{"context":{"query":">>hgnc>>msigdb","source_dataset":"hgnc","target_dataset":"msigdb"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]HGNC:8760,10,HGNC:8760,8,1]["},"schema":"id|standard_name|collection|description|gene_count","mappings":[{"input":"HGNC:8760","source":"HGNC:8760|programmed cell death 1","targets":["M10107|GOBP_REGULATION_OF_CELL_ACTIVATION|C5:GO|Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:ai]|663","M10232|GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS|C5:GO|Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|20","M10277|MULLIGHAN_NPM1_SIGNATURE_3_UP|C2|The 'NPM1 signature 3': genes up-regulated in pediatric AML (acute myeloid leukemia) with mutated NPM1 [GeneID=4869] compared to the AML cases with intact NPM1 and MLL [GeneID=4297].|335","M10422|GOBP_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE|C5:GO|Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. [GOC:add]|69","M10485|GOBP_TOLERANCE_INDUCTION|C5:GO|A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. [GO_REF:0000022, GOC:jal, ISBN:0781735149]|31","M1058|REACTOME_ADAPTIVE_IMMUNE_SYSTEM|C2:CP|Adaptive Immune System|824","M10581|GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS|C5:GO|Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]|33","M10649|GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS|C5:GO|Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]|98","M10757|GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE|C5:GO|Any process that modulates the frequency, rate, or extent of an adaptive immune response. [GOC:add]|222","M10874|GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY|C5:GO|Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]|76","M11182|GOCC_CELL_SURFACE|C5:GO|The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]|916","M11217|GOBP_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS|C5:GO|Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|64","M11239|GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION|C5:GO|Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. [GOC:isa_complete]|215","M11555|GOBP_REGULATION_OF_TOLERANCE_INDUCTION|C5:GO|Any process that modulates the frequency, rate, or extent of tolerance induction. [GOC:add]|20","M11678|GOBP_LEUKOCYTE_MEDIATED_IMMUNITY|C5:GO|Any process involved in the carrying out of an immune response by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]|479","M11755|MORF_RAD51L3|C4|Neighborhood of RAD51L3|387","M11884|GOLDRATH_ANTIGEN_RESPONSE|C2|Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells.|369","M11979|GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]|59","M11984|FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN|C2|Genes down-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones.|96","M12015|GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]|135","M12087|GOBP_CELL_CELL_ADHESION|C5:GO|The attachment of one cell to another cell via adhesion molecules. [GOC:dos]|999","M12336|GOBP_REGULATION_OF_IMMUNE_RESPONSE|C5:GO|Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]|1043","M12401|MODULE_75|C4|Immune response.|398","M1241|GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai]|1284","M12536|GOBP_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS|C5:GO|Any process that modulates the occurrence or rate of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|43","M12663|GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY|C5:GO|Any process involved in the carrying out of an immune response by a lymphocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]|377","M13205|MORF_IL4|C4|Neighborhood of IL4|192","M13319|ABE_VEGFA_TARGETS_2HR|C2|Genes up-regulated in HUVEC cells (endothelium) at 2 h after VEGFA [GeneID=7422] stimulation.|35","M13637|GOBP_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY|C5:GO|Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]|202","M13701|GOBP_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS|C5:GO|Any process that modulates the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]|22","M13774|GOBP_HUMORAL_IMMUNE_RESPONSE|C5:GO|An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732]|307","M13847|GOBP_ADAPTIVE_IMMUNE_RESPONSE|C5:GO|An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]|765","M13947|GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|39","M13996|GOBP_LEUKOCYTE_APOPTOTIC_PROCESS|C5:GO|Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]|126","M14330|GOBP_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY|C5:GO|Any process that modulates the frequency, rate, or extent of T cell mediated immunity. [GOC:add]|107","M14544|GOBP_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY|C5:GO|Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]|263","M14560|CHO_NR4A1_TARGETS|C2|Genes up-regulated in RKO cells (colon cancer) after treatment with the NR4A1 [GeneID=3164] agonist, DIM-C-pPhOCH3.|32","M14645|GOBP_LEUKOCYTE_CELL_CELL_ADHESION|C5:GO|The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators]|436","M14715|GOBP_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY|C5:GO|Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. [GOC:add]|33","M14753|GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS|C5:GO|Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]|1046","M14774|GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS|C5:GO|Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]|593","M14818|GOBP_IMMUNE_EFFECTOR_PROCESS|C5:GO|Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. [GO_REF:0000022, GOC:add, ISBN:0781735149]|745","M14878|GOBP_NEGATIVE_REGULATION_OF_CELL_ACTIVATION|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. [GOC:ai]|229","M15584|GOBP_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS|C5:GO|Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|16","M15641|GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]|215","M15651|GOBP_T_CELL_MEDIATED_IMMUNITY|C5:GO|Any process involved in the carrying out of an immune response by a T cell. [GO_REF:0000022, GOC:add, ISBN:0781735149]|139","M15983|MODULE_46|C4|Genes in the cancer module 46.|394","M16089|GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. [GOC:add]|135","M16177|GOBP_LYMPHOCYTE_APOPTOTIC_PROCESS|C5:GO|Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|86","M16183|GOBP_REGULATION_OF_LYMPHOCYTE_ACTIVATION|C5:GO|Any process that modulates the frequency, rate or extent of lymphocyte activation. [GOC:ai]|530","M16192|GOBP_REGULATION_OF_RESPONSE_TO_TUMOR_CELL|C5:GO|Any process that modulates the frequency, rate, or extent of a response to tumor cell. [GOC:add]|30","M16253|GOBP_REGULATION_OF_T_CELL_ACTIVATION|C5:GO|Any process that modulates the frequency, rate or extent of T cell activation. [GOC:ai]|401","M16401|GOBP_T_CELL_APOPTOTIC_PROCESS|C5:GO|Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]|61","M16476|KEGG_CELL_ADHESION_MOLECULES_CAMS|C2:CP|Cell adhesion molecules (CAMs)|133","M16499|GOBP_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS|C5:GO|Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]|16","M16548|GOBP_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS|C5:GO|An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]|390","M16922|YAGI_AML_WITH_T_9_11_TRANSLOCATION|C2|Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing t(9;11) translocation.|131","M17233|MODULE_104|C4|Genes in the cancer module 104.|353","M17386|REACTOME_REGULATION_OF_T_CELL_ACTIVATION_BY_CD28_FAMILY|C2:CP|Regulation of T cell activation by CD28 family|79","M1742|MARSON_BOUND_BY_FOXP3_STIMULATED|C2|Genes with promoters bound by FOXP3 [GeneID=50943] in hybridoma cells stimulated by PMA [PubChem=4792] and ionomycin [PubChem=3733].|1016","M1743|MARSON_BOUND_BY_FOXP3_UNSTIMULATED|C2|Genes with promoters bound by FOXP3 [GeneID=50943] in unstimulated hybridoma cells.|1228","M17514|GOCC_SIDE_OF_MEMBRANE|C5:GO|A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos]|746","M17747|GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. [GOC:go_curators]|318","M1846|MODULE_220|C4|Developmental processes.|333","M18517|MATSUDA_NATURAL_KILLER_DIFFERENTIATION|C2|Genes changed between developmental stages of Valpha14i  natural killer T lymphocyte cells (NKT).|488","M18810|REACTOME_CO_INHIBITION_BY_PD_1|C2:CP|Co-inhibition by PD-1|28","M18890|MODULE_7|C4|Genes in the cancer module 7.|239","M19170|MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP|C2|The 'NPM1-mutated signature 1': genes up-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to all AML cases with the intact gene.|265","M19749|MORF_ERCC4|C4|Neighborhood of ERCC4|321","M1977|ONO_AML1_TARGETS_UP|C2|Genes up-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector.|24","M2098|MARTENS_TRETINOIN_RESPONSE_UP|C2|Genes up-regulated in NB4 cells (acute promyelocytic leukemia, APL) in response to tretinoin [PubChem=444795]; based on Chip-seq data.|854","M22189|GOBP_B_CELL_APOPTOTIC_PROCESS|C5:GO|Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]|28","M22241|GOBP_RESPONSE_TO_TUMOR_CELL|C5:GO|Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]|49","M22250|GOBP_IMMUNE_RESPONSE_TO_TUMOR_CELL|C5:GO|An immune system process that functions in the response of an organism to a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]|34","M2251|GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE|C5:GO|The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]|403","M2283|MODULE_41|C4|Genes in the cancer module 41.|566","M2297|GOBP_LYMPHOCYTE_ACTIVATION|C5:GO|A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]|846","M230|MORF_FSHR|C4|Neighborhood of FSHR|279","M2317|KASLER_HDAC7_TARGETS_1_UP|C2|Genes up-regulated in DO11.10 cells (hybridoma) by expression of transciptionally activating form of HDAC7 [GeneID=51564] and down-regulated by its transcriptionally repressing form.|192","M2388|BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS|C2|Transcripts in hematopoietic stem cells (HSC) which are trans-regulated (i.e., modulated by a QTL (quantitative trait locus) not in a close proximity to the gene).|783","M23970|GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION|C5:GO|Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. [GOC:ai]|177","M25132|GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION|C5:GO|Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]|159","M27|BENPORATH_MYC_TARGETS_WITH_EBOX|C2|Set 'Myc targets1': targets of c-Myc [GeneID=4609] identified by ChIP on chip in cultured cell lines, focusing on E-box-containing genes; high affinity bound subset|230","M2749|MORF_CAMK4|C4|Neighborhood of CAMK4|290","M27548|REACTOME_INFECTIOUS_DISEASE|C2:CP|Infectious disease|1071","M2810|GOBP_T_CELL_ACTIVATION|C5:GO|The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]|604","M2859|KRAS.AMP.LUNG_UP.V1_DN|C6|Genes down-regulated in epithelial lung cancer cell lines over-expressing KRAS [Gene ID=3845] gene.|142","M2889|KRAS.KIDNEY_UP.V1_DN|C6|Genes down-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene.|135","M2930|GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_IFNAR_KO_DN|C7|Genes down-regulated in skin after injection of Trypanosoma cruzi (strain Y): wildtype (129S1) versus IFNAR1 [GeneID=3454] knockout.|200","M294|GSE5503_MLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_DN|C7|Genes down-regulated in allogeneic T cells after stimulation with dendritic cells from: mesenteric lymph nodes (mLN) versus spleen.|200","M2976|GSE14415_NATURAL_TREG_VS_TCONV_UP|C7|Genes up-regulated in natural T reg versus T conv.|158","M2979|GSE14386_UNTREATED_VS_IFNA_TREATED_ACT_PBMC_MS_PATIENT_DN|C7|Genes down-regulated in peripheral blood mononclear cells (PBMC) from multiple sclerosis (MS) patient: untreated versus IFNB1 [GeneID=3456].|159","M2981|GSE13547_2H_VS_12_H_ANTI_IGM_STIM_BCELL_UP|C7|Genes up-regulated in B lymphocytes stimulated by anti-IgM: 2h versus 12h.|176","M2993|GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP|C7|Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 2h.|182","M30025|IGLV5_37_TARGET_GENES|C3:TFT|Genes containing one or more binding sites for UniProt:A0A075B6J1 (IGLV5-37) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.|651","M30161|SKIL_TARGET_GENES|C3:TFT|Genes containing one or more binding sites for UniProt:P12757 (SKIL) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.|1984","M3027|KAECH_DAY8_EFF_VS_MEMORY_CD8_TCELL_UP|C7|Genes up-regulated in effector CD8 T cells at the peak expansion phase (day 8 after LCMV-Armstrong infection) compared to memory CD8 T cells (day 40+ after LCMV-Armstrong infection).|200","M303|GSE10240_CTRL_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP|C7|Genes up-regulated in primary bronchial epithelial cells: control versus stimulated with IL17A and IL22 [GeneID=3605;50616].|200","M3036|GOLDRATH_NAIVE_VS_EFF_CD8_TCELL_DN|C7|Genes down-regulated in comparison of naïve CD8 T cells versus effector CD8 T cells.|200","M3041|GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_UP|C7|Genes up-regulated in comparison of effector CD8 T cells versus memory CD8 T cells.|200"]}]}