{"context":{"query":">>hgnc>>msigdb","source_dataset":"hgnc","target_dataset":"msigdb"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:7577,10,HGNC:7577,130,1]["},"schema":"id|standard_name|collection|description|gene_count","mappings":[{"input":"HGNC:7577","source":"HGNC:7577|myosin heavy chain 7","targets":["M10039|GOBP_CARDIAC_CHAMBER_DEVELOPMENT|C5:GO|The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]|177","M10365|GOBP_MUSCLE_TISSUE_DEVELOPMENT|C5:GO|The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. [GOC:dph]|454","M10531|GOBP_CIRCULATORY_SYSTEM_PROCESS|C5:GO|An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. [GOC:mtg_cardio]|645","M10573|SWEET_KRAS_ONCOGENIC_SIGNATURE|C2|Genes that contributed maximally to the GSEA score of the up-regulated gene set from the KrasLA mouse model in two human lung cancer expression data sets comparing mutant vs normal KRAS [GeneID=3845].|89","M10631|GOBP_CARDIAC_CHAMBER_MORPHOGENESIS|C5:GO|The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]|135","M10779|GOBP_SKELETAL_MUSCLE_ADAPTATION|C5:GO|Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]|23","M11355|KEGG_TIGHT_JUNCTION|C2:CP|Tight junction|132","M11372|GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS|C5:GO|The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. [ISBN:0198506732]|1076","M11399|GOBP_MULTICELLULAR_ORGANISMAL_MOVEMENT|C5:GO|Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. [GOC:dph, GOC:mtg_muscle, GOC:tb]|65","M11492|MODULE_329|C4|Genes in the cancer module 329.|51","M11647|GOBP_SKELETAL_MUSCLE_CONTRACTION|C5:GO|A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. [GOC:mtg_cardio, GOC:mtg_muscle]|51","M11742|GNF2_MYL3|C4|Neighborhood of MYL3|31","M11818|GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS|C5:GO|The chemical reactions and pathways involving carbohydrate derivative. [GOC:TermGenie]|1018","M11821|CEBPB_01|C3:TFT|Genes having at least one occurrence of the motif RNRTKDNGMAAKNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPB [GeneSymbol=CEBPB] transcription factor binding site V$CEBPB_01 (v7.4 TRANSFAC).|267","M11969|GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS|C5:GO|The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. [GOC:vw]|686","M12174|GOBP_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION|C5:GO|Any process that modulates the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]|105","M12294|KEGG_VIRAL_MYOCARDITIS|C2:CP|Viral myocarditis|70","M12326|GOBP_ANIMAL_ORGAN_MORPHOGENESIS|C5:GO|Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]|1038","M12365|GCM_RING1|C4|Neighborhood of RING1|112","M12506|GOBP_REGULATION_OF_MUSCLE_CONTRACTION|C5:GO|Any process that modulates the frequency, rate or extent of muscle contraction. [GOC:go_curators]|179","M12538|GOBP_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT|C5:GO|The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. [GOC:mtg_heart]|62","M12572|GOBP_MUSCLE_STRUCTURE_DEVELOPMENT|C5:GO|The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. [GOC:dph]|731","M12628|GOBP_MUSCLE_CONTRACTION|C5:GO|A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]|368","M12699|MODULE_202|C4|Genes in the cancer module 202.|28","M1281|SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5|C2|Cluster PAM5: genes changed exclusively in hepatocellular carcinoma (HCC) samples from 27 month old mice deficient for TXNIP [GeneID=10628].|111","M12997|GOBP_HEART_MORPHOGENESIS|C5:GO|The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:dph, GOC:isa_complete]|278","M13090|GOBP_CARDIAC_VENTRICLE_MORPHOGENESIS|C5:GO|The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]|74","M13092|GOBP_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION|C5:GO|Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:dph, GOC:tb, PMID:10358008]|26","M13109|GOBP_MUSCLE_ADAPTATION|C5:GO|A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]|126","M13168|GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS|C5:GO|The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]|283","M13192|GOBP_REGULATION_OF_HEART_RATE|C5:GO|Any process that modulates the frequency or rate of heart contraction. [GOC:dph, GOC:tb, PMID:10358008]|112","M13226|GOMF_CYTOSKELETAL_MOTOR_ACTIVITY|C5:GO|Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]|115","M13376|GOBP_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS|C5:GO|The process in which the anatomical structures of cardiac muscle tissue are generated and organized. [GOC:devbiol]|62","M13393|GOBP_MUSCLE_ORGAN_MORPHOGENESIS|C5:GO|The process in which the anatomical structures of muscle are generated and organized. [GOC:jid]|86","M13718|GOBP_CARDIAC_VENTRICLE_DEVELOPMENT|C5:GO|The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]|134","M14073|GOBP_ACTIN_MEDIATED_CELL_CONTRACTION|C5:GO|The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. [GOC:mah]|123","M14115|GOBP_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION|C5:GO|Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]|14","M14153|MORF_EPHA7|C4|Neighborhood of EPHA7|139","M14210|MORF_RAB3A|C4|Neighborhood of RAB3A|89","M14237|GOBP_REGULATION_OF_SYSTEM_PROCESS|C5:GO|Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. [GOC:jl]|594","M14272|MORF_BMPR2|C4|Neighborhood of BMPR2|53","M14585|GCM_TEC|C4|Neighborhood of TEC|32","M1466|AFFAR_YY1_TARGETS_UP|C2|Genes up-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528].|201","M14748|GOBP_MUSCLE_HYPERTROPHY|C5:GO|The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. [GOC:mtg_muscle]|109","M14786|CREB_Q3|C3:TFT|Genes having at least one occurrence of the motif CGTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_Q3 (v7.4 TRANSFAC).|255","M14799|GOMF_ACTIN_BINDING|C5:GO|Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]|447","M14929|GOBP_HEART_PROCESS|C5:GO|A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:mtg_cardio]|275","M14930|GOBP_MUSCLE_SYSTEM_PROCESS|C5:GO|An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. [GOC:mtg_cardio]|479","M15256|MORF_WNT1|C4|Neighborhood of WNT1|107","M15404|GOBP_ADULT_HEART_DEVELOPMENT|C5:GO|The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. [GOC:bf]|14","M15469|GOBP_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION|C5:GO|Any process that modulates the frequency, rate or extent of skeletal muscle contraction. [GOC:ef, GOC:mtg_muscle]|19","M15550|MODULE_387|C4|Genes in the cancer module 387.|49","M1572|LEE_CALORIE_RESTRICTION_MUSCLE_UP|C2|Up-regulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction diet since young adulthood.|40","M15722|GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS|C5:GO|Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. [GOC:dph, GOC:tb]|262","M15744|GOBP_NEUROMUSCULAR_PROCESS|C5:GO|Any process pertaining to the functions of the nervous and muscular systems of an organism. [GOC:ai]|185","M15746|GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS|C5:GO|The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. [GOC:mah]|576","M16009|ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN|C2|Genes whose DNA is hypo-methylated in hepatocellular carcinoma (HCC) compared to normal liver.|875","M16049|GOBP_STRIATED_MUSCLE_ADAPTATION|C5:GO|Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]|56","M16102|GOBP_REGULATION_OF_MUSCLE_ADAPTATION|C5:GO|Any process that modulates the frequency, rate or extent of muscle adaptation. [GOC:go_curators, GOC:mtg_muscle]|99","M16103|GOBP_TISSUE_MORPHOGENESIS|C5:GO|The process in which the anatomical structures of a tissue are generated and organized. [GOC:dph, GOC:jid]|638","M16249|GCM_VAV1|C4|Neighborhood of VAV1|47","M16396|AP2GAMMA_01|C3:TFT|Genes having at least one occurrence of the motif GCCYNNGGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP2C [GeneSymbol=TFAP2C] transcription factor binding site V$AP2GAMMA_01 (v7.4 TRANSFAC).|252","M16442|GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT|C5:GO|The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. [GOC:mah, UBERON:0001009]|1268","M16569|MORF_DCC|C4|Neighborhood of DCC|112","M16818|GOBP_REGULATION_OF_BLOOD_CIRCULATION|C5:GO|Any process that modulates the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]|279","M16979|GOCC_I_BAND|C5:GO|A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. [ISBN:0321204131]|150","M17009|GOCC_MUSCLE_MYOSIN_COMPLEX|C5:GO|A filament of myosin found in a muscle cell of any type. [GOC:mah]|15","M17213|GOCC_MYOSIN_FILAMENT|C5:GO|A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. [GOC:mah]|24","M17227|GOCC_ACTIN_FILAMENT_BUNDLE|C5:GO|An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. [GOC:mah]|96","M17284|GOCC_ACTOMYOSIN|C5:GO|Any complex of actin, myosin, and accessory proteins. [GOC:go_curators]|94","M17420|WGGAATGY_TEF1_Q6|C3:TFT|Genes having at least one occurrence of the highly conserved motif M79 WGGAATGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TEAD1 [GeneSymbol=TEAD1] transcription factor binding site V$TEF1_Q6 (v7.4 TRANSFAC).|387","M17509|MODULE_438|C4|Intermediate filaments and MT.|68","M17673|KEGG_CARDIAC_MUSCLE_CONTRACTION|C2:CP|Cardiac muscle contraction|79","M17709|GOCC_MYOSIN_II_COMPLEX|C5:GO|A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. [Wikipedia:Myosin]|27","M17820|GOBP_ACTIN_FILAMENT_BASED_MOVEMENT|C5:GO|Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. [GOC:BHF, GOC:mah]|146","M18503|GOMF_CYTOSKELETAL_PROTEIN_BINDING|C5:GO|Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]|1002","M18569|GOMF_MICROFILAMENT_MOTOR_ACTIVITY|C5:GO|A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. [PMID:29716949]|38","M1901|MODULE_533|C4|Genes in the cancer module 533.|45","M19097|SWEET_LUNG_CANCER_KRAS_UP|C2|Genes up-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845].|482","M19102|GOMF_ADENYL_NUCLEOTIDE_BINDING|C5:GO|Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate. [ISBN:0198506732]|1633","M19150|GOMF_ISOMERASE_ACTIVITY|C5:GO|Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]|450","M19295|GCM_BNIP1|C4|Neighborhood of BNIP1|78","M19924|GOBP_STRIATED_MUSCLE_CONTRACTION|C5:GO|A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]|202","M2127|GCM_FANCC|C4|Neighborhood of FANCC|126","M22303|GOBP_VOLUNTARY_SKELETAL_MUSCLE_CONTRACTION|C5:GO|A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control. [GOC:mtg_cardio, GOC:mtg_muscle]|6","M22339|GOBP_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS|C5:GO|The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. [GOC:mtg_heart]|34","M22754|GOBP_TRANSITION_BETWEEN_FAST_AND_SLOW_FIBER|C5:GO|The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. [GOC:ef, GOC:mtg_muscle]|9","M2299|VANDESLUIS_COMMD1_TARGETS_GROUP_3_UP|C2|Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout compared to normal 9.5 dpc embryos.|82","M2307|WANG_NFKB_TARGETS|C2|Representative genes up-regulated in C2C12 cells (myoblast) lacking NFkB activity due to expression of a super repressor form of NFKBIA [GeneID=4792].|24","M23771|GOBP_ATP_METABOLIC_PROCESS|C5:GO|The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]|236","M24087|GOBP_CARDIAC_MUSCLE_CONTRACTION|C5:GO|Muscle contraction of cardiac muscle tissue. [GOC:dph]|154","M2495|GCM_HMGA2|C4|Neighborhood of HMGA2|123","M26011|GOCC_SUPRAMOLECULAR_COMPLEX|C5:GO|A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. [GOC:dos]|1453","M2610|RREB1_01|C3:TFT|Genes having at least one occurrence of the motif CCCCAAACMMCCCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RREB1 [GeneSymbol=RREB1] transcription factor binding site V$RREB1_01 (v7.4 TRANSFAC).|210","M26674|GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING|C5:GO|Binding to a macromolecular complex. [GOC:jl]|1308","M2885|KRAS.600.LUNG.BREAST_UP.V1_DN|C6|Genes down-regulated in epithelial lung and breast cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene.|285","M2887|KRAS.BREAST_UP.V1_DN|C6|Genes down-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of  KRAS [Gene ID=3845] gene.|143","M29440|GOCC_SUPRAMOLECULAR_POLYMER|C5:GO|A polymeric supramolecular structure. [GOC:dos]|1076","M3213|GSE13229_MATURE_VS_INTMATURE_NKCELL_UP|C7|Genes up-regulated in comparison of mature NK cells versus intermediate mature KN cells.|200","M3317|GSE13493_CD4INTCD8POS_VS_CD8POS_THYMOCYTE_DN|C7|Genes down-regulated in comparison of CD4 [GeneID=920] CD8 Int thymocytes versus CD8 thymocytes.|198"]}]}