p.Gly761Ser)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1007540|NC_000002.11:g.(?_29917706)_(29940573_?)dup|Duplication|Uncertain significance|ALK|criteria provided, single submitter|2","1007946|NM_004304.5(ALK):c.4594A>T (p.Asn1532Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1008011|NM_004304.5(ALK):c.464T>A (p.Val155Asp)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1008443|NM_004304.5(ALK):c.1079G>A (p.Arg360Lys)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1008474|NM_004304.5(ALK):c.4655G>C (p.Gly1552Ala)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1008561|NM_004304.5(ALK):c.4294C>G (p.Arg1432Gly)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1008766|NM_004304.5(ALK):c.1766G>T (p.Gly589Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1008978|NM_004304.5(ALK):c.1262C>A (p.Ala421Asp)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1009087|NM_004304.5(ALK):c.3902del (p.Phe1301fs)|Deletion|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1009325|NM_004304.5(ALK):c.237G>T (p.Glu79Asp)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1009502|NM_004304.5(ALK):c.4529G>A (p.Trp1510Ter)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1009720|NM_004304.5(ALK):c.1155-9T>C|single nucleotide variant|Likely benign|ALK|criteria provided, single submitter|2","1009938|NM_004304.5(ALK):c.1656G>A (p.Met552Ile)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010130|NM_004304.5(ALK):c.1254C>A (p.Asp418Glu)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1010224|NM_004304.5(ALK):c.4226_4231del (p.Glu1409_Lys1410del)|Deletion|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010396|NM_004304.5(ALK):c.1571C>G (p.Thr524Ser)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1010479|NM_004304.5(ALK):c.2965C>T (p.His989Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010541|NM_004304.5(ALK):c.925del (p.Ala309fs)|Deletion|Uncertain significance|ALK|criteria provided, single submitter|2","1010622|NM_004304.5(ALK):c.3140C>G (p.Ala1047Gly)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1010773|NM_004304.5(ALK):c.2564C>T (p.Thr855Met)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010866|NM_004304.5(ALK):c.439G>A (p.Glu147Lys)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010914|NM_004304.5(ALK):c.2286C>G (p.Ile762Met)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010916|NM_004304.5(ALK):c.3359G>A (p.Arg1120Gln)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1010934|NM_004304.5(ALK):c.2420dup (p.Asn808fs)|Duplication|Uncertain significance|ALK|criteria provided, single submitter|2","1011027|NM_004304.5(ALK):c.4121C>A (p.Pro1374His)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1011171|NM_004304.5(ALK):c.4127T>A (p.Phe1376Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1011299|NM_004304.5(ALK):c.4151A>T (p.Glu1384Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1011315|NM_004304.5(ALK):c.2881_2885del (p.Pro961fs)|Deletion|Uncertain significance|ALK|criteria provided, single submitter|2","1011551|NM_004304.5(ALK):c.1637C>G (p.Ser546Cys)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1011650|NM_004304.5(ALK):c.2599G>A (p.Val867Ile)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1011652|NM_004304.5(ALK):c.110C>T (p.Pro37Leu)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1011920|NM_004304.5(ALK):c.2359A>G (p.Asn787Asp)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1012364|PRRC2B-ALK fusion|Translocation|other|ALK|criteria provided, single submitter|","1013961|NM_004304.5(ALK):c.1882A>G (p.Ile628Val)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1014027|NC_000002.12:g.29207270_29207273del|Deletion|Uncertain significance|ALK|criteria provided, single submitter|2","1014055|NM_004304.5(ALK):c.2993A>C (p.Asp998Ala)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1014087|NM_004304.5(ALK):c.4405C>T (p.Pro1469Ser)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1014221|NM_004304.5(ALK):c.2657A>T (p.Asn886Ile)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1014664|NM_004304.5(ALK):c.4247A>C (p.Lys1416Thr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1014679|NM_004304.5(ALK):c.3981T>G (p.Tyr1327Ter)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1015171|NM_004304.5(ALK):c.1036A>C (p.Thr346Pro)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1015251|NM_004304.5(ALK):c.4780G>A (p.Glu1594Lys)|single nucleotide variant|Conflicting classifications of pathogenicity|ALK|criteria provided, conflicting classifications|2","1015313|NM_004304.5(ALK):c.3440T>C (p.Val1147Ala)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1015782|NM_004304.5(ALK):c.1718C>A (p.Thr573Asn)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1016230|NM_004304.5(ALK):c.131T>C (p.Leu44Pro)|single nucleotide variant|Uncertain significance|ALK|criteria provided, single submitter|2","1016481|NM_004304.5(ALK):c.344C>G (p.Pro115Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1016540|NM_004304.5(ALK):c.463G>A (p.Val155Ile)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1016731|NM_004304.5(ALK):c.670C>T (p.His224Tyr)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1016794|NM_004304.5(ALK):c.3712_3715del (p.Gln1238fs)|Deletion|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1016830|NM_004304.5(ALK):c.701_702delinsGA (p.Pro234Arg)|Indel|Uncertain significance|ALK|criteria provided, single submitter|2","1016842|NM_004304.5(ALK):c.892G>T (p.Ala298Ser)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1017010|NM_004304.5(ALK):c.2430C>G (p.Ser810Arg)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2","1017169|NM_004304.5(ALK):c.2744G>C (p.Trp915Ser)|single nucleotide variant|Uncertain significance|ALK|criteria provided, multiple submitters, no conflicts|2"]}]}