{"context":{"query":">>uniprot>>string","source_dataset":"uniprot","target_dataset":"string"},"stats":{"queried":8,"total":8,"mapped":8},"pagination":{"has_next":false},"schema":"id|preferred_name|protein_size|interaction_count|annotation","mappings":[{"input":"O14746","source":"O14746|Telomerase reverse transcriptase","targets":["9606.ENSP00000309572|TERT|1132|5450|Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] "]},{"input":"P84022","source":"P84022|SMAD family member 3","targets":["9606.ENSP00000332973|SMAD3|425|5036|Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] "]},{"input":"Q02297","source":"Q02297|Pro-neuregulin-1, membrane-bound isoform","targets":["9606.ENSP00000287842|NRG1|645|2704|Pro-neuregulin-1, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gla [...] "]},{"input":"P04818","source":"P04818|Thymidylate synthase","targets":["9606.ENSP00000315644|TYMS|313|4470|Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway."]},{"input":"P06241","source":"P06241|Tyrosine-protein kinase Fyn","targets":["9606.ENSP00000346671|FYN|537|5014|Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through  [...] "]},{"input":"P61812","source":"P61812|Transforming growth factor beta-2 proprotein","targets":["9606.ENSP00000355896|TGFB2|442|3596|Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth fact [...] "]},{"input":"O00358","source":"O00358|Forkhead box protein E1","targets":["9606.ENSP00000364265|FOXE1|373|1500|Forkhead box protein E1; Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression."]},{"input":"P01266","source":"P01266|Thyroglobulin","targets":["9606.ENSP00000220616|TG|2768|1476|Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (By similarity). Following TG re- internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity)."]}]}