{"context":{"query":">>hgnc>>uniprot>>pdb","source_dataset":"hgnc","target_dataset":"pdb"},"stats":{"queried":6,"total":158,"mapped":6},"pagination":{"has_next":true,"next_token":"-1[]HGNC:8783,10,HGNC:8783,39,0,Q08499,158,4]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"IL6R","source":"HGNC:6019|interleukin 6 receptor","targets":["1N26|Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain|X-RAY DIFFRACTION|2.4|Homo sapiens|0|CYTOKINE","1P9M|Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex|X-RAY DIFFRACTION|3.65|Homo sapiens|0|signaling protein/cytokine","2ARW|The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor|SOLUTION NMR||Homo sapiens|0|CYTOKINE","5FUC|Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies|X-RAY DIFFRACTION|2.7|CAMELUS DROMEDARIUS; HOMO SAPIENS|0|IMMUNE SYSTEM","7DC8|Crystal structure of Switch Ab Fab and hIL6R in complex with ATP|X-RAY DIFFRACTION|2.757|Homo sapiens|0|IMMUNE SYSTEM","8D82|Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains|ELECTRON MICROSCOPY|3.22|Homo sapiens|0|CYTOKINE","8IOW|Cryo-EM structure of the sarilumab Fab/IL-6R complex|ELECTRON MICROSCOPY|3.2|Homo sapiens|0|IMMUNE SYSTEM","8J6F|Cryo-EM structure of the Tocilizumab Fab/IL-6R complex|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|IMMUNE SYSTEM","8QY5|Structure of interleukin 6.|ELECTRON MICROSCOPY|3.1|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","8QY6|Structure of interleukin 6 (gp130 P496L mutant).|ELECTRON MICROSCOPY|3.16|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM"]},{"input":"IL13","source":"HGNC:5973|interleukin 13","targets":["1GA3|NMR STRUCTURE OF INTERLEUKIN-13|SOLUTION NMR||Homo sapiens|0|CYTOKINE","1IJZ|Solution Structure of Human IL-13|SOLUTION NMR||Homo sapiens|0|CYTOKINE","1IK0|Solution Structure of Human IL-13|SOLUTION NMR||Homo sapiens|0|CYTOKINE","3BPO|Crystal structure of the IL13-IL4R-IL13Ra ternary complex|X-RAY DIFFRACTION|3|Homo sapiens|0|Cytokine/Cytokine receptor","3G6D|Crystal structure of the complex between CNTO607 Fab and IL-13|X-RAY DIFFRACTION|3.2|Homo sapiens|0|IMMUNE SYSTEM","3L5W|Crystal structure of the complex between IL-13 and C836 FAB|X-RAY DIFFRACTION|2|Homo sapiens; Mus musculus, Homo sapiens|0|IMMUNE SYSTEM","3L5X|Crystal structure of the complex between IL-13 and H2L6 FAB|X-RAY DIFFRACTION|1.9|Homo sapiens|0|IMMUNE SYSTEM","3LB6|The structure of IL-13 in complex with IL-13Ralpha2|X-RAY DIFFRACTION|3.05|Homo sapiens|0|signaling protein/signaling protein","4I77|Lebrikizumab Fab bound to IL-13|X-RAY DIFFRACTION|1.9|Homo sapiens|0|IMMUNE SYSTEM/CYTOKINE","4PS4|Crystal structure of the complex between IL-13 and M1295 FAB|X-RAY DIFFRACTION|2.8|Homo sapiens|0|IMMUNE SYSTEM","5E4E|Engineered Interleukin-13 bound to receptor|X-RAY DIFFRACTION|3|Homo sapiens|0|SIGNALING PROTEIN","5L6Y|il13 in complex with tralokinumab|X-RAY DIFFRACTION|1.99|Homo sapiens|0|IMMUNE SYSTEM","8BLQ|Cryo-EM structure of the CODV-IL13-RefAb triple complex|ELECTRON MICROSCOPY|3.97|Homo sapiens|0|IMMUNE SYSTEM"]},{"input":"IL4R","source":"HGNC:6015|interleukin 4 receptor","targets":["1IAR|INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX|X-RAY DIFFRACTION|2.3|Homo sapiens|0|CYTOKINE/RECEPTOR","1IRS|IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE|SOLUTION NMR||Homo sapiens|0|COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)","3BPL|Crystal structure of the IL4-IL4R-Common Gamma ternary complex|X-RAY DIFFRACTION|2.93|Homo sapiens|0|Cytokine/Cytokine receptor","3BPN|Crystal structure of the IL4-IL4R-IL13Ra ternary complex|X-RAY DIFFRACTION|3.02|Homo sapiens|0|Cytokine/Cytokine receptor","3BPO|Crystal structure of the IL13-IL4R-IL13Ra ternary complex|X-RAY DIFFRACTION|3|Homo sapiens|0|Cytokine/Cytokine receptor","5E4E|Engineered Interleukin-13 bound to receptor|X-RAY DIFFRACTION|3|Homo sapiens|0|SIGNALING PROTEIN","6OEL|Engineered Fab bound to IL-4 receptor|X-RAY DIFFRACTION|3.1|Homo sapiens|0|IMMUNE SYSTEM","6WGL|Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor|X-RAY DIFFRACTION|2.82|Homo sapiens|0|IMMUNE SYSTEM","8K4Q|Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha|X-RAY DIFFRACTION|2.59|Camelus dromedarius; Homo sapiens|0|CYTOKINE","8Z8L|structure of IL-4Ra in complex with an nanobody 4E9|X-RAY DIFFRACTION|3.96|Homo sapiens; Vicugna pacos|0|CYTOKINE"]},{"input":"SMAD3","source":"HGNC:6769|SMAD family member 3","targets":["1MHD|CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|COMPLEX (TRANSCRIPTION ACTIVATOR/DNA)","1MJS|MH2 domain of transcriptional factor SMAD3|X-RAY DIFFRACTION|1.91|Homo sapiens|0|TRANSCRIPTION","1MK2|SMAD3 SBD complex|X-RAY DIFFRACTION|2.74|Homo sapiens|0|TRANSCRIPTION","1OZJ|Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","1U7F|Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex|X-RAY DIFFRACTION|2.6|Homo sapiens|0|SIGNALING PROTEIN","2LAJ|Third WW domain of human Nedd4L in complex with doubly phosphorylated human smad3 derived peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|LIGASE/TRANSCRIPTION REGULATOR","2LB2|Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/TRANSCRIPTION","5OD6|Crystal structure of Smad3-MH1 bound to the GGCGC site.|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","5ODG|Crystal structure of Smad3-MH1 bound to the GGCT site.|X-RAY DIFFRACTION|2.12|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","5XOC|Crystal structure of human Smad3-FoxH1 complex|X-RAY DIFFRACTION|2.4|Escherichia coli (strain K12); Homo sapiens|0|TRANSCRIPTION","6YIB|14-3-3 sigma in complex with SMAD3 pS423 peptide|X-RAY DIFFRACTION|1.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|PEPTIDE BINDING PROTEIN","6ZMN|Crystal structure of the Smad3-Smad5 MH1 domain chimera bound to the GGCGC site|X-RAY DIFFRACTION|2.333|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN"]},{"input":"PDE4D","source":"HGNC:8783|phosphodiesterase 4D","targets":["1E9K|The structure of the RACK1 interaction sites located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.|SOLUTION NMR|||0|HYDROLASE","1MKD|crystal structure of PDE4D catalytic domain and zardaverine complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HYDROLASE","1OYN|Crystal structure of PDE4D2 in complex with (R,S)-rolipram|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","1PTW|The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","1Q9M|Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","1TB7|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With AMP|X-RAY DIFFRACTION|1.63|Homo sapiens|0|HYDROLASE","1TBB|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram|X-RAY DIFFRACTION|1.6|Homo sapiens|0|HYDROLASE","1XOM|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast|X-RAY DIFFRACTION|1.55|Homo sapiens|0|HYDROLASE","1XON|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast|X-RAY DIFFRACTION|1.72|Homo sapiens|0|HYDROLASE","1XOQ|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast|X-RAY DIFFRACTION|1.83|Homo sapiens|0|HYDROLASE","1XOR|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine|X-RAY DIFFRACTION|1.54|Homo sapiens|0|HYDROLASE","1Y2B|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.4|Homo sapiens|0|HYDROLASE","1Y2C|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.67|Homo sapiens|0|HYDROLASE","1Y2D|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE","1Y2E|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-amino-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","1Y2K|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.36|Homo sapiens|0|HYDROLASE","1ZKN|Structure of PDE4D2-IBMX|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","2FM0|Crystal structure of PDE4D in complex with L-869298|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","2FM5|Crystal structure of PDE4D2 in complex with inhibitor L-869299|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","2PW3|Structure of the PDE4D-cAMP complex|X-RAY DIFFRACTION|1.56|Homo sapiens|0|HYDROLASE","2QYN|Crystal structure of PDE4D2 in complex with inhibitor NPV|X-RAY DIFFRACTION|1.57|Homo sapiens|0|HYDROLASE","3G4G|Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","3G4I|Crystal structure of human phosphodiesterase 4d with d155871|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HYDROLASE","3G4K|Crystal structure of human phosphodiesterase 4d with rolipram|X-RAY DIFFRACTION|1.95|Homo sapiens|0|HYDROLASE","3G4L|Crystal structure of human phosphodiesterase 4d with roflumilast|X-RAY DIFFRACTION|2.5|Homo sapiens|0|HYDROLASE","3G58|Crystal structure of human phosphodiesterase 4d with d155988/pmnpq|X-RAY DIFFRACTION|2.05|Homo sapiens|0|HYDROLASE","3IAD|Crystal structure of human phosphodiesterase 4D with bound allosteric modulator|X-RAY DIFFRACTION|2.65|Homo sapiens|0|HYDROLASE","3IAK|Crystal structure of human phosphodiesterase 4d (PDE4d) with papaverine.|X-RAY DIFFRACTION|2.8|Homo sapiens|0|HYDROLASE","3K4S|The structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone|X-RAY DIFFRACTION|2.05|Homo sapiens|0|HYDROLASE","3SL3|Crystal structure of the apo form of the catalytic domain of PDE4D2|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","3SL4|Crystal structure of the catalytic domain of PDE4D2 with compound 10D|X-RAY DIFFRACTION|1.9|Homo sapiens|0|Hydrolase/Inhibitor","3SL5|Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d|X-RAY DIFFRACTION|2.65|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","3SL6|Crystal structure of the catalytic domain of PDE4D2 with compound 12c|X-RAY DIFFRACTION|2.44|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","3SL8|Crystal structure of the catalytic domain of PDE4D2 with compound 10o|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","3V9B|Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","4OGB|Crystal structure of the catalytic domain of PDE4D2 with compound 2|X-RAY DIFFRACTION|2.032|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","4W1O|PDE4D complexed with inhibitor|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HYDROLASE","4WCU|PDE4 complexed with inhibitor|X-RAY DIFFRACTION|2.35|Homo sapiens|0|HYDROLASE","5K1I|PDE4 crystal structure in complex with small molecule inhibitor|X-RAY DIFFRACTION|2.61|Homo sapiens|0|HYDROLASE","5K32|PDE4D crystal structure in complex with small molecule inhibitor|X-RAY DIFFRACTION|1.99|Homo sapiens|0|HYDROLASE","5LBO|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001|X-RAY DIFFRACTION|2.25|Homo sapiens|0|HYDROLASE","5TKB|CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND|X-RAY DIFFRACTION|2.16|Homo sapiens|0|HYDROLASE/HYDROLASE inhibitor","5WH5|Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91|X-RAY DIFFRACTION|1.8|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","5WH6|Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)|X-RAY DIFFRACTION|1.6|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","5WQA|Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE/INHIBITOR","6AKR|Crystal structure of the PDE4D catalytic domain in complex with osthole|X-RAY DIFFRACTION|2.326|Homo sapiens|0|HYDROLASE","6BOJ|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN5004|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6F6U|Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b|X-RAY DIFFRACTION|1.828|Homo sapiens|0|HYDROLASE","6F8R|Crystal structure of the PDE4D catalytic domain in complex with GEBR-54|X-RAY DIFFRACTION|1.826|Homo sapiens|0|HYDROLASE","6F8T|Crystal structure of the PDE4D catalytic domain in complex with GEBR-4a|X-RAY DIFFRACTION|1.8|Homo sapiens|0|HYDROLASE","6F8U|Crystal structure of the PDE4D catalytic domain in complex with GEBR-20b|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","6F8V|Crystal structure of the PDE4D catalytic domain in complex with GEBR-18b|X-RAY DIFFRACTION|1.85|Homo sapiens|0|HYDROLASE","6F8W|Crystal structure of the PDE4D catalytic domain in complex with GEBR-18a|X-RAY DIFFRACTION|1.601|Homo sapiens|0|HYDROLASE","6F8X|Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g|X-RAY DIFFRACTION|1.95|Homo sapiens|0|HYDROLASE","6FDC|Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a|X-RAY DIFFRACTION|1.45|Homo sapiens|0|HYDROLASE","6FDI|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-226|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HYDROLASE","6FE7|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-356|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","6FEB|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1086|X-RAY DIFFRACTION|1.93|Homo sapiens|0|HYDROLASE","6FET|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1439|X-RAY DIFFRACTION|1.88|Homo sapiens|0|HYDROLASE","6FT0|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-425|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","6FTA|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-3098|X-RAY DIFFRACTION|2.34|Homo sapiens|0|HYDROLASE","6FTW|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-048|X-RAY DIFFRACTION|2.16|Homo sapiens|0|HYDROLASE","6FW3|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007|X-RAY DIFFRACTION|1.78|Homo sapiens|0|HYDROLASE","6HWO|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335|X-RAY DIFFRACTION|1.99|Homo sapiens|0|HYDROLASE","6IAG|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-637|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","6IBF|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-417|X-RAY DIFFRACTION|2.31|Homo sapiens|0|HYDROLASE","6IM6|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.702|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMB|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.549|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMD|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.499|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMI|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.46|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMO|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.55|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMR|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.503|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMT|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.483|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IND|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.872|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6INK|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6INM|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.999|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6KJZ|Crystal structure of PDE4D catalytic domain complexed with compound 1|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HYDROLASE","6KK0|Crystal structure of PDE4D catalytic domain complexed with compound 4e|X-RAY DIFFRACTION|2.20009|Homo sapiens|0|HYDROLASE","6LRM|Crystal structure of PDE4D catalytic domain in complex with arctigenin|X-RAY DIFFRACTION|1.45|Homo sapiens|0|HYDROLASE","6NJH|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48|X-RAY DIFFRACTION|2.15|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6NJI|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-49|X-RAY DIFFRACTION|2.45|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6NJJ|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN14770|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6RCW|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-053|X-RAY DIFFRACTION|2.08|Homo sapiens|0|HYDROLASE","6ZBA|Crystal structure of PDE4D2 in complex with inhibitor LEO39652|X-RAY DIFFRACTION|1.6|Homo sapiens|0|HYDROLASE","7A8Q|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-654|X-RAY DIFFRACTION|2.24|Homo sapiens|0|HYDROLASE","7A9V|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-635|X-RAY DIFFRACTION|2.17|Homo sapiens|0|HYDROLASE","7AAG|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-617|X-RAY DIFFRACTION|1.79|Homo sapiens|0|HYDROLASE","7AB9|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-656|X-RAY DIFFRACTION|2.19|Homo sapiens|0|HYDROLASE","7ABD|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-768|X-RAY DIFFRACTION|2.41|Homo sapiens|0|HYDROLASE","7ABE|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-769|X-RAY DIFFRACTION|1.83|Homo sapiens|0|HYDROLASE","7ABJ|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1361|X-RAY DIFFRACTION|2.11|Homo sapiens|0|HYDROLASE","7AY6|Crystal structure of the PDE4D catalytic domain in complex with GEBR-41b|X-RAY DIFFRACTION|1.66|Homo sapiens|0|HYDROLASE","7B9H|Crystal structure of the PDE4D catalytic domain in complex with GEBR-42a|X-RAY DIFFRACTION|1.5|Homo sapiens|0|HYDROLASE","7CBJ|Crystal structure of PDE4D catalytic domain in complex with compound 36|X-RAY DIFFRACTION|1.5|Homo sapiens|0|HYDROLASE","7CBQ|Crystal structure of PDE4D catalytic domain in complex with Apremilast|X-RAY DIFFRACTION|1.59|Homo sapiens|0|HYDROLASE","7F2K|Crystal structure of PDE4D catalytic domain complexed with compound 17a|X-RAY DIFFRACTION|2.10002|Homo sapiens|0|HYDROLASE","7F2L|Crystal structure of PDE4D catalytic domain complexed with compound 18a|X-RAY DIFFRACTION|2.10111|Homo sapiens|0|HYDROLASE","7F2M|Crystal structure of PDE4D catalytic domain complexed with compound 18d|X-RAY DIFFRACTION|2.20004|Homo sapiens|0|HYDROLASE","7W4X|Crystal structure of PDE4D catalytic domain complexed with 17|X-RAY DIFFRACTION|2.20007|Homo sapiens|0|HYDROLASE","7W4Y|Crystal structure of PDE4D catalytic domain complexed with 33a|X-RAY DIFFRACTION|2.10003|Homo sapiens|0|HYDROLASE"]},{"input":"ORMDL3","source":"HGNC:16038|ORMDL sphingolipid biosynthesis regulator 3","targets":["6M4N|Cryo-EM structure of the dimeric SPT-ORMDL3 complex|ELECTRON MICROSCOPY|3.8|Homo sapiens|0|TRANSFERASE","6M4O|Cryo-EM structure of the monomeric SPT-ORMDL3 complex|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|TRANSFERASE","7CQI|Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex|ELECTRON MICROSCOPY|3.2|Homo sapiens|0|TRANSFERASE","7CQK|Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|TRANSFERASE","7K0M|Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|MEMBRANE PROTEIN","7K0N|Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|MEMBRANE PROTEIN","7K0O|Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|MEMBRANE PROTEIN","7K0P|Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 4|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|MEMBRANE PROTEIN","7K0Q|Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, myriocin-bound|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|MEMBRANE PROTEIN","7YIU|Cryo-EM structure of the C6-ceramide-bound SPT-ORMDL3 complex|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|TRANSFERASE/inhibitor","7YIY|Cryo-EM structure of SPT-ORMDL3 complex|ELECTRON MICROSCOPY|2.7|Homo sapiens|0|TRANSFERASE/INHIBITOR COMPLEX","7YJ1|Cryo-EM structure of SPT-ORMDL3 (ORMDL3-deltaN2) complex|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|TRANSFERASE/INHIBITOR","7YJ2|Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|TRANSFERASE/INHIBITOR"]}]}