{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:613,10,HGNC:613,29,1]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:613","source":"HGNC:613|apolipoprotein E","targets":["1077013|NM_000041.4(APOE):c.494G>C (p.Arg165Pro)|single nucleotide variant|Likely pathogenic|APOE|criteria provided, single submitter|19","1175067|NM_000041.4(APOE):c.-24+69C>G|single nucleotide variant|Benign|APOE|criteria provided, single submitter|19","1197019|NC_000019.10:g.44909484C>G|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1209955|NM_000041.4(APOE):c.786G>A (p.Glu262=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1209987|NM_000041.4(APOE):c.90C>G (p.Pro30=)|single nucleotide variant|Likely benign|APOE|criteria provided, multiple submitters, no conflicts|19","1210034|NM_000041.4(APOE):c.69G>A (p.Ala23=)|single nucleotide variant|Likely benign|APOE|criteria provided, multiple submitters, no conflicts|19","1210067|NM_000041.4(APOE):c.237-16_237-13del|Deletion|Likely benign|APOE|criteria provided, single submitter|19","126456|NM_000041.4(APOE):c.497TCC[1] (p.Leu167del)|Microsatellite|Pathogenic|APOE|criteria provided, multiple submitters, no conflicts|19","1264941|NM_000041.4(APOE):c.43+78G>A|single nucleotide variant|Benign|APOE|criteria provided, multiple submitters, no conflicts|19","1287640|NC_000019.10:g.44909535del|Deletion|Benign|APOE|criteria provided, single submitter|19","1298772|NM_000041.4(APOE):c.120C>T (p.Ser40=)|single nucleotide variant|Likely benign|APOE|criteria provided, multiple submitters, no conflicts|19","1315806|NM_000041.4(APOE):c.688G>A (p.Glu230Lys)|single nucleotide variant|Uncertain significance|APOE|criteria provided, multiple submitters, no conflicts|19","1315880|NM_000041.4(APOE):c.335C>A (p.Ser112Tyr)|single nucleotide variant|Uncertain significance|APOE|criteria provided, multiple submitters, no conflicts|19","1317910|NM_000041.4(APOE):c.394C>T (p.Arg132Cys)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1320334|NM_000041.4(APOE):c.167G>A (p.Arg56His)|single nucleotide variant|Uncertain significance|APOE|criteria provided, multiple submitters, no conflicts|19","1320871|NM_000041.4(APOE):c.114G>A (p.Trp38Ter)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1328619|NM_000041.4(APOE):c.108C>G (p.Thr36=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1329718|NM_000041.4(APOE):c.-23-280C>T|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1341575|NM_000041.4(APOE):c.548G>C (p.Gly183Ala)|single nucleotide variant|Likely pathogenic|APOE|criteria provided, single submitter|19","143248|NM_000041.4(APOE):c.292del (p.Glu98fs)|Deletion|not provided|APOE|no classification provided|19","1687222|NM_000041.4(APOE):c.488G>T (p.Arg163Leu)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1706316|NM_000041.4(APOE):c.866A>C (p.Asp289Ala)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1710568|NM_000041.4(APOE):c.356A>C (p.Gln119Pro)|single nucleotide variant|Uncertain significance|APOE|criteria provided, multiple submitters, no conflicts|19","1722323|NM_000041.4(APOE):c.-24+82G>A|single nucleotide variant|Conflicting classifications of pathogenicity|APOE|criteria provided, conflicting classifications|19","1727733|NM_000041.4(APOE):c.310G>A (p.Ala104Thr)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1727945|NM_000041.4(APOE):c.312G>A (p.Ala104=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1732582|NM_000041.4(APOE):c.354G>T (p.Ala118=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1733394|NM_000041.4(APOE):c.362G>A (p.Arg121Gln)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1739764|NM_000041.4(APOE):c.432C>T (p.Leu144=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1740672|NM_000041.4(APOE):c.444C>G (p.Thr148=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1741558|NM_000041.4(APOE):c.456G>T (p.Arg152=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1743923|NM_000041.4(APOE):c.489T>G (p.Arg163=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1747154|NM_000041.4(APOE):c.537G>A (p.Val179=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1747488|NM_000041.4(APOE):c.542A>T (p.Gln181Leu)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1747722|NM_000041.4(APOE):c.546C>T (p.Ala182=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1748127|NM_000041.4(APOE):c.552C>T (p.Ala184=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1748286|NM_000041.4(APOE):c.555C>T (p.Arg185=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1750302|NM_000041.4(APOE):c.588C>T (p.Arg196=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1750497|NM_000041.4(APOE):c.591G>A (p.Glu197=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1750896|NM_000041.4(APOE):c.598G>C (p.Gly200Arg)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1751939|NM_000041.4(APOE):c.615G>A (p.Gln205=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1752261|NM_000041.4(APOE):c.621C>A (p.Arg207=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1752385|NM_000041.4(APOE):c.623T>G (p.Val208Gly)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1752588|NM_000041.4(APOE):c.627G>A (p.Arg209=)|single nucleotide variant|Likely benign|APOE|criteria provided, multiple submitters, no conflicts|19","1753235|NM_000041.4(APOE):c.638T>G (p.Val213Gly)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1753374|NM_000041.4(APOE):c.640G>A (p.Gly214Ser)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1755132|NM_000041.4(APOE):c.672G>T (p.Arg224=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1756154|NM_000041.4(APOE):c.691C>A (p.Arg231=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1756513|NM_000041.4(APOE):c.699C>T (p.Arg233=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1756777|NM_000041.4(APOE):c.702G>A (p.Ala234=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1757142|NM_000041.4(APOE):c.709G>A (p.Glu237Lys)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1758697|NM_000041.4(APOE):c.739C>G (p.Leu247Val)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1760098|NM_000041.4(APOE):c.767A>T (p.Glu256Val)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1760393|NM_000041.4(APOE):c.773G>A (p.Arg258His)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1761097|NM_000041.4(APOE):c.789G>A (p.Glu263=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1762036|NM_000041.4(APOE):c.810G>A (p.Leu270=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1762635|NM_000041.4(APOE):c.125A>C (p.Gln42Pro)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1762954|NM_000041.4(APOE):c.832C>T (p.Arg278Cys)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1763601|NM_000041.4(APOE):c.849C>T (p.Phe283=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1763883|NM_000041.4(APOE):c.856C>T (p.Leu286=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1764810|NM_000041.4(APOE):c.882G>T (p.Trp294Cys)|single nucleotide variant|Uncertain significance|APOE|criteria provided, multiple submitters, no conflicts|19","1765256|NM_000041.4(APOE):c.895G>C (p.Glu299Gln)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1765901|NM_000041.4(APOE):c.912C>T (p.Ala304=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1766316|NM_000041.4(APOE):c.924C>T (p.Ser308=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1766409|NM_000041.4(APOE):c.927C>G (p.Ala309=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1771513|NM_000041.4(APOE):c.138G>A (p.Leu46=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","17848|NM_000041.2(APOE):c.526C>T (p.Arg176Cys)|single nucleotide variant|drug response|APOE|reviewed by expert panel|19","17849|NM_000041.4(APOE):c.61G>A (p.Glu21Lys)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17850|NM_000041.4(APOE):c.460C>A (p.Arg154Ser)|single nucleotide variant|Likely pathogenic|APOE|criteria provided, single submitter|19","17851|NM_000041.4(APOE):c.487C>T (p.Arg163Cys)|single nucleotide variant|Conflicting classifications of pathogenicity|APOE|criteria provided, conflicting classifications|19","17852|NM_000041.4(APOE):c.237-2A>G|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17853|NM_000041.4(APOE):c.415_435dup (p.Glu139_Gly145dup)|Duplication|Pathogenic|APOE|no assertion criteria provided|19","17857|NM_000041.4(APOE):c.490A>G (p.Lys164Glu)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17858|NM_000041.4(APOE):c.490A>C (p.Lys164Gln)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17859|NM_000041.4(APOE):c.736C>T (p.Arg246Cys)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","1786056|NM_000041.4(APOE):c.210C>T (p.Leu70=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","17861|NM_000041.4(APOE):c.146del (p.Gly49fs)|Deletion|Pathogenic|APOE|no assertion criteria provided|19","17862|NM_000041.4(APOE):c.683G>A (p.Trp228Ter)|single nucleotide variant|Likely pathogenic|APOE|criteria provided, multiple submitters, no conflicts|19","17864|NM_000041.4(APOE):c.388T>C (p.Cys130Arg)|single nucleotide variant|Conflicting classifications of pathogenicity; other; risk factor|APOE|criteria provided, conflicting classifications|19","17865|NM_000041.4(APOE):c.488G>A (p.Arg163His)|single nucleotide variant|Likely pathogenic|APOE|criteria provided, single submitter|19","1786732|NM_000041.4(APOE):c.214T>G (p.Ser72Ala)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","17871|NM_000041.4(APOE):c.178A>G (p.Thr60Ala)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","17874|NM_000041.4(APOE):c.455G>A (p.Arg152Gln)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17875|NM_000041.4(APOE):c.875G>A (p.Arg292His)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17876|NM_000041.4(APOE):c.940A>C (p.Ser314Arg)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","17877|NC_000019.10:g.44905579=|single nucleotide variant|risk factor|APOE|no assertion criteria provided|19","17879|NM_000041.4(APOE):c.488G>C (p.Arg163Pro)|single nucleotide variant|Pathogenic|APOE|no assertion criteria provided|19","17880|NM_000041.4(APOE):c.127C>T (p.Arg43Cys)|single nucleotide variant|Pathogenic/Likely pathogenic|APOE|criteria provided, multiple submitters, no conflicts|19","1789275|NM_000041.4(APOE):c.22T>C (p.Leu8=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1796120|NM_000041.4(APOE):c.279A>G (p.Lys93=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1796422|NM_000041.4(APOE):c.281C>G (p.Ser94Trp)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1798256|NM_000041.4(APOE):c.296A>G (p.Gln99Arg)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","1799478|NM_000041.4(APOE):c.306G>A (p.Pro102=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1799480|NM_000041.4(APOE):c.306G>C (p.Pro102=)|single nucleotide variant|Likely benign|APOE|criteria provided, single submitter|19","1803815|NM_000041.4(APOE):c.31A>G (p.Thr11Ala)|single nucleotide variant|Conflicting classifications of pathogenicity|APOE|criteria provided, conflicting classifications|19","2219434|NM_000041.4(APOE):c.714G>T (p.Glu238Asp)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","2307328|NM_000041.4(APOE):c.416A>G (p.Glu139Gly)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","2338186|NM_000041.4(APOE):c.670C>T (p.Arg224Trp)|single nucleotide variant|Uncertain significance|APOE|criteria provided, single submitter|19","2412586|NM_000041.4(APOE):c.237-4G>T|single nucleotide variant|Uncertain significance|APOE|no assertion criteria provided|19","242765|NM_000041.4(APOE):c.137T>C (p.Leu46Pro)|single nucleotide variant|Conflicting classifications of pathogenicity|APOE|criteria provided, conflicting classifications|19"]}]}