{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":6,"total":375,"mapped":6},"pagination":{"has_next":true,"next_token":"-1[]P00533,1,P00533,16,3][P04637,1,P04637,143,1]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P00533","source":"P00533|Epidermal growth factor receptor","targets":["1IVO|Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN","1M14|Tyrosine Kinase Domain from Epidermal Growth Factor Receptor|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","1M17|Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","1MOX|Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha|X-RAY DIFFRACTION|2.5|Homo sapiens|0|transferase/growth factor","1NQL|Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.|X-RAY DIFFRACTION|2.8|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1XKK|EGFR kinase domain complexed with a quinazoline inhibitor- GW572016|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","1YY9|Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225|X-RAY DIFFRACTION|2.605|Homo sapiens; Mus musculus, Homo sapiens|0|IMMUNE SYSTEM/Transferase","1Z9I|A Structural Model for the Membrane-Bound Form of the Juxtamembrane Domain of the Epidermal Growth Factor Receptor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2EB2|Crystal structure of mutated EGFR kinase domain (G719S)|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","2EB3|Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP|X-RAY DIFFRACTION|2.84|Homo sapiens|0|TRANSFERASE","2GS2|Crystal Structure of the active EGFR kinase domain|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","2GS6|Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate|X-RAY DIFFRACTION|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2GS7|Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","2ITN|Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP|X-RAY DIFFRACTION|2.47|HOMO SAPIENS|0|TRANSFERASE","2ITO|Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa|X-RAY DIFFRACTION|3.25|HOMO SAPIENS|0|TRANSFERASE","2ITP|Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788|X-RAY DIFFRACTION|2.74|HOMO SAPIENS|0|TRANSFERASE","2ITQ|Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941|X-RAY DIFFRACTION|2.68|HOMO SAPIENS|0|TRANSFERASE","2ITT|Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788|X-RAY DIFFRACTION|2.73|HOMO SAPIENS|0|TRANSFERASE","2ITU|Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|TRANSFERASE","2ITV|Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP|X-RAY DIFFRACTION|2.47|HOMO SAPIENS|0|TRANSFERASE","2ITW|Crystal structure of EGFR kinase domain in complex with AFN941|X-RAY DIFFRACTION|2.88|HOMO SAPIENS|0|TRANSFERASE","2ITX|Crystal structure of EGFR kinase domain in complex with AMP-PNP|X-RAY DIFFRACTION|2.98|HOMO SAPIENS|0|TRANSFERASE","2ITY|Crystal structure of EGFR kinase domain in complex with Iressa|X-RAY DIFFRACTION|3.42|HOMO SAPIENS|0|TRANSFERASE","2ITZ|Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|TRANSFERASE","2J5E|Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","2J5F|Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","2J6M|Crystal structure of EGFR kinase domain in complex with AEE788|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","2JIT|Crystal structure of EGFR kinase domain T790M mutation|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","2JIU|Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788|X-RAY DIFFRACTION|3.05|HOMO SAPIENS|0|TRANSFERASE","2JIV|Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272|X-RAY DIFFRACTION|3.5|HOMO SAPIENS|0|TRANSFERASE","2KS1|Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2M0B|Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","2M20|EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.|SOLUTION NMR||Homo sapiens|0|SIGNALING PROTEIN","2N5S|Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2RF9|Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE","2RFD|Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide|X-RAY DIFFRACTION|3.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2RFE|Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2RGP|Structure of EGFR in complex with hydrazone, a potent dual inhibitor|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3B2U|Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8|X-RAY DIFFRACTION|2.58|Homo sapiens|0|IMMUNE SYSTEM/TRANSFERASE","3B2V|Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8|X-RAY DIFFRACTION|3.3|Homo sapiens|0|IMMUNE SYSTEM/TRANSFERASE","3BEL|X-ray structure of EGFR in complex with oxime inhibitor|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","3BUO|Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'|X-RAY DIFFRACTION|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|LIGASE/SIGNALING PROTEIN","3C09|Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR|X-RAY DIFFRACTION|3.2|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM/TRANSFERASE","3G5V|Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR|X-RAY DIFFRACTION|2.001|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3G5Y|Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR|X-RAY DIFFRACTION|1.59|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3GOP|Crystal structure of the EGF receptor juxtamembrane and kinase domains|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","3GT8|Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP|X-RAY DIFFRACTION|2.955|Homo sapiens|0|TRANSFERASE","3IKA|Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3LZB|EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3NJP|The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling|X-RAY DIFFRACTION|3.304|Homo sapiens|0|TRANSFERASE","3OB2|Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|Ligase/signaling Protein","3OP0|Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide|X-RAY DIFFRACTION|2.52|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/SIGNALING PROTEIN REGULATOR","3P0Y|anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region|X-RAY DIFFRACTION|1.8|Homo sapiens|0|IMMUNE SYSTEM","3PFV|Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide|X-RAY DIFFRACTION|2.27|Homo sapiens; SYNTHETIC CONSTRUCT|0|LIGASE/PROTEIN BINDING","3POZ|EGFR Kinase domain complexed with tak-285|X-RAY DIFFRACTION|1.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3QWQ|Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin|X-RAY DIFFRACTION|2.75|Homo sapiens|0|PROTEIN BINDING/SIGNALING PROTEIN","3UG1|Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form|X-RAY DIFFRACTION|2.75|Homo sapiens|0|TRANSFERASE","3UG2|Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3VJN|Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with AMPPNP.|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3VJO|Crystal structure of the wild-type EGFR kinase domain in complex with AMPPNP.|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE","3VRP|Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide|X-RAY DIFFRACTION|1.52|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING/Transferase","3VRR|Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING/TRANSFERASE","3W2O|EGFR Kinase domain T790M/L858R Mutant with TAK-285|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2P|EGFR Kinase domain T790M/L858R mutant with compound 2|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2Q|EGFR kinase domain T790M/L858R mutant with HKI-272|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2R|EGFR Kinase domain T790M/L858R mutant with compound 4|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2S|EGFR kinase domain with compound4|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W32|EGFR kinase domain complexed with compound 20a|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W33|EGFR kinase domain complexed with compound 19b|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4G5J|Crystal structure of EGFR kinase in complex with BIBW2992|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4G5P|Crystal structure of EGFR kinase T790M in complex with BIBW2992|X-RAY DIFFRACTION|3.17|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4HJO|Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib|X-RAY DIFFRACTION|2.75|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4I1Z|Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","4I20|Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain|X-RAY DIFFRACTION|3.34|Homo sapiens|0|TRANSFERASE","4I21|Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide|X-RAY DIFFRACTION|3.37|Homo sapiens|0|Transferase/Transferase Inhibitor","4I22|Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","4I23|Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4I24|Structure of T790M EGFR kinase domain co-crystallized with dacomitinib|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","4JQ7|Crystal structure of EGFR kinase domain in complex with compound 2a|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JQ8|Crystal structure of EGFR kinase domain in complex with compound 4b|X-RAY DIFFRACTION|2.83|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JR3|Crystal structure of EGFR kinase domain in complex with compound 3g|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JRV|Crystal structure of EGFR kinase domain in complex with compound 4c|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4KRL|Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0|X-RAY DIFFRACTION|2.849|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","4KRM|Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5|X-RAY DIFFRACTION|2.655|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","4KRO|Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR|X-RAY DIFFRACTION|3.054|Homo sapiens; Lama glama; Mus musculus, Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4KRP|Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR|X-RAY DIFFRACTION|2.823|Homo sapiens; Lama glama; Mus musculus, Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4LI5|EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4LL0|EGFR L858R/T790M in complex with PD168393|X-RAY DIFFRACTION|4|Homo sapiens|0|transferase/transferase inhibitor","4LQM|EGFR L858R in complex with PD168393|X-RAY DIFFRACTION|2.5|Homo sapiens|0|transferase/transferase inhibitor","4LRM|EGFR D770_N771insNPG in complex with PD168393|X-RAY DIFFRACTION|3.526|Homo sapiens|0|transferase/transferase inhibitor","4R3P|Crystal structures of EGFR in complex with Mig6|X-RAY DIFFRACTION|2.905|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","4R3R|Crystal structures of EGFR in complex with Mig6|X-RAY DIFFRACTION|3.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","4R5S|Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3|X-RAY DIFFRACTION|3.001|Homo sapiens|0|TRANSFERASE","4RIW|Crystal structure of an EGFR/HER3 kinase domain heterodimer|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","4RIX|Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","4RIY|Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation|X-RAY DIFFRACTION|2.981|Homo sapiens|0|TRANSFERASE","4RJ4|EGFR kinase (T790M/L858R) with inhibitor compound 6|X-RAY DIFFRACTION|2.78|Homo sapiens|0|Transferase/transferase inhibitor","4RJ5|EGFR kinase (T790M/L858R) with inhibitor compound 5|X-RAY DIFFRACTION|3.1|Homo sapiens|0|Transferase/Transferase inhibitor","4RJ6|EGFR kinase (T790M/L858R) with inhibitor compound 4|X-RAY DIFFRACTION|2.7|Homo sapiens|0|Transferase/Transferase inhibitor","4RJ7|EGFR kinase (T790M/L858R) with inhibitor compound 1|X-RAY DIFFRACTION|2.55|Homo sapiens|0|Transferase/Transferase inhibitor"]},{"input":"O14746","source":"O14746|Telomerase reverse transcriptase","targets":["2BCK|Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","4B18|The crystal structure of human Importin alpha 5 with TERT NLS peptide|X-RAY DIFFRACTION|2.52|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|TRANSPORT PROTEIN / PEPTIDE","4MNQ|TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions|X-RAY DIFFRACTION|2.742|Homo sapiens; Pan troglodytes; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","5MEN|Human Leukocyte Antigen A02 presenting ILAKFLHWL, in complex with cognate T-Cell Receptor|X-RAY DIFFRACTION|2.81|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","5MEO|Human Leukocyte Antigen presenting ILGKFLHRL|X-RAY DIFFRACTION|1.772|Homo sapiens|0|IMMUNE SYSTEM","5MEP|Human Leukocyte Antigen A02 presenting ILGKFLHWL|X-RAY DIFFRACTION|2.71|Homo sapiens|0|IMMUNE SYSTEM","5MEQ|Human Leukocyte Antigen A02 presenting ILAKFLHTL|X-RAY DIFFRACTION|2.27|Homo sapiens|0|IMMUNE SYSTEM","5MER|Human Leukocyte Antigen A02 presenting ILAKFLHEL|X-RAY DIFFRACTION|1.88|Homo sapiens|0|IMMUNE SYSTEM","5UGW|STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN|X-RAY DIFFRACTION|2.31|Homo sapiens|0|TRANSFERASE","7BG9|The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate|ELECTRON MICROSCOPY|3.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7QXA|Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened)|ELECTRON MICROSCOPY|3.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7QXB|Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)|ELECTRON MICROSCOPY|3.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7QXS|Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains)|ELECTRON MICROSCOPY|3.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7TRD|Human telomerase catalytic core structure at 3.3 Angstrom|ELECTRON MICROSCOPY|3.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","7TRE|Human telomerase catalytic core with shelterin protein TPP1|ELECTRON MICROSCOPY|3.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","7TRF|Human telomerase catalytic core RNP with H2A/H2B|ELECTRON MICROSCOPY|3.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","7V99|catalytic core of human telomerase holoenzyme|ELECTRON MICROSCOPY|3.54|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","9QAX|The catalytic core with C2 symmetry of human telomerase dimer|ELECTRON MICROSCOPY|3.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","9QAY|Catalytic core 1 of dimeric human telomerase|ELECTRON MICROSCOPY|3.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN","9QAZ|Catalytic core 2 of dimeric human telomerase|ELECTRON MICROSCOPY|3.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN","9SHY|Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle|ELECTRON MICROSCOPY|3.53|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","9SHZ|Cryo-EM structure of the catalytic core of human telomerase at the elongation state of the repeat addition cycle|ELECTRON MICROSCOPY|3.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","9SI0|Cryo-EM structure of the catalytic core of human telomerase at the pre-termination state of the repeat addition cycle|ELECTRON MICROSCOPY|3.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN"]},{"input":"P04637","source":"P04637|Cellular tumor antigen p53","targets":["1A1U|SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1AIE|P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE|X-RAY DIFFRACTION|1.5|Homo sapiens|0|P53 TETRAMERIZATION","1C26|CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN|X-RAY DIFFRACTION|1.7|Homo sapiens|0|GENE REGULATION","1DT7|SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)|SOLUTION NMR||Rattus norvegicus; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1GZH|Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|GENE REGULATION","1H26|CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53|X-RAY DIFFRACTION|2.24|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|CELL CYCLE","1HS5|NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER|SOLUTION NMR||Homo sapiens|0|GENE REGULATION","1JSP|NMR Structure of CBP Bromodomain in complex with p53 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN","1KZY|Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53|X-RAY DIFFRACTION|2.5|Homo sapiens|0|DNA BINDING PROTEIN, PROTEIN BINDING","1MA3|Structure of a Sir2 enzyme bound to an acetylated p53 peptide|X-RAY DIFFRACTION|2|Archaeoglobus fulgidus; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING, TRANSCRIPTION","1OLG|HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1OLH|HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE PROTEIN","1PES|NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53|SOLUTION NMR||Homo sapiens|0|DNA-BINDING","1PET|NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53|SOLUTION NMR||Homo sapiens|0|DNA-BINDING","1SAE|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1SAF|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1SAK|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1SAL|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1TSR|P53 CORE DOMAIN IN COMPLEX WITH DNA|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","1TUP|TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","1UOL|Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|DNA BINDING PROTEIN","1XQH|Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH|X-RAY DIFFRACTION|1.75|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","1YC5|Sir2-p53 peptide-nicotinamide|X-RAY DIFFRACTION|1.4|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","1YCQ|XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53|X-RAY DIFFRACTION|2.3|Xenopus laevis|0|COMPLEX (ONCOGENE PROTEIN/PEPTIDE)","1YCR|MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53|X-RAY DIFFRACTION|2.6|Homo sapiens|0|COMPLEX (ONCOGENE PROTEIN/PEPTIDE)","1YCS|P53-53BP2 COMPLEX|X-RAY DIFFRACTION|2.2|Homo sapiens|0|COMPLEX (ANTI-ONCOGENE/ANKYRIN REPEATS)","2AC0|Structural Basis of DNA Recognition by p53 Tetramers (complex I)|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2ADY|Structural Basis of DNA Recognition by p53 Tetramers (complex IV)|X-RAY DIFFRACTION|2.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2AHI|Structural Basis of DNA Recognition by p53 Tetramers (complex III)|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2ATA|Structural Basis of DNA Recognition by p53 Tetramers (complex II)|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2B3G|p53N (fragment 33-60) bound to RPA70N|X-RAY DIFFRACTION|1.6|Homo sapiens|0|REPLICATION","2BIM|human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H|X-RAY DIFFRACTION|1.98|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIN|human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIO|human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIP|human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIQ|human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|DNA BINDING PROTEIN","2FEJ|Solution structure of human p53 DNA binding domain.|SOLUTION NMR||Homo sapiens|0|TRANSCRIPTION","2FOJ|The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367|X-RAY DIFFRACTION|1.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","2FOO|The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","2GS0|NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53|SOLUTION NMR||Homo sapiens; Saccharomyces cerevisiae|0|TRANSCRIPTION","2H1L|The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex|X-RAY DIFFRACTION|3.16|Homo sapiens; Simian virus 40|0|VIRAL PROTEIN","2H2D|The Structural Basis for Sirtuin Substrate Affinity|X-RAY DIFFRACTION|1.7|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H2F|The Structural basis for Sirtuin Substrate affinity|X-RAY DIFFRACTION|2.2|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H4F|Sir2-p53 peptide-NAD+|X-RAY DIFFRACTION|2|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H4H|Sir2 H116Y mutant-p53 peptide-NAD|X-RAY DIFFRACTION|1.99|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H4J|Sir2-deacetylated peptide (from enzymatic turnover in crystal)|X-RAY DIFFRACTION|2.1|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H59|Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose|X-RAY DIFFRACTION|1.9|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2J0Z|p53 tetramerization domain wild type|SOLUTION NMR|||0|TRANSCRIPTION","2J10|p53 tetramerization domain mutant T329F Q331K|SOLUTION NMR|||0|TRANSCRIPTION","2J11|p53 tetramerization domain mutant Y327S T329G Q331G|SOLUTION NMR|||0|TRANSCRIPTION","2J1W|Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J1X|Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D|X-RAY DIFFRACTION|1.65|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J1Y|Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D|X-RAY DIFFRACTION|1.69|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J1Z|Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J20|Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J21|Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|NUCLEAR PROTEIN","2K8F|Structural Basis for the Regulation of p53 Function by p300|SOLUTION NMR||Homo sapiens|0|Transferase/Transcription","2L14|Structure of CBP nuclear coactivator binding domain in complex with p53 TAD|SOLUTION NMR||Homo sapiens; Mus musculus|0|PROTEIN BINDING","2LY4|HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail|SOLUTION NMR||Homo sapiens|0|NUCLEAR PROTEIN/ANTITUMOUR PROTEIN","2MEJ|Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints|SOLUTION NMR||Homo sapiens|0|APOPTOSIS","2MWO|Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/ANTITUMOR PROTEIN","2MWP|Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/ANTITUMOR PROTEIN","2MWY|Mdmx-p53|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|Cell Cycle/Antitumor Protein","2MZD|Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex|SOLUTION NMR||Homo sapiens|0|PROTEIN BINDING","2OCJ|Human p53 core domain in the absence of DNA|X-RAY DIFFRACTION|2.05|Homo sapiens|0|DNA BINDING PROTEIN","2PCX|Crystal structure of p53DBD(R282Q) at 1.54-angstrom Resolution|X-RAY DIFFRACTION|1.54|Homo sapiens|0|TRANSCRIPTION","2RUK|Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain|SOLUTION NMR||Homo sapiens|0|TRANSCRIPTION","2V5W|Crystal structure of HDAC8-substrate complex|X-RAY DIFFRACTION|2|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE SUBSTRATE","2VUK|Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083|X-RAY DIFFRACTION|1.5|HOMO SAPIENS|0|TRANSCRIPTION","2WGX|HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D|X-RAY DIFFRACTION|1.75|HOMO SAPIENS|0|CELL CYCLE","2X0U|STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|CELL CYCLE","2X0V|STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|CELL CYCLE","2X0W|STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|CELL CYCLE","2XWR|Crystal structure of the DNA-binding domain of human p53 with extended N terminus|X-RAY DIFFRACTION|1.68|HOMO SAPIENS|0|CELL CYCLE","2YBG|Structure of Lys120-acetylated p53 core domain|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|CELL CYCLE","2YDR|CpOGA D298N in complex with p53-derived O-GlcNAc peptide|X-RAY DIFFRACTION|2.75|CLOSTRIDIUM PERFRINGENS; SYNTHETIC CONSTRUCT|0|HYDROLASE/PEPTIDE","2Z5S|Molecular basis for the inhibition of p53 by Mdmx|X-RAY DIFFRACTION|2.3|Danio rerio; SYNTHETIC CONSTRUCT|0|CELL CYCLE","2Z5T|Molecular basis for the inhibition of p53 by Mdmx|X-RAY DIFFRACTION|2.3|Danio rerio; SYNTHETIC CONSTRUCT|0|CELL CYCLE","3D05|Human p53 core domain with hot spot mutation R249S (II)|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSCRIPTION","3D06|Human p53 core domain with hot spot mutation R249S (I)|X-RAY DIFFRACTION|1.2|Homo sapiens|0|TRANSCRIPTION","3D07|Human p53 core domain with hot spot mutation R249S (III)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSCRIPTION","3D08|Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R|X-RAY DIFFRACTION|1.4|Homo sapiens|0|TRANSCRIPTION","3D09|Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSCRIPTION","3D0A|Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3DAB|Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain|X-RAY DIFFRACTION|1.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|CELL CYCLE","3DAC|Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain|X-RAY DIFFRACTION|1.8|Danio rerio; SYNTHETIC CONSTRUCT|0|CELL CYCLE","3IGK|Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2)|X-RAY DIFFRACTION|1.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3IGL|Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1)|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3KMD|Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer|X-RAY DIFFRACTION|2.15|Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN/DNA","3KZ8|Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)|X-RAY DIFFRACTION|1.91|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3LW1|Binary complex of 14-3-3 sigma and p53 pT387-peptide|X-RAY DIFFRACTION|1.28|Homo sapiens; SYNTHETIC CONSTRUCT|0|PEPTIDE BINDING PROTEIN","3OQ5|Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1|X-RAY DIFFRACTION|2.5005|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","3PDH|Structure of Sir2Tm bound to a propionylated peptide|X-RAY DIFFRACTION|1.8|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","3Q01|An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity|X-RAY DIFFRACTION|2.1|Homo sapiens|0|ANTITUMOR PROTEIN","3Q05|An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","3Q06|An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity|X-RAY DIFFRACTION|3.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|CELL CYCLE/DNA","3SAK|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)|SOLUTION NMR||Homo sapiens|0|APOPTOSIS/CELL CYCLE/GENE REGULATION","3TG5|Structure of SMYD2 in complex with p53 and SAH|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","3TS8|Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","3ZME|Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242|X-RAY DIFFRACTION|1.35|Homo sapiens|0|CELL CYCLE"]},{"input":"Q9UM73","source":"Q9UM73|ALK tyrosine kinase receptor","targets":["2KUP|Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/ONCOPROTEIN","2KUQ|Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK|SOLUTION NMR||Homo sapiens; synthetic construct|0|SIGNALING PROTEIN","2XB7|Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2XBA|Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429|X-RAY DIFFRACTION|1.95|HOMO SAPIENS|0|TRANSFERASE","2XP2|Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YFX|Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","2YHV|Structure of L1196M Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YJR|Structure of F1174L Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YJS|Structure of C1156Y Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YS5|Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2YT2|Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK|SOLUTION NMR||Homo sapiens|0|SIGNALING PROTEIN","3AOX|X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802|X-RAY DIFFRACTION|1.75|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3L9P|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3LCS|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|1.95|Homo sapiens|0|TRANSFERASE","3LCT|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4ANL|Structure of G1269A Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","4ANQ|Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.76|HOMO SAPIENS|0|TRANSFERASE","4ANS|Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.85|HOMO SAPIENS|0|TRANSFERASE","4CCB|Structure of the Human Anaplastic Lymphoma Kinase in Complex with 3-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl-1H- pyrazol-4-yl)pyridin-2-amine|X-RAY DIFFRACTION|2.03|HOMO SAPIENS|0|TRANSFERASE","4CCU|Structure of the Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol|X-RAY DIFFRACTION|2|HOMO SAPIENS|0|TRANSFERASE","4CD0|Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol|X-RAY DIFFRACTION|2.23|HOMO SAPIENS|0|TRANSFERASE","4CLI|Structure of the Human Anaplastic Lymphoma Kinase in Complex with PF- 06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16, 17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","4CLJ|Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.66|HOMO SAPIENS|0|TRANSFERASE","4CMO|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 2-((1R)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-N-methylbenzamide|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","4CMT|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine|X-RAY DIFFRACTION|1.73|HOMO SAPIENS|0|TRANSFERASE","4CMU|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|TRANSFERASE","4CNH|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","4CTB|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20- tetrahydro-7,11-(azeno)pyrido(2',1':2,3)imidazo(4,5-h)(2,5,11) benzoxadiazacyclotetradecine-14-carbonitrile|X-RAY DIFFRACTION|1.79|HOMO SAPIENS|0|TRANSFERASE","4CTC|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one|X-RAY DIFFRACTION|2.03|HOMO SAPIENS|0|TRANSFERASE","4DCE|Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor|X-RAY DIFFRACTION|2.03|Homo sapiens|0|Transferase/Inhibitor","4FNW|Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain|X-RAY DIFFRACTION|1.75|Homo sapiens|0|TRANSFERASE","4FNX|Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSFERASE","4FNY|Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor|X-RAY DIFFRACTION|2.45|Homo sapiens|0|Transferase/Inhibitor","4FNZ|Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Inhibitor","4FOB|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1|X-RAY DIFFRACTION|1.9|Homo sapiens|0|Transferase/Inhibitor","4FOC|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2|X-RAY DIFFRACTION|1.7|Homo sapiens|0|Transferase/Inhibitor","4FOD|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36|X-RAY DIFFRACTION|2|Homo sapiens|0|Transferase/Inhibitor","4JOA|Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MKC|Crystal Structure of Anaplastic Lymphoma Kinase Complexed with LDK378|X-RAY DIFFRACTION|2.01|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4TT7|Crystal structure of human ALK with a covalent modification|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4Z55|Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378|X-RAY DIFFRACTION|1.55|Homo sapiens|0|Transferase/Transferase Inhibitor","5A9U|Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|TRANSFERASE","5AA8|Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.86|HOMO SAPIENS|0|TRANSFERASE","5AA9|Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.93|HOMO SAPIENS|0|TRANSFERASE","5AAA|Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.73|HOMO SAPIENS|0|TRANSFERASE","5AAB|Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","5AAC|Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","5FTO|Crystal structure of the ALK kinase domain in complex with Entrectinib|X-RAY DIFFRACTION|2.22|HOMO SAPIENS|0|TRANSFERASE","5FTQ|Crystal structure of the ALK kinase domain in complex with Cmpd 17|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","5IMX|Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine|X-RAY DIFFRACTION|2.12|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5IUG|Crystal Structure of Anaplastic Lymphoma Kinase (ALK) in complex with 5a|X-RAY DIFFRACTION|1.93|Homo sapiens|0|TRANSFERASE","5IUH|Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","5IUI|Crystal Structure of Anaplastic Lyphoma Kinase (ALK) in complex with 4|X-RAY DIFFRACTION|1.88|Homo sapiens|0|TRANSFERASE","5KZ0|Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide|X-RAY DIFFRACTION|2.3|Homo sapiens|0|Transferase/Transferase Inhibitor","5VZ5|Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501|X-RAY DIFFRACTION|2.5901|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","6AT9|Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-A*0101|X-RAY DIFFRACTION|2.9503|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","6CDT|Structure of Human Anaplastic Lymphoma Kinase Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","6E0R|hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine|X-RAY DIFFRACTION|2.303|Homo sapiens|0|PROTEIN BINDING","6EBW|hALK in complex with compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-yl)ethyl)amino)-1-(3-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(morpholin-4-yl)methanone|X-RAY DIFFRACTION|2.455|Homo sapiens|0|TRANSFERASE/INHIBITOR","6EDL|hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine|X-RAY DIFFRACTION|2.799|Homo sapiens|0|TRANSFERASE/INHIBITOR","6MX8|Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","7BTT|A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain|X-RAY DIFFRACTION|1.86|Homo sapiens|0|TRANSFERASE","7JY4|hALK in complex with ((1S,2S)-1-(2,4-difluorophenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)cyclopropyl)methanamine|X-RAY DIFFRACTION|2.42|Homo sapiens|0|TRANSFERASE","7JYR|hALK in complex with 1-[(1R,2R)-1-(2,4-difluorophenyl)-2-[2-(5-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine|X-RAY DIFFRACTION|2.32|Homo sapiens|0|TRANSFERASE","7JYS|hALK in complex with 3-(3-chlorophenyl)-5-methyl-1H-pyrazole|X-RAY DIFFRACTION|2.22|Homo sapiens|0|TRANSFERASE","7JYT|hALK in complex with 3-(3-methyl-1H-pyrazol-5-yl)pyridine|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","7LRZ|Structure of the Human ALK GRD|X-RAY DIFFRACTION|1.91|Homo sapiens|0|TRANSFERASE","7LS0|Structure of the Human ALK GRD bound to AUG|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE ACTIVATOR","7MZW|Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","7MZY|Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986|X-RAY DIFFRACTION|1.5|Homo sapiens|0|TRANSFERASE","7N00|Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha|ELECTRON MICROSCOPY|2.27|Homo sapiens|0|TRANSFERASE","7NWZ|ALK:ALKAL2 complex|X-RAY DIFFRACTION|4.17|Homo sapiens|0|PROTEIN BINDING","7NX3|Crystal structure of ALK in complex with Fab324|X-RAY DIFFRACTION|2.81|Homo sapiens; Mus musculus|0|PROTEIN BINDING","7NX4|Crystal structure of the TG and EGF-like domains of ALK|X-RAY DIFFRACTION|3|Homo sapiens|0|PROTEIN BINDING","7R7K|Structure of Human Anaplastic Lymphoma Kinase Domain in complex with (4-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]isoindolin-1-one)|X-RAY DIFFRACTION|1.831|Homo sapiens|0|TRANSFERASE","7R7R|Structure of Human Anaplastic Lymphoma Kinase Domain in complex with ((2~{R})-2-[5-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]-4-methyl-thiazol-2-yl]propane-1,2-diol)|X-RAY DIFFRACTION|1.935|Homo sapiens|0|TRANSFERASE","8ARJ|Anaplastic Lymphoma Kinase with a novel carboline inhibitor|X-RAY DIFFRACTION|1.645|Homo sapiens|0|ANTITUMOR PROTEIN","9G5I|Cryo-EM structure of a 2:1 ALK:ALKAL2 complex obtained after re-processing of EMPIAR-10930 data|ELECTRON MICROSCOPY|3.2|Homo sapiens|0|CYTOKINE","9GBE|Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655|X-RAY DIFFRACTION|1.58|Homo sapiens|0|ONCOPROTEIN"]},{"input":"Q13315","source":"Q13315|Serine-protein kinase ATM","targets":["5NP0|Closed dimer of human ATM (Ataxia telangiectasia mutated)|ELECTRON MICROSCOPY|5.7|Homo sapiens|0|SIGNALING PROTEIN","5NP1|Open protomer of human ATM (Ataxia telangiectasia mutated)|ELECTRON MICROSCOPY|5.7|Homo sapiens|0|TRANSFERASE","6HKA|The solution structure of the micelle-associated FATC domain of the human protein kinase ataxia telangiectasia mutated (ATM)|SOLUTION NMR||Homo sapiens; Streptococcus sp. group G|0|TRANSFERASE","6K9K|Monomeric human ATM (Ataxia telangiectasia mutated) kinase|ELECTRON MICROSCOPY|7.82|Homo sapiens|0|CELL CYCLE","6K9L|4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase|ELECTRON MICROSCOPY|4.27|Homo sapiens|0|CELL CYCLE","7NI4|Human ATM kinase domain with bound M4076 inhibitor|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|SIGNALING PROTEIN","7NI5|Human ATM kinase with bound inhibitor KU-55933|ELECTRON MICROSCOPY|2.78|Homo sapiens|0|SIGNALING PROTEIN","7NI6|Human ATM kinase with bound ATPyS|ELECTRON MICROSCOPY|2.8|Homo sapiens|0|SIGNALING PROTEIN","7SIC|Human ATM Dimer|ELECTRON MICROSCOPY|2.51|Homo sapiens|0|SIGNALING PROTEIN","7SID|Human ATM Dimer Bound to Nbs1|ELECTRON MICROSCOPY|2.53|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8OXM|ATM(Q2971A) activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide|ELECTRON MICROSCOPY|3.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8OXO|ATM(Q2971A) dimeric C-terminal region activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide|ELECTRON MICROSCOPY|3.0|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8OXP|ATM(Q2971A) in complex with Mg AMP-PNP|ELECTRON MICROSCOPY|2.6|Homo sapiens|0|SIGNALING PROTEIN","8OXQ|ATM(Q2971A) dimeric C-terminal region in complex with Mg AMP-PNP|ELECTRON MICROSCOPY|2.5|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["1DJS|LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1|X-RAY DIFFRACTION|2.4|Homo sapiens|0|HORMONE/GROWTH FACTOR/RECEPTOR","1E0O|CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|GROWTH FACTOR","1EV2|CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1GJO|The FGFr2 tyrosine kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1II4|CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.7|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1IIL|CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.3|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1NUN|Crystal Structure Analysis of the FGF10-FGFR2b Complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HORMONE/GROWTH FACTOR/MEMBRANE PROTEIN","1OEC|FGFr2 kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1WVZ|Solution Structure of the D2 Domain of the Fibroblast Growth Factor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2FDB|Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c|X-RAY DIFFRACTION|2.28|Homo sapiens|0|HORMONE/GROWTH FACTOR/TRANSFERASE","2PSQ|Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PVF|Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2PVY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","2PWL|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PY3|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","2PZ5|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZP|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZR|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","2Q0B|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3B2T|Structure of phosphotransferase|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3CAF|Crystal Structure of hFGFR2 D2 Domain|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","3CLY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3CU1|Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Hormone","3DAR|Crystal structure of D2 domain from human FGFR2|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","3EUU|Crystal structure of the FGFR2 D2 domain|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3OJ2|Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation|X-RAY DIFFRACTION|2.2|Homo sapiens|0|Cytokine/Signaling Protein","3OJM|Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Cytokine/Signaling Protein","3RI1|Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Transferase/Transferase Inhibitor","4J23|Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex|X-RAY DIFFRACTION|3.882|Homo sapiens|0|SIGNALING PROTEIN/transferase","4J95|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.|X-RAY DIFFRACTION|2.3767|Homo sapiens|0|TRANSFERASE","4J96|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.|X-RAY DIFFRACTION|2.2972|Homo sapiens|0|TRANSFERASE","4J97|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.|X-RAY DIFFRACTION|2.5482|Homo sapiens|0|TRANSFERASE","4J98|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.|X-RAY DIFFRACTION|2.3067|Homo sapiens|0|TRANSFERASE","4J99|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.|X-RAY DIFFRACTION|1.8474|Homo sapiens|0|TRANSFERASE","4WV1|Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3|X-RAY DIFFRACTION|2.362|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","5EG3|Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)|X-RAY DIFFRACTION|2.606|Homo sapiens; Rattus norvegicus|0|Transferase/Hydrolase","5UGL|Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation|X-RAY DIFFRACTION|1.861|Homo sapiens|0|TRANSFERASE","5UGX|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.349|Homo sapiens|0|TRANSFERASE","5UHN|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.909|Homo sapiens|0|TRANSFERASE","5UI0|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE","6AGX|The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE/INHIBITOR","6LVK|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.29|Homo sapiens|0|TRANSFERASE","6LVL|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE","6V6Q|Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657|X-RAY DIFFRACTION|2.46|Homo sapiens|0|TRANSFERASE","7KIA|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 19|X-RAY DIFFRACTION|2.22|Homo sapiens|0|SIGNALING PROTEIN","7KIE|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3|X-RAY DIFFRACTION|2.47|Homo sapiens|0|SIGNALING PROTEIN","7OZY|FGFR2 kinase domain (residues 461-763) in complex with 38.|X-RAY DIFFRACTION|2.28|Homo sapiens|0|TRANSFERASE","8E1X|FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)|X-RAY DIFFRACTION|2.68|Homo sapiens|0|STRUCTURAL PROTEIN","8H75|FGFR2 in complex with YJ001|X-RAY DIFFRACTION|3.75|Homo sapiens|0|TRANSFERASE","8STG|Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations|X-RAY DIFFRACTION|3.79|Homo sapiens|0|TRANSFERASE/INHIBITOR","8SWE|FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3|X-RAY DIFFRACTION|2.24|Homo sapiens|0|ONCOPROTEIN","8U1F|FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10|X-RAY DIFFRACTION|3.33|Homo sapiens|0|Transferase/Inhibitor","8W2X|TAS-120 covalent structure with FGFR2|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W38|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3B|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.23|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3D|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.04|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","9U3N|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","9U7E|FGFR2 kinase domain with a macrocyclic compound 8g|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","9U7S|FGFR2 kinase domain with a macrocyclic compound 8r|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE"]}]}