{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":8,"total":637,"mapped":8},"pagination":{"has_next":true,"next_token":"-1[]P00533,1,P00533,16,3][P15056,1,P15056,96,1][P01116,1,P01116,190,0][P42336,1,P42336,76,1]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P00533","source":"P00533|Epidermal growth factor receptor","targets":["1IVO|Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN","1M14|Tyrosine Kinase Domain from Epidermal Growth Factor Receptor|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","1M17|Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","1MOX|Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha|X-RAY DIFFRACTION|2.5|Homo sapiens|0|transferase/growth factor","1NQL|Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.|X-RAY DIFFRACTION|2.8|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1XKK|EGFR kinase domain complexed with a quinazoline inhibitor- GW572016|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","1YY9|Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225|X-RAY DIFFRACTION|2.605|Homo sapiens; Mus musculus, Homo sapiens|0|IMMUNE SYSTEM/Transferase","1Z9I|A Structural Model for the Membrane-Bound Form of the Juxtamembrane Domain of the Epidermal Growth Factor Receptor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2EB2|Crystal structure of mutated EGFR kinase domain (G719S)|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","2EB3|Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP|X-RAY DIFFRACTION|2.84|Homo sapiens|0|TRANSFERASE","2GS2|Crystal Structure of the active EGFR kinase domain|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","2GS6|Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate|X-RAY DIFFRACTION|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2GS7|Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","2ITN|Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP|X-RAY DIFFRACTION|2.47|HOMO SAPIENS|0|TRANSFERASE","2ITO|Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa|X-RAY DIFFRACTION|3.25|HOMO SAPIENS|0|TRANSFERASE","2ITP|Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788|X-RAY DIFFRACTION|2.74|HOMO SAPIENS|0|TRANSFERASE","2ITQ|Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941|X-RAY DIFFRACTION|2.68|HOMO SAPIENS|0|TRANSFERASE","2ITT|Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788|X-RAY DIFFRACTION|2.73|HOMO SAPIENS|0|TRANSFERASE","2ITU|Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|TRANSFERASE","2ITV|Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP|X-RAY DIFFRACTION|2.47|HOMO SAPIENS|0|TRANSFERASE","2ITW|Crystal structure of EGFR kinase domain in complex with AFN941|X-RAY DIFFRACTION|2.88|HOMO SAPIENS|0|TRANSFERASE","2ITX|Crystal structure of EGFR kinase domain in complex with AMP-PNP|X-RAY DIFFRACTION|2.98|HOMO SAPIENS|0|TRANSFERASE","2ITY|Crystal structure of EGFR kinase domain in complex with Iressa|X-RAY DIFFRACTION|3.42|HOMO SAPIENS|0|TRANSFERASE","2ITZ|Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|TRANSFERASE","2J5E|Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","2J5F|Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","2J6M|Crystal structure of EGFR kinase domain in complex with AEE788|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","2JIT|Crystal structure of EGFR kinase domain T790M mutation|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","2JIU|Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788|X-RAY DIFFRACTION|3.05|HOMO SAPIENS|0|TRANSFERASE","2JIV|Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272|X-RAY DIFFRACTION|3.5|HOMO SAPIENS|0|TRANSFERASE","2KS1|Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2M0B|Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","2M20|EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.|SOLUTION NMR||Homo sapiens|0|SIGNALING PROTEIN","2N5S|Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2RF9|Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE","2RFD|Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide|X-RAY DIFFRACTION|3.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2RFE|Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2RGP|Structure of EGFR in complex with hydrazone, a potent dual inhibitor|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3B2U|Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8|X-RAY DIFFRACTION|2.58|Homo sapiens|0|IMMUNE SYSTEM/TRANSFERASE","3B2V|Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8|X-RAY DIFFRACTION|3.3|Homo sapiens|0|IMMUNE SYSTEM/TRANSFERASE","3BEL|X-ray structure of EGFR in complex with oxime inhibitor|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","3BUO|Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'|X-RAY DIFFRACTION|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|LIGASE/SIGNALING PROTEIN","3C09|Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR|X-RAY DIFFRACTION|3.2|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM/TRANSFERASE","3G5V|Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR|X-RAY DIFFRACTION|2.001|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3G5Y|Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR|X-RAY DIFFRACTION|1.59|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3GOP|Crystal structure of the EGF receptor juxtamembrane and kinase domains|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","3GT8|Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP|X-RAY DIFFRACTION|2.955|Homo sapiens|0|TRANSFERASE","3IKA|Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3LZB|EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3NJP|The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling|X-RAY DIFFRACTION|3.304|Homo sapiens|0|TRANSFERASE","3OB2|Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|Ligase/signaling Protein","3OP0|Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide|X-RAY DIFFRACTION|2.52|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/SIGNALING PROTEIN REGULATOR","3P0Y|anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region|X-RAY DIFFRACTION|1.8|Homo sapiens|0|IMMUNE SYSTEM","3PFV|Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide|X-RAY DIFFRACTION|2.27|Homo sapiens; SYNTHETIC CONSTRUCT|0|LIGASE/PROTEIN BINDING","3POZ|EGFR Kinase domain complexed with tak-285|X-RAY DIFFRACTION|1.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3QWQ|Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin|X-RAY DIFFRACTION|2.75|Homo sapiens|0|PROTEIN BINDING/SIGNALING PROTEIN","3UG1|Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form|X-RAY DIFFRACTION|2.75|Homo sapiens|0|TRANSFERASE","3UG2|Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3VJN|Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with AMPPNP.|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3VJO|Crystal structure of the wild-type EGFR kinase domain in complex with AMPPNP.|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE","3VRP|Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide|X-RAY DIFFRACTION|1.52|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING/Transferase","3VRR|Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING/TRANSFERASE","3W2O|EGFR Kinase domain T790M/L858R Mutant with TAK-285|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2P|EGFR Kinase domain T790M/L858R mutant with compound 2|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2Q|EGFR kinase domain T790M/L858R mutant with HKI-272|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2R|EGFR Kinase domain T790M/L858R mutant with compound 4|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2S|EGFR kinase domain with compound4|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W32|EGFR kinase domain complexed with compound 20a|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W33|EGFR kinase domain complexed with compound 19b|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4G5J|Crystal structure of EGFR kinase in complex with BIBW2992|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4G5P|Crystal structure of EGFR kinase T790M in complex with BIBW2992|X-RAY DIFFRACTION|3.17|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4HJO|Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib|X-RAY DIFFRACTION|2.75|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4I1Z|Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","4I20|Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain|X-RAY DIFFRACTION|3.34|Homo sapiens|0|TRANSFERASE","4I21|Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide|X-RAY DIFFRACTION|3.37|Homo sapiens|0|Transferase/Transferase Inhibitor","4I22|Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","4I23|Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4I24|Structure of T790M EGFR kinase domain co-crystallized with dacomitinib|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","4JQ7|Crystal structure of EGFR kinase domain in complex with compound 2a|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JQ8|Crystal structure of EGFR kinase domain in complex with compound 4b|X-RAY DIFFRACTION|2.83|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JR3|Crystal structure of EGFR kinase domain in complex with compound 3g|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JRV|Crystal structure of EGFR kinase domain in complex with compound 4c|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4KRL|Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0|X-RAY DIFFRACTION|2.849|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","4KRM|Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5|X-RAY DIFFRACTION|2.655|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","4KRO|Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR|X-RAY DIFFRACTION|3.054|Homo sapiens; Lama glama; Mus musculus, Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4KRP|Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR|X-RAY DIFFRACTION|2.823|Homo sapiens; Lama glama; Mus musculus, Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4LI5|EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4LL0|EGFR L858R/T790M in complex with PD168393|X-RAY DIFFRACTION|4|Homo sapiens|0|transferase/transferase inhibitor","4LQM|EGFR L858R in complex with PD168393|X-RAY DIFFRACTION|2.5|Homo sapiens|0|transferase/transferase inhibitor","4LRM|EGFR D770_N771insNPG in complex with PD168393|X-RAY DIFFRACTION|3.526|Homo sapiens|0|transferase/transferase inhibitor","4R3P|Crystal structures of EGFR in complex with Mig6|X-RAY DIFFRACTION|2.905|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","4R3R|Crystal structures of EGFR in complex with Mig6|X-RAY DIFFRACTION|3.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","4R5S|Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3|X-RAY DIFFRACTION|3.001|Homo sapiens|0|TRANSFERASE","4RIW|Crystal structure of an EGFR/HER3 kinase domain heterodimer|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","4RIX|Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","4RIY|Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation|X-RAY DIFFRACTION|2.981|Homo sapiens|0|TRANSFERASE","4RJ4|EGFR kinase (T790M/L858R) with inhibitor compound 6|X-RAY DIFFRACTION|2.78|Homo sapiens|0|Transferase/transferase inhibitor","4RJ5|EGFR kinase (T790M/L858R) with inhibitor compound 5|X-RAY DIFFRACTION|3.1|Homo sapiens|0|Transferase/Transferase inhibitor","4RJ6|EGFR kinase (T790M/L858R) with inhibitor compound 4|X-RAY DIFFRACTION|2.7|Homo sapiens|0|Transferase/Transferase inhibitor","4RJ7|EGFR kinase (T790M/L858R) with inhibitor compound 1|X-RAY DIFFRACTION|2.55|Homo sapiens|0|Transferase/Transferase inhibitor"]},{"input":"P04626","source":"P04626|Receptor tyrosine-protein kinase erbB-2","targets":["1MFG|The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor|X-RAY DIFFRACTION|1.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1MFL|The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor|X-RAY DIFFRACTION|1.88|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1MW4|Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR/TRANSFERASE","1N8Z|Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab|X-RAY DIFFRACTION|2.52|Homo sapiens; Mus musculus, Homo sapiens|0|TRANSFERASE","1QR1|POOR BINDING OF A HER-2/NEU EPITOPE (GP2) TO HLA-A2.1 IS DUE TO A LACK OF INTERACTIONS IN THE CENTER OF THE PEPTIDE|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","1S78|Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex|X-RAY DIFFRACTION|3.25|Homo sapiens; Mus musculus|0|TRANSFERASE","2A91|Crystal structure of ErbB2 domains 1-3|X-RAY DIFFRACTION|2.5|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE,MEMBRANE PROTEIN","2JWA|ErbB2 transmembrane segment dimer spatial structure|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2KS1|Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2L4K|Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2N2A|Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","3BE1|Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3H3B|Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain|X-RAY DIFFRACTION|2.45|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","3MZW|HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","3N85|Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody fragment|X-RAY DIFFRACTION|3.2|Homo sapiens|0|Transferase/immune system","3PP0|Crystal Structure of the Kinase domain of Human HER2 (erbB2).|X-RAY DIFFRACTION|2.25|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3RCD|HER2 Kinase Domain Complexed with TAK-285|X-RAY DIFFRACTION|3.21|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3WLW|Molecular Architecture of the ErbB2 Extracellular Domain Homodimer|X-RAY DIFFRACTION|3.088|Homo sapiens|0|HYDROLASE/IMMUNE SYSTEM","3WSQ|Structure of HER2 with an Fab|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4GFU|PTPN18 in complex with HER2-pY1248 phosphor-peptides|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/Peptide","4HRL|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|2.55|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4HRM|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|3.2|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4HRN|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|2.65|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4NND|Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites|X-RAY DIFFRACTION|2.502|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","5K33|Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19|X-RAY DIFFRACTION|3.3|Homo sapiens|0|IMMUNE SYSTEM","5KWG|Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6|X-RAY DIFFRACTION|4.3|Homo sapiens|0|IMMUNE SYSTEM","5MY6|Crystal structure of a HER2-Nb complex|X-RAY DIFFRACTION|2.246|Camelus dromedarius; Homo sapiens|0|TRANSFERASE","5O4G|HER2 in complex with Fab MF3958|X-RAY DIFFRACTION|3|Homo sapiens|0|ONCOPROTEIN","5OB4|NMR spatial structure of HER2 TM domain dimer in DPC micelles.|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","5TQS|Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2|X-RAY DIFFRACTION|1.876|Bos taurus; SYNTHETIC CONSTRUCT|0|HYDROLASE","6ATT|39S Fab bound to HER2 ecd|X-RAY DIFFRACTION|3.77|Homo sapiens|0|IMMUNE SYSTEM","6BGT|Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","6J71|HuA21-scFv in complex with the extracellular domain(ECD) of HER2|X-RAY DIFFRACTION|2.918|Homo sapiens|0|SIGNALING PROTEIN","6LBX|Crystal structure of HER2 Domain IV and Rb-H2|X-RAY DIFFRACTION|2.03|Cyclostomata; Homo sapiens|0|PROTEIN BINDING","6OGE|Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex|ELECTRON MICROSCOPY|4.36|Homo sapiens|0|transferase/immune system","7JXH|HER2 in complex with JBJ-08-178-01|X-RAY DIFFRACTION|3.27|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","7MN5|Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|2.93|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7MN6|Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.09|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7MN8|Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab|ELECTRON MICROSCOPY|3.45|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN/IMMUNE SYSTEM","7PCD|HER2 IN COMPLEX WITH A COVALENT INHIBITOR|X-RAY DIFFRACTION|1.77|Homo sapiens|0|TRANSFERASE","7QVK|NM-02 in complex with HER2-ECD|X-RAY DIFFRACTION|3.1|Camelus bactrianus; Homo sapiens|0|ONCOPROTEIN","8FFJ|Structure of Zanidatamab bound to HER2|ELECTRON MICROSCOPY|7.5|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","8HGO|The EGF-bound EGFR/HER2 ectodomain complex|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN","8HGP|The EREG-bound EGFR/HER2 ectodomain complex|ELECTRON MICROSCOPY|4.53|Homo sapiens|0|MEMBRANE PROTEIN","8JYQ|Crystal structure of cancer-specific anti-HER2 antibody H2Mab-214 in complex with epitope peptide|X-RAY DIFFRACTION|1.75|Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","8JYR|Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I|X-RAY DIFFRACTION|1.69|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","8PWH|Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex|ELECTRON MICROSCOPY|3.17|Homo sapiens|0|STRUCTURAL PROTEIN","8Q6J|Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|STRUCTURAL PROTEIN","8U4K|Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|4.27|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U4L|Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U8X|crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27|X-RAY DIFFRACTION|1.69|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE/INHIBITOR","8VB5|Crystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib|X-RAY DIFFRACTION|1.48|Homo sapiens|0|TRANSFERASE","8VQD|HER2 S310F in complex with TL1 Fab|ELECTRON MICROSCOPY|2.61|Homo sapiens|0|SIGNALING PROTEIN","8VQE|Homodimeric structure of HER2 S310F extracellular region|ELECTRON MICROSCOPY|2.67|Homo sapiens|0|SIGNALING PROTEIN","9IUT|Crystal structure of cancer-specific anti-HER2 antibody H2Mab-250 in complex with epitope peptide|X-RAY DIFFRACTION|2.09|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","9L1S|Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|IMMUNE SYSTEM","9MTE|CryoEM structure of extracellular domain of human HER2 complexed with two nano-bodies 27A05 and 47D05|ELECTRON MICROSCOPY|2.66|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","9MTX|CryoEM structure of extracellular domain of human HER2 complexed with nano-bodies 29E09|ELECTRON MICROSCOPY|3.06|Homo sapiens; Lama glama|0|TRANSFERASE","9QBF|HER2/ErbB2 extracellular domain (ECD) in compact conformation in complex with trastuzumab (TZB) antibody|ELECTRON MICROSCOPY|3.8|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN","9QBG|HER2/ErbB2 extracellular domain (ECD) in extended conformation in complex with trastuzumab (TZB) antibody|ELECTRON MICROSCOPY|3.6|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN","9QBH|HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.|ELECTRON MICROSCOPY|3.77|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"Q9UM73","source":"Q9UM73|ALK tyrosine kinase receptor","targets":["2KUP|Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/ONCOPROTEIN","2KUQ|Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK|SOLUTION NMR||Homo sapiens; synthetic construct|0|SIGNALING PROTEIN","2XB7|Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2XBA|Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429|X-RAY DIFFRACTION|1.95|HOMO SAPIENS|0|TRANSFERASE","2XP2|Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YFX|Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","2YHV|Structure of L1196M Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YJR|Structure of F1174L Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YJS|Structure of C1156Y Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YS5|Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2YT2|Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK|SOLUTION NMR||Homo sapiens|0|SIGNALING PROTEIN","3AOX|X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802|X-RAY DIFFRACTION|1.75|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3L9P|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3LCS|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|1.95|Homo sapiens|0|TRANSFERASE","3LCT|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4ANL|Structure of G1269A Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","4ANQ|Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.76|HOMO SAPIENS|0|TRANSFERASE","4ANS|Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.85|HOMO SAPIENS|0|TRANSFERASE","4CCB|Structure of the Human Anaplastic Lymphoma Kinase in Complex with 3-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl-1H- pyrazol-4-yl)pyridin-2-amine|X-RAY DIFFRACTION|2.03|HOMO SAPIENS|0|TRANSFERASE","4CCU|Structure of the Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol|X-RAY DIFFRACTION|2|HOMO SAPIENS|0|TRANSFERASE","4CD0|Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol|X-RAY DIFFRACTION|2.23|HOMO SAPIENS|0|TRANSFERASE","4CLI|Structure of the Human Anaplastic Lymphoma Kinase in Complex with PF- 06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16, 17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","4CLJ|Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.66|HOMO SAPIENS|0|TRANSFERASE","4CMO|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 2-((1R)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-N-methylbenzamide|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","4CMT|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine|X-RAY DIFFRACTION|1.73|HOMO SAPIENS|0|TRANSFERASE","4CMU|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|TRANSFERASE","4CNH|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","4CTB|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20- tetrahydro-7,11-(azeno)pyrido(2',1':2,3)imidazo(4,5-h)(2,5,11) benzoxadiazacyclotetradecine-14-carbonitrile|X-RAY DIFFRACTION|1.79|HOMO SAPIENS|0|TRANSFERASE","4CTC|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one|X-RAY DIFFRACTION|2.03|HOMO SAPIENS|0|TRANSFERASE","4DCE|Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor|X-RAY DIFFRACTION|2.03|Homo sapiens|0|Transferase/Inhibitor","4FNW|Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain|X-RAY DIFFRACTION|1.75|Homo sapiens|0|TRANSFERASE","4FNX|Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSFERASE","4FNY|Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor|X-RAY DIFFRACTION|2.45|Homo sapiens|0|Transferase/Inhibitor","4FNZ|Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Inhibitor","4FOB|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1|X-RAY DIFFRACTION|1.9|Homo sapiens|0|Transferase/Inhibitor","4FOC|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2|X-RAY DIFFRACTION|1.7|Homo sapiens|0|Transferase/Inhibitor","4FOD|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36|X-RAY DIFFRACTION|2|Homo sapiens|0|Transferase/Inhibitor","4JOA|Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MKC|Crystal Structure of Anaplastic Lymphoma Kinase Complexed with LDK378|X-RAY DIFFRACTION|2.01|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4TT7|Crystal structure of human ALK with a covalent modification|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4Z55|Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378|X-RAY DIFFRACTION|1.55|Homo sapiens|0|Transferase/Transferase Inhibitor","5A9U|Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|TRANSFERASE","5AA8|Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.86|HOMO SAPIENS|0|TRANSFERASE","5AA9|Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.93|HOMO SAPIENS|0|TRANSFERASE","5AAA|Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.73|HOMO SAPIENS|0|TRANSFERASE","5AAB|Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","5AAC|Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","5FTO|Crystal structure of the ALK kinase domain in complex with Entrectinib|X-RAY DIFFRACTION|2.22|HOMO SAPIENS|0|TRANSFERASE","5FTQ|Crystal structure of the ALK kinase domain in complex with Cmpd 17|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","5IMX|Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine|X-RAY DIFFRACTION|2.12|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5IUG|Crystal Structure of Anaplastic Lymphoma Kinase (ALK) in complex with 5a|X-RAY DIFFRACTION|1.93|Homo sapiens|0|TRANSFERASE","5IUH|Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","5IUI|Crystal Structure of Anaplastic Lyphoma Kinase (ALK) in complex with 4|X-RAY DIFFRACTION|1.88|Homo sapiens|0|TRANSFERASE","5KZ0|Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide|X-RAY DIFFRACTION|2.3|Homo sapiens|0|Transferase/Transferase Inhibitor","5VZ5|Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501|X-RAY DIFFRACTION|2.5901|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","6AT9|Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-A*0101|X-RAY DIFFRACTION|2.9503|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","6CDT|Structure of Human Anaplastic Lymphoma Kinase Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","6E0R|hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine|X-RAY DIFFRACTION|2.303|Homo sapiens|0|PROTEIN BINDING","6EBW|hALK in complex with compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-yl)ethyl)amino)-1-(3-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(morpholin-4-yl)methanone|X-RAY DIFFRACTION|2.455|Homo sapiens|0|TRANSFERASE/INHIBITOR","6EDL|hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine|X-RAY DIFFRACTION|2.799|Homo sapiens|0|TRANSFERASE/INHIBITOR","6MX8|Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","7BTT|A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain|X-RAY DIFFRACTION|1.86|Homo sapiens|0|TRANSFERASE","7JY4|hALK in complex with ((1S,2S)-1-(2,4-difluorophenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)cyclopropyl)methanamine|X-RAY DIFFRACTION|2.42|Homo sapiens|0|TRANSFERASE","7JYR|hALK in complex with 1-[(1R,2R)-1-(2,4-difluorophenyl)-2-[2-(5-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine|X-RAY DIFFRACTION|2.32|Homo sapiens|0|TRANSFERASE","7JYS|hALK in complex with 3-(3-chlorophenyl)-5-methyl-1H-pyrazole|X-RAY DIFFRACTION|2.22|Homo sapiens|0|TRANSFERASE","7JYT|hALK in complex with 3-(3-methyl-1H-pyrazol-5-yl)pyridine|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","7LRZ|Structure of the Human ALK GRD|X-RAY DIFFRACTION|1.91|Homo sapiens|0|TRANSFERASE","7LS0|Structure of the Human ALK GRD bound to AUG|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE ACTIVATOR","7MZW|Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","7MZY|Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986|X-RAY DIFFRACTION|1.5|Homo sapiens|0|TRANSFERASE","7N00|Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha|ELECTRON MICROSCOPY|2.27|Homo sapiens|0|TRANSFERASE","7NWZ|ALK:ALKAL2 complex|X-RAY DIFFRACTION|4.17|Homo sapiens|0|PROTEIN BINDING","7NX3|Crystal structure of ALK in complex with Fab324|X-RAY DIFFRACTION|2.81|Homo sapiens; Mus musculus|0|PROTEIN BINDING","7NX4|Crystal structure of the TG and EGF-like domains of ALK|X-RAY DIFFRACTION|3|Homo sapiens|0|PROTEIN BINDING","7R7K|Structure of Human Anaplastic Lymphoma Kinase Domain in complex with (4-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]isoindolin-1-one)|X-RAY DIFFRACTION|1.831|Homo sapiens|0|TRANSFERASE","7R7R|Structure of Human Anaplastic Lymphoma Kinase Domain in complex with ((2~{R})-2-[5-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]-4-methyl-thiazol-2-yl]propane-1,2-diol)|X-RAY DIFFRACTION|1.935|Homo sapiens|0|TRANSFERASE","8ARJ|Anaplastic Lymphoma Kinase with a novel carboline inhibitor|X-RAY DIFFRACTION|1.645|Homo sapiens|0|ANTITUMOR PROTEIN","9G5I|Cryo-EM structure of a 2:1 ALK:ALKAL2 complex obtained after re-processing of EMPIAR-10930 data|ELECTRON MICROSCOPY|3.2|Homo sapiens|0|CYTOKINE","9GBE|Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655|X-RAY DIFFRACTION|1.58|Homo sapiens|0|ONCOPROTEIN"]},{"input":"P15056","source":"P15056|Serine/threonine-protein kinase B-raf","targets":["1UWH|The complex of wild type B-RAF and BAY439006.|X-RAY DIFFRACTION|2.95|HOMO SAPIENS|0|TRANSFERASE","1UWJ|The complex of mutant V599E B-RAF and BAY439006.|X-RAY DIFFRACTION|3.5|HOMO SAPIENS|0|TRANSFERASE","2FB8|Structure of the B-Raf kinase domain bound to SB-590885|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","2L05|Solution NMR Structure of the Ras-binding domain of Serine/threonine-protein kinase B-raf from Homo sapiens, Northeast Structural Genomics Consortium Target HR4694F|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","3C4C|B-Raf Kinase in Complex with PLX4720|X-RAY DIFFRACTION|2.57|Homo sapiens|0|TRANSFERASE","3D4Q|Pyrazole-based inhibitors of B-Raf kinase|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","3IDP|B-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE","3II5|The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor|X-RAY DIFFRACTION|2.79|Homo sapiens|0|TRANSFERASE","3NY5|Crystal structure of the RBD domain of serine/threonine-protein kinase B-raf from Homo sapiens. Northeast Structural Genomics Consortium Target HR4694F|X-RAY DIFFRACTION|1.993|Homo sapiens|0|TRANSFERASE","3OG7|B-Raf Kinase V600E oncogenic mutant in complex with PLX4032|X-RAY DIFFRACTION|2.45|Homo sapiens|0|transferase/transferase inhibitor","3PPJ|Human B-Raf Kinase in Complex with a Furopyridine Inhibitor|X-RAY DIFFRACTION|3.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3PPK|Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3PRF|Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3PRI|Crystal Structure of Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3PSB|Furo[2,3-c]pyridine-based Indanone Oximes as Potent and Selective B-Raf Inhibitors|X-RAY DIFFRACTION|3.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3PSD|Non-oxime pyrazole based inhibitors of B-Raf kinase|X-RAY DIFFRACTION|3.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3Q4C|Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292|X-RAY DIFFRACTION|3.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3Q96|B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3SKC|Human B-Raf Kinase in Complex with an Amide Linked Pyrazolopyridine Inhibitor|X-RAY DIFFRACTION|3.2|Homo sapiens|0|Transferase/Transferase Inhibitor","3TV4|Human B-Raf Kinase Domain in Complex with an Bromopyridine Benzamide Inhibitor|X-RAY DIFFRACTION|3.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3TV6|Human B-Raf Kinase Domain in Complex with a Methoxypyrazolopyridinyl Benzamide Inhibitor|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4CQE|B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor|X-RAY DIFFRACTION|2.3|HOMO SAPIENS|0|TRANSFERASE","4DBN|Crystal Structure of the Kinase domain of Human B-raf with a [1,3]thiazolo[5,4-b]pyridine derivative|X-RAY DIFFRACTION|3.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4E26|BRAF in complex with an organic inhibitor 7898734|X-RAY DIFFRACTION|2.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4E4X|Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor|X-RAY DIFFRACTION|3.6|Homo sapiens|0|Transferase/Transferase Inhibitor","4EHE|B-Raf Kinase Domain in Complex with an Aminothienopyrimidine-based Inhibitor|X-RAY DIFFRACTION|3.3|Homo sapiens|0|Transferase/Transferase Inhibitor","4EHG|B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor|X-RAY DIFFRACTION|3.5|Homo sapiens|0|Transferase/Transferase Inhibitor","4FC0|Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4FK3|B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX3203|X-RAY DIFFRACTION|2.65|Homo sapiens|0|Transferase/Transferase inhibitor","4G9C|Human B-Raf Kinase Domain bound to a Type II Pyrazolopyridine Inhibitor|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4G9R|B-Raf V600E Kinase Domain Bound to a Type II Dihydroquinazoline Inhibitor|X-RAY DIFFRACTION|3.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4H58|BRAF in complex with compound 3|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4JVG|B-Raf Kinase in Complex with Birb796|X-RAY DIFFRACTION|3.09|Homo sapiens|0|Transferase/transferase inhibitor","4KSP|Crystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-632|X-RAY DIFFRACTION|2.93|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4KSQ|Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MBJ|Human B-Raf Kinase Domain in Complex with an Imidazopyridine-based Inhibitor|X-RAY DIFFRACTION|3.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MNE|Crystal structure of the BRAF:MEK1 complex|X-RAY DIFFRACTION|2.8483|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MNF|Crystal structure of BRAF-V600E bound to GDC0879|X-RAY DIFFRACTION|2.802|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4PP7|Highly Potent and Selective 3-N-methylquinazoline-4(3H)-one Based Inhibitors of B-RafV600E Kinase|X-RAY DIFFRACTION|3.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4R5Y|The complex structure of Braf V600E kinase domain with a novel Braf inhibitor|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4RZV|Crystal structure of the BRAF (R509H) kinase domain monomer bound to Vemurafenib|X-RAY DIFFRACTION|2.994|Homo sapiens|0|Transferase/Transferase Inhibitor","4RZW|Crystal structure of BRAF (R509H) kinase domain bound to AZ628|X-RAY DIFFRACTION|3.493|Homo sapiens|0|Transferase/Transferase Inhibitor","4WO5|Crystal structure of a BRAF kinase domain monomer|X-RAY DIFFRACTION|2.83|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","4XV1|B-Raf Kinase V600E oncogenic mutant in complex with PLX7904|X-RAY DIFFRACTION|2.47|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4XV2|B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4XV3|B-Raf Kinase V600E oncogenic mutant in complex with PLX7922|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4XV9|B-Raf Kinase domain in complex with PLX5568|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4YHT|bRaf complexed with an inhibitor|X-RAY DIFFRACTION|3.05|Homo sapiens|0|Transferase/Transferase Inhibitor","5C9C|CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5CSW|B-RAF in complex with Dabrafenib|X-RAY DIFFRACTION|2.66|Homo sapiens|0|TRANSFERASE","5CSX|CRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 882370|X-RAY DIFFRACTION|2.51|Homo sapiens|0|TRANSFERASE","5CT7|BRAF in Complex with RAF265|X-RAY DIFFRACTION|3.17|Homo sapiens|0|TRANSFERASE","5FD2|B-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor|X-RAY DIFFRACTION|2.89|Homo sapiens|0|Transferase/Transferase Inhibitor","5HI2|BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib|X-RAY DIFFRACTION|2.512|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5HID|BRAF Kinase domain b3aC loop deletion mutant in complex with AZ628|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5HIE|BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5ITA|Crystal Structure of BRAF Kinase Domain Bound to AZ-VEM|X-RAY DIFFRACTION|1.95|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5J17|Solution structure of Ras Binding Domain (RBD) of B-Raf|SOLUTION NMR||Homo sapiens|0|PROTEIN BINDING","5J18|Solution structure of Ras Binding Domain (RBD) of B-Raf complexed with Rigosertib (Complex I)|SOLUTION NMR||Homo sapiens|0|PROTEIN BINDING","5J2R|Solution structure of Ras Binding Domain (RBD) of B-Raf|SOLUTION NMR||Homo sapiens|0|PROTEIN BINDING","5JRQ|BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM|X-RAY DIFFRACTION|2.287|Homo sapiens|0|TRANSFERASE/TRANSFERASE inhibitor","5JSM|BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-3-VEM|X-RAY DIFFRACTION|2.19|Homo sapiens|0|TRANSFERASE/TRANSFERASE inhibitor","5JT2|BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-BISAMIDE|X-RAY DIFFRACTION|2.702|Homo sapiens|0|TRANSFERASE/TRANSFERASE inhibitor","5VAL|BRAF in Complex with N-(3-(tert-butyl)phenyl)-4-methyl-3-(6-morpholinopyrimidin-4-yl)benzamide|X-RAY DIFFRACTION|2.26|Homo sapiens|0|TRANSFERASE/TRANSFERASE inhibitor","5VAM|BRAF in Complex with RAF709|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE/TRANSFERASE inhibitor","5VR3|Crystal structure of the BRS domain of BRAF|X-RAY DIFFRACTION|2.102|Homo sapiens|0|TRANSFERASE","5VYK|Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1|X-RAY DIFFRACTION|1.749|Homo sapiens|0|SIGNALING PROTEIN","6B8U|Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor|X-RAY DIFFRACTION|2.68|Homo sapiens|0|Transferase/Transferase Inhibitor","6CAD|Crystal structure of RAF kinase domain bound to the inhibitor 2a|X-RAY DIFFRACTION|2.55|Homo sapiens|0|SIGNALING PROTEIN","6N0P|BRAF in complex with N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254)|X-RAY DIFFRACTION|2.37|Homo sapiens|0|transferase/transferase inhibitor","6N0Q|BRAF in complex with N-(4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)phenyl)-3-(trifluoromethyl)benzamide.|X-RAY DIFFRACTION|2.04|Homo sapiens|0|transferase/transferase inhibitor","6NSQ|Crystal structure of BRAF kinase domain bound to the inhibitor 2l|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6NYB|Structure of a MAPK pathway complex|ELECTRON MICROSCOPY|4.1|Homo sapiens; Spodoptera exigua|0|TRANSFERASE","6P3D|The co-crystal structure of BRAF(V600E) with ponatinib|X-RAY DIFFRACTION|2.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6P7G|The co-crystal structure of BRAF(V600E) with PHI1|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6PP9|Crystal structure of BRAF:MEK1 complex|X-RAY DIFFRACTION|2.59|Homo sapiens|0|TRANSFERASE","6Q0J|Structure of a MAPK pathway complex|ELECTRON MICROSCOPY|4.9|Homo sapiens; Spodoptera exigua|0|Transferase/PROTEIN BINDING","6Q0K|Structure of a MAPK pathway complex|ELECTRON MICROSCOPY|6.8|Homo sapiens|0|SIGNALING PROTEIN/Transferase","6Q0T|Structure of a MAPK pathway complex|ELECTRON MICROSCOPY|5.7|Homo sapiens; Spodoptera exigua|0|TRANSFERASE/PROTEIN BINDING","6U2G|BRAF-MEK complex with AMP-PCP bound to BRAF|X-RAY DIFFRACTION|2.886|Homo sapiens|0|TRANSFERASE","6U2H|BRAF dimer bound to 14-3-3|X-RAY DIFFRACTION|2.5|Homo sapiens|0|SIGNALING PROTEIN/Transferase","6UAN|B-Raf:14-3-3 complex|ELECTRON MICROSCOPY|3.9|Homo sapiens; Spodoptera aff. frugiperda 1 BOLD-2017|0|SIGNALING PROTEIN","6UUO|Crystal structure of BRAF kinase domain bound to the PROTAC P4B|X-RAY DIFFRACTION|3.288|Homo sapiens|0|SIGNALING PROTEIN","6V2U|Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib|X-RAY DIFFRACTION|3.78|Homo sapiens|0|TRANSFERASE","6V2W|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP|X-RAY DIFFRACTION|3.12|Homo sapiens|0|TRANSFERASE","6V34|Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580|X-RAY DIFFRACTION|3.15|Homo sapiens|0|TRANSFERASE","6XAG|Apo BRAF dimer bound to 14-3-3|X-RAY DIFFRACTION|3.3|Homo sapiens|0|SIGNALING PROTEIN/Transferase","6XFP|Crystal Structure of BRAF kinase domain bound to Belvarafenib|X-RAY DIFFRACTION|2|Homo sapiens|0|SIGNALING PROTEIN","6XLO|Crystal structure of bRaf in complex with inhibitor|X-RAY DIFFRACTION|2.493|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7K0V|Crystal structure of bRaf in complex with inhibitor GNE-0749|X-RAY DIFFRACTION|1.93|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7M0T|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib|X-RAY DIFFRACTION|3.19|Homo sapiens|0|TRANSFERASE","7M0U|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib|X-RAY DIFFRACTION|3.09|Homo sapiens|0|TRANSFERASE","7M0V|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib|X-RAY DIFFRACTION|3.16|Homo sapiens|0|TRANSFERASE","7M0W|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib|X-RAY DIFFRACTION|3.09|Homo sapiens|0|TRANSFERASE","7M0X|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and PD0325901|X-RAY DIFFRACTION|2.47|Homo sapiens|0|TRANSFERASE","7M0Y|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib|X-RAY DIFFRACTION|3.45|Homo sapiens|0|TRANSFERASE","7M0Z|Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and CH5126766|X-RAY DIFFRACTION|3.12|Homo sapiens|0|TRANSFERASE","7MFD|Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved|ELECTRON MICROSCOPY|3.66|Homo sapiens|0|SIGNALING PROTEIN/TRANSFERASE","7MFE|Autoinhibited BRAF:(14-3-3)2 complex with the BRAF RBD resolved|ELECTRON MICROSCOPY|4.07|Homo sapiens|0|SIGNALING PROTEIN","7MFF|Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor|ELECTRON MICROSCOPY|3.89|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"P01116","source":"P01116|GTPase KRas","targets":["1D8D|CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION|X-RAY DIFFRACTION|2|Rattus norvegicus; SYNTHETIC CONSTRUCT|0|TRANSFERASE","1D8E|Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog.|X-RAY DIFFRACTION|3|Rattus norvegicus; SYNTHETIC CONSTRUCT|0|TRANSFERASE","1KZO|PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY|X-RAY DIFFRACTION|2.2|Rattus norvegicus; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE SUBSTRATE","1KZP|PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYLATED K-RAS4B PEPTIDE PRODUCT|X-RAY DIFFRACTION|2.1|Rattus norvegicus; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE SUBSTRATE","2MSC|NMR data-driven model of GTPase KRas-GDP tethered to a lipid-bilayer nanodisc|SOLUTION NMR||Homo sapiens|0|LIPID BINDING PROTEIN","2MSD|NMR data-driven model of GTPase KRas-GNP tethered to a lipid-bilayer nanodisc|SOLUTION NMR||Homo sapiens|0|LIPID BINDING PROTEIN","2MSE|NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc|SOLUTION NMR||Homo sapiens|0|LIPID BINDING PROTEIN","3GFT|Human K-Ras (Q61H) in complex with a GTP analogue|X-RAY DIFFRACTION|2.27|Homo sapiens|0|SIGNALING PROTEIN","4DSN|Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","4DSO|Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity|X-RAY DIFFRACTION|1.85|Homo sapiens|0|HYDROLASE","4DST|Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","4DSU|Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE","4EPR|Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","4EPT|Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","4EPV|Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation|X-RAY DIFFRACTION|1.35|Homo sapiens|0|HYDROLASE","4EPW|Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation|X-RAY DIFFRACTION|1.7|Homo sapiens|0|PROTEIN BINDING","4EPX|Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation|X-RAY DIFFRACTION|1.76|Homo sapiens|0|HYDROLASE","4EPY|Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation|X-RAY DIFFRACTION|1.801|Homo sapiens|0|HYDROLASE","4L8G|Crystal Structure of K-Ras G12C, GDP-bound|X-RAY DIFFRACTION|1.521|Homo sapiens|0|SIGNALING PROTEIN","4LDJ|Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas|X-RAY DIFFRACTION|1.15|Homo sapiens|0|HYDROLASE","4LPK|Crystal Structure of K-Ras WT, GDP-bound|X-RAY DIFFRACTION|1.5|Homo sapiens|0|SIGNALING PROTEIN","4LRW|Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound|X-RAY DIFFRACTION|2.151|Homo sapiens|0|SIGNALING PROTEIN","4LUC|Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C|X-RAY DIFFRACTION|1.29|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4LV6|Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.5|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4LYF|Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.568|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4LYH|Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.371|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4LYJ|Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group|X-RAY DIFFRACTION|1.927|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M1O|Crystal Structure of small molecule vinylsulfonamide 7 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.571|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M1S|Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.552|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M1T|Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.703|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M1W|Crystal Structure of small molecule vinylsulfonamide covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.58|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M1Y|Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.491|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M21|Crystal Structure of small molecule acrylamide 11 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.94|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4M22|Crystal Structure of small molecule acrylamide 16 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|2.09|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","4NMM|Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor|X-RAY DIFFRACTION|1.89|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","4OBE|Crystal Structure of GDP-bound Human KRas|X-RAY DIFFRACTION|1.24|Homo sapiens|0|HYDROLASE","4PZY|Second-site screening of K-Ras in the presence of covalently attached first-site ligands|X-RAY DIFFRACTION|1.88|Homo sapiens|0|HYDROLASE","4PZZ|Second-site screening of K-Ras in the presence of covalently attached first-site ligands|X-RAY DIFFRACTION|1.403|Homo sapiens|0|HYDROLASE","4Q01|Second-site screening of K-Ras in the presence of covalently attached first-site ligands|X-RAY DIFFRACTION|1.291|Homo sapiens|0|HYDROLASE","4Q02|Second-site screening of K-Ras in the presence of covalently attached first-site ligands|X-RAY DIFFRACTION|1.702|Homo sapiens|0|HYDROLASE","4Q03|Second-site screening of K-Ras in the presence of covalently attached first-site ligands|X-RAY DIFFRACTION|1.201|Homo sapiens|0|HYDROLASE","4QL3|Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas|X-RAY DIFFRACTION|1.041|Homo sapiens|0|HYDROLASE","4TQ9|Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas|X-RAY DIFFRACTION|1.491|Homo sapiens|0|HYDROLASE","4TQA|Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas|X-RAY DIFFRACTION|1.13|Homo sapiens|0|HYDROLASE","4WA7|Crystal Structure of a GDP-bound Q61L Oncogenic Mutant of Human GT- Pase KRas|X-RAY DIFFRACTION|1.986|Homo sapiens|0|signaling protein, hydrolase","5F2E|Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.4|Homo sapiens|0|HYDROLASE","5KYK|Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs|X-RAY DIFFRACTION|2.702|Homo sapiens|0|HYDROLASE/HYDROLASE inhibitor","5MLA|Crystal structure of human RAS in complex with darpin K55|X-RAY DIFFRACTION|2.19|Homo sapiens; Synthetic construct|0|HYDROLASE","5MLB|Crystal structure of human RAS in complex with darpin K27|X-RAY DIFFRACTION|3.22|Homo sapiens; synthetic construct|0|HYDROLASE","5O2S|Human KRAS in complex with darpin K27|X-RAY DIFFRACTION|3.22|Homo sapiens|0|SIGNALING PROTEIN","5O2T|Human KRAS in complex with darpin K27|X-RAY DIFFRACTION|2.19|Homo sapiens|0|SIGNALING PROTEIN","5OCG|Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.|X-RAY DIFFRACTION|1.48|Homo sapiens|0|HYDROLASE","5OCO|Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.|X-RAY DIFFRACTION|1.66|Homo sapiens|0|HYDROLASE","5OCT|Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.|X-RAY DIFFRACTION|2.07|Homo sapiens|0|HYDROLASE","5TAR|Crystal structure of farnesylated and methylated kras4b in complex with PDE-delta (crystal form II - with ordered hypervariable region)|X-RAY DIFFRACTION|1.9|Homo sapiens|0|ONCOPROTEIN","5TB5|Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)|X-RAY DIFFRACTION|2|Homo sapiens|0|ONCOPROTEIN","5UFE|Wild-type K-Ras(GNP)/R11.1.6 complex|X-RAY DIFFRACTION|2.302|Homo sapiens; Sulfolobus solfataricus|0|Hydrolase/DE NOVO PROTEIN","5UFQ|K-RasG12D(GNP)/R11.1.6 complex|X-RAY DIFFRACTION|2.199|Homo sapiens; Sulfolobus solfataricus|0|Hydrolase/DE NOVO PROTEIN","5UK9|Wild-type K-Ras(GCP) pH 6.5|X-RAY DIFFRACTION|1.887|Homo sapiens|0|HYDROLASE","5UQW|Crystal structure of human KRAS G12V mutant in complex with GDP|X-RAY DIFFRACTION|1.5|Homo sapiens|0|HYDROLASE","5US4|Crystal structure of human KRAS G12D mutant in complex with GDP|X-RAY DIFFRACTION|1.83|Homo sapiens|0|HYDROLASE","5USJ|Crystal Structure of human KRAS G12D mutant in complex with GDPNP|X-RAY DIFFRACTION|1.94|Homo sapiens|0|HYDROLASE","5V6S|Crystal structure of small molecule acrylamide 1 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","5V6V|Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.72|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","5V71|KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder|X-RAY DIFFRACTION|2.228|Homo sapiens|0|HYDROLASE/HYDROLASE inhibitor","5V9L|KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder|X-RAY DIFFRACTION|1.981|Homo sapiens|0|HYDROLASE/HYDROLASE inhibitor","5V9O|KRAS G12C inhibitor|X-RAY DIFFRACTION|1.56|Homo sapiens|0|HYDROLASE/HYDROLASE inhibitor","5V9U|Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.38|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","5VBM|Crystal Structure of Small Molecule Disulfide 2C07 Bound to K-Ras Cys Light M72C GDP|X-RAY DIFFRACTION|1.49|Homo sapiens|0|HYDROLASE","5VP7|Crystal structure of human KRAS G12A mutant in complex with GDP|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE","5VPI|Crystal structure of human KRAS G12A mutant in complex with GTP|X-RAY DIFFRACTION|1.62|Homo sapiens|0|HYDROLASE","5VPY|Crystal structure of human KRAS G12A mutant in complex with GppNHp|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","5VPZ|Crystal structure of human KRAS G12A mutant in complex with GTP-gamma-S|X-RAY DIFFRACTION|1.85|Homo sapiens|0|HYDROLASE","5VQ0|Crystal structure of human KRAS G12A mutant in complex with GDP (EDTA soaked)|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","5VQ1|Crystal structure of human KRAS Q61A mutant in complex with GDP|X-RAY DIFFRACTION|1.78|Homo sapiens|0|HYDROLASE","5VQ2|Crystal structure of human WT-KRAS in complex with GTP|X-RAY DIFFRACTION|1.96|Homo sapiens|0|HYDROLASE","5VQ6|Crystal structure of human WT-KRAS in complex with GTP-gamma-S|X-RAY DIFFRACTION|1.99|Homo sapiens|0|HYDROLASE","5VQ8|Crystal structure of human WT-KRAS in complex with GDP (EDTA soaked)|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","5W22|Crystal structure of human WT-KRAS in complex with GDP|X-RAY DIFFRACTION|1.762|Homo sapiens|0|HYDROLASE","5WHA|KRas G12V, bound to GDP and miniprotein 225-11|X-RAY DIFFRACTION|2.04|Homo sapiens; synthetic construct|0|PROTEIN BINDING","5WHB|KRas G12V, bound to GDP and miniprotein 225-11(A30R)|X-RAY DIFFRACTION|2.18|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","5WHD|Crystal structure of KRas G12V/D38P, bound to GDP|X-RAY DIFFRACTION|1.641|Homo sapiens|0|PROTEIN BINDING","5WHE|KRas G12V/D38P, bound to GppNHp and miniprotein 225-11|X-RAY DIFFRACTION|1.91|Homo sapiens; synthetic construct|0|PROTEIN BINDING","5WLB|KRas G12V, bound to GppNHp and miniprotein 225-15a/b|X-RAY DIFFRACTION|1.72|Homo sapiens; synthetic construct|0|PROTEIN BINDING","5WPM|KRas G12V, bound to GppNHp and miniprotein 225-11(A30R)|X-RAY DIFFRACTION|1.72|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","5XCO|Crystal structure of human K-Ras G12D Mutant in complex with GDP and Cyclic Inhibitory Peptide|X-RAY DIFFRACTION|1.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","5YXZ|Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSFERASE","5YY1|Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI739|X-RAY DIFFRACTION|1.69|Homo sapiens|0|TRANSFERASE","6ARK|Crystal Structure of compound 10 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.75|Homo sapiens|0|signaling protein/inhibitor","6ASA|KRAS mutant-D33E in GDP-bound|X-RAY DIFFRACTION|2.545|Homo sapiens|0|HYDROLASE","6ASE|KRAS mutant-A59G in GDP-bound|X-RAY DIFFRACTION|1.554|Homo sapiens|0|HYDROLASE","6B0V|Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.29|Homo sapiens|0|SIGNALING PROTEIN","6B0Y|Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C|X-RAY DIFFRACTION|1.43|Homo sapiens|0|SIGNALING PROTEIN","6BOF|Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation|X-RAY DIFFRACTION|1.401|Homo sapiens|0|HYDROLASE","6BP1|Crystal structure of human KRAS A59G mutant in complex with GCP|X-RAY DIFFRACTION|2.001|Homo sapiens|0|HYDROLASE","6CC9|NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN/ONCOPROTEIN","6CCH|NMR data-driven model of GTPase KRas-GMPPNP tethered to a nanodisc (E3 state)|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN/ONCOPROTEIN","6CCX|NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN/ONCOPROTEIN","6CU6|Crystal structure of GMPPNP-bound G12R mutant of human KRAS4b|X-RAY DIFFRACTION|1.5|Homo sapiens|0|ONCOPROTEIN","6E6F|KRAS G13D bound to GppNHp (K13GNP)|X-RAY DIFFRACTION|3.401|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"P42336","source":"P42336|Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","targets":["2ENQ|Solution structure of the C2 domain from human PI3-kinase p110 subunit alpha|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2RD0|Structure of a human p110alpha/p85alpha complex|X-RAY DIFFRACTION|3.05|Homo sapiens|0|Transferase/Oncoprotein","3HHM|Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/ONCOPROTEIN","3HIZ|Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/ONCOPROTEIN","3ZIM|Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","4JPS|Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4L1B|Crystal Structure of p110alpha complexed with niSH2 of p85alpha|X-RAY DIFFRACTION|2.586|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4L23|Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103|X-RAY DIFFRACTION|2.501|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4L2Y|Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d|X-RAY DIFFRACTION|2.8|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4OVU|Crystal Structure of p110alpha in complex with niSH2 of p85alpha|X-RAY DIFFRACTION|2.96|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","4OVV|Crystal Structure of PI3Kalpha in complex with diC4-PIP2|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","4TUU|Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE","4TV3|Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","4WAF|Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha|X-RAY DIFFRACTION|2.39|Homo sapiens|0|transferase/transferase inhibitor","4YKN|Pi3K alpha lipid kinase with Active Site Inhibitor|X-RAY DIFFRACTION|2.9|Homo sapiens|0|Transferase/Transferase Inhibitor","4ZOP|Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor|X-RAY DIFFRACTION|2.62|Homo sapiens|0|transferase/transferase inhibitor","5DXH|p110alpha/p85alpha with compound 5|X-RAY DIFFRACTION|3|Bos taurus; Homo sapiens|0|Transferase/Transferase Inhibitor","5DXT|p110alpha with GDC-0326|X-RAY DIFFRACTION|2.25|Homo sapiens|0|Transferase/Inhibitor","5FI4|Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5ITD|Crystal structure of PI3K alpha with PI3K delta inhibitor|X-RAY DIFFRACTION|3.02|Homo sapiens|0|Transferase/Protein Transport/Inhibitor","5SW8|Crystal structure of PI3Kalpha in complex with fragments 7 and 11|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWG|Crystal Structure of PI3Kalpha in complex with fragments 5 and 21|X-RAY DIFFRACTION|3.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWO|Crystal Structure of PI3Kalpha in complex with fragments 4 and 19|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWP|Crystal Structure of PI3Kalpha in complex with fragments 6 and 24|X-RAY DIFFRACTION|3.41|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWR|Crystal Structure of PI3Kalpha in complex with fragments 20 and 26|X-RAY DIFFRACTION|3.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWT|Crystal Structure of PI3Kalpha in complex with fragments 17 and 27|X-RAY DIFFRACTION|3.49|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SX8|Crystal Structure of PI3Kalpha in complex with fragments 12 and 15|X-RAY DIFFRACTION|3.47|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SX9|Crystal Structure of PI3Kalpha in complex with fragment 14|X-RAY DIFFRACTION|3.52|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXA|Crystal Structure of PI3Kalpha in complex with fragment 10|X-RAY DIFFRACTION|3.35|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXB|Crystal Structure of PI3Kalpha in complex with fragment 23|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXC|Crystal Structure of PI3Kalpha in complex with fragment 8|X-RAY DIFFRACTION|3.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXD|Crystal Structure of PI3Kalpha in complex with fragment 22|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXE|Crystal Structure of PI3Kalpha in complex with fragments 19 and 28|X-RAY DIFFRACTION|3.51|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXF|Crystal Structure of PI3Kalpha in complex with fragment 9|X-RAY DIFFRACTION|3.46|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXI|Crystal Structure of PI3Kalpha in complex with fragment 13|X-RAY DIFFRACTION|3.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXJ|Crystal Structure of PI3Kalpha in complex with fragment 29|X-RAY DIFFRACTION|3.42|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXK|Crystal Structure of PI3Kalpha in complex with fragment 18|X-RAY DIFFRACTION|3.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5UBR|CRYSTAL STRUCTURE OF PI3K ALPHA IN COMPLEX WITH A 7-(3-(PIPERAZIN-1-YL)PHENYL)PYRROLO[2,1-F][1,2,4] TRIAZIN-4-AMINE DERIVIATINE|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","5UK8|The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5UKJ|The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5UL1|The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5XGH|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.97|Homo sapiens|0|TRANSFERASE/INHIBITOR","5XGI|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE/INHIBITOR","5XGJ|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.97|Homo sapiens|0|TRANSFERASE/INHIBITOR","6GVF|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","6GVG|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-4-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","6GVH|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine|X-RAY DIFFRACTION|2.74|Homo sapiens|0|TRANSFERASE","6GVI|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","6NCT|Structure of p110alpha/niSH2 - vector data collection|X-RAY DIFFRACTION|3.35|Homo sapiens|0|TRANSFERASE","6OAC|PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha|X-RAY DIFFRACTION|3.15|Homo sapiens|0|TRANSFERASE","6PYS|Human PI3Kalpha in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one)|X-RAY DIFFRACTION|2.19|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VO7|Crystal structure of PI3K-alpha Ras Binding Domain (RBD)|X-RAY DIFFRACTION|2.31|Homo sapiens|0|ONCOPROTEIN","7JIU|HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F|X-RAY DIFFRACTION|2.12||0|TRANSFERASE/TRANSFERASE INHIBITOR","7K6M|Crystal structure of PI3Kalpha selective Inhibitor PF-06843195|X-RAY DIFFRACTION|2.413|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K6N|Crystal structure of PI3Kalpha selective Inhibitor 11-1575|X-RAY DIFFRACTION|2.77|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K6O|Crystal structure of PI3Kalpha inhibitor 10-5429|X-RAY DIFFRACTION|2.738|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K71|Crystal structure of PI3Kalpha inhibitor 4-0686|X-RAY DIFFRACTION|2.9|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7L1B|Crystal structure of HLA-A*03:01 in complex with a wild-type PIK3CA peptide|X-RAY DIFFRACTION|2.04|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7L1C|Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|1.96|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7L1D|Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|3.11|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7MLK|Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/INHIBITOR","7MYN|Cryo-EM Structure of p110alpha in complex with p85alpha|ELECTRON MICROSCOPY|2.79|Homo sapiens|0|TRANSFERASE","7MYO|Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719|ELECTRON MICROSCOPY|2.92|Homo sapiens|0|TRANSFERASE","7PG5|Crystal Structure of PI3Kalpha|X-RAY DIFFRACTION|2.20029|Homo sapiens|0|TRANSFERASE","7PG6|Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719|X-RAY DIFFRACTION|2.49944|Homo sapiens|0|TRANSFERASE","7R9V|Structure of PIK3CA with covalent inhibitor 19|X-RAY DIFFRACTION|2.69|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7R9Y|Structure of PIK3CA with covalent inhibitor 22|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7RRG|Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|2.12|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7TZ7|PI3K alpha in complex with an inhibitor|X-RAY DIFFRACTION|2.41|Homo sapiens|0|transferase/inhibitor","8AM0|Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib)|X-RAY DIFFRACTION|2.818|Homo sapiens|0|TRANSFERASE","8BFU|Crystal structure of the apo p110alpha catalytic subunit from homo sapiens|X-RAY DIFFRACTION|2.41|Homo sapiens|0|TRANSFERASE","8DCP|PI 3-kinase alpha with nanobody 3-126|ELECTRON MICROSCOPY|2.41|Homo sapiens|0|TRANSFERASE","8DCX|PI 3-kinase alpha with nanobody 3-159|ELECTRON MICROSCOPY|2.8|Homo sapiens|0|TRANSFERASE","8DD4|PI 3-kinase alpha with nanobody 3-142|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|TRANSFERASE","8DD8|PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|TRANSFERASE","8EXL|Crystal structure of PI3K-alpha in complex with taselisib|X-RAY DIFFRACTION|1.989|Homo sapiens|0|CELL CYCLE","8EXO|Crystal structure of PI3K-alpha in complex with compound 19|X-RAY DIFFRACTION|2.46|Homo sapiens|0|CELL CYCLE","8EXU|Crystal structure of PI3K-alpha in complex with compound 30|X-RAY DIFFRACTION|2.68|Homo sapiens|0|CELL CYCLE","8EXV|Crystal structure of PI3K-alpha in complex with compound 32|X-RAY DIFFRACTION|2.48|Homo sapiens|0|CELL CYCLE","8GUA|Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719|ELECTRON MICROSCOPY|2.77|Homo sapiens|0|STRUCTURAL PROTEIN","8GUB|Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719|ELECTRON MICROSCOPY|2.73|Homo sapiens|0|STRUCTURAL PROTEIN","8GUD|Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719|ELECTRON MICROSCOPY|2.62|Homo sapiens|0|STRUCTURAL PROTEIN","8ILR|Cryo-EM structure of PI3Kalpha in complex with compound 16|ELECTRON MICROSCOPY|3.05|Homo sapiens|0|STRUCTURAL PROTEIN","8ILS|Cryo-EM structure of PI3Kalpha in complex with compound 17|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|STRUCTURAL PROTEIN","8ILV|Cryo-EM structure of PI3Kalpha in complex with compound 18|ELECTRON MICROSCOPY|3.19|Homo sapiens|0|STRUCTURAL PROTEIN","8OW2|Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938|X-RAY DIFFRACTION|2.57|Homo sapiens|0|TRANSFERASE","8SBC|Co-structure of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and brain penetrant inhibitors|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","8SBJ|Co-structure Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform complexed with brain penetrant inhibitors|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","8TDU|STX-478, a Mutant-Selective, Allosteric Inhibitor bound to PI3Kalpha|X-RAY DIFFRACTION|3.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8TGD|STX-478, a Mutant-Selective, Allosteric Inhibitor bound to H1047R PI3Kalpha|X-RAY DIFFRACTION|2.928|Homo sapiens|0|TRANSFERASE/TRANSFERSE INHIBITOR","8TS7|Human PI3K p85alpha/p110alpha|X-RAY DIFFRACTION|2.71|Homo sapiens|0|SIGNALING PROTEIN","8TS8|p85alpha/p110alpha heterodimer H1047R mutant|X-RAY DIFFRACTION|2.72|Homo sapiens|0|SIGNALING PROTEIN","8TS9|Human PI3K p85alpha/p110alpha H1047R bound to compound 1|X-RAY DIFFRACTION|2.83|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSA|Human PI3K p85alpha/p110alpha H1047R bound to compound 2|X-RAY DIFFRACTION|2.51|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSB|Human PI3K p85alpha/p110alpha bound to compound 2|X-RAY DIFFRACTION|3.53|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSC|Human PI3K p85alpha/p110alpha H1047R bound to compound 3|X-RAY DIFFRACTION|3.62|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSD|Human PI3K p85alpha/p110alpha bound to RLY-2608|X-RAY DIFFRACTION|2.7|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE/INHIBITOR","8TU6|CryoEM structure of PI3Kalpha|ELECTRON MICROSCOPY|3.12|Homo sapiens|0|CYTOSOLIC PROTEIN","8TWY|Structure of p110 alpha bound to (S)-1-(4-((2-(4-(4-(2-amino-4-(difluoromethyl)pyrimidin-5-yl)-6-(3-methylmorpholino)-1,3,5- triazin-2-yl)piperazin-1-yl)-2-oxoethoxy)methyl)piperidin-1-yl)prop-2-en-1-one (compound 9)|X-RAY DIFFRACTION|2.67|Homo sapiens|0|TRANSFERASE/Inhibitor","8V8H|PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4).|X-RAY DIFFRACTION|3.58|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"O96017","source":"O96017|Serine/threonine-protein kinase Chk2","targets":["1GXC|FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide|X-RAY DIFFRACTION|2.7|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|PHOSPHOPROTEIN-BINDING DOMAIN","2CN5|Crystal structure of human Chk2 in complex with ADP|X-RAY DIFFRACTION|2.25|HOMO SAPIENS|0|TRANSFERASE","2CN8|Crystal structure of human Chk2 in complex with debromohymenialdisine|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","2W0J|Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","2W7X|Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019|X-RAY DIFFRACTION|2.07|HOMO SAPIENS|0|TRANSFERASE","2WTC|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","2WTD|Crystal structure of Chk2 in complex with an inhibitor|X-RAY DIFFRACTION|2.75|HOMO SAPIENS|0|TRANSFERASE","2WTI|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2WTJ|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","2XBJ|Crystal Structure of Chk2 in complex with an inhibitor|X-RAY DIFFRACTION|2.3|HOMO SAPIENS|0|TRANSFERASE","2XK9|Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533|X-RAY DIFFRACTION|2.35|HOMO SAPIENS|0|TRANSFERASE","2XM8|Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2|X-RAY DIFFRACTION|3.4|HOMO SAPIENS|0|TRANSFERASE","2XM9|Structure of a small molecule inhibitor with the kinase domain of Chk2|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2YCF|Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531|X-RAY DIFFRACTION|1.77|HOMO SAPIENS|0|TRANSFERASE","2YCQ|Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","2YCR|Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","2YCS|Crystal structure of checkpoint kinase 2 in complex with PV788|X-RAY DIFFRACTION|2.35|HOMO SAPIENS|0|TRANSFERASE","2YIQ|Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322|X-RAY DIFFRACTION|1.89|HOMO SAPIENS|0|TRANSFERASE","2YIR|Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","2YIT|Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","3I6U|Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","3I6W|Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","3VA4|Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide|X-RAY DIFFRACTION|1.54|Mus musculus; SYNTHETIC CONSTRUCT|0|CELL CYCLE","4A9R|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","4A9S|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.66|HOMO SAPIENS|0|TRANSFERASE","4A9T|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4A9U|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.48|HOMO SAPIENS|0|TRANSFERASE","4BDA|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|TRANSFERASE","4BDB|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","4BDC|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","4BDD|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.67|HOMO SAPIENS|0|TRANSFERASE","4BDE|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.55|HOMO SAPIENS|0|TRANSFERASE","4BDF|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4BDG|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.84|HOMO SAPIENS|0|TRANSFERASE","4BDH|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4BDI|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.32|HOMO SAPIENS|0|TRANSFERASE","4BDJ|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3.01|HOMO SAPIENS|0|TRANSFERASE","4BDK|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3.3|HOMO SAPIENS|0|TRANSFERASE"]},{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["1DJS|LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1|X-RAY DIFFRACTION|2.4|Homo sapiens|0|HORMONE/GROWTH FACTOR/RECEPTOR","1E0O|CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|GROWTH FACTOR","1EV2|CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1GJO|The FGFr2 tyrosine kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1II4|CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.7|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1IIL|CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.3|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1NUN|Crystal Structure Analysis of the FGF10-FGFR2b Complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HORMONE/GROWTH FACTOR/MEMBRANE PROTEIN","1OEC|FGFr2 kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1WVZ|Solution Structure of the D2 Domain of the Fibroblast Growth Factor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2FDB|Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c|X-RAY DIFFRACTION|2.28|Homo sapiens|0|HORMONE/GROWTH FACTOR/TRANSFERASE","2PSQ|Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PVF|Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2PVY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","2PWL|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PY3|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","2PZ5|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZP|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZR|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","2Q0B|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3B2T|Structure of phosphotransferase|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3CAF|Crystal Structure of hFGFR2 D2 Domain|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","3CLY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3CU1|Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Hormone","3DAR|Crystal structure of D2 domain from human FGFR2|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","3EUU|Crystal structure of the FGFR2 D2 domain|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3OJ2|Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation|X-RAY DIFFRACTION|2.2|Homo sapiens|0|Cytokine/Signaling Protein","3OJM|Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Cytokine/Signaling Protein","3RI1|Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Transferase/Transferase Inhibitor","4J23|Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex|X-RAY DIFFRACTION|3.882|Homo sapiens|0|SIGNALING PROTEIN/transferase","4J95|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.|X-RAY DIFFRACTION|2.3767|Homo sapiens|0|TRANSFERASE","4J96|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.|X-RAY DIFFRACTION|2.2972|Homo sapiens|0|TRANSFERASE","4J97|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.|X-RAY DIFFRACTION|2.5482|Homo sapiens|0|TRANSFERASE","4J98|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.|X-RAY DIFFRACTION|2.3067|Homo sapiens|0|TRANSFERASE","4J99|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.|X-RAY DIFFRACTION|1.8474|Homo sapiens|0|TRANSFERASE","4WV1|Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3|X-RAY DIFFRACTION|2.362|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","5EG3|Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)|X-RAY DIFFRACTION|2.606|Homo sapiens; Rattus norvegicus|0|Transferase/Hydrolase","5UGL|Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation|X-RAY DIFFRACTION|1.861|Homo sapiens|0|TRANSFERASE","5UGX|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.349|Homo sapiens|0|TRANSFERASE","5UHN|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.909|Homo sapiens|0|TRANSFERASE","5UI0|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE","6AGX|The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE/INHIBITOR","6LVK|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.29|Homo sapiens|0|TRANSFERASE","6LVL|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE","6V6Q|Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657|X-RAY DIFFRACTION|2.46|Homo sapiens|0|TRANSFERASE","7KIA|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 19|X-RAY DIFFRACTION|2.22|Homo sapiens|0|SIGNALING PROTEIN","7KIE|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3|X-RAY DIFFRACTION|2.47|Homo sapiens|0|SIGNALING PROTEIN","7OZY|FGFR2 kinase domain (residues 461-763) in complex with 38.|X-RAY DIFFRACTION|2.28|Homo sapiens|0|TRANSFERASE","8E1X|FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)|X-RAY DIFFRACTION|2.68|Homo sapiens|0|STRUCTURAL PROTEIN","8H75|FGFR2 in complex with YJ001|X-RAY DIFFRACTION|3.75|Homo sapiens|0|TRANSFERASE","8STG|Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations|X-RAY DIFFRACTION|3.79|Homo sapiens|0|TRANSFERASE/INHIBITOR","8SWE|FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3|X-RAY DIFFRACTION|2.24|Homo sapiens|0|ONCOPROTEIN","8U1F|FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10|X-RAY DIFFRACTION|3.33|Homo sapiens|0|Transferase/Inhibitor","8W2X|TAS-120 covalent structure with FGFR2|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W38|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3B|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.23|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3D|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.04|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","9U3N|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","9U7E|FGFR2 kinase domain with a macrocyclic compound 8g|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","9U7S|FGFR2 kinase domain with a macrocyclic compound 8r|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE"]}]}