{"context":{"query":">>hgnc>>clinvar","source_dataset":"hgnc","target_dataset":"clinvar"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:7127,10,HGNC:7127,96,1]["},"schema":"id|name|type|germline_classification|gene_symbol|review_status|chromosome","mappings":[{"input":"HGNC:7127","source":"HGNC:7127|mutL homolog 1","targets":["1000222|NM_000249.4(MLH1):c.1963A>T (p.Ile655Phe)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1001077|NM_000249.4(MLH1):c.1718T>C (p.Val573Ala)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1001235|NM_000249.4(MLH1):c.580G>A (p.Val194Ile)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1001928|NM_000249.4(MLH1):c.380+6G>T|single nucleotide variant|Conflicting classifications of pathogenicity|MLH1|criteria provided, conflicting classifications|3","1003938|NM_000249.4(MLH1):c.689A>G (p.Glu230Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1004997|NM_000249.4(MLH1):c.1138G>A (p.Ala380Thr)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1005587|NM_000249.4(MLH1):c.208-8T>C|single nucleotide variant|Likely benign|MLH1|criteria provided, multiple submitters, no conflicts|3","1005917|NM_000249.4(MLH1):c.235A>G (p.Arg79Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1006114|NM_000249.4(MLH1):c.2006A>G (p.Glu669Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1006220|NM_000249.4(MLH1):c.193G>A (p.Gly65Ser)|single nucleotide variant|Likely pathogenic|MLH1|criteria provided, single submitter|3","1006568|NM_000249.4(MLH1):c.207+3A>G|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1006575|NM_000249.4(MLH1):c.463C>G (p.Leu155Val)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1007174|NM_000249.4(MLH1):c.10G>C (p.Val4Leu)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1007596|NM_000249.4(MLH1):c.742A>G (p.Asn248Asp)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1009131|NM_000249.4(MLH1):c.421C>T (p.Pro141Ser)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1009527|NM_000249.4(MLH1):c.380+3A>T|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1009528|NM_000249.4(MLH1):c.1572G>A (p.Met524Ile)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1009544|NM_000249.4(MLH1):c.657_662del (p.Phe220_Gly221del)|Deletion|Uncertain significance|MLH1|criteria provided, single submitter|3","1009558|NM_000249.4(MLH1):c.1385G>C (p.Arg462Thr)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1009766|NM_000249.4(MLH1):c.1346G>C (p.Gly449Ala)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1010053|NM_000249.4(MLH1):c.124G>A (p.Ala42Thr)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1010078|NM_000249.4(MLH1):c.2030G>T (p.Ser677Ile)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1010470|NM_000249.4(MLH1):c.117-3C>T|single nucleotide variant|Conflicting classifications of pathogenicity|MLH1|criteria provided, conflicting classifications|3","1011510|NM_000249.4(MLH1):c.117-6T>G|single nucleotide variant|Likely benign|MLH1|criteria provided, single submitter|3","1012206|NM_000249.4(MLH1):c.1003del (p.Leu335fs)|Deletion|Pathogenic|MLH1|criteria provided, multiple submitters, no conflicts|3","1013907|NM_000249.4(MLH1):c.317G>T (p.Ser106Ile)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1014139|NM_000249.4(MLH1):c.1054C>T (p.Leu352Phe)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1015120|NM_000249.4(MLH1):c.1552C>T (p.His518Tyr)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1015357|NM_000249.4(MLH1):c.117-6T>A|single nucleotide variant|Conflicting classifications of pathogenicity|MLH1|criteria provided, conflicting classifications|3","1015471|NM_000249.4(MLH1):c.494C>T (p.Ala165Val)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1015796|NM_000249.4(MLH1):c.2069A>G (p.Tyr690Cys)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1016955|NM_000249.4(MLH1):c.783C>G (p.Phe261Leu)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1017893|NM_000249.4(MLH1):c.463C>T (p.Leu155Phe)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1020800|NM_000249.4(MLH1):c.941T>G (p.Val314Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1021363|NM_000249.4(MLH1):c.401A>G (p.Lys134Arg)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1021372|NM_000249.4(MLH1):c.269A>G (p.Asp90Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1022025|NM_000249.4(MLH1):c.134C>G (p.Thr45Arg)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1023802|NM_000249.4(MLH1):c.1831A>C (p.Ile611Leu)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1023950|NM_000249.4(MLH1):c.1681_1686del (p.Tyr561_Gln562del)|Deletion|Pathogenic|MLH1|criteria provided, single submitter|3","1024548|NM_000249.4(MLH1):c.1583A>G (p.His528Arg)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1026102|NM_000249.4(MLH1):c.427G>T (p.Ala143Ser)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1026991|NM_000249.4(MLH1):c.1736C>A (p.Pro579Gln)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1034510|NM_000249.4(MLH1):c.569_571del (p.Ile190del)|Deletion|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1035503|NM_000249.4(MLH1):c.929C>A (p.Thr310Lys)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1036208|NM_000249.4(MLH1):c.1349A>T (p.Asp450Val)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1036341|NM_000249.4(MLH1):c.185A>G (p.Gln62Arg)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1037410|NM_000249.4(MLH1):c.1146G>T (p.Gln382His)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1037473|NM_000249.4(MLH1):c.1442_1450del (p.Met481_Asp484delinsAsn)|Deletion|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1037949|NM_000249.4(MLH1):c.1732-3T>C|single nucleotide variant|Conflicting classifications of pathogenicity|MLH1|criteria provided, conflicting classifications|3","1038381|NM_000249.4(MLH1):c.1252G>A (p.Asp418Asn)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1039815|NM_000249.4(MLH1):c.1058C>G (p.Ala353Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1040440|NM_000249.4(MLH1):c.1406C>A (p.Pro469His)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1042024|NM_000249.4(MLH1):c.1782G>C (p.Glu594Asp)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1042255|NM_000249.4(MLH1):c.1419T>G (p.His473Gln)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1043401|NM_000249.4(MLH1):c.553G>A (p.Val185Ile)|single nucleotide variant|Conflicting classifications of pathogenicity|MLH1|criteria provided, conflicting classifications|3","1043462|NM_000249.4(MLH1):c.1157C>T (p.Thr386Ile)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1043637|NM_000249.4(MLH1):c.454-3C>G|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1045407|NM_000249.4(MLH1):c.1442TGG[1] (p.Val482del)|Microsatellite|Uncertain significance|MLH1|criteria provided, single submitter|3","1047299|NM_000249.4(MLH1):c.175A>T (p.Ile59Phe)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1047528|NM_000249.4(MLH1):c.2014T>A (p.Cys672Ser)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, multiple submitters, no conflicts|3","1047688|NM_000249.4(MLH1):c.1552C>A (p.His518Asn)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1048862|NM_000249.4(MLH1):c.497T>G (p.Leu166Ter)|single nucleotide variant|Pathogenic|MLH1|criteria provided, multiple submitters, no conflicts|3","1048888|NM_000249.4(MLH1):c.2131dup (p.Ser711fs)|Duplication|Pathogenic|MLH1|no assertion criteria provided|3","1048895|NM_000249.4(MLH1):c.908T>G (p.Val303Gly)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1048910|NM_000249.4(MLH1):c.131_132delinsTT (p.Ser44Phe)|Indel|Pathogenic/Likely pathogenic|MLH1|criteria provided, multiple submitters, no conflicts|3","1048973|NM_000249.4(MLH1):c.2258_2259dup (p.Glu754fs)|Duplication|Likely pathogenic|MLH1|no assertion criteria provided|3","1049099|NM_000249.4(MLH1):c.2031del (p.Ser677fs)|Deletion|Uncertain significance|MLH1|no assertion criteria provided|3","1049107|NM_000249.4(MLH1):c.588+1G>C|single nucleotide variant|Likely pathogenic|MLH1|criteria provided, single submitter|3","1049169|NM_000249.4(MLH1):c.117-2_207+1del|Deletion|Uncertain significance|MLH1|no assertion criteria provided|3","1049248|NM_000249.4(MLH1):c.1039-2_1409+1del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1049302|NM_000249.4(MLH1):c.1275dup (p.Gln426fs)|Duplication|Pathogenic|MLH1|criteria provided, single submitter|3","1049395|NM_000249.4(MLH1):c.1504A>G (p.Asn502Asp)|single nucleotide variant|Uncertain significance|MLH1|criteria provided, single submitter|3","1049396|NM_000249.4(MLH1):c.1999del (p.Asp667fs)|Deletion|Pathogenic|MLH1|criteria provided, single submitter|3","1049423|NM_000249.4(MLH1):c.1952A>T (p.Glu651Val)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1049435|NM_000249.4(MLH1):c.864A>C (p.Thr288=)|single nucleotide variant|Likely benign|MLH1|criteria provided, single submitter|3","1049508|NM_000249.4(MLH1):c.631_632del (p.Ser211fs)|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1049646|NM_000249.4(MLH1):c.546-2_589-59del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1049670|NM_000249.4(MLH1):c.1896+1G>C|single nucleotide variant|Pathogenic|MLH1|criteria provided, multiple submitters, no conflicts|3","1049673|NM_000249.4(MLH1):c.1367del (p.Thr455_Ser456insTer)|Deletion|Pathogenic|MLH1|criteria provided, single submitter|3","1049699|NM_000249.4(MLH1):c.1082A>T (p.Lys361Ile)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1049812|NM_000249.4(MLH1):c.2126C>T (p.Pro709Leu)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1049818|NM_000249.4(MLH1):c.1615G>A (p.Ala539Thr)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1049886|NM_000249.4(MLH1):c.-2_116+1del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1050017|NM_000249.4(MLH1):c.365del (p.Gly122fs)|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1050049|NM_000249.4(MLH1):c.772T>C (p.Phe258Leu)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1050062|NM_000249.4(MLH1):c.1270del (p.Ala424fs)|Deletion|Uncertain significance|MLH1|no assertion criteria provided|3","1050070|NM_000249.4(MLH1):c.-11C>A|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1050185|NM_000249.4(MLH1):c.1039-2_1409+150del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1050240|NM_000249.4(MLH1):c.1816G>C (p.Gly606Arg)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1050350|NM_000249.4(MLH1):c.1571T>G (p.Met524Arg)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1050374|NM_000249.4(MLH1):c.1922_1932del (p.Leu641fs)|Deletion|Uncertain significance|MLH1|no assertion criteria provided|3","1050376|NM_000249.4(MLH1):c.1203C>G (p.Ser401Arg)|single nucleotide variant|Uncertain significance|MLH1|no assertion criteria provided|3","1050388|NM_000249.4(MLH1):c.2050_2071delinsATTTT (p.Tyr684fs)|Indel|Uncertain significance|MLH1|no assertion criteria provided|3","1050410|NM_000249.4(MLH1):c.1410-2_1558+1del|Deletion|Uncertain significance|MLH1|no assertion criteria provided|3","1050435|NM_000249.4(MLH1):c.1667+8A>C|single nucleotide variant|Likely benign|MLH1|criteria provided, multiple submitters, no conflicts|3","1050489|NM_000249.4(MLH1):c.1770_1772delinsC (p.Leu590fs)|Indel|Pathogenic|MLH1|no assertion criteria provided|3","1050518|NM_000249.4(MLH1):c.1732-2_1896+1del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1050645|NM_000249.4(MLH1):c.1559-2_1667+1del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1050662|NM_000249.4(MLH1):c.1559-4_1667+63del|Deletion|Pathogenic|MLH1|no assertion criteria provided|3","1050751|NM_000249.4(MLH1):c.995_996insA (p.Ser332fs)|Insertion|Pathogenic|MLH1|no assertion criteria provided|3"]}]}