{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":1,"total":60,"mapped":1},"pagination":{"has_next":false},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"O75874","source":"O75874|Isocitrate dehydrogenase [NADP] cytoplasmic","targets":["1T09|Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex NADP|X-RAY DIFFRACTION|2.7|Homo sapiens|0|OXIDOREDUCTASE","1T0L|Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP, isocitrate, and calcium(2+)|X-RAY DIFFRACTION|2.41|Homo sapiens|0|OXIDOREDUCTASE","3INM|Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)|X-RAY DIFFRACTION|2.1|Homo sapiens|0|OXIDOREDUCTASE","3MAP|Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate|X-RAY DIFFRACTION|2.8|Homo sapiens|0|OXIDOREDUCTASE","3MAR|Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP|X-RAY DIFFRACTION|3.41|Homo sapiens|0|OXIDOREDUCTASE","3MAS|Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate|X-RAY DIFFRACTION|3.2|Homo sapiens|0|OXIDOREDUCTASE","4I3K|Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one|X-RAY DIFFRACTION|3.3056|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","4I3L|Crystal structure of a metabolic reductase with 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one|X-RAY DIFFRACTION|3.292|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","4KZO|Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate|X-RAY DIFFRACTION|2.204|Homo sapiens|0|OXIDOREDUCTASE","4L03|Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate|X-RAY DIFFRACTION|2.1|Homo sapiens|0|OXIDOREDUCTASE","4L04|Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate|X-RAY DIFFRACTION|2.87|Homo sapiens|0|OXIDOREDUCTASE","4L06|Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate|X-RAY DIFFRACTION|2.282|Homo sapiens|0|OXIDOREDUCTASE","4UMX|IDH1 R132H in complex with cpd 1|X-RAY DIFFRACTION|1.88|HOMO SAPIENS|0|OXIDOREDUCTASE","4UMY|IDH1 R132H in complex with cpd 1|X-RAY DIFFRACTION|2.07|HOMO SAPIENS|0|OXIDOREDUCTASE","4XRX|Crystal structure of a metabolic reductase with (E)-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one|X-RAY DIFFRACTION|3.2|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","4XS3|Crystal structure of a metabolic reductase with (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one|X-RAY DIFFRACTION|3.291|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","5DE1|Crystal structure of human IDH1 in complex with GSK321A|X-RAY DIFFRACTION|2.25|Homo sapiens|0|Oxidoreductase/Oxidoreductase Inhibitor","5GIR|Crystal structure of a Fab fragment with its ligand peptide|X-RAY DIFFRACTION|1.93|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","5K10|Cryo-EM structure of isocitrate dehydrogenase (IDH1)|ELECTRON MICROSCOPY|3.8|Homo sapiens|0|OXIDOREDUCTASE","5K11|Cryo-EM structure of isocitrate dehydrogenase (IDH1) in inhibitor-bound state|ELECTRON MICROSCOPY|3.8|Homo sapiens|0|OXIDOREDUCTASE","5L57|Crystal structure of Iso-citrate Dehydrogenase R132H in complex with a novel inhibitor (compound 13a)|X-RAY DIFFRACTION|2.695|Homo sapiens|0|OXIDOREDUCTASE","5L58|Crystal structure of Iso-citrate Dehydrogenase 1 [IDH1 (R132H)] in complex with a novel inhibitor (Compound 2)|X-RAY DIFFRACTION|3.04|Homo sapiens|0|OXIDOREDUCTASE","5LGE|Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032|X-RAY DIFFRACTION|2.7|Homo sapiens|0|OXIDOREDUCTASE","5SUN|IDH1 R132H in complex with IDH146|X-RAY DIFFRACTION|2.477|Homo sapiens|0|OXIDOREDUCTASE","5SVF|IDH1 R132H in complex with IDH125|X-RAY DIFFRACTION|2.34|Homo sapiens|0|OXIDOREDUCTASE","5TQH|IDH1 R132H mutant in complex with IDH889|X-RAY DIFFRACTION|2.2|Homo sapiens|0|OXIDOREDUCTASE","5YFM|Human isocitrate dehydrogenase 1 bound with NADP|X-RAY DIFFRACTION|2.4|Homo sapiens|0|OXIDOREDUCTASE","5YFN|Human isocitrate dehydrogenase 1 bound with isocitrate|X-RAY DIFFRACTION|2.5|Homo sapiens|0|OXIDOREDUCTASE","6ADG|Crystal Structures of IDH1 R132H in complex with AG-881|X-RAY DIFFRACTION|3|Homo sapiens|0|OXIDOREDUCTASE","6B0Z|IDH1 R132H mutant in complex with IDH305|X-RAY DIFFRACTION|2.334|Homo sapiens|0|OXIDOREDUCTASE","6BKX|Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd1|X-RAY DIFFRACTION|1.65|Homo sapiens|0|OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor","6BKY|Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with Cmpd2|X-RAY DIFFRACTION|2.17|Homo sapiens|0|OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor","6BKZ|Novel Modes of Inhibition of Wild-Type IDH1: Non-equivalent Allosteric Inhibition with Cmpd3|X-RAY DIFFRACTION|2.01|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","6BL0|Novel Modes of Inhibition of Wild-Type IDH1:Direct Covalent Modification of His315 with Cmpd11|X-RAY DIFFRACTION|2.17|Homo sapiens|0|OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor","6BL1|Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd13|X-RAY DIFFRACTION|2.02|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","6BL2|Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd15|X-RAY DIFFRACTION|1.92|Homo sapiens|0|oxidoreductase/oxidoreductase inhibitor","6IO0|Human IDH1 R132C mutant complexed with compound A.|X-RAY DIFFRACTION|2.2|Homo sapiens|0|OXIDOREDUCTASE","6O2Y|Crystal structure of IDH1 R132H mutant in complex with compound 24|X-RAY DIFFRACTION|2.8|Homo sapiens|0|Oxidoreductase/Inhibitor","6O2Z|Crystal structure of IDH1 R132H mutant in complex with compound 32|X-RAY DIFFRACTION|2.5|Homo sapiens|0|Oxidoreductase/Inhibitor","6PAY|Structure of HsICDH1:Mg(II):ICT:NADPH(50%) complex reveals structural basis for observation of half-sites reactivity|X-RAY DIFFRACTION|2.199|Homo sapiens|0|OXIDOREDUCTASE","6Q6F|Crystal structure of IDH1 R132H in complex with HMS101|X-RAY DIFFRACTION|3.3|Homo sapiens|0|OXIDOREDUCTASE","6U4J|Crystal structure of IDH1 R132H mutant in complex with FT-2102|X-RAY DIFFRACTION|2.11|Homo sapiens|0|Oxidoreductase/Inhibitor","6VEI|Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with NADPH and AG-881 (Vorasidenib) Inhibitor|X-RAY DIFFRACTION|2.1|Homo sapiens|0|ANTITUMOR PROTEIN","6VG0|CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN COMPLEX WITH NADPH and AGI-15056|X-RAY DIFFRACTION|2.66|Homo sapiens|0|OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor","7PJM|Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and Ca2+/2-Oxoglutarate|X-RAY DIFFRACTION|2.1|Homo sapiens|0|OXIDOREDUCTASE","7PJN|Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and inhibitor DS-1001B|X-RAY DIFFRACTION|2.45|Homo sapiens|0|OXIDOREDUCTASE","8BAY|Crystal Structure of IDH1 variant R132C S280F in complex with NADPH, Ca2+ and 3-butyl-2-oxoglutarate|X-RAY DIFFRACTION|2.35|Homo sapiens|0|OXIDOREDUCTASE","8HB9|Crystal Structure of Human IDH1 R132H Mutant in Complex with NADPH and Compound IHMT-IDH1-053|X-RAY DIFFRACTION|2.8|Homo sapiens|0|OXIDOREDUCTASE","8T7D|Crystal structure of wild type IDH1 bound to compound 1|X-RAY DIFFRACTION|3.444|Homo sapiens|0|OXIDOREDUCTASE","8T7N|Crystal structure of the R132H mutant of IDH1 bound to compound 1|X-RAY DIFFRACTION|2.26|Homo sapiens|0|OXIDOREDUCTASE/INHIBITOR","8T7O|Crystal structure of the R132H mutant of IDH1 bound to AG-120|X-RAY DIFFRACTION|2.053|Homo sapiens|0|OXIDOREDUCTASE/INHIBITOR","8VH9|Crystal Structure of Human IDH1 R132Q in complex with NADPH|X-RAY DIFFRACTION|2.13|Homo sapiens|0|OXIDOREDUCTASE","8VHA|Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate|X-RAY DIFFRACTION|2.28|Homo sapiens|0|OXIDOREDUCTASE","8VHB|Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate|X-RAY DIFFRACTION|1.89|Homo sapiens|0|OXIDOREDUCTASE","8VHC|Crystal Structure of Human IDH1 R132Q in complex with NADPH|X-RAY DIFFRACTION|2.44|Homo sapiens|0|OXIDOREDUCTASE","8VHD|Crystal Structure of Human IDH1 R132Q in complex with NADPH and Isocitrate|X-RAY DIFFRACTION|2.38|Homo sapiens|0|OXIDOREDUCTASE","8VHE|Crystal Structure of Human IDH1 R132Q in Complex with NADPH-TCEP Adduct|X-RAY DIFFRACTION|2.16|Homo sapiens|0|OXIDOREDUCTASE","9B81|Crystal structure of wild type IDH1 bound to compound 4|X-RAY DIFFRACTION|2.56|Homo sapiens|0|OXIDOREDUCTASE","9YHA|Cryo-EM structure of IDH1 R132H|ELECTRON MICROSCOPY|2.69|Homo sapiens|0|CYTOSOLIC PROTEIN","9YHB|Cryo-EM structure of IDH1 R132H C269S|ELECTRON MICROSCOPY|2.85|Homo sapiens|0|CYTOSOLIC PROTEIN"]}]}