{"context":{"query":">>hgnc>>msigdb","source_dataset":"hgnc","target_dataset":"msigdb"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:6407,10,HGNC:6407,136,1]["},"schema":"id|standard_name|collection|description|gene_count","mappings":[{"input":"HGNC:6407","source":"HGNC:6407|KRAS proto-oncogene, GTPase","targets":["M100|PID_SHP2_PATHWAY|C2:CP|SHP2 signaling|57","M10083|GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM|C5:GO|The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]|517","M1021|REACTOME_SIGNALING_BY_INSULIN_RECEPTOR|C2:CP|Signaling by Insulin receptor|82","M10229|GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]|181","M10249|GOBP_HEPATICOBILIARY_SYSTEM_DEVELOPMENT|C5:GO|The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. [GOC:dph]|145","M10268|GOBP_EPITHELIUM_DEVELOPMENT|C5:GO|The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:dph, GOC:mtg_lung]|1281","M10346|GOBP_LUNG_EPITHELIUM_DEVELOPMENT|C5:GO|The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. [GOC:dph, GOC:mtg_lung]|48","M1036|REACTOME_INNATE_IMMUNE_SYSTEM|C2:CP|Innate Immune System|1114","M10365|GOBP_MUSCLE_TISSUE_DEVELOPMENT|C5:GO|The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. [GOC:dph]|454","M10386|GOBP_COGNITION|C5:GO|The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. [ISBN:0721619908]|332","M10401|BIOCARTA_TEL_PATHWAY|C2:CP|Telomeres, Telomerase, Cellular Aging, and  Immortality|17","M10431|GRUETZMANN_PANCREATIC_CANCER_DN|C2|Genes down-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies.|200","M10444|GOBP_BEHAVIOR|C5:GO|The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]|697","M1058|REACTOME_ADAPTIVE_IMMUNE_SYSTEM|C2:CP|Adaptive Immune System|824","M1060|REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM|C2:CP|Cytokine Signaling in Immune system|785","M10640|GOBP_RESPONSE_TO_PEPTIDE|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]|1010","M10720|GOBP_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY|C5:GO|A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:jid, PMID:11891290]|61","M10732|GOBP_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS|C5:GO|The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:mtg_lung]|32","M10764|GOBP_RESPONSE_TO_CORTICOSTEROID|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. [GOC:mah, PMID:11027914]|153","M10792|KEGG_MAPK_SIGNALING_PATHWAY|C2:CP|MAPK signaling pathway|267","M10854|GOBP_LUNG_CELL_DIFFERENTIATION|C5:GO|The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, GOC:mtg_lung]|30","M10883|GOBP_ASSOCIATIVE_LEARNING|C5:GO|Learning by associating a stimulus (the cause) with a particular outcome (the effect). [ISBN:0582227089]|93","M1090|REACTOME_SIGNALING_BY_FGFR|C2:CP|Signaling by FGFR|89","M1105|GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN|C2|Genes down-regulated in ME-A cells (breast cancer) undergoing apoptosis in response to doxorubicin [PubChem=31703].|1775","M1108|GOBP_GROWTH|C5:GO|The increase in size or mass of an entire organism, a part of an organism or a cell. [GOC:bf, GOC:ma]|975","M11130|GOBP_GLIAL_CELL_DEVELOPMENT|C5:GO|The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]|136","M11134|GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION|C5:GO|The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]|321","M11142|GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION|C5:GO|Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:go_curators]|312","M11145|GOBP_LUNG_MORPHOGENESIS|C5:GO|The process in which the anatomical structures of the lung are generated and organized. [GOC:dph]|61","M11187|REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH|C2:CP|NCAM signaling for neurite out-growth|63","M11189|SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE|C2|IRF4 [GeneID=3662] target genes induced after activation of primary B lymphocytes by anti-IgM crosslinking.|81","M11190|KEGG_DORSO_VENTRAL_AXIS_FORMATION|C2:CP|Dorso-ventral axis formation|24","M11351|GOBP_NEUROGENESIS|C5:GO|Generation of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]|1821","M11355|KEGG_TIGHT_JUNCTION|C2:CP|Tight junction|132","M11416|ATGCAGT_MIR217|C3:MIR|Genes having at least one occurence of the motif ATGCAGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-217 (v7.1 miRBase).|114","M11450|GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT|C5:GO|Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]|458","M11549|GOBP_MUSCLE_CELL_PROLIFERATION|C5:GO|The expansion of a muscle cell population by cell division. [CL:0000187, GOC:mah]|253","M11558|GOBP_CELLULAR_SENESCENCE|C5:GO|A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. [GOC:BHF, PMID:28682291]|111","M11582|GOBP_RESPONSE_TO_GRAVITY|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. [GOC:hb]|8","M11606|GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT|C5:GO|Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]|285","M1176|MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_2|C2|Amplification hot spot 2: colocolized fragile sites and cancer genes in the 12p13-p11.1 region.|5","M11811|GOBP_FOREBRAIN_DEVELOPMENT|C5:GO|The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [PMID:4975589, PMID:4992177]|414","M11816|KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY|C2:CP|Fc epsilon RI signaling pathway|79","M11865|BRUNEAU_SEPTATION_VENTRICULAR|C2|Genes for which mutations result in developmental defects in ventricular septation and atrioventricular cushion formation, a major class of congenital heart disease.|10","M11874|GOBP_CELL_CELL_SIGNALING|C5:GO|Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]|1375","M11932|REACTOME_TIE2_SIGNALING|C2:CP|Tie2 Signaling|18","M11961|PUJANA_CHEK2_PCC_NETWORK|C2|Genes constituting the CHEK2-PCC network of transcripts whose expression positively correlates (Pearson correlation coefficient, PCC >= 0.4) with that of CHEK2 [GeneID=11200].|762","M12037|SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE|C2|IRF4 [GeneID=3662] target genes up-regulated in plasma cells compared to mature B lymphocytes.|67","M12058|GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION|C5:GO|Any process that modulates the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]|177","M121|PID_MTOR_4PATHWAY|C2:CP|mTOR signaling pathway|69","M122|PID_IL2_1PATHWAY|C2:CP|IL2-mediated signaling events|55","M12224|MARTINEZ_RB1_TARGETS_UP|C2|Genes up-regulated in mice with skin specific knockout of RB1 [GeneID=5925] by Cre-lox.|685","M12256|REACTOME_SIGNALLING_TO_RAS|C2:CP|Signalling to RAS|20","M12326|GOBP_ANIMAL_ORGAN_MORPHOGENESIS|C5:GO|Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]|1038","M12467|KEGG_ERBB_SIGNALING_PATHWAY|C2:CP|ErbB signaling pathway|87","M12474|GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY|C5:GO|A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]|229","M12542|GOBP_REGULATION_OF_GLIAL_CELL_PROLIFERATION|C5:GO|Any process that modulates the frequency, rate or extent of glial cell proliferation. [GOC:dph, GOC:tb]|43","M12572|GOBP_MUSCLE_STRUCTURE_DEVELOPMENT|C5:GO|The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. [GOC:dph]|731","M127|PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY|C2:CP|EGF receptor (ErbB1) signaling pathway|35","M12707|MILI_PSEUDOPODIA_HAPTOTAXIS_UP|C2|Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin, FN1 [GeneID=2335].|521","M12730|KORKOLA_EMBRYONAL_CARCINOMA_UP|C2|Genes from the 12p region that were up-regulated in embryonic carcinoma tumors compared to normal testis.|42","M12868|KEGG_PATHWAYS_IN_CANCER|C2:CP|Pathways in cancer|325","M12912|GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION|C5:GO|Any process that activates or increases the frequency, rate or extent of cell differentiation. [GOC:go_curators]|915","M12923|GOBP_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION|C5:GO|Any process that modulates the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]|32","M13048|GOBP_LEARNING|C5:GO|Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. [ISBN:0582227089, ISBN:0721662544]|162","M13162|GTGTTGA_MIR505|C3:MIR|Genes having at least one occurence of the motif GTGTTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-505 (v7.1 miRBase).|104","M13191|KEGG_PROSTATE_CANCER|C2:CP|Prostate cancer|89","M13253|GOBP_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT|C5:GO|The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. [GOC:dph]|196","M13266|KEGG_RENAL_CELL_CARCINOMA|C2:CP|Renal cell carcinoma|70","M134|PID_TCR_RAS_PATHWAY|C2:CP|Ras signaling in the CD4+ TCR pathway|14","M13469|GOBP_ASTROCYTE_DIFFERENTIATION|C5:GO|The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GOC:vp, PMID:15139015]|90","M1347|SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN|C2|Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 6 h.|466","M13487|GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION|C5:GO|An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]|116","M13518|GOBP_ORGAN_GROWTH|C5:GO|The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. [GOC:bf, ISBN:0471245208, ISBN:0721662544]|188","M13646|GOBP_RESPONSE_TO_RADIATION|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. [GOC:jl, Wikipedia:Electromagnetic_radiation]|461","M13651|GOCC_MITOCHONDRIAL_ENVELOPE|C5:GO|The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. [GOC:ai, GOC:pz]|836","M13661|CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5|C2|The 'group 5 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 but not ERBB2 [GeneID=2099;2064].|493","M1367|BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP|C2|Genes from cluster 1: up-regulated in group C of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.|36","M13849|TGACATY_UNKNOWN|C3:TFT|Genes having at least one occurrence of the highly conserved motif M42 TGACATY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.|677","M13881|REACTOME_SIGNALLING_TO_ERKS|C2:CP|Signalling to ERKs|34","M13901|GOBP_RESPONSE_TO_STEROID_HORMONE|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:go_curators]|342","M13925|MODULE_86|C4|Small monomeric GTPases.|43","M13987|GOBP_RESPONSE_TO_HORMONE|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:jl]|927","M14019|DING_LUNG_CANCER_MUTATED_RECURRENTLY|C2|The lung adenocarcinoma TSP (tumor sequencing project) genes bearing recurrent somatic mutations.|6","M14034|GOBP_SYNAPTIC_SIGNALING|C5:GO|Cell-cell signaling to, from or within a synapse. [GOC:dos]|834","M14037|GOBP_RESPONSE_TO_LIPID|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:sl]|955","M141|PID_PI3KCI_PATHWAY|C2:CP|Class I PI3K signaling events|48","M14106|GOBP_NEURON_APOPTOTIC_PROCESS|C5:GO|Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]|318","M14159|GOBP_RESPONSE_TO_ABIOTIC_STIMULUS|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. [GOC:hb]|1185","M14200|GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS|C5:GO|A multicellular organism process which involves another multicellular organism of the same or different species. [GOC:jl]|226","M14232|GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION|C5:GO|Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]|1159","M14257|GOBP_HEAD_DEVELOPMENT|C5:GO|The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. [GOC:dph]|808","M1441|REACTOME_P38MAPK_EVENTS|C2:CP|p38MAPK events|13","M14463|AACTTT_UNKNOWN|C3:TFT|Genes having at least one occurrence of the highly conserved motif M17 AACTTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.|1928","M14631|KEGG_COLORECTAL_CANCER|C2:CP|Colorectal cancer|62","M14669|GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS|C5:GO|Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. [GOC:isa_complete]|859","M14678|TGAGATT_MIR216|C3:MIR|Genes having at least one occurence of the motif TGAGATT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-216 (v7.1 miRBase).|107","M14709|TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P|C3:MIR|Genes having at least one occurence of the motif TGTTTAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-30a-5p, hsa-miR-30c, hsa-miR-30d, hsa-miR-30b and hsa-miR-30e-5p (v7.1 miRBase).|580","M14729|GOBP_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE|C5:GO|The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. [ISBN:0721662544]|214","M14753|GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS|C5:GO|Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]|1046"]}]}