{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":8,"total":337,"mapped":8},"pagination":{"has_next":true,"next_token":"-1[]Q08499,1,Q08499,158,4]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P04626","source":"P04626|Receptor tyrosine-protein kinase erbB-2","targets":["1MFG|The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor|X-RAY DIFFRACTION|1.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1MFL|The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor|X-RAY DIFFRACTION|1.88|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1MW4|Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR/TRANSFERASE","1N8Z|Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab|X-RAY DIFFRACTION|2.52|Homo sapiens; Mus musculus, Homo sapiens|0|TRANSFERASE","1QR1|POOR BINDING OF A HER-2/NEU EPITOPE (GP2) TO HLA-A2.1 IS DUE TO A LACK OF INTERACTIONS IN THE CENTER OF THE PEPTIDE|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","1S78|Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex|X-RAY DIFFRACTION|3.25|Homo sapiens; Mus musculus|0|TRANSFERASE","2A91|Crystal structure of ErbB2 domains 1-3|X-RAY DIFFRACTION|2.5|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE,MEMBRANE PROTEIN","2JWA|ErbB2 transmembrane segment dimer spatial structure|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2KS1|Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2L4K|Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2N2A|Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","3BE1|Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3H3B|Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain|X-RAY DIFFRACTION|2.45|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","3MZW|HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","3N85|Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody fragment|X-RAY DIFFRACTION|3.2|Homo sapiens|0|Transferase/immune system","3PP0|Crystal Structure of the Kinase domain of Human HER2 (erbB2).|X-RAY DIFFRACTION|2.25|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3RCD|HER2 Kinase Domain Complexed with TAK-285|X-RAY DIFFRACTION|3.21|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3WLW|Molecular Architecture of the ErbB2 Extracellular Domain Homodimer|X-RAY DIFFRACTION|3.088|Homo sapiens|0|HYDROLASE/IMMUNE SYSTEM","3WSQ|Structure of HER2 with an Fab|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4GFU|PTPN18 in complex with HER2-pY1248 phosphor-peptides|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/Peptide","4HRL|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|2.55|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4HRM|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|3.2|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4HRN|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|2.65|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4NND|Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites|X-RAY DIFFRACTION|2.502|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","5K33|Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19|X-RAY DIFFRACTION|3.3|Homo sapiens|0|IMMUNE SYSTEM","5KWG|Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6|X-RAY DIFFRACTION|4.3|Homo sapiens|0|IMMUNE SYSTEM","5MY6|Crystal structure of a HER2-Nb complex|X-RAY DIFFRACTION|2.246|Camelus dromedarius; Homo sapiens|0|TRANSFERASE","5O4G|HER2 in complex with Fab MF3958|X-RAY DIFFRACTION|3|Homo sapiens|0|ONCOPROTEIN","5OB4|NMR spatial structure of HER2 TM domain dimer in DPC micelles.|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","5TQS|Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2|X-RAY DIFFRACTION|1.876|Bos taurus; SYNTHETIC CONSTRUCT|0|HYDROLASE","6ATT|39S Fab bound to HER2 ecd|X-RAY DIFFRACTION|3.77|Homo sapiens|0|IMMUNE SYSTEM","6BGT|Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","6J71|HuA21-scFv in complex with the extracellular domain(ECD) of HER2|X-RAY DIFFRACTION|2.918|Homo sapiens|0|SIGNALING PROTEIN","6LBX|Crystal structure of HER2 Domain IV and Rb-H2|X-RAY DIFFRACTION|2.03|Cyclostomata; Homo sapiens|0|PROTEIN BINDING","6OGE|Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex|ELECTRON MICROSCOPY|4.36|Homo sapiens|0|transferase/immune system","7JXH|HER2 in complex with JBJ-08-178-01|X-RAY DIFFRACTION|3.27|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","7MN5|Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|2.93|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7MN6|Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.09|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7MN8|Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab|ELECTRON MICROSCOPY|3.45|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN/IMMUNE SYSTEM","7PCD|HER2 IN COMPLEX WITH A COVALENT INHIBITOR|X-RAY DIFFRACTION|1.77|Homo sapiens|0|TRANSFERASE","7QVK|NM-02 in complex with HER2-ECD|X-RAY DIFFRACTION|3.1|Camelus bactrianus; Homo sapiens|0|ONCOPROTEIN","8FFJ|Structure of Zanidatamab bound to HER2|ELECTRON MICROSCOPY|7.5|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","8HGO|The EGF-bound EGFR/HER2 ectodomain complex|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN","8HGP|The EREG-bound EGFR/HER2 ectodomain complex|ELECTRON MICROSCOPY|4.53|Homo sapiens|0|MEMBRANE PROTEIN","8JYQ|Crystal structure of cancer-specific anti-HER2 antibody H2Mab-214 in complex with epitope peptide|X-RAY DIFFRACTION|1.75|Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","8JYR|Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I|X-RAY DIFFRACTION|1.69|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","8PWH|Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex|ELECTRON MICROSCOPY|3.17|Homo sapiens|0|STRUCTURAL PROTEIN","8Q6J|Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|STRUCTURAL PROTEIN","8U4K|Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|4.27|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U4L|Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U8X|crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27|X-RAY DIFFRACTION|1.69|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE/INHIBITOR","8VB5|Crystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib|X-RAY DIFFRACTION|1.48|Homo sapiens|0|TRANSFERASE","8VQD|HER2 S310F in complex with TL1 Fab|ELECTRON MICROSCOPY|2.61|Homo sapiens|0|SIGNALING PROTEIN","8VQE|Homodimeric structure of HER2 S310F extracellular region|ELECTRON MICROSCOPY|2.67|Homo sapiens|0|SIGNALING PROTEIN","9IUT|Crystal structure of cancer-specific anti-HER2 antibody H2Mab-250 in complex with epitope peptide|X-RAY DIFFRACTION|2.09|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","9L1S|Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|IMMUNE SYSTEM","9MTE|CryoEM structure of extracellular domain of human HER2 complexed with two nano-bodies 27A05 and 47D05|ELECTRON MICROSCOPY|2.66|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","9MTX|CryoEM structure of extracellular domain of human HER2 complexed with nano-bodies 29E09|ELECTRON MICROSCOPY|3.06|Homo sapiens; Lama glama|0|TRANSFERASE","9QBF|HER2/ErbB2 extracellular domain (ECD) in compact conformation in complex with trastuzumab (TZB) antibody|ELECTRON MICROSCOPY|3.8|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN","9QBG|HER2/ErbB2 extracellular domain (ECD) in extended conformation in complex with trastuzumab (TZB) antibody|ELECTRON MICROSCOPY|3.6|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN","9QBH|HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.|ELECTRON MICROSCOPY|3.77|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["1DJS|LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1|X-RAY DIFFRACTION|2.4|Homo sapiens|0|HORMONE/GROWTH FACTOR/RECEPTOR","1E0O|CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|GROWTH FACTOR","1EV2|CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1GJO|The FGFr2 tyrosine kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1II4|CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.7|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1IIL|CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.3|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1NUN|Crystal Structure Analysis of the FGF10-FGFR2b Complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HORMONE/GROWTH FACTOR/MEMBRANE PROTEIN","1OEC|FGFr2 kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1WVZ|Solution Structure of the D2 Domain of the Fibroblast Growth Factor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2FDB|Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c|X-RAY DIFFRACTION|2.28|Homo sapiens|0|HORMONE/GROWTH FACTOR/TRANSFERASE","2PSQ|Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PVF|Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2PVY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","2PWL|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PY3|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","2PZ5|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZP|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZR|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","2Q0B|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3B2T|Structure of phosphotransferase|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3CAF|Crystal Structure of hFGFR2 D2 Domain|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","3CLY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3CU1|Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Hormone","3DAR|Crystal structure of D2 domain from human FGFR2|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","3EUU|Crystal structure of the FGFR2 D2 domain|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3OJ2|Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation|X-RAY DIFFRACTION|2.2|Homo sapiens|0|Cytokine/Signaling Protein","3OJM|Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Cytokine/Signaling Protein","3RI1|Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Transferase/Transferase Inhibitor","4J23|Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex|X-RAY DIFFRACTION|3.882|Homo sapiens|0|SIGNALING PROTEIN/transferase","4J95|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.|X-RAY DIFFRACTION|2.3767|Homo sapiens|0|TRANSFERASE","4J96|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.|X-RAY DIFFRACTION|2.2972|Homo sapiens|0|TRANSFERASE","4J97|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.|X-RAY DIFFRACTION|2.5482|Homo sapiens|0|TRANSFERASE","4J98|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.|X-RAY DIFFRACTION|2.3067|Homo sapiens|0|TRANSFERASE","4J99|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.|X-RAY DIFFRACTION|1.8474|Homo sapiens|0|TRANSFERASE","4WV1|Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3|X-RAY DIFFRACTION|2.362|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","5EG3|Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)|X-RAY DIFFRACTION|2.606|Homo sapiens; Rattus norvegicus|0|Transferase/Hydrolase","5UGL|Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation|X-RAY DIFFRACTION|1.861|Homo sapiens|0|TRANSFERASE","5UGX|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.349|Homo sapiens|0|TRANSFERASE","5UHN|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.909|Homo sapiens|0|TRANSFERASE","5UI0|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE","6AGX|The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE/INHIBITOR","6LVK|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.29|Homo sapiens|0|TRANSFERASE","6LVL|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE","6V6Q|Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657|X-RAY DIFFRACTION|2.46|Homo sapiens|0|TRANSFERASE","7KIA|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 19|X-RAY DIFFRACTION|2.22|Homo sapiens|0|SIGNALING PROTEIN","7KIE|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3|X-RAY DIFFRACTION|2.47|Homo sapiens|0|SIGNALING PROTEIN","7OZY|FGFR2 kinase domain (residues 461-763) in complex with 38.|X-RAY DIFFRACTION|2.28|Homo sapiens|0|TRANSFERASE","8E1X|FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)|X-RAY DIFFRACTION|2.68|Homo sapiens|0|STRUCTURAL PROTEIN","8H75|FGFR2 in complex with YJ001|X-RAY DIFFRACTION|3.75|Homo sapiens|0|TRANSFERASE","8STG|Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations|X-RAY DIFFRACTION|3.79|Homo sapiens|0|TRANSFERASE/INHIBITOR","8SWE|FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3|X-RAY DIFFRACTION|2.24|Homo sapiens|0|ONCOPROTEIN","8U1F|FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10|X-RAY DIFFRACTION|3.33|Homo sapiens|0|Transferase/Inhibitor","8W2X|TAS-120 covalent structure with FGFR2|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W38|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3B|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.23|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3D|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.04|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","9U3N|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","9U7E|FGFR2 kinase domain with a macrocyclic compound 8g|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","9U7S|FGFR2 kinase domain with a macrocyclic compound 8r|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE"]},{"input":"O96017","source":"O96017|Serine/threonine-protein kinase Chk2","targets":["1GXC|FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide|X-RAY DIFFRACTION|2.7|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|PHOSPHOPROTEIN-BINDING DOMAIN","2CN5|Crystal structure of human Chk2 in complex with ADP|X-RAY DIFFRACTION|2.25|HOMO SAPIENS|0|TRANSFERASE","2CN8|Crystal structure of human Chk2 in complex with debromohymenialdisine|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","2W0J|Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","2W7X|Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019|X-RAY DIFFRACTION|2.07|HOMO SAPIENS|0|TRANSFERASE","2WTC|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","2WTD|Crystal structure of Chk2 in complex with an inhibitor|X-RAY DIFFRACTION|2.75|HOMO SAPIENS|0|TRANSFERASE","2WTI|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2WTJ|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","2XBJ|Crystal Structure of Chk2 in complex with an inhibitor|X-RAY DIFFRACTION|2.3|HOMO SAPIENS|0|TRANSFERASE","2XK9|Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533|X-RAY DIFFRACTION|2.35|HOMO SAPIENS|0|TRANSFERASE","2XM8|Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2|X-RAY DIFFRACTION|3.4|HOMO SAPIENS|0|TRANSFERASE","2XM9|Structure of a small molecule inhibitor with the kinase domain of Chk2|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2YCF|Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531|X-RAY DIFFRACTION|1.77|HOMO SAPIENS|0|TRANSFERASE","2YCQ|Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","2YCR|Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","2YCS|Crystal structure of checkpoint kinase 2 in complex with PV788|X-RAY DIFFRACTION|2.35|HOMO SAPIENS|0|TRANSFERASE","2YIQ|Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322|X-RAY DIFFRACTION|1.89|HOMO SAPIENS|0|TRANSFERASE","2YIR|Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","2YIT|Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","3I6U|Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","3I6W|Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","3VA4|Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide|X-RAY DIFFRACTION|1.54|Mus musculus; SYNTHETIC CONSTRUCT|0|CELL CYCLE","4A9R|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","4A9S|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.66|HOMO SAPIENS|0|TRANSFERASE","4A9T|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4A9U|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.48|HOMO SAPIENS|0|TRANSFERASE","4BDA|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|TRANSFERASE","4BDB|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","4BDC|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","4BDD|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.67|HOMO SAPIENS|0|TRANSFERASE","4BDE|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.55|HOMO SAPIENS|0|TRANSFERASE","4BDF|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4BDG|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.84|HOMO SAPIENS|0|TRANSFERASE","4BDH|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4BDI|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.32|HOMO SAPIENS|0|TRANSFERASE","4BDJ|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3.01|HOMO SAPIENS|0|TRANSFERASE","4BDK|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3.3|HOMO SAPIENS|0|TRANSFERASE"]},{"input":"Q08499","source":"Q08499|3',5'-cyclic-AMP phosphodiesterase 4D","targets":["1E9K|The structure of the RACK1 interaction sites located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.|SOLUTION NMR|||0|HYDROLASE","1MKD|crystal structure of PDE4D catalytic domain and zardaverine complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HYDROLASE","1OYN|Crystal structure of PDE4D2 in complex with (R,S)-rolipram|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","1PTW|The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","1Q9M|Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","1TB7|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With AMP|X-RAY DIFFRACTION|1.63|Homo sapiens|0|HYDROLASE","1TBB|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram|X-RAY DIFFRACTION|1.6|Homo sapiens|0|HYDROLASE","1XOM|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast|X-RAY DIFFRACTION|1.55|Homo sapiens|0|HYDROLASE","1XON|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast|X-RAY DIFFRACTION|1.72|Homo sapiens|0|HYDROLASE","1XOQ|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast|X-RAY DIFFRACTION|1.83|Homo sapiens|0|HYDROLASE","1XOR|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine|X-RAY DIFFRACTION|1.54|Homo sapiens|0|HYDROLASE","1Y2B|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.4|Homo sapiens|0|HYDROLASE","1Y2C|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.67|Homo sapiens|0|HYDROLASE","1Y2D|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE","1Y2E|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-amino-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","1Y2K|Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester|X-RAY DIFFRACTION|1.36|Homo sapiens|0|HYDROLASE","1ZKN|Structure of PDE4D2-IBMX|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","2FM0|Crystal structure of PDE4D in complex with L-869298|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","2FM5|Crystal structure of PDE4D2 in complex with inhibitor L-869299|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","2PW3|Structure of the PDE4D-cAMP complex|X-RAY DIFFRACTION|1.56|Homo sapiens|0|HYDROLASE","2QYN|Crystal structure of PDE4D2 in complex with inhibitor NPV|X-RAY DIFFRACTION|1.57|Homo sapiens|0|HYDROLASE","3G4G|Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE","3G4I|Crystal structure of human phosphodiesterase 4d with d155871|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HYDROLASE","3G4K|Crystal structure of human phosphodiesterase 4d with rolipram|X-RAY DIFFRACTION|1.95|Homo sapiens|0|HYDROLASE","3G4L|Crystal structure of human phosphodiesterase 4d with roflumilast|X-RAY DIFFRACTION|2.5|Homo sapiens|0|HYDROLASE","3G58|Crystal structure of human phosphodiesterase 4d with d155988/pmnpq|X-RAY DIFFRACTION|2.05|Homo sapiens|0|HYDROLASE","3IAD|Crystal structure of human phosphodiesterase 4D with bound allosteric modulator|X-RAY DIFFRACTION|2.65|Homo sapiens|0|HYDROLASE","3IAK|Crystal structure of human phosphodiesterase 4d (PDE4d) with papaverine.|X-RAY DIFFRACTION|2.8|Homo sapiens|0|HYDROLASE","3K4S|The structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone|X-RAY DIFFRACTION|2.05|Homo sapiens|0|HYDROLASE","3SL3|Crystal structure of the apo form of the catalytic domain of PDE4D2|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","3SL4|Crystal structure of the catalytic domain of PDE4D2 with compound 10D|X-RAY DIFFRACTION|1.9|Homo sapiens|0|Hydrolase/Inhibitor","3SL5|Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d|X-RAY DIFFRACTION|2.65|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","3SL6|Crystal structure of the catalytic domain of PDE4D2 with compound 12c|X-RAY DIFFRACTION|2.44|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","3SL8|Crystal structure of the catalytic domain of PDE4D2 with compound 10o|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","3V9B|Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","4OGB|Crystal structure of the catalytic domain of PDE4D2 with compound 2|X-RAY DIFFRACTION|2.032|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","4W1O|PDE4D complexed with inhibitor|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HYDROLASE","4WCU|PDE4 complexed with inhibitor|X-RAY DIFFRACTION|2.35|Homo sapiens|0|HYDROLASE","5K1I|PDE4 crystal structure in complex with small molecule inhibitor|X-RAY DIFFRACTION|2.61|Homo sapiens|0|HYDROLASE","5K32|PDE4D crystal structure in complex with small molecule inhibitor|X-RAY DIFFRACTION|1.99|Homo sapiens|0|HYDROLASE","5LBO|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001|X-RAY DIFFRACTION|2.25|Homo sapiens|0|HYDROLASE","5TKB|CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND|X-RAY DIFFRACTION|2.16|Homo sapiens|0|HYDROLASE/HYDROLASE inhibitor","5WH5|Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91|X-RAY DIFFRACTION|1.8|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","5WH6|Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)|X-RAY DIFFRACTION|1.6|Homo sapiens|0|Hydrolase/Hydrolase Inhibitor","5WQA|Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE/INHIBITOR","6AKR|Crystal structure of the PDE4D catalytic domain in complex with osthole|X-RAY DIFFRACTION|2.326|Homo sapiens|0|HYDROLASE","6BOJ|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN5004|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6F6U|Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b|X-RAY DIFFRACTION|1.828|Homo sapiens|0|HYDROLASE","6F8R|Crystal structure of the PDE4D catalytic domain in complex with GEBR-54|X-RAY DIFFRACTION|1.826|Homo sapiens|0|HYDROLASE","6F8T|Crystal structure of the PDE4D catalytic domain in complex with GEBR-4a|X-RAY DIFFRACTION|1.8|Homo sapiens|0|HYDROLASE","6F8U|Crystal structure of the PDE4D catalytic domain in complex with GEBR-20b|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","6F8V|Crystal structure of the PDE4D catalytic domain in complex with GEBR-18b|X-RAY DIFFRACTION|1.85|Homo sapiens|0|HYDROLASE","6F8W|Crystal structure of the PDE4D catalytic domain in complex with GEBR-18a|X-RAY DIFFRACTION|1.601|Homo sapiens|0|HYDROLASE","6F8X|Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g|X-RAY DIFFRACTION|1.95|Homo sapiens|0|HYDROLASE","6FDC|Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a|X-RAY DIFFRACTION|1.45|Homo sapiens|0|HYDROLASE","6FDI|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-226|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HYDROLASE","6FE7|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-356|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","6FEB|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1086|X-RAY DIFFRACTION|1.93|Homo sapiens|0|HYDROLASE","6FET|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1439|X-RAY DIFFRACTION|1.88|Homo sapiens|0|HYDROLASE","6FT0|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-425|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HYDROLASE","6FTA|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-3098|X-RAY DIFFRACTION|2.34|Homo sapiens|0|HYDROLASE","6FTW|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-048|X-RAY DIFFRACTION|2.16|Homo sapiens|0|HYDROLASE","6FW3|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007|X-RAY DIFFRACTION|1.78|Homo sapiens|0|HYDROLASE","6HWO|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335|X-RAY DIFFRACTION|1.99|Homo sapiens|0|HYDROLASE","6IAG|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-637|X-RAY DIFFRACTION|2|Homo sapiens|0|HYDROLASE","6IBF|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-417|X-RAY DIFFRACTION|2.31|Homo sapiens|0|HYDROLASE","6IM6|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.702|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMB|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.549|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMD|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.499|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMI|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.46|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMO|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.55|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMR|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.503|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IMT|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.483|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6IND|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.872|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6INK|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6INM|Crystal structure of PDE4D complexed with a novel inhibitor|X-RAY DIFFRACTION|1.999|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6KJZ|Crystal structure of PDE4D catalytic domain complexed with compound 1|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HYDROLASE","6KK0|Crystal structure of PDE4D catalytic domain complexed with compound 4e|X-RAY DIFFRACTION|2.20009|Homo sapiens|0|HYDROLASE","6LRM|Crystal structure of PDE4D catalytic domain in complex with arctigenin|X-RAY DIFFRACTION|1.45|Homo sapiens|0|HYDROLASE","6NJH|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48|X-RAY DIFFRACTION|2.15|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6NJI|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-49|X-RAY DIFFRACTION|2.45|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6NJJ|Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN14770|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6RCW|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-053|X-RAY DIFFRACTION|2.08|Homo sapiens|0|HYDROLASE","6ZBA|Crystal structure of PDE4D2 in complex with inhibitor LEO39652|X-RAY DIFFRACTION|1.6|Homo sapiens|0|HYDROLASE","7A8Q|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-654|X-RAY DIFFRACTION|2.24|Homo sapiens|0|HYDROLASE","7A9V|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-635|X-RAY DIFFRACTION|2.17|Homo sapiens|0|HYDROLASE","7AAG|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-617|X-RAY DIFFRACTION|1.79|Homo sapiens|0|HYDROLASE","7AB9|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-656|X-RAY DIFFRACTION|2.19|Homo sapiens|0|HYDROLASE","7ABD|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-768|X-RAY DIFFRACTION|2.41|Homo sapiens|0|HYDROLASE","7ABE|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-769|X-RAY DIFFRACTION|1.83|Homo sapiens|0|HYDROLASE","7ABJ|Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1361|X-RAY DIFFRACTION|2.11|Homo sapiens|0|HYDROLASE","7AY6|Crystal structure of the PDE4D catalytic domain in complex with GEBR-41b|X-RAY DIFFRACTION|1.66|Homo sapiens|0|HYDROLASE","7B9H|Crystal structure of the PDE4D catalytic domain in complex with GEBR-42a|X-RAY DIFFRACTION|1.5|Homo sapiens|0|HYDROLASE","7CBJ|Crystal structure of PDE4D catalytic domain in complex with compound 36|X-RAY DIFFRACTION|1.5|Homo sapiens|0|HYDROLASE","7CBQ|Crystal structure of PDE4D catalytic domain in complex with Apremilast|X-RAY DIFFRACTION|1.59|Homo sapiens|0|HYDROLASE","7F2K|Crystal structure of PDE4D catalytic domain complexed with compound 17a|X-RAY DIFFRACTION|2.10002|Homo sapiens|0|HYDROLASE","7F2L|Crystal structure of PDE4D catalytic domain complexed with compound 18a|X-RAY DIFFRACTION|2.10111|Homo sapiens|0|HYDROLASE","7F2M|Crystal structure of PDE4D catalytic domain complexed with compound 18d|X-RAY DIFFRACTION|2.20004|Homo sapiens|0|HYDROLASE","7W4X|Crystal structure of PDE4D catalytic domain complexed with 17|X-RAY DIFFRACTION|2.20007|Homo sapiens|0|HYDROLASE","7W4Y|Crystal structure of PDE4D catalytic domain complexed with 33a|X-RAY DIFFRACTION|2.10003|Homo sapiens|0|HYDROLASE"]},{"input":"P17706","source":"P17706|Tyrosine-protein phosphatase non-receptor type 2","targets":["1L8K|T Cell Protein-Tyrosine Phosphatase Structure|X-RAY DIFFRACTION|2.56|Homo sapiens|0|HYDROLASE","6ZZ4|Crystal structure of the PTPN2 C216G mutant|X-RAY DIFFRACTION|2.43|Homo sapiens|0|SIGNALING PROTEIN","7F5N|Crystal structure of TCPTP catalytic domain|X-RAY DIFFRACTION|1.93|Homo sapiens|0|HYDROLASE","7F5O|Crystal structure of PTPN2 catalytic domain|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HYDROLASE","7UAD|Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484|X-RAY DIFFRACTION|2.044|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8U0H|Crystal structure of PTPN2 with a PROTAC|X-RAY DIFFRACTION|1.93|Homo sapiens|0|HYDROLASE","8UH6|Degrader-induced complex between PTPN2 and CRBN-DDB1|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|HYDROLASE","9C54|Crystal structure of human PTPN2 catalytic domain|X-RAY DIFFRACTION|2.05|Homo sapiens|0|HYDROLASE","9C55|Crystal structure of human PTPN2 in complex with active site inhibitor|X-RAY DIFFRACTION|2.36|Homo sapiens|0|HYDROLASE/INHIBITOR","9C56|Crystal structure of human PTPN2 in complex with allosteric inhibitor|X-RAY DIFFRACTION|2.43|Homo sapiens|0|HYDROLASE/INHIBITOR","9UZT|Crystal structure of human PTPN2 with inhibitor K-38|X-RAY DIFFRACTION|2.17|Homo sapiens|0|IMMUNE SYSTEM","9VRR|Crystal structure of human PTPN2 with inhibitor WS3|X-RAY DIFFRACTION|1.95|Homo sapiens|0|IMMUNE SYSTEM","9VRS|Crystal structure of human PTPN2 with inhibitor WS19|X-RAY DIFFRACTION|2|Homo sapiens|0|IMMUNE SYSTEM"]},{"input":"Q14790","source":"Q14790|Caspase-8","targets":["1F9E|CASPASE-8 SPECIFICITY PROBED AT SUBSITE S4: CRYSTAL STRUCTURE OF THE CASPASE-8-Z-DEVD-CHO|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","1I4E|CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX|X-RAY DIFFRACTION|3|Autographa californica nucleopolyhedrovirus; Homo sapiens|0|APOPTOSIS/HYDROLASE","1QDU|CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","1QTN|CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TETRAPEPTIDE INHIBITOR ACE-IETD-ALDEHYDE|X-RAY DIFFRACTION|1.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","2C2Z|Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor|X-RAY DIFFRACTION|1.95|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","2FUN|alternative p35-caspase-8 complex|X-RAY DIFFRACTION|3|Autographa californica nucleopolyhedrovirus; Homo sapiens|0|APOPTOSIS/HYDROLASE","2K7Z|Solution Structure of the Catalytic Domain of Procaspase-8|SOLUTION NMR||Homo sapiens|0|HYDROLASE","2Y1L|Caspase-8 in Complex with DARPin-8.4|X-RAY DIFFRACTION|1.8|; Homo sapiens; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT|0|HYDROLASE/INHIBITOR","3H11|Zymogen caspase-8:c-FLIPL protease domain complex|X-RAY DIFFRACTION|1.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS","3KJN|Caspase 8 bound to a covalent inhibitor|X-RAY DIFFRACTION|1.8|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","3KJQ|Caspase 8 with covalent inhibitor|X-RAY DIFFRACTION|1.8|Homo sapiens|0|HYDROLASE","4JJ7|Caspase-3 specific unnatural amino acid-based peptides|X-RAY DIFFRACTION|1.178|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","4PRZ|Caspase-8 specific unnatural amino acid peptides|X-RAY DIFFRACTION|2.123|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","4PS1|Caspase-8 specific unnatural amino acid peptides|X-RAY DIFFRACTION|1.731|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","4ZBW|Crystal structure of death effector domain of Caspase8 in Homo Sapiens|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HYDROLASE","5H31|Structural basis for dimerization of the death effector domains of Caspase-8|X-RAY DIFFRACTION|3.16954|Homo sapiens|0|HYDROLASE","5H33|Structural basis for dimerization of the death effector domains of Caspase-8|X-RAY DIFFRACTION|3.60014|Homo sapiens|0|HYDROLASE","5JQE|Crystal structure of caspase8 tDED|X-RAY DIFFRACTION|3.157|Escherichia coli, Homo sapiens|0|HYDROLASE","5L08|Cryo-EM structure of Casp-8 tDED filament|ELECTRON MICROSCOPY|4.6|Homo sapiens|0|APOPTOSIS","6AGW|Pro-domain of Caspase-8|X-RAY DIFFRACTION|2.093|Homo sapiens|0|HYDROLASE","6PX9|Crystal structure of procaspase-8 in complex with covalent small molecule inhibitor 63-R|X-RAY DIFFRACTION|2.88|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","6X8H|Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct|X-RAY DIFFRACTION|1.48|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","7DEE|Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8|SOLUTION NMR||Homo sapiens|0|APOPTOSIS","7LVJ|CASP8 isoform G DED domain|X-RAY DIFFRACTION|1.5|Homo sapiens|0|HYDROLASE","7LVM|CASP8 isoform B DED domain|X-RAY DIFFRACTION|1.47|Homo sapiens|0|HYDROLASE","8YBX|Structure of the FADD/Caspase-8/cFLIP death effector domain assembly|ELECTRON MICROSCOPY|3.68|Homo sapiens|0|APOPTOSIS","8YD7|Structure of FADD/Caspase-8/cFLIP death effector domain assembly|X-RAY DIFFRACTION|3.32|Homo sapiens|0|APOPTOSIS","8YD8|Structure of FADD/Caspase-8/cFLIP death effector domain assembly|X-RAY DIFFRACTION|3.11|Homo sapiens|0|APOPTOSIS","8YM4|Structure of Caspase-8/cFLIP death effector domain assembly|X-RAY DIFFRACTION|2.34|Homo sapiens|0|APOPTOSIS","8YM5|Structure of Caspase-8/cFLIP death effector domain assembly|X-RAY DIFFRACTION|2.09|Homo sapiens|0|APOPTOSIS","8YM6|Structure of Caspase-8/cFLIP death effector domain assembly|X-RAY DIFFRACTION|3.3|Homo sapiens|0|APOPTOSIS","8YNI|Structure of the FADD/Caspase-8/cFLIP death effector domain assembly|ELECTRON MICROSCOPY|3.66|Homo sapiens|0|APOPTOSIS","8YNK|Structure of the Caspase-8/cFLIP death effector domain assembly|ELECTRON MICROSCOPY|3.62|Homo sapiens|0|APOPTOSIS","8YNL|Structure of the Caspase-8/cFLIP death effector domain assembly|ELECTRON MICROSCOPY|3.55|Homo sapiens|0|APOPTOSIS","8YNM|Structure of the Caspase-8/cFLIP death effector domain assembly|ELECTRON MICROSCOPY|3.49|Homo sapiens|0|APOPTOSIS","8YNN|Structure of the Caspase-8/cFLIP death effector domain assembly|ELECTRON MICROSCOPY|3.97|Homo sapiens|0|APOPTOSIS"]},{"input":"P37173","source":"P37173|TGF-beta receptor type-2","targets":["1KTZ|Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3|X-RAY DIFFRACTION|2.15|Homo sapiens|0|CYTOKINE/CYTOKINE RECEPTOR","1M9Z|CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN|X-RAY DIFFRACTION|1.05|Homo sapiens|0|HORMONE/GROWTH FACTOR","1PLO|TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAIN|SOLUTION NMR||Homo sapiens|0|Cytokine receptor","2PJY|Structural basis for cooperative assembly of the TGF-beta signaling complex|X-RAY DIFFRACTION|3|Homo sapiens|0|CYTOKINE/CYTOKINE RECEPTOR","3KFD|Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily|X-RAY DIFFRACTION|2.995|Homo sapiens|0|CYTOKINE/CYTOKINE RECEPTOR","4P7U|Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with NDSB-201|X-RAY DIFFRACTION|1.502|Homo sapiens|0|SIGNALING PROTEIN","4XJJ|Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201|X-RAY DIFFRACTION|1.4|Homo sapiens|0|Cytokine Receptor","5E8V|TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A)|X-RAY DIFFRACTION|1.69|Homo sapiens|0|TRANSFERASE","5E8Y|TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH STAUROSPORINE|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5E91|TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH 3-AMINO-6-[4-(2- HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL] PYRAZINE-2-CARBOXAMIDE|X-RAY DIFFRACTION|2.42|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5E92|TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH AMPPNP|X-RAY DIFFRACTION|2.08|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5QIN|TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE|X-RAY DIFFRACTION|1.57|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5TX4|Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130|X-RAY DIFFRACTION|1.876|Homo sapiens|0|TRANSFERASE/CYTOKINE","5TY4|MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution|ELECTRON CRYSTALLOGRAPHY|2.9|Homo sapiens|0|TRANSFERASE","7DV6|Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents|X-RAY DIFFRACTION|2.39|Homo sapiens|0|IMMUNE SYSTEM","8G4K|Complex of TbRII mini protein binder bound to the TbRII ECD|X-RAY DIFFRACTION|1.24|Homo sapiens; synthetic construct|0|SIGNALING PROTEIN","8YGZ|The Crystal Structure of TGF beta R2 kinase domain from Biortus.|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","9B9F|Zebrafish Betaglycan Orphan Domain (zfBGo) in complex with TGF-B3 and extracellular domains of TGFBRI and TGFBRII|X-RAY DIFFRACTION|3|Danio rerio; Homo sapiens|0|MEMBRANE PROTEIN","9E9G|Heligmosomoides polygyrus TGF-beta Mimic 6 Domain 3 (TGM6-D3) Bound to Human TGF-beta Type II Receptor Extracellular Domain|X-RAY DIFFRACTION|1.4|Heligmosomoides polygyrus; Homo sapiens|0|IMMUNOSUPPRESSANT","9FDY|Betaglycan Orphan Domain (ratBGo) in complex with TGF-b1 and extracellular domain of TGFBRII|ELECTRON MICROSCOPY|3.4|Homo sapiens; Rattus norvegicus|0|MEMBRANE PROTEIN","9FK5|Zebrafish Betaglycan Orphan Domain (zfBGo) in complex with TGF-B3 and extracellular domains of TGFBRI and TGFBRII|ELECTRON MICROSCOPY|4.1|Danio rerio; Homo sapiens|0|MEMBRANE PROTEIN","9FKP|Zebrafish Betaglycan Orphan Domain (zfBGo) in complex with TGF-b1 and extracellular domain of TGFBRII|ELECTRON MICROSCOPY|3.72|Danio rerio; Homo sapiens|0|MEMBRANE PROTEIN"]},{"input":"P42224","source":"P42224|Signal transducer and activator of transcription 1-alpha/beta","targets":["1BF5|TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX|X-RAY DIFFRACTION|2.9|Homo sapiens|0|GENE REGULATION/DNA","1YVL|Structure of Unphosphorylated STAT1|X-RAY DIFFRACTION|3|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2KA6|NMR structure of the CBP-TAZ2/STAT1-TAD complex|SOLUTION NMR||Homo sapiens; Mus musculus|0|TRANSCRIPTION REGULATOR","3WWT|Crystal Structure of the Y3:STAT1ND complex|X-RAY DIFFRACTION|2|Homo sapiens; Sendai virus (Z)|0|TRANSCRIPTION/VIRAL PROTEIN","7NUF|Vaccinia virus protein 018 in complex with STAT1|X-RAY DIFFRACTION|2.0004|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","8D3F|Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST|X-RAY DIFFRACTION|2.97|Homo sapiens; Toxoplasma gondii GT1|0|TRANSCRIPTION","8YYU|A tetrameric STAT1-DNA complex|ELECTRON MICROSCOPY|3.84|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","8YYV|A dimeric STAT1-DNA complex|ELECTRON MICROSCOPY|3.07|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM"]}]}