{"context":{"query":">>uniprot>>string","source_dataset":"uniprot","target_dataset":"string"},"stats":{"queried":6,"total":5,"mapped":5},"pagination":{"has_next":false},"schema":"id|preferred_name|protein_size|interaction_count|annotation","mappings":[{"input":"P60568","source":"P60568|Interleukin-2","targets":["9606.ENSP00000226730|IL2|153|6356|Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells."]},{"input":"P16410","source":"P16410|Cytotoxic T-lymphocyte protein 4","targets":["9606.ENSP00000497102|CTLA4|223|3692|Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28."]},{"input":"P17706","source":"P17706|Tyrosine-protein phosphatase non-receptor type 2","targets":["9606.ENSP00000311857|PTPN2|415|2336|Tyrosine-protein phosphatase non-receptor type 2; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the develop [...] "]},{"input":"P41597","source":"P41597|C-C chemokine receptor type 2","targets":["9606.ENSP00000292301|CCR2|374|3236|C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of matur [...] "]},{"input":"P51681","source":"P51681|C-C chemokine receptor type 5","targets":["9606.ENSP00000292303|CCR5|352|3338|C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation."]}],"not_found":["P01909"]}